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Functional outcome of anterior cruciate ligament reconstruction with hamstring tendon autograft in Indian population: A systematic review and meta-analysis 在印度人群中使用腘绳肌腱自体移植进行前交叉韧带重建的功能结果:系统回顾和荟萃分析
Q2 Medicine Pub Date : 2024-11-12 DOI: 10.1016/j.jcot.2024.102805
R. Annamalai , C. Venkatramanaiah , A. Sujhithra , N. Vignesh , D. Danis Vijay

Background

Anterior cruciate ligament (ACL) injury is a significant orthopedic issue globally with varying success rates among different populations. Better understanding of functional outcome can help design suitable protocols for ACL reconstruction and recovery. This review aims to evaluate the epidemiological trends and functional outcomes of ACLR procedures in India.

Methods

The review was conducted following PRISMA guidelines, by searching in Google Scholar, Pubmed, Web of Science and Science Direct databases in February 2024. The study encompassed patient demographics, and postoperative outcomes in Indian populations upon ACLR using hamstring tendon autografts. Meta-analysis was conducted with RevMan 5.4 using random-effects models. Funnel plots were used to explore publication bias. Subgroup analyses of follow-up terms and age were also performed.

Results

A total of 26 studies were pooled for overall qualitative and quantitative analysis. Sports injuries (52 %) were found to be more common, followed by road traffic accidents (31 %). Injuries were mostly on the right knees (56 %). Functional outcome analysis using Lysholm Knee Scoring Scale (MD 34.74, 95 % CI 31.58 to 37.89), International Knee Documentation Committee (MD 36.74, 95 % CI 32.36 to 41.13), Tegner Activity Scale (MD 0.90, 95 % CI -0.01 to 1.80) revealed statistically significant overall outcome effect. Statistically non-significant differences were found between follow-up to 6 months and follow-up above 6 months as well as with age. However, meta-analysis showed high level of heterogeneity.

Conclusion

ACLR in Indian population is largely successful in restoring functional activity. However, the outcome of this review is limited by the heterogeneity factor. Further, the Indian studies have not focused on factors affecting the outcome. Therefore, future studies in this direction are needed for understanding the clinical success.
背景前十字韧带(ACL)损伤是全球范围内的一个重要骨科问题,不同人群的成功率各不相同。更好地了解功能结果有助于设计合适的前交叉韧带重建和恢复方案。本综述旨在评估印度前交叉韧带重建手术的流行病学趋势和功能结果。方法该综述遵循 PRISMA 指南,于 2024 年 2 月在 Google Scholar、Pubmed、Web of Science 和 Science Direct 数据库中进行搜索。研究涵盖了印度使用腘绳肌腱自体移植进行前交叉韧带重建术的患者人口统计学特征和术后效果。使用RevMan 5.4进行Meta分析,采用随机效应模型。漏斗图用于探讨发表偏倚。此外,还对随访条件和年龄进行了分组分析。研究发现,运动损伤(52%)更为常见,其次是道路交通事故(31%)。受伤部位主要是右膝盖(56%)。使用 Lysholm 膝关节评分量表(MD 34.74,95 % CI 31.58 至 37.89)、国际膝关节文献委员会(MD 36.74,95 % CI 32.36 至 41.13)和 Tegner 活动量表(MD 0.90,95 % CI -0.01 至 1.80)进行的功能结果分析表明,总体结果具有显著的统计学意义。随访 6 个月与随访 6 个月以上之间以及与年龄之间的差异无统计学意义。然而,荟萃分析显示存在高度异质性。然而,本综述的结果受到了异质性因素的限制。此外,印度的研究并未关注影响结果的因素。因此,今后需要在这方面进行研究,以了解临床成功率。
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引用次数: 0
Avascular necrosis of femoral head – Demographic profile, natural history of asymptomatic hips and native hip survivorship in an indian subcontinent cohort 股骨头血管性坏死--印度次大陆队列中的人口概况、无症状髋关节的自然病史和原生髋关节存活率
Q2 Medicine Pub Date : 2024-11-10 DOI: 10.1016/j.jcot.2024.102801
Jeremy Bliss Dorai , Bhim Bahadur , Arun Shankar , Anil Thomas Oommen , Manasseh Nithyananth

Background

Avascular Necrosis of the femoral head is still considered an unsolved orthopedic problem despite significant research and advances in treatment.

Purposes

  • 1.
    Describe the demographic pattern
  • 2.
    Assess postoperative survival of the native hip
  • 3.
    Observe the natural history in asymptomatic hips

Patients and methods

A South Indian quaternary care hospital based retrospective study. Patients diagnosed with non-traumatic avascular necrosis of the femoral head who underwent hip-preserving procedures between 2004 and 2017 were studied. The clinical and radiological outcomes were assessed. Statistical analysis for hip survival was done using Kaplan–Meier survival analysis.

Results

The study was conducted on 306 hips of 190 patients. The most common etiology was steroid intake. The average follow-up period was 8 years. 216(76 %) hips survived clinically and 125(44 %) hips survived radiologically. The mean duration of clinical survival was 8 years and radiological survival was 7.5 years. The overall regression was highest in the fibula grafting. In asymptomatic hips clinical failure was observed in 36(53 %) hips and radiological failure in 52(77 %) hips with a mean follow-up of 5.9 years.

Conclusion

The earlier stage of presentation and a hip-preserving surgery exhibited a 70 % chance of survival of the native hip. Core decompression decreased the rate of progression in the early stages. Disease regression rates were significant in fibula grafting for stages 2a and 2b. Non-operative treatment is not advisable given rapid disease progression.
背景尽管在治疗方面进行了大量研究并取得了进展,但股骨头血管性坏死仍被认为是一个尚未解决的骨科问题。目的1.描述人口统计学模式2.评估原位髋关节的术后存活率3.观察无症状髋关节的自然病史患者和方法一项基于南印度四级护理医院的回顾性研究。研究对象为 2004 年至 2017 年期间接受保髋手术的股骨头非创伤性血管性坏死患者。对临床和放射学结果进行了评估。采用 Kaplan-Meier 生存分析法对髋关节存活率进行了统计分析。最常见的病因是摄入类固醇。平均随访时间为 8 年。临床存活的髋关节有 216 个(76%),放射学存活的髋关节有 125 个(44%)。平均临床存活时间为 8 年,放射学存活时间为 7.5 年。腓骨移植术的总体回归率最高。在无症状的髋关节中,36(53%)髋关节的临床治疗失败,52(77%)髋关节的放射学治疗失败,平均随访时间为 5.9 年。核心减压降低了早期病变的进展率。2a期和2b期腓骨移植的疾病消退率显著。鉴于疾病进展迅速,非手术治疗并不可取。
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引用次数: 0
Do two distal locking screws in two planes offer the best option in the nailing of diaphyseal tibial fractures? 胫骨远端两个平面的锁定螺钉是否是胫骨二骺骨折钉入的最佳选择?
Q2 Medicine Pub Date : 2024-11-07 DOI: 10.1016/j.jcot.2024.102802
Sebastian Pereira , Germán Garabano , Leonel Perez Alamino , Fernando Bidolegui , Cesar Angel Pesciallo

Background

Although the intramedullary nail represents the treatment for most tibia diaphyseal fractures, there is no agreement on the configuration of the distal locking screws. Therefore, this study aimed to investigate the impact of the configuration of distal locking bolts on the healing of a tibial shaft fracture.

Methods

We retrospectively analyzed 170 closed fractures of the tibia diaphyseal operated consecutively between 2018 and 2021. Patients with postoperative unacceptable reduction (>5° in any plane or gap >4 mm), nail-canal ratio <0.78, and less than 12 months of follow-up were excluded. Using a univariate and multivariate analysis, we analyzed comorbidities (smoking, Body mass index >30, diabetes), fracture type (OTA/AO), the number (one, two, three distal locking screws), and configuration (uniplanar, biplanar, triplanar) of distal locking screws between patients with and without a bone union.

Results

One hundred and forty-two fractures were available for analysis. The bone union and non-union rates were 89.4 % (n = 127) and 10.6 % (n = 15), respectively. The multivariate analysis showed that type A fractures (OR 6.67, p = 0.010) and using two distal locking screws with a biplanar configuration (OR 3.63, p = 0.036) were independent variables related to bone union. In contrast, smoking habit (OR 0.12, p = 0.041), fractures type B (OR 0.22, p = 0.013), and uniplanar fixation (OR 0.51, p = 0.003) were related to non-union.

Conclusion

The findings of this study suggest that using two distal locking screws (anteroposterior + mediolateral) in the nailing of closed tibial diaphyseal fracture represents the optimal configuration, offering a higher likelihood of healing compared to other locking options.
背景虽然髓内钉是治疗大多数胫骨骺端骨折的方法,但对于远端锁定螺钉的配置还没有达成一致意见。因此,本研究旨在探讨远端锁定螺钉的配置对胫骨轴骨折愈合的影响。方法我们回顾性分析了 2018 年至 2021 年间连续手术的 170 例胫骨骺闭合性骨折。排除了术后不能接受的复位(>任何平面内5°或间隙>4 mm)、钉髓比<0.78、随访时间少于12个月的患者。通过单变量和多变量分析,我们对合并症(吸烟、体重指数30、糖尿病)、骨折类型(OTA/AO)、远端锁定螺钉的数量(1枚、2枚、3枚)和配置(单平面、双平面、三平面)进行了分析。骨结合率和非骨结合率分别为 89.4%(127 人)和 10.6%(15 人)。多变量分析显示,A 型骨折(OR 6.67,P = 0.010)和使用双平面配置的两枚远端锁定螺钉(OR 3.63,P = 0.036)是与骨结合相关的独立变量。相比之下,吸烟习惯(OR 0.12,p = 0.041)、B 型骨折(OR 0.22,p = 0.013)和单平面固定(OR 0.51,p = 0.003)与骨不连相关。
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引用次数: 0
Patient experiences with a smartphone application dedicated to postoperative recovery after elective arthroplasty 选择性关节置换术后术后恢复专用智能手机应用程序的患者体验
Q2 Medicine Pub Date : 2024-11-07 DOI: 10.1016/j.jcot.2024.102557
Abdul-Rahman Gomaa , Momna Sajjad Raja , Sara Monteiro , Sriram Srinivasan , Srinivasan Shyamsundar , Hamidreza Khairandish , Faizal Rayan

Introduction

In the rapidly evolving landscape of digital health technologies, the widespread use of smartphones has paved the way for innovative applications designed to enhance healthcare experiences. This introduction underscores the global prevalence of smartphone users and their potential in healthcare, particularly exemplified by therapeutic apps such as the ‘Post Op’ smartphone application. Focused on postoperative support, this app prioritises user-friendly design, data recording, and adherence to national standards. The study aims to evaluate the app's success in achieving these objectives, highlighting its continuous improvement based on real user feedback and its potential impact on improving patient experiences and recovery processes.

Methods and materials

A cohort of elective joint arthroplasty procedure patients at Kettering General Hospital (KGH), spanning a timeframe of one to 12 months post-surgery were surveyed over the telephone regarding their experience of the ‘Post Op’ smartphone utilising a custom, well-structured standardised questionnaire.

Results

The study surveyed 42 consecutive patients who had undergone elective joint arthroplasty procedures at Kettering General Hospital, including 22 total hip replacement (THR) and 20 total knee replacement (TKR) patients. The respondents, with a median age of 66 years, provided overwhelmingly positive feedback about the ‘Post Op’ smartphone application. On a scale of 1–6, the mean ease-of-use score was 5.31, with only two THR patients providing lower scores due to difficulties with photography. However, the app's overall functionality, particularly in uploading photos, received a mean score of 4.78. Despite some technical issues, 97.6 % of respondents would recommend the app, emphasising its positive impact on confidence in the recovery and reducing unnecessary healthcare visits. Narrative responses highlighted the app's simplicity, support, and prompt communication with healthcare teams. Overall, the feedback indicates a high level of satisfaction with the ‘Post Op’ application among elective arthroplasty patients, showcasing its potential benefits for postoperative care.

Conclusion

The study provides valuable insights into the impact of the ‘Post Op’ smartphone application on postoperative care, acknowledging both its successes and areas for enhancement. Further research and iterative improvements are crucial for optimising patient experiences and ensuring the app aligns effectively with healthcare needs.
导言在数字医疗技术迅速发展的今天,智能手机的广泛使用为旨在提升医疗体验的创新应用铺平了道路。本介绍强调了智能手机用户在全球的普及程度及其在医疗保健领域的潜力,"术后 "智能手机应用程序等治疗应用程序尤其是这方面的典范。这款应用程序专注于术后支持,将用户友好型设计、数据记录和遵守国家标准放在首位。本研究旨在评估该应用在实现这些目标方面取得的成功,强调其基于真实用户反馈的持续改进及其对改善患者体验和恢复过程的潜在影响。方法和材料通过电话对凯特林总医院(Kettering General Hospital,KGH)的择期关节置换术患者进行了调查,调查时间跨度为术后1至12个月,使用的是定制的、结构合理的标准化问卷,调查内容是他们对 "术后 "智能手机的使用体验。结果该研究连续调查了42名在凯特林总医院接受择期关节置换术的患者,其中包括22名全髋关节置换术(THR)患者和20名全膝关节置换术(TKR)患者。受访者的年龄中位数为 66 岁,他们对 "Post Op "智能手机应用的反馈非常积极。在 1-6 级评分中,易用性平均得分为 5.31 分,只有两名髋关节置换术患者因拍照困难而得分较低。不过,该应用程序的整体功能,尤其是上传照片的功能,平均得分为 4.78 分。尽管存在一些技术问题,但仍有 97.6% 的受访者愿意推荐该应用程序,强调其对恢复信心和减少不必要的医疗就诊产生了积极影响。叙述性回复强调了该应用程序的简易性、支持性以及与医疗团队的及时沟通。总之,反馈意见表明关节置换术择期手术患者对 "Post Op "应用程序的满意度很高,显示了该应用程序对术后护理的潜在益处。 结论该研究就 "Post Op "智能手机应用程序对术后护理的影响提供了有价值的见解,既肯定了其成功之处,也指出了需要改进的地方。进一步的研究和迭代改进对于优化患者体验和确保应用程序有效满足医疗需求至关重要。
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引用次数: 0
Analgesic use may not decrease in the first postoperative year in patients underwent total knee arthroplasty due to advanced osteoarthritis 因晚期骨关节炎接受全膝关节置换术的患者在术后第一年的镇痛剂使用量可能不会减少
Q2 Medicine Pub Date : 2024-11-07 DOI: 10.1016/j.jcot.2024.102800
Ahmet Aslan , Erkan Maytalman , Anil Gulcu

Background

Total knee arthroplasty (TKA) is expected to relieve pain and reduce the use of analgesics in patients with advanced knee osteoarthritis. However, in some cases, there is no relief in the pain of the patients and the use of analgesics continues. The aim of this study was to compare analgesic consumption one year before and after TKA in the same patient group and to evaluate whether there is a decrease in analgesic consumption after TKA.

Method

The cumulative amounts of analgesia used by the patients in the one-year periods before and after the operation were checked from the automated patient records system and the national systems showing drug prescriptions. The dosages of all the analgesics used in the one-year periods before and after the operation were calculated and converted to oral morphine equivalents (OME). The demographic data of the patients, cumulative OME and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores were used in the assessment.

Results

It was observed that there was a statistically significant improvement in Womac scores after the treatment compared to the pre-treatment. Although the mean amount of analgesics decreased compared to pre-treatment, it was not statistically significant. Also, age and preoperative analgesic use were found to be the two most important factors in relation to total postoperative analgesic consumption.

Conclusion

The results of this study indicate that there may not be a substantial reduction in the use of analgesic by patients within the first year after TKA. Furthermore, the age and preoperative analgesic use were identified as the two primary factors influencing postoperative analgesic consumption.

Level of evidence

Retrospective Cohort Study.
背景全膝关节置换术(TKA)有望减轻晚期膝关节骨性关节炎患者的疼痛并减少止痛药的使用。然而,在某些情况下,患者的疼痛并未得到缓解,镇痛剂的使用仍在继续。本研究的目的是比较同一患者组在 TKA 手术前后一年的镇痛剂用量,并评估 TKA 手术后镇痛剂用量是否会减少。计算手术前后一年内所有镇痛药的用量,并将其转换为口服吗啡当量(OME)。评估中使用了患者的人口统计学数据、累积口服吗啡当量以及西安大略和麦克马斯特大学骨关节炎指数(WOMAC)的评分。虽然镇痛剂的平均用量比治疗前有所减少,但没有统计学意义。此外,年龄和术前镇痛药使用量是影响术后镇痛药总用量的两个最重要因素。此外,年龄和术前镇痛药的使用被认为是影响术后镇痛药消耗量的两个主要因素。
{"title":"Analgesic use may not decrease in the first postoperative year in patients underwent total knee arthroplasty due to advanced osteoarthritis","authors":"Ahmet Aslan ,&nbsp;Erkan Maytalman ,&nbsp;Anil Gulcu","doi":"10.1016/j.jcot.2024.102800","DOIUrl":"10.1016/j.jcot.2024.102800","url":null,"abstract":"<div><h3>Background</h3><div>Total knee arthroplasty (TKA) is expected to relieve pain and reduce the use of analgesics in patients with advanced knee osteoarthritis. However, in some cases, there is no relief in the pain of the patients and the use of analgesics continues. The aim of this study was to compare analgesic consumption one year before and after TKA in the same patient group and to evaluate whether there is a decrease in analgesic consumption after TKA.</div></div><div><h3>Method</h3><div>The cumulative amounts of analgesia used by the patients in the one-year periods before and after the operation were checked from the automated patient records system and the national systems showing drug prescriptions. The dosages of all the analgesics used in the one-year periods before and after the operation were calculated and converted to oral morphine equivalents (OME). The demographic data of the patients, cumulative OME and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores were used in the assessment.</div></div><div><h3>Results</h3><div>It was observed that there was a statistically significant improvement in Womac scores after the treatment compared to the pre-treatment. Although the mean amount of analgesics decreased compared to pre-treatment, it was not statistically significant. Also, age and preoperative analgesic use were found to be the two most important factors in relation to total postoperative analgesic consumption.</div></div><div><h3>Conclusion</h3><div>The results of this study indicate that there may not be a substantial reduction in the use of analgesic by patients within the first year after TKA. Furthermore, the age and preoperative analgesic use were identified as the two primary factors influencing postoperative analgesic consumption.</div></div><div><h3>Level of evidence</h3><div>Retrospective Cohort Study.</div></div>","PeriodicalId":53594,"journal":{"name":"Journal of Clinical Orthopaedics and Trauma","volume":"59 ","pages":"Article 102800"},"PeriodicalIF":0.0,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142652364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Accuracy of femoral tunnel placement using three different techniques in performing arthroscopic all-inside anterior Cruciate Ligament reconstruction; A randomized study 使用三种不同技术进行关节镜下全内侧前十字韧带重建时股骨隧道置入的准确性;随机研究
Q2 Medicine Pub Date : 2024-11-07 DOI: 10.1016/j.jcot.2024.102799
Pankaj Rai , Vikas Kulshrestha , Munish Sood , Santhosh Kumar , Mustajib Ali , Soma Kulshrestha

Background

One of the key steps in arthroscopic Anterior Cruciate Ligament Reconstruction (ACLR) is getting the femoral tunnel at the right position to attach the graft. While the correct position has been described as a low and posterior position behind the bifurcate ridge on the medial surface of lateral femoral condyle, to reproducibly achieve it more than one technique is being used by surgeons. There are no randomized studies in literature which have evaluated the efficacy of these in a surgeon's hand. This study attempts to do that.

Methods

This randomized study was performed at a military sports injury centre by a single surgical team led by two sports fellowship-trained surgeons. One hundred fifty patients undergoing ACLR surgery were randomized to Anteromedial Portal technique e (AMP)group, Far Anteromedial portal technique (FAMP) group and Outside in drilling (OI) group. We used postoperative three-dimensional Computed Tomogram (3D CT) to study tunnel position (Magnussen method), length and orientation (Basdekis method).

Results

80 % of femoral entry points were in satisfactory position using all three techniques. The ideal position was achieved more often using FAMP & OI technique which was better than AMP, however it was not below level of significance set at P < 0.025 (18, 13 & 5 respectively using FAMP, OI and AMP techniques, p-value 0.08 OI vs AMP & 0.07 AMP vs FAMP). The average femoral tunnel length was longest in OI group 34.72 ± 2.41 mm. The mean FAMP tunnel lengths were significantly smaller than the mean tunnel length of AMP and OI groups. (p-value <0.01 FAMP vs OI and p-value <0.01 FAMP vs AMP)

Conclusion

Our study showed that all three techniques achieved acceptable femoral tunnel placement in 80 % cases. However, FAMP and OI technique further improved accuracy of achieving ideal tunnel location and OI technique predictably achieved longer tunnel length preventing risk of lateral blow out while using suspensory fixation.
背景在关节镜下进行前交叉韧带重建(ACLR)的关键步骤之一是使股骨隧道处于连接移植物的正确位置。虽然正确的位置被描述为股骨外侧髁内侧表面分叉嵴后方的低位和后方位置,但外科医生正在使用多种技术来重复实现这一目标。目前还没有文献对外科医生使用这些技术的效果进行随机评估。这项随机研究是在一家军事运动损伤中心进行的,由两名受过运动研究培训的外科医生带领一个手术团队进行。接受前交叉韧带重建手术的 150 名患者被随机分为前内侧门户技术(AMP)组、远端前内侧门户技术(FAMP)组和钻孔外(OI)组。我们使用术后三维计算机断层扫描(3D CT)研究隧道位置(马格努森法)、长度和方向(巴斯德基斯法)。FAMP、OI 和 AMP 技术分别为 18、13 和 5,P 值为 0.08 OI vs AMP & 0.07 AMP vs FAMP)。OI 组的股骨隧道平均长度最长,为 34.72 ± 2.41 毫米。FAMP 隧道的平均长度明显小于 AMP 组和 OI 组。(结论我们的研究表明,在 80% 的病例中,所有三种技术都实现了可接受的股骨隧道置入。不过,FAMP 和 OI 技术进一步提高了实现理想隧道位置的准确性,而 OI 技术可预测地实现了更长的隧道长度,从而在使用悬吊固定时避免了侧吹的风险。
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引用次数: 0
Safety and efficacy of autologous adipose-derived stem cells for knee osteoarthritis in the elderly population: A systematic review 自体脂肪干细胞治疗老年人膝关节骨关节炎的安全性和有效性:系统综述
Q2 Medicine Pub Date : 2024-11-07 DOI: 10.1016/j.jcot.2024.102804
Biagio Zampogna , Francesco Rosario Parisi , Augusto Ferrini , Andrea Zampoli , Giuseppe Francesco Papalia , Saseendar Shanmugasundaram , Rocco Papalia

Introduction

Osteoarthritis (OA) is a progressive joint disease, and over 240 million people suffer from symptomatic OA, primarily in the knee, and mainly affects the elderly population over 65. A combination of different risk factors leads to biological changes in the microenvironments of the joints, causing cartilage overload and chondrocyte aging. Adipose-derived MSCs (ADSCs) are demonstrated to improve joint environments with an effective therapy for Knee OA. This review focused on patients over 65 years old to evaluate the effectiveness of ADSC therapies in treating KOA in elderly patients and demonstrate that complications are not higher in this cohort of patients.

Materials and methods

We conducted a bibliography search through the PubMed, Scopus, and Cochrane databases for English-language and human clinical trials published until Feb 7, 2024. We extracted the following study characteristics: Authors, year of publication, type of study, number of patients, number of knees, sex, Kellgren-Lawrence classification, culture ADSC, Number of cells injected, mean follow-up, adverse events, significant complications, and clinical outcomes data were extracted recorded and analyzed.

Results

According to inclusion criteria, seven clinical trials on autologous adipose-derived stem cells were considered. Four studies analyzed stem cells as a stromal vascular fraction (SVF), two as ADSC cultured, and 1 study investigated the MAT procedure. All studies reported improved clinical outcomes using autologous adipose-derived stem cells, on 339 knees. Post-treatment increased KOOS, WOMAC, IKS, VAS, and Lysholm knee scores were highlighted. All studies showed an improvement in all outcomes scores, and regarding complications, only 44 knees underwent adverse events, but no significant complications were found in all the studies reported.

Conclusions

The current systematic review demonstrated that using autologous adipose-derived stem cells improved clinical outcomes and is effective and safe in elderly patients. Additionally, this study will encourage orthopedic surgeons not to consider surgery as the only solution in elderly patients who are refractory to treatment and do not show end-stage knee osteoarthritis.

Level of evidence

Level IV, systematic review of level IV studies.
导言骨关节炎(OA)是一种进行性关节疾病,超过 2.4 亿人患有无症状的骨关节炎,主要发生在膝关节,主要影响 65 岁以上的老年人群。不同风险因素的综合作用导致关节微环境发生生物变化,造成软骨超负荷和软骨细胞老化。脂肪来源间充质干细胞(ADSCs)被证明能改善关节环境,是治疗膝关节OA的有效疗法。本综述重点关注 65 岁以上的患者,以评估 ADSC 疗法治疗老年患者 KOA 的有效性,并证明该类患者的并发症并不高。材料与方法我们通过 PubMed、Scopus 和 Cochrane 数据库对 2024 年 2 月 7 日之前发表的英语人类临床试验进行了文献检索。我们提取了以下研究特征:作者、发表年份、研究类型、患者人数、膝关节数量、性别、Kellgren-Lawrence分类、培养ADSC、注射细胞数量、平均随访时间、不良事件、重大并发症和临床结果数据均被提取记录并进行分析。四项研究分析了作为基质血管成分(SVF)的干细胞,两项研究分析了培养的ADSC,一项研究调查了MAT程序。所有研究均报告称,使用自体脂肪衍生干细胞可改善339个膝关节的临床疗效。研究强调了治疗后KOOS、WOMAC、IKS、VAS和Lysholm膝关节评分的提高。在并发症方面,只有44个膝关节发生了不良事件,但在所有报告的研究中均未发现明显的并发症。结论目前的系统综述表明,使用自体脂肪衍生干细胞可改善老年患者的临床疗效,且有效、安全。此外,这项研究将鼓励骨科医生不要将手术作为治疗难治且未显示出终末期膝骨关节炎的老年患者的唯一解决方案。
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引用次数: 0
New evidence on patella resurfacing in modern total knee arthroplasty for all inflammatory arthritis in a mixed Asian population 现代全膝关节置换术治疗亚洲混血儿所有炎症性关节炎的髌骨复位新证据
Q2 Medicine Pub Date : 2024-11-01 DOI: 10.1016/j.jcot.2024.102798
Sherlyn Yen Yu Tham , Wu Chean Lee , Zavier Yongxuan Lim , Remesh Kunnasegaran

Background

Traditional teaching advocates for routine patella resurfacing (PR) during total knee arthroplasty (TKA) in patients with inflammatory arthritis. However, evidence on this topic remains limited in the Asian population. This study aims to evaluate the postoperative outcomes and complication of patella resurfacing (PR) during primary total knee arthroplasty (TKA) in Asian patients with inflammatory arthritis.

Methods

A retrospective analysis was conducted using registry data from our institution. Patients with inflammatory arthritis who underwent primary TKA from August 2017 to December 2021 were included in the study. Patients were divided into two groups - patella resurfaced (PR, n = 25) and non-resurfaced patella (PNR, n = 31) groups. Demographics, operative data, patient reported outcome measures, and complications were compared.

Results

Preoperative range of motion (ROM) (PR:95.3 ± 23.6° vs PNR:105 ± 19.5°, p = 0.106), Knee Society Scoring System Knee score (KS-KS) (PR:44.6 ± 17.4 vs PNR:49.3 ± 17.7, p = 0.331) and Knee Society Function Score (KS-FS) (PR:40.9 ± 27.3 vs PNR:47.7 ± 27.0, p = 0.325) and Oxford Knee Score (OKS) (PR:25.0 ± 7.8 vs PNR:23.3 ± 10.3, p = 0.525) were similar in both groups. Outcomes between PR and PNR groups at the one-year mark in terms of ROM (PR:112.7 ± 18.1 vs PNR:114.6 ± 16.5, p = 0.455), OKS (PR:41.5 ± 3.9 vs PNR:41 ± 4.7, p = 0.954), KS-KS (PR:84.5 ± 13.2 vs PNR:89.2 ± 9.3, p = 0.095) and KS-FS (PR:73.6 ± 18.3 vs PNR:78.7 ± 19.3, p = 0.173) were also similar. Intraoperative complication (PR:0/25 vs PNR: 3/31 (9.6 %), p = 0.245) and re-operation rates (PR: 1/25 (4 %) vs PNR: 1/31 (3.2 %), p = 0.877) were also similar in both groups.

