Polyetheretherketone (PEEK) is a polymer material widely used for artificial bone implants but known to exhibit a low affinity for bone tissue and lack osteoconductivity and osseointegration. Because strontium (Sr) is known to enhance bone growth, PEEK implants coated with strontium titanate (SrTiO3, STO) is expected to improve the bone growth around them. In this study, STO was deposited on model PEEK implants by magnetron sputtering deposition and its ability to release Sr2+ ions to a surrounding phosphate-buffered saline (PBS) solution was examined. It is found that, in an early stage of the deposition process, STO on a PEEK surface exhibits irregular surface structures with many holes. The amount of Sr stored in the STO film increases with the increasing film thickness but the release rate of Sr2+ ions from the STO film to the surrounding PBS also increases with the film thickness, limiting the duration of effectiveness of the STO-coated PEEK films. It is found, however, that a three-layer titanium (Ti)-STO-Ti film deposited on PEEK allows a steady release of Sr2+ ions to the surrounding PBS for an extended period.
{"title":"Polyetheretherketone (PEEK) implant functionalization with magnetron-sputtered SrTiO3 for regenerative medicine","authors":"Anjar Anggraini Harumningtyas, Tomoko Ito, Masato Ikuta, Takashi Kaito, Satoshi Hamaguchi","doi":"10.1615/plasmamed.2023051355","DOIUrl":"https://doi.org/10.1615/plasmamed.2023051355","url":null,"abstract":"Polyetheretherketone (PEEK) is a polymer material widely used for artificial bone implants but known to exhibit a low affinity for bone tissue and lack osteoconductivity and osseointegration. Because strontium (Sr) is known to enhance bone growth, PEEK implants coated with strontium titanate (SrTiO3, STO) is expected to improve the bone growth around them. In this study, STO was deposited on model PEEK implants by magnetron sputtering deposition and its ability to release Sr2+ ions to a surrounding phosphate-buffered saline (PBS) solution was examined. It is found that, in an early stage of the deposition process, STO on a PEEK surface exhibits irregular surface structures with many holes. The amount of Sr stored in the STO film increases with the increasing film thickness but the release rate of Sr2+ ions from the STO film to the surrounding PBS also increases with the film thickness, limiting the duration of effectiveness of the STO-coated PEEK films. It is found, however, that a three-layer titanium (Ti)-STO-Ti film deposited on PEEK allows a steady release of Sr2+ ions to the surrounding PBS for an extended period.","PeriodicalId":53607,"journal":{"name":"Plasma Medicine","volume":"71 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135609787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.1615/plasmamed.2023047809
Maryam Ali Raheem, Ban H. Adil
{"title":"Thermal effect of laser on silver nanoparticles synthesized by cold plasma method on cancer cells","authors":"Maryam Ali Raheem, Ban H. Adil","doi":"10.1615/plasmamed.2023047809","DOIUrl":"https://doi.org/10.1615/plasmamed.2023047809","url":null,"abstract":"","PeriodicalId":53607,"journal":{"name":"Plasma Medicine","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67348885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.1615/plasmamed.2023048800
Chaoxian Liang, Cao Fang, Han Wang, Mona Alrasheed Bashir, Qing Huang
{"title":"Removal of ampicillin using cold atmospheric-pressure plasma jet (CAPJ) and its plasma-activated water (PAW)","authors":"Chaoxian Liang, Cao Fang, Han Wang, Mona Alrasheed Bashir, Qing Huang","doi":"10.1615/plasmamed.2023048800","DOIUrl":"https://doi.org/10.1615/plasmamed.2023048800","url":null,"abstract":"","PeriodicalId":53607,"journal":{"name":"Plasma Medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67349596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.1615/plasmamed.2023049359
Mohammadreza Lotfi, M. Khani, Babak Shokri
{"title":"A review of cold atmospheric plasma applications in dermatology and aesthetics","authors":"Mohammadreza Lotfi, M. Khani, Babak Shokri","doi":"10.1615/plasmamed.2023049359","DOIUrl":"https://doi.org/10.1615/plasmamed.2023049359","url":null,"abstract":"","PeriodicalId":53607,"journal":{"name":"Plasma Medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67349609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.1615/plasmamed.2023049741
Maher Hadaya, Alexander Blackbay, Jinjie He, A. Rabinovich, Christopher Sales, A. Fridman
{"title":"Harnessing Plasma Technology in Cream Formulations for Medical Applications as a Nitric Oxide Donor: Proof-of-Concept","authors":"Maher Hadaya, Alexander Blackbay, Jinjie He, A. Rabinovich, Christopher Sales, A. Fridman","doi":"10.1615/plasmamed.2023049741","DOIUrl":"https://doi.org/10.1615/plasmamed.2023049741","url":null,"abstract":"","PeriodicalId":53607,"journal":{"name":"Plasma Medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67349660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Viruses are serious pathogenic contaminants that gravely threaten human health. There is an urgent need for environment-friendly and novel disinfection methods to inactivate various viruses. In this study, we applied the technique of cold atmospheric plasma (CAP) for virus disinfection. Particularly, we utilized the cold atmospheric plasma jet (CAPJ) and the plasma-activated solution (PAS) approaches for the treatment of bacteriophage MS2, and we added NaCl in the treatment system to enhance the disinfection efficiency. The inactivation effects under different CAPJ-PAS conditions using various plasma working gases were investigated. Also, the involved inactivation mechanisms due to respective active species were scrutinized. Our results showed that the addition of NaCl could considerably enhance the virus inactivation efficiency in the air/oxygen-CAPJ-PAS treatment, and during the direct CAPJ treatment, the primary inactivation factors were attributed to ·OH, 1O2, ONOOH and active chlorine, while for the indirect PAS treatment, the major inactivation contributors stemmed from 1O2 and active chlorine. This work therefore demonstrates the usefulness of NaCl in the CAPJ-PAS treatment in the virus inactivation and offers new perspectives on the application of CAP technology in disinfection of viruses.
{"title":"Application of chloride in cold atmospheric plasma jet (CAPJ) and plasma-activated solution (PAS) to enhance virus inactivation","authors":"Qing Huang, Han Wang, Chao Liu, Yahui Wu, Mona Alrasheed Bashir, Changsheng Shao","doi":"10.1615/plasmamed.2023051186","DOIUrl":"https://doi.org/10.1615/plasmamed.2023051186","url":null,"abstract":"Viruses are serious pathogenic contaminants that gravely threaten human health. There is an urgent need for environment-friendly and novel disinfection methods to inactivate various viruses. In this study, we applied the technique of cold atmospheric plasma (CAP) for virus disinfection. Particularly, we utilized the cold atmospheric plasma jet (CAPJ) and the plasma-activated solution (PAS) approaches for the treatment of bacteriophage MS2, and we added NaCl in the treatment system to enhance the disinfection efficiency. The inactivation effects under different CAPJ-PAS conditions using various plasma working gases were investigated. Also, the involved inactivation mechanisms due to respective active species were scrutinized. Our results showed that the addition of NaCl could considerably enhance the virus inactivation efficiency in the air/oxygen-CAPJ-PAS treatment, and during the direct CAPJ treatment, the primary inactivation factors were attributed to ·OH, 1O2, ONOOH and active chlorine, while for the indirect PAS treatment, the major inactivation contributors stemmed from 1O2 and active chlorine. This work therefore demonstrates the usefulness of NaCl in the CAPJ-PAS treatment in the virus inactivation and offers new perspectives on the application of CAP technology in disinfection of viruses.","PeriodