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Determining the change in functional outcome score and CT fusion ratio following arthroscopic subtalar arthrodesis: A prospective observational study 确定关节镜距下关节融合术后功能结局评分和CT融合率的变化:一项前瞻性观察研究
Q2 Medicine Pub Date : 2025-11-20 DOI: 10.1016/j.jcot.2025.103280
Bishwa Bandhu Niraula , Anil Regmi , Shivam Bansal , Saptarshi Barman , Rohan Gowda , Pradeep Kumar Meena

Background

This study aimed to evaluate the change in foot and ankle functional outcome scores and the CT fusion ratio after Posterior Arthroscopic Subtalar Arthrodesis (PASTA) in patients with isolated subtalar arthritis.

Methods

A prospective observational study was conducted from March 2021 to March 2023, enrolling 20 patients (12 males, 8 females) with posttraumatic or degenerative isolated subtalar arthritis. Functional outcomes were assessed at 6 weeks, 3 months, and 6 months postoperatively using AOFAS, FADI, FAOS, and VAS scores. Fusion was assessed via CT scan at 6 months to calculate the CT fusion ratio.

Results

Functional outcomes significantly improved over time. The mean AOFAS score increased from 48.0 ± 8.53 preoperatively to 83.8 ± 9.73 at 6 months. The mean FADI and FAOS scores improved from 42.85 ± 7.11 and 43.35 ± 8.78 preoperatively to 86.5 ± 11.38 and 86.75 ± 11.15, respectively, at 6 months. The VAS score decreased from a mean of 4.9 ± 0.89 at 6 weeks to 1.6 at 6 months. The mean CT fusion ratio at 6 months was 65.39 % ± 13.98 %. Only one patient showed a fusion ratio below 33 % and later required ankle arthrodesis. A significant positive correlation was observed between CT fusion ratio and AOFAS (ρ = 0.64, p = 0.002), FADI (ρ = 0.55, p = 0.010), and FAOS (ρ = 0.45, p = 0.043). Most patients rated satisfaction as “excellent” at final follow-up. Minor complications such as transient pain and swelling were observed but resolved over time.

Conclusion

Arthroscopic subtalar arthrodesis significantly improved functional outcomes and demonstrated a high CT fusion rate with minimal complications in patients with isolated subtalar arthritis.

Level of evidence

Level III.
本研究旨在评估孤立性距下关节炎患者后路关节镜距下关节融合术(PASTA)后足部和踝关节功能评分和CT融合率的变化。方法前瞻性观察研究于2021年3月至2023年3月进行,纳入20例创伤后或退行性孤立距下关节炎患者(男性12例,女性8例)。分别在术后6周、3个月和6个月使用AOFAS、FADI、FAOS和VAS评分评估功能结局。6个月时通过CT扫描评估融合情况,计算CT融合率。结果:随着时间的推移,功能预后显著改善。平均AOFAS评分由术前的48.0±8.53分上升至6个月时的83.8±9.73分。6个月时,FADI和FAOS平均评分分别从术前的42.85±7.11和43.35±8.78提高到86.5±11.38和86.75±11.15。VAS评分从6周时的平均4.9±0.89降至6个月时的1.6。6个月平均CT融合率为65.39%±13.98%。只有1例患者融合率低于33%,随后需要进行踝关节融合术。CT融合率与AOFAS (ρ = 0.64, p = 0.002)、FADI (ρ = 0.55, p = 0.010)、FAOS (ρ = 0.45, p = 0.043)呈正相关。在最后的随访中,大多数患者的满意度为“优秀”。观察到轻微的并发症,如短暂的疼痛和肿胀,但随着时间的推移而消退。结论关节镜下距下关节融合术可显著改善孤立性距下关节炎患者的功能预后,CT融合率高,并发症少。证据等级:III级。
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引用次数: 0
Salvage options following failed surgical hip fracture repair: Part II, extracapsular proximal femoral fractures 髋部骨折手术修复失败后的抢救选择:第二部分,股骨近端囊外骨折
Q2 Medicine Pub Date : 2025-11-15 DOI: 10.1016/j.jcot.2025.103265
Bradley A. Lezak , Meghan Maseda , Alexander J. Egol , Nathaniel P. Mercer , Kenneth A. Egol
Surgical repair of extracapsular hip fractures is associated with a higher rate of successful healing compared to intracapsular fractures; however, a small subset of patients may still experience complications or treatment failure. Potential modes of failure include nonunion, peri-implant fracture, malalignment, cortical impingement or perforation and hardware failure with or without lag screw cutout. Factors determining salvage method include physiologic age, functionality, bone quality, and fracture stability. In this review, potential complications of extracapsular hip fracture repair are described with proposed solutions and supporting literature, when available.
与囊内骨折相比,髋部囊外骨折的手术修复成功率更高;然而,一小部分患者仍可能出现并发症或治疗失败。潜在的失败模式包括骨不连、种植体周围骨折、对齐不良、皮质撞击或穿孔以及有或没有拉力螺钉切断的硬件故障。决定抢救方法的因素包括生理年龄、功能、骨质量和骨折稳定性。在这篇综述中,描述了髋关节囊外骨折修复术的潜在并发症,并提出了解决方案和支持文献,如果有的话。
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引用次数: 0
Medial patellofemoral ligament reconstruction descends the patella: results from an observational retrospective study with two different surgical techniques 髌骨内侧股韧带重建下行:两种不同手术技术的观察性回顾性研究结果
Q2 Medicine Pub Date : 2025-11-13 DOI: 10.1016/j.jcot.2025.103263
José Andreu Castelo , Juan Francisco Londoño , Jacobo Triviño-Arias , Gilberto Antonio Herrera , Paulo José Llinás , Juan Pablo Martinez-Cano

Background

Patella alta is a known risk factor in recurrent patellofemoral dislocation. It is recommended to add a tibial tubercle distalization osteotomy for managing patella alta. Medial patellofemoral ligament reconstruction (MPFLr) could alter patellar height. The aim of this study is to quantify the possible decreasing effect of the MPFLr on patellar height in patients with patellofemoral instability treated with two different techniques: the anatomical (Schoettle's point) technique and the adductor's tendon sling technique, in three different indexes.

Methods

Retrospective observational study in patients with recurrent patellofemoral dislocation who underwent medial patellofemoral ligament reconstruction with an anatomical technique and an adductor's tendon sling technique between 2011 and 2020, comparing the preoperative and postoperative patellar height.

Results

A total of 15 knees and 14 patients were included, with a mean age of 19.2 ± 4.84 years. Eight patients (53.33 %) were treated with the adductor tendon technique and seven (46.67 %) with the anatomic technique. The change between preoperative and postoperative patellar height showed a statistically significant decrease in the three indexes measured, Caton-Deschamps (CD) (p = 0.0017), modified Insall-Salvati (IS) (p = 0.0022), and Blackburne-Peel (BP) (p = 0.0067). No statistically significant difference was found when comparing the delta of patellar descent between anatomic and adductor tendon groups. The mean decrease for the three measurements was 9 %, equivalent to 0.12 for CD, 0.17 for modified IS, and 0.11 for BP.

Conclusion

MPFL reconstruction contributes to a mild decrease in patellar height. This effect should be considered in surgical planning. Selected cases of patients with subtle patella alta could avoid the need for additional distalization procedures. Both techniques showed to decrease patellar height, and no differences could be demonstrated between them.
背景:上髌骨是复发性髌股脱位的已知危险因素。建议加胫骨结节远端截骨术治疗髌骨上端。髌股内侧韧带重建(MPFLr)可改变髌骨高度。本研究的目的是量化MPFLr对髌股不稳患者的髌骨高度可能的降低作用,这些患者采用解剖(Schoettle’s point)技术和内收肌腱悬吊技术,在三个不同的指标上进行治疗。方法回顾性观察2011 ~ 2020年复发性髌骨脱位行解剖技术和内收肌腱悬吊技术髌股内侧韧带重建的患者,比较术前和术后髌骨高度。结果共纳入15个膝关节,14例患者,平均年龄19.2±4.84岁。采用内收肌腱法治疗8例(53.33%),解剖法治疗7例(46.67%)。术前与术后髌骨高度的变化显示,Caton-Deschamps (CD) (p = 0.0017)、改良Insall-Salvati (IS) (p = 0.0022)、blackburn - peel (BP) (p = 0.0067)三项指标均有统计学意义的降低。在解剖组和内收肌腱组之间髌骨下降delta的比较无统计学差异。三种测量方法的平均降幅为9%,相当于CD 0.12,改良IS 0.17, BP 0.11。结论mpfl重建可使髌骨高度轻度降低。在手术计划时应考虑到这种影响。有轻微髌骨上翘的患者可以避免额外的远端手术。两种技术均可降低髌骨高度,两者之间无差异。
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引用次数: 0
Prognostic significance of biomarker expression on immunohistochemistry for overall survival in osteosarcoma: An overview of systematic reviews 免疫组化生物标志物表达对骨肉瘤总生存期的预后意义:系统综述
Q2 Medicine Pub Date : 2025-11-12 DOI: 10.1016/j.jcot.2025.103264
Duddukunta Vishal Reddy, Aritra Chattopadhyay, Madhubari Vathulya, Mohit Dhingra

Background

To summarize evidence from systematic reviews on the prognostic value of tissue immunohistochemistry biomarkers in predicting overall survival in patients with osteosarcoma.

Methodology

The Overview was prospectively registered on PROSPERO (ID Number: CRD42024615273), and a comprehensive search of Cochrane Database, PubMed, EMBASE, and Web of Science was conducted for all systematic reviews (SRs) published in English using the term ‘osteosarcoma’. Eligible SRs reported survival prognostication of IHC-detected tumor biomarkers using hazard ratios (HR) as the effect measure. These SRs contained primary studies exclusively involving participants with bone and soft tissue sarcomas. The AMSTAR-2 tool was used to assess the risk of bias, and the GRADE framework was applied to evaluate the certainty of synthesized evidence.

Results

The search yielded 1467 systematic reviews, of which 10 SRs comprising 5288 participants met the inclusion criteria. Overexpression of Ezrin (HR: 3.15 [2.39–4.14], p < 0.001), HIF-1α (HR: 2.6 [2.09–3.24], p < 0.001), p53 (HR: 2.49 [1.50–4.12], p < 0.001), VEGF (HR: 2.42 [1.87–3.11], p < 0.001), IGF-1R (HR: 2.2 [1.36–3.03], p < 0.001), CXCR4 (HR: 2.13 [1.78–2.55], p < 0.001), HER2 (HR: 2.03 [1.36–3.03], p < 0.001), PD-L1 (HR: 1.72 [1.30–2.28], p < 0.001), and CD44V6 (HR: 1.53 [1.25–1.88], p < 0.001) was significantly associated with poorer survival outcomes. Conversely, p16 expression (HR: 0.33 [0.02–5.74], p = 0.448) suggested a protective effect, though not statistically significant. The certainty of evidence varied from very low to high, while AMSTAR-2 ratings for the included SRs ranged from critically low to low.

Conclusions

Overexpression of VEGF, HIF-1α, Ezrin, and p53 was strongly associated with increased mortality risk in osteosarcoma. These findings may guide patient counselling, biomarker panel optimization, and the development of targeted therapies.
背景:总结来自系统综述的关于组织免疫组化生物标志物在预测骨肉瘤患者总生存期方面的预后价值的证据。本综述前瞻性地在PROSPERO上注册(ID号:CRD42024615273),并对Cochrane数据库、PubMed、EMBASE和Web of Science进行全面检索,检索所有使用“骨肉瘤”一词发表的英文系统综述(SRs)。符合条件的SRs报告了ihc检测的肿瘤生物标志物的生存预后,使用风险比(HR)作为效果衡量标准。这些SRs包含了专门涉及骨和软组织肉瘤患者的初步研究。AMSTAR-2工具用于评估偏倚风险,GRADE框架用于评估综合证据的确定性。结果共检索到1467篇系统评价,其中10篇系统评价(5288名受试者)符合纳入标准。超表达Ezrin(人力资源:3.15 (2.39 - -4.14),p & lt; 0.001), HIF-1α(人力资源:2.6 (2.09 - -3.24),p & lt; 0.001), p53(人力资源:2.49 (1.50 - -4.12),p & lt; 0.001), VEGF(人力资源:2.42 (1.87 - -3.11),p & lt; 0.001), IGF-1R(人力资源:2.2 (1.36 - -3.03),p & lt; 0.001),趋化因子受体CXCR4(人力资源:2.13 (1.78 - -2.55),p & lt; 0.001), HER2(人力资源:2.03 (1.36 - -3.03),p & lt; 0.001), PD-L1(人力资源:1.72 (1.30 - -2.28),p & lt; 0.001),和CD44V6(人力资源:1.53 (1.25 - -1.88),p & lt; 0.001)与贫穷的生存结果显著相关。相反,p16表达(HR: 0.33 [0.02-5.74], p = 0.448)提示有保护作用,但无统计学意义。证据的确定性从非常低到高不等,而纳入的SRs的AMSTAR-2评级从极低到低不等。结论VEGF、HIF-1α、Ezrin和p53的过表达与骨肉瘤死亡风险增高密切相关。这些发现可以指导患者咨询,生物标志物面板优化和靶向治疗的发展。
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引用次数: 0
BMI extremes predict distinct trajectories following hip fracture BMI极值预测髋部骨折后的不同轨迹
Q2 Medicine Pub Date : 2025-11-12 DOI: 10.1016/j.jcot.2025.103262
Benjamin Hammond , Alexander Lashgari , Abhishek Ganta , Steven Rivero , Sanjit Konda , Kenneth Egol

Background

While extremes of body mass index (BMI) are known to influence surgical risks, their distinct impacts on short- and long-term outcomes following hip fracture remain poorly defined. This study compared outcomes in severely underweight, normal weight, and obese elderly patients.

Methods

A retrospective cohort study was conducted using a prospectively collected hip fracture database (2014–2024) at a single academic medical center. Patients with BMI ≤16.5 (severely underweight) or ≥35 (class 2+ obesity) were compared to a randomly selected cohort of normal-weight controls (BMI 18.5–25.0). Outcomes included complications, discharge disposition, mortality, and functional recovery.

Results

A total of 282 patients were included. Obese patients had significantly higher odds of intensive care unit (ICU) admission compared to normal weight patients (OR 5.75 [2.00–16.39], p = .001) and were less likely to be discharged home (OR 0.31 [0.14–0.66], p = .003). In contrast, underweight status was significantly associated with increased six-month mortality compared to normal weight (OR 4.95 [1.34–18.18], p = .016). No significant differences were found in healing or functionality across groups.

Conclusion

Obese patients were more likely to require ICU admission but did not face increased long-term mortality. Severely underweight patients demonstrated the opposite pattern, with minimal short-term morbidity but significantly higher risk of death at six months. These findings suggest that short- and long-term risks after hip fracture diverge at the extremes of BMI and highlight the need for tailored perioperative strategies based on metabolic status.
虽然已知身体质量指数(BMI)的极端值会影响手术风险,但其对髋部骨折后短期和长期预后的明显影响仍不明确。这项研究比较了严重体重不足、正常体重和肥胖老年患者的结局。方法采用前瞻性收集的单个学术医疗中心髋部骨折数据库(2014-2024年)进行回顾性队列研究。BMI≤16.5(严重体重不足)或≥35(2+级肥胖)的患者与随机选择的正常体重对照组(BMI 18.5-25.0)进行比较。结果包括并发症、出院处置、死亡率和功能恢复。结果共纳入282例患者。肥胖患者进入重症监护病房(ICU)的几率显著高于正常体重患者(OR 5.75 [2.00-16.39], p = .001),出院回家的几率显著低于正常体重患者(OR 0.31 [0.14-0.66], p = .003)。相反,与正常体重相比,体重不足与六个月死亡率增加显著相关(OR 4.95 [1.34-18.18], p = 0.016)。各组间在愈合或功能方面没有发现显著差异。结论肥胖患者更有可能需要进入ICU,但长期死亡率没有增加。严重体重不足的患者表现出相反的模式,短期发病率最低,但6个月时死亡风险明显较高。这些发现表明,髋部骨折后的短期和长期风险在BMI的极端情况下存在差异,并强调了根据代谢状态量身定制围手术期策略的必要性。
{"title":"BMI extremes predict distinct trajectories following hip fracture","authors":"Benjamin Hammond ,&nbsp;Alexander Lashgari ,&nbsp;Abhishek Ganta ,&nbsp;Steven Rivero ,&nbsp;Sanjit Konda ,&nbsp;Kenneth Egol","doi":"10.1016/j.jcot.2025.103262","DOIUrl":"10.1016/j.jcot.2025.103262","url":null,"abstract":"<div><h3>Background</h3><div>While extremes of body mass index (BMI) are known to influence surgical risks, their distinct impacts on short- and long-term outcomes following hip fracture remain poorly defined. This study compared outcomes in severely underweight, normal weight, and obese elderly patients.</div></div><div><h3>Methods</h3><div>A retrospective cohort study was conducted using a prospectively collected hip fracture database (2014–2024) at a single academic medical center. Patients with BMI ≤16.5 (severely underweight) or ≥35 (class 2+ obesity) were compared to a randomly selected cohort of normal-weight controls (BMI 18.5–25.0). Outcomes included complications, discharge disposition, mortality, and functional recovery.</div></div><div><h3>Results</h3><div>A total of 282 patients were included. Obese patients had significantly higher odds of intensive care unit (ICU) admission compared to normal weight patients (OR 5.75 [2.00–16.39], p = .001) and were less likely to be discharged home (OR 0.31 [0.14–0.66], p = .003). In contrast, underweight status was significantly associated with increased six-month mortality compared to normal weight (OR 4.95 [1.34–18.18], p = .016). No significant differences were found in healing or functionality across groups.</div></div><div><h3>Conclusion</h3><div>Obese patients were more likely to require ICU admission but did not face increased long-term mortality. Severely underweight patients demonstrated the opposite pattern, with minimal short-term morbidity but significantly higher risk of death at six months. These findings suggest that short- and long-term risks after hip fracture diverge at the extremes of BMI and highlight the need for tailored perioperative strategies based on metabolic status.</div></div>","PeriodicalId":53594,"journal":{"name":"Journal of Clinical Orthopaedics and Trauma","volume":"72 ","pages":"Article 103262"},"PeriodicalIF":0.0,"publicationDate":"2025-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145499920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pathogen virulence and host response: A systematic review of severe illness in childhood musculoskeletal infection 病原体毒力和宿主反应:儿童肌肉骨骼感染严重疾病的系统综述
Q2 Medicine Pub Date : 2025-11-10 DOI: 10.1016/j.jcot.2025.103261
Sarah Hunter , Haemish Crawford , Jonathan G. Schoenecker

Background

Severe forms of childhood bone and joint infection (BJI) involve multifocal sepsis, often requiring multiple surgeries and intensive care. Dysregulation of the Acute Phase Response (APR) occurs, as bacterial virulence factors disrupt protective inflammatory and coagulation mechanisms.1,2 Many algorithms attempt to identify severe cases at diagnosis. Factors driving progression to life-threatening disease remain incompletely understood. This review summarizes risk associations for severe BJI in the context of host-pathogen interactions.

Methods

A systematic review of the literature was undertaken from 01/01/2000-1/08/2025. Studies reporting host or pathogen factors associated with BJI severity for children </ = 18 years were included. Studies focussed on Kingella kingae or atypical organisms were excluded. C-reactive protein (CRP) trends in the context of severe illness were also examined. ROBINS-E was used to assess risk of bias. As it does not consider specific interventions and exposures, this review was not registered with PROSPERO.

Results

Literature search of electronic databases returned 1171 articles, of which 38 met full criteria. These comprised 10,084 patients across multiple continents. Pathogen factors associated with severe illness included Methicillin-resistant Staphylococcus aureus (MRSA), Panton-Valentine Leukocidin (PVL), and individual bacterial virulence factors identified genomically. Notably, these virulence factors may be more important than methicillin resistance, with some MSSA strains causing equally severe disease. Very young children, specific ethnic groups, and those with congenital abnormalities were at higher risk. Early genetic studies propose variability in host inflammatory response genes. Sustained CRP elevation was a feature of worse disease, independent of pathogen subtype.

Conclusion

These findings indicate that severe pediatric BJI results from complex interactions between bacterial virulence factors and host response capacity. Awareness of these factors should equip clinicians to recognise potentially high-risk cases early in the course of illness. Future research should ascertain how virulence factors dysregulate the host APR, guiding therapeutic interventions targeting the underlying pathophysiology.
儿童骨和关节感染(BJI)的严重形式包括多灶性败血症,通常需要多次手术和重症监护。急性期反应(APR)发生失调,因为细菌毒力因子破坏了保护性炎症和凝血机制许多算法试图在诊断时识别严重病例。导致危及生命的疾病进展的因素仍然不完全清楚。本文综述了宿主-病原体相互作用背景下严重BJI的风险关联。方法系统回顾2000年1月1日至2025年8月1日的文献。研究报告了与18岁儿童BJI严重程度相关的宿主或病原体因素。研究集中在Kingella kingae或非典型生物被排除在外。c反应蛋白(CRP)的趋势在严重疾病的情况下也进行了检查。采用ROBINS-E评估偏倚风险。由于没有考虑具体的干预措施和暴露,本综述未在PROSPERO登记。结果电子数据库检索文献1171篇,其中38篇符合全部标准。其中包括来自多个大洲的10084名患者。与严重疾病相关的病原体因素包括耐甲氧西林金黄色葡萄球菌(MRSA)、潘通-瓦伦丁白细胞杀死素(PVL)和基因组鉴定的单个细菌毒力因素。值得注意的是,这些毒力因素可能比甲氧西林耐药性更重要,一些MSSA菌株引起同样严重的疾病。非常年幼的儿童、特定的种族群体和那些有先天性异常的人有更高的风险。早期的遗传学研究提出宿主炎症反应基因的可变性。持续的CRP升高是病情加重的特征,与病原体亚型无关。结论小儿重度BJI是细菌毒力因子与宿主反应能力复杂相互作用的结果。对这些因素的认识应使临床医生能够在病程早期识别潜在的高危病例。未来的研究应该确定毒力因素是如何失调宿主APR的,从而指导针对潜在病理生理的治疗干预。
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引用次数: 0
Is guided growth a viable treatment option for angular deformity correction in distal renal tubular acidosis patients? 引导生长是远端肾小管酸中毒患者角畸形矫正的可行治疗选择吗?
Q2 Medicine Pub Date : 2025-11-06 DOI: 10.1016/j.jcot.2025.103260
Siddharth Jain , Prateek Behera , Girish Chandra Bhatt , Sourabh Kumar Sinha , Vikas Gupta , Ajai Singh

Background

Distal renal tubular acidosis (dRTA) is a rare disorder marked by impaired hydrogen ion secretion in the distal nephron, leading to metabolic acidosis and skeletal manifestations resembling rickets. While medical treatment with alkali, calcium, and vitamin D supplementation is essential, severe coronal plane knee deformities may necessitate surgical correction. Traditional osteotomy is an invasive modality, and data on less invasive options such as guided growth with eight-plate hemiepiphysiodesis in dRTA is limited.

Methods

This retrospective study included seven children (6 males, 1 female; mean age: 11 years) of dRTA who underwent growth modulation with eight-platesfor genu valgum between 2019–2024 concurrently with medical management. Rate of angular deformity correction based on time interval between 8 plate placement and removal, and postoperative complications were recorded.

Results

Six patients had distal femoral involvement and one had proximal tibial deformity. Correction was achieved in all cases, with no implant-related complications. The average rate of angular correction was 1.18°/month (range: 0.71–1.84°) in distal femoral cases and 0.54°/month (range: 0.52–0.56°) in the tibial case. One patient required staged implant removal due to initial difference in severity of deformity. No rebound deformity or recurrence was noted till last follow-up.

Conclusion

Concurrent medical management and growth modulation using 8 plate is a feasible option for management of angular deformities in children with active distal renal tubular acidosis. This approach may reduce or eliminate the need for osteotomy, offering a less invasive alternative with promising outcomes.
远端肾小管酸中毒(dRTA)是一种罕见的疾病,其特征是远端肾单位氢离子分泌受损,导致代谢性酸中毒和类似佝偻病的骨骼表现。虽然补充碱、钙和维生素D的医学治疗是必不可少的,但严重的冠状面膝关节畸形可能需要手术矫正。传统的截骨术是一种侵入性的手术方式,而在dRTA中采用8钢板半骨骺成形术的引导生长等侵入性较小的选择的数据有限。方法回顾性研究包括7名dRTA患儿(6男1女,平均年龄11岁),在2019-2024年期间接受了8个膝外翻板的生长调节,同时进行了医疗管理。记录8次钢板置入与取出时间间隔的角度畸形矫正率及术后并发症。结果股骨远端受累6例,胫骨近端畸形1例。所有病例均获得矫正,无种植体相关并发症。股骨远端病例的平均角度矫正率为1.18°/月(范围:0.71-1.84°),胫骨病例的平均角度矫正率为0.54°/月(范围:0.52-0.56°)。由于畸形严重程度的初始差异,一名患者需要分阶段移除植入物。截至最后一次随访,未见反弹畸形或复发。结论8钢板同步治疗和生长调节是治疗活动性肾远端小管酸中毒患儿角状畸形的可行方法。这种方法可以减少或消除截骨术的需要,提供了一种侵入性较小的替代方法,效果良好。
{"title":"Is guided growth a viable treatment option for angular deformity correction in distal renal tubular acidosis patients?","authors":"Siddharth Jain ,&nbsp;Prateek Behera ,&nbsp;Girish Chandra Bhatt ,&nbsp;Sourabh Kumar Sinha ,&nbsp;Vikas Gupta ,&nbsp;Ajai Singh","doi":"10.1016/j.jcot.2025.103260","DOIUrl":"10.1016/j.jcot.2025.103260","url":null,"abstract":"<div><h3>Background</h3><div>Distal renal tubular acidosis (dRTA) is a rare disorder marked by impaired hydrogen ion secretion in the distal nephron, leading to metabolic acidosis and skeletal manifestations resembling rickets. While medical treatment with alkali, calcium, and vitamin D supplementation is essential, severe coronal plane knee deformities may necessitate surgical correction. Traditional osteotomy is an invasive modality, and data on less invasive options such as guided growth with eight-plate hemiepiphysiodesis in dRTA is limited.</div></div><div><h3>Methods</h3><div>This retrospective study included seven children (6 males, 1 female; mean age: 11 years) of dRTA who underwent growth modulation with eight-platesfor genu valgum between 2019–2024 concurrently with medical management. Rate of angular deformity correction based on time interval between 8 plate placement and removal, and postoperative complications were recorded.</div></div><div><h3>Results</h3><div>Six patients had distal femoral involvement and one had proximal tibial deformity. Correction was achieved in all cases, with no implant-related complications. The average rate of angular correction was 1.18°/month (range: 0.71–1.84°) in distal femoral cases and 0.54°/month (range: 0.52–0.56°) in the tibial case. One patient required staged implant removal due to initial difference in severity of deformity. No rebound deformity or recurrence was noted till last follow-up.</div></div><div><h3>Conclusion</h3><div>Concurrent medical management and growth modulation using 8 plate is a feasible option for management of angular deformities in children with active distal renal tubular acidosis. This approach may reduce or eliminate the need for osteotomy, offering a less invasive alternative with promising outcomes.</div></div>","PeriodicalId":53594,"journal":{"name":"Journal of Clinical Orthopaedics and Trauma","volume":"71 ","pages":"Article 103260"},"PeriodicalIF":0.0,"publicationDate":"2025-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145520202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Salvage options following biological and mechanical failure of surgical hip fracture repair: Part I, intracapsular femoral neck fractures 髋关节骨折手术修复生物和机械失败后的抢救选择:第一部分,股骨颈囊内骨折
Q2 Medicine Pub Date : 2025-11-04 DOI: 10.1016/j.jcot.2025.103259
Alexander J. Egol , Meghan Maseda , Bradley A. Lezak , Nathaniel P. Mercer , Kenneth A. Egol
Most surgically repaired proximal femoral fractures heal uneventfully, however a small percentage of surgical interventions lead to failures. Salvage of failed treatment is challenging and dependent on the type and location of the complication. Potential complications of intracapsular hip fractures and their treatment include fixation failure, nonunion, and osteonecrosis of the femoral head. Factors guiding the choice of salvage option include patient age and quality of remaining bone. This article aims to present several potential complications and corresponding potential solutions using supporting literature, when available. This narrative review focuses on salvage treatment options of failed fixation of femoral neck fractures. Total hip arthroplasty is always the last resort salvage option.
大多数手术修复股骨近端骨折愈合顺利,但一小部分手术干预导致失败。抢救失败的治疗是具有挑战性的,取决于并发症的类型和位置。髋囊内骨折及其治疗的潜在并发症包括固定失败、骨不连和股骨头坏死。选择保留骨的因素包括患者的年龄和剩余骨的质量。本文的目的是提出几个潜在的复杂性和相应的潜在解决方案,使用支持文献,当可用的。本文综述了股骨颈骨折固定失败的抢救治疗方案。全髋关节置换术通常是最后的选择。
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引用次数: 0
Hexapod external fixation for treating joint displacement and soft tissue contractures in mistreated ankle fractures: a case series 六足外固定架治疗治疗不当踝关节骨折的关节移位和软组织挛缩:一个病例系列
Q2 Medicine Pub Date : 2025-11-03 DOI: 10.1016/j.jcot.2025.103252
Giovanni Lovisetti , Marco Domenicucci , Alberto Scanferlato , Enricomaria Lunini , Alessandro Casiraghi

Background

In displaced distal tibia articular fractures, the thin soft tissue envelope dictates time dependent precise realignment and stabilization in order to avoid pressure complications induced by displaced bone segments on overlying structures, consenting a safer approach to definitive surgery. Damage control techniques have been conceived to undertake this task. Nevertheless, problems can arise in cases not achieving initial adequate reduction or losing reduction in the meantime before a delayed surgery. Otherwise, complex distal tibia fractures treated with circular external fixation (CEF) can drift out of alignment during treatment due to unsatisfactory stabilization.

Methods

In three cases where soft tissue contractures and skin compromise posed significant challenges to acute reduction and osteosynthesis, hexapod external fixation was used to progressively achieve precise reduction, allowing resolution of contractures and associated skin ulcers. Definitive internal fixation was subsequently performed.

Results

At the end of treatment, all three patients were able to walk with full weight bearing, reporting mild or no symptoms, and regained a functional ankle range of motion.

Conclusion

This case series emphasizes the importance of adaptive management strategies in trauma cases with soft tissue complications, highlighting the potential benefits of using circular external fixation with hexapod systems.
背景:在移位的胫骨远端关节骨折中,薄的软组织包膜决定了随时间的精确调整和稳定,以避免移位的骨段对上覆结构引起的压力并发症,从而为确定手术提供了更安全的方法。已经设想了损害控制技术来承担这项任务。然而,在延迟手术前未达到初始充分复位或失去复位的情况下,可能会出现问题。否则,使用圆形外固定架(CEF)治疗的复杂胫骨远端骨折在治疗过程中可能由于稳定性不理想而偏离直线。方法在3例软组织挛缩和皮肤损伤对急性复位和骨整合构成重大挑战的病例中,采用六足外固定支架逐步实现精确复位,使挛缩和相关皮肤溃疡得以解决。随后进行了明确的内固定。结果治疗结束时,3例患者均能完全负重行走,症状轻微或无症状,踝关节活动范围恢复正常。结论:本病例系列强调了适应性管理策略在创伤软组织并发症病例中的重要性,强调了使用六足系统环形外固定架的潜在益处。
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引用次数: 0
Post-traumatic genu recurvatum with slope reversal and arthritis treated with imageless robotic total knee replacement – Case report 用无图像机器人全膝关节置换术治疗创伤后膝反斜和关节炎- 1例报告
Q2 Medicine Pub Date : 2025-10-31 DOI: 10.1016/j.jcot.2025.103257
Sayyadshadab Jafri, Unmesh Mahajan, Anurag Daxini
Post-traumatic bony genu recurvatum is not so rare a condition in orthopedic practice. Multiple surgical options are available and are duly reported in literature, i.e., arthrodesis, tibial osteotomy, and soft tissue procedures. But no procedure has perfect relief of symptoms, as arthritis component is never corrected. We present a case of a 65-years old male who had a proximal tibia intra-articular fracture at age of 13, treated conservatively. And, now presenting with post-traumatic severe genu recurvatum with tibial slope reversal and secondary knee osteoarthritis. The patient reported progressive functional limitations and significant pain interfering with daily activities. Given the severity of the deformity and the associated degenerative changes, the patient was managed with an imageless robotic-assisted total knee arthroplasty (TKA). The procedure allowed for precise correction of the deformity and optimal prosthetic alignment without the need for preoperative imaging for navigation. With good functional outcome.
创伤后骨性膝后屈在骨科实践中并不罕见。多种手术选择是可用的,并在文献中有适当的报道,即关节融合术,胫骨截骨术和软组织手术。但没有任何手术能完全缓解症状,因为关节炎的成分永远不会得到纠正。我们提出一个病例65岁的男性谁有近端胫骨关节内骨折在13岁,保守治疗。现在表现为创伤后严重膝后屈伴胫骨斜度反转和继发性膝骨关节炎。患者报告进行性功能限制和明显疼痛干扰日常活动。考虑到畸形的严重程度和相关的退行性改变,患者接受无图像机器人辅助全膝关节置换术(TKA)。该手术允许精确矫正畸形和最佳假体对齐,而无需术前成像导航。有良好的功能结果。
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Journal of Clinical Orthopaedics and Trauma
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