Conclusion

This study conducted on a mixed Asian population with inflammatory arthritis demonstrated that the one-year postoperative ROM and functional outcomes, complication, and re-operation rates between PR and PNR groups were similar. Hence, routine patella resurfacing on all Asian patients with inflammatory arthritis undergoing TKA may not be necessary.
背景传统教学主张炎症性关节炎患者在进行全膝关节置换术(TKA)时常规进行髌骨复位(PR)。然而,在亚洲人群中,这方面的证据仍然有限。本研究旨在评估亚洲炎症性关节炎患者在初级全膝关节置换术(TKA)中进行髌骨翻修(PR)的术后效果和并发症。研究纳入了2017年8月至2021年12月期间接受初级TKA手术的炎症性关节炎患者。患者分为两组--髌骨复位组(PR,n = 25)和非髌骨复位组(PNR,n = 31)。结果术前活动范围(ROM)(PR:95.3 ± 23.6° vs PNR:105 ± 19.5°,P = 0.106)、膝关节协会评分系统膝关节评分(KS-KS)(PR:44.6 ± 17.4 vs PNR:49.3 ± 17.7,p = 0.331)、膝关节社会功能评分(KS-FS)(PR:40.9 ± 27.3 vs PNR:47.7 ± 27.0,p = 0.325)和牛津膝关节评分(OKS)(PR:25.0 ± 7.8 vs PNR:23.3 ± 10.3,p = 0.525)在两组中相似。PR 组和 PNR 组在一年后的 ROM(PR:112.7 ± 18.1 vs PNR:114.6 ± 16.5,p = 0.455)、OKS(PR:41.5 ± 3.9 vs PNR:41 ± 4.7,p = 0.954)、KS-KS(PR:84.5 ± 13.2 vs PNR:89.2 ± 9.3,p = 0.095)和 KS-FS(PR:73.6 ± 18.3 vs PNR:78.7 ± 19.3,p = 0.173)也相似。两组的术中并发症(PR:0/25 vs PNR:3/31 (9.6%),p = 0.245)和再次手术率(PR:1/25 (4 %) vs PNR:1/31 (3.2%),p = 0.877)也相似。因此,对所有接受 TKA 的亚洲炎症性关节炎患者进行常规髌骨复位可能并无必要。
{"title":"New evidence on patella resurfacing in modern total knee arthroplasty for all inflammatory arthritis in a mixed Asian population","authors":"Sherlyn Yen Yu Tham ,&nbsp;Wu Chean Lee ,&nbsp;Zavier Yongxuan Lim ,&nbsp;Remesh Kunnasegaran","doi":"10.1016/j.jcot.2024.102798","DOIUrl":"10.1016/j.jcot.2024.102798","url":null,"abstract":"<div><h3>Background</h3><div>Traditional teaching advocates for routine patella resurfacing (PR) during total knee arthroplasty (TKA) in patients with inflammatory arthritis. However, evidence on this topic remains limited in the Asian population. This study aims to evaluate the postoperative outcomes and complication of patella resurfacing (PR) during primary total knee arthroplasty (TKA) in Asian patients with inflammatory arthritis.</div></div><div><h3>Methods</h3><div>A retrospective analysis was conducted using registry data from our institution. Patients with inflammatory arthritis who underwent primary TKA from August 2017 to December 2021 were included in the study. Patients were divided into two groups - patella resurfaced (PR, n = 25) and non-resurfaced patella (PNR, n = 31) groups. Demographics, operative data, patient reported outcome measures, and complications were compared.</div></div><div><h3>Results</h3><div>Preoperative range of motion (ROM) (PR:95.3 ± 23.6° vs PNR:105 ± 19.5°, p = 0.106), Knee Society Scoring System Knee score (KS-KS) (PR:44.6 ± 17.4 vs PNR:49.3 ± 17.7, p = 0.331) and Knee Society Function Score (KS-FS) (PR:40.9 ± 27.3 vs PNR:47.7 ± 27.0, p = 0.325) and Oxford Knee Score (OKS) (PR:25.0 ± 7.8 vs PNR:23.3 ± 10.3, p = 0.525) were similar in both groups. Outcomes between PR and PNR groups at the one-year mark in terms of ROM (PR:112.7 ± 18.1 vs PNR:114.6 ± 16.5, p = 0.455), OKS (PR:41.5 ± 3.9 vs PNR:41 ± 4.7, p = 0.954), KS-KS (PR:84.5 ± 13.2 vs PNR:89.2 ± 9.3, p = 0.095) and KS-FS (PR:73.6 ± 18.3 vs PNR:78.7 ± 19.3, p = 0.173) were also similar. Intraoperative complication (PR:0/25 vs PNR: 3/31 (9.6 %), p = 0.245) and re-operation rates (PR: 1/25 (4 %) vs PNR: 1/31 (3.2 %), p = 0.877) were also similar in both groups.</div></div><div><h3>Conclusion</h3><div>This study conducted on a mixed Asian population with inflammatory arthritis demonstrated that the one-year postoperative ROM and functional outcomes, complication, and re-operation rates between PR and PNR groups were similar. Hence, routine patella resurfacing on all Asian patients with inflammatory arthritis undergoing TKA may not be necessary.</div></div>","PeriodicalId":53594,"journal":{"name":"Journal of Clinical Orthopaedics and Trauma","volume":"58 ","pages":"Article 102798"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142593323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rehabilitation from delayed bilateral complete quadriceps tendon repairs with knee extension assist braces: A case report 使用膝关节伸展辅助支架进行延迟性双侧股四头肌肌腱完全修复术后康复:病例报告
Q2 Medicine Pub Date : 2024-11-01 DOI: 10.1016/j.jcot.2024.102789
Benjamin Hewins, Sara Sparavalo, Ivan Wong
Simultaneous bilateral quadriceps tears are rare with fewer than 150 cases reported in the literature and typically occur in male patients greater than 40 years of age. If left untreated or with delayed clinical intervention, these injuries often lead to chronic disability including pain and reduced ambulation. Typical treatments include surgical repair with considerable post-operative rehabilitation and a guarded prognosis. However, given the scarcity of these cases, a consensus on a standard course of treatment remains unclear and ultimately at the discretion of the clinician.
A 67-year-old male presented 6-months after complete, retracted tears of bilateral quadriceps tendons after a fall onto both knees in flexion. Treatment included: immediate bilateral quadriceps tendon repairs, immobilization, physiotherapy, and the daily use of novel tri-compartment offloader knee braces providing knee-extension assist. To our knowledge, this is the first report of a full return to independent ambulation following a delayed diagnosis and surgical intervention of complete bilateral quadriceps tendon tears.
同时发生的双侧股四头肌撕裂非常罕见,文献报道的病例不到 150 例,通常发生在 40 岁以上的男性患者身上。如果不及时治疗或延误临床干预,这些损伤通常会导致慢性残疾,包括疼痛和行动不便。典型的治疗方法包括手术修复,术后需要大量的康复治疗,预后较差。一名 67 岁的男性在双膝屈曲摔倒后,双侧股四头肌肌腱完全撕裂并回缩,6 个月后就诊。治疗包括:立即进行双侧股四头肌肌腱修复、固定、理疗,以及每天使用新型三腔卸力膝关节支架提供膝关节伸展辅助。据我们所知,这是第一份关于双侧股四头肌肌腱完全撕裂延迟诊断和手术干预后完全恢复独立行走的报告。
{"title":"Rehabilitation from delayed bilateral complete quadriceps tendon repairs with knee extension assist braces: A case report","authors":"Benjamin Hewins,&nbsp;Sara Sparavalo,&nbsp;Ivan Wong","doi":"10.1016/j.jcot.2024.102789","DOIUrl":"10.1016/j.jcot.2024.102789","url":null,"abstract":"<div><div>Simultaneous bilateral quadriceps tears are rare with fewer than 150 cases reported in the literature and typically occur in male patients greater than 40 years of age. If left untreated or with delayed clinical intervention, these injuries often lead to chronic disability including pain and reduced ambulation. Typical treatments include surgical repair with considerable post-operative rehabilitation and a guarded prognosis. However, given the scarcity of these cases, a consensus on a standard course of treatment remains unclear and ultimately at the discretion of the clinician.</div><div>A 67-year-old male presented 6-months after complete, retracted tears of bilateral quadriceps tendons after a fall onto both knees in flexion. Treatment included: immediate bilateral quadriceps tendon repairs, immobilization, physiotherapy, and the daily use of novel tri-compartment offloader knee braces providing knee-extension assist. To our knowledge, this is the first report of a full return to independent ambulation following a delayed diagnosis and surgical intervention of complete bilateral quadriceps tendon tears.</div></div>","PeriodicalId":53594,"journal":{"name":"Journal of Clinical Orthopaedics and Trauma","volume":"58 ","pages":"Article 102789"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142571370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Factors influencing surgical treatment of De Quervain's tendinopathy: A retrospective cross-sectional observational study 影响德-夸尔曼肌腱病手术治疗的因素:回顾性横断面观察研究
Q2 Medicine Pub Date : 2024-11-01 DOI: 10.1016/j.jcot.2024.102790
Arjuna Thakker , Nicholas Johnson , Joseph Dias

Background

The literature surrounding how different patient, sociodemographic, and anatomical factors influence surgical treatment of De Quervain's tendinopathy (DQT) is limited.

Purpose

We hypothesised that different patient, anatomical, or sociodemographic factors influence the management of DQT with regard to non-operative vs. surgical management.

Methods

This retrospective cross-sectional study reviewed 155 cases of patients with DQT seen over a 10 year period. Patient-specific factors included age, gender, hand affected, dominant hand, steroid injection given and mean number of injections. Sociodemographic factors included ethnicity, employment, and deprivation, were measured using deprivation quintiles through The Index of Multiple Deprivation. Anatomical factors included the presence of subcompartmentalization, number of APL and EPB tendon slips, tendon thickening, exudative tenosynovitis, hypervascularization, and the presence of a sheath ganglion Patients were categorized into either non-operative or surgical cohort. Bivariate analysis was used to compare factors between the cohorts, and significant factors (p < 0.05) were included in the logistic regression model, used to predict factors influencing surgical management.

Results

Bivariate analysis detected a significant difference in the mean number of steroids given between the non-operative and surgical cohort (p = 0.001) patient factors. For sociodemographic factors, a significant difference was found between deprivation quintiles (p = 0.02). From the anatomical factors, the surgical cohort had more patients with multiple APL tendon slips (p = 0.02) and the presence of a tendon ganglion sheath ganglion (p = 0.02). For patient and sociodemographic factors, logistic regression identified that the number of steroids (per patient) and being in deprivation quintile 4 were associated with surgical treatment. For anatomical factors, multiple APL tendon slips and the presence of a tendon sheath ganglion were associated with the surgical treatment.

Conclusion

This study suggests that several factors are associated with the need for surgical treatment of DQT, including the number of steroid injections received, social deprivation, and anatomical factors, such as the presence of multiple tendon slips and a tendon sheath ganglion. Our findings add to the growing body of literature exploring factors that may influence treatment pathways for patients with DQT.
背景有关不同患者、社会人口和解剖学因素如何影响德-夸尔曼氏肌腱病(DQT)手术治疗的文献十分有限。目的我们假设,不同患者、解剖学或社会人口因素会影响德-夸尔曼氏肌腱病的非手术治疗与手术治疗。患者特异性因素包括年龄、性别、患手、主导手、类固醇注射量和平均注射次数。社会人口学因素包括种族、就业和贫困程度,这些因素通过 "多重贫困指数"(The Index of Multiple Deprivation)中的贫困五分位数来衡量。解剖学因素包括是否存在关节间隙下化、APL和EPB肌腱滑脱的数量、肌腱增厚、渗出性腱鞘炎、血管过多以及是否存在鞘神经节。采用双变量分析比较两组患者之间的因素,并将重要因素(p <0.05)纳入逻辑回归模型,用于预测影响手术治疗的因素。结果双变量分析发现,非手术组和手术组患者服用类固醇的平均次数存在显著差异(p = 0.001)。在社会人口学因素方面,贫困五分位数之间存在显著差异(p = 0.02)。从解剖学因素来看,手术队列中有更多患者患有多发性 APL 肌腱滑脱(p = 0.02)和存在腱鞘节(p = 0.02)。就患者和社会人口学因素而言,逻辑回归发现,类固醇的数量(每名患者)和处于贫困的五分位数4与手术治疗有关。结论本研究表明,多种因素与 DQT 的手术治疗需求相关,包括接受类固醇注射的次数、社会贫困程度以及解剖因素(如存在多处肌腱滑脱和腱鞘节)。我们的研究结果为越来越多探讨可能影响 DQT 患者治疗途径的因素的文献增添了新的内容。
{"title":"Factors influencing surgical treatment of De Quervain's tendinopathy: A retrospective cross-sectional observational study","authors":"Arjuna Thakker ,&nbsp;Nicholas Johnson ,&nbsp;Joseph Dias","doi":"10.1016/j.jcot.2024.102790","DOIUrl":"10.1016/j.jcot.2024.102790","url":null,"abstract":"<div><h3>Background</h3><div>The literature surrounding how different patient, sociodemographic, and anatomical factors influence surgical treatment of De Quervain's tendinopathy (DQT) is limited.</div></div><div><h3>Purpose</h3><div>We hypothesised that different patient, anatomical, or sociodemographic factors influence the management of DQT with regard to non-operative vs. surgical management.</div></div><div><h3>Methods</h3><div>This retrospective cross-sectional study reviewed 155 cases of patients with DQT seen over a 10 year period. Patient-specific factors included age, gender, hand affected, dominant hand, steroid injection given and mean number of injections. Sociodemographic factors included ethnicity, employment, and deprivation, were measured using deprivation quintiles through The Index of Multiple Deprivation. Anatomical factors included the presence of subcompartmentalization, number of APL and EPB tendon slips, tendon thickening, exudative tenosynovitis, hypervascularization, and the presence of a sheath ganglion Patients were categorized into either non-operative or surgical cohort. Bivariate analysis was used to compare factors between the cohorts, and significant factors (p &lt; 0.05) were included in the logistic regression model, used to predict factors influencing surgical management.</div></div><div><h3>Results</h3><div>Bivariate analysis detected a significant difference in the mean number of steroids given between the non-operative and surgical cohort (p = 0.001) patient factors. For sociodemographic factors, a significant difference was found between deprivation quintiles (p = 0.02). From the anatomical factors, the surgical cohort had more patients with multiple APL tendon slips (p = 0.02) and the presence of a tendon ganglion sheath ganglion (p = 0.02). For patient and sociodemographic factors, logistic regression identified that the number of steroids (per patient) and being in deprivation quintile 4 were associated with surgical treatment. For anatomical factors, multiple APL tendon slips and the presence of a tendon sheath ganglion were associated with the surgical treatment.</div></div><div><h3>Conclusion</h3><div>This study suggests that several factors are associated with the need for surgical treatment of DQT, including the number of steroid injections received, social deprivation, and anatomical factors, such as the presence of multiple tendon slips and a tendon sheath ganglion. Our findings add to the growing body of literature exploring factors that may influence treatment pathways for patients with DQT.</div></div>","PeriodicalId":53594,"journal":{"name":"Journal of Clinical Orthopaedics and Trauma","volume":"58 ","pages":"Article 102790"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142593243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Journal of Clinical Orthopaedics and Trauma
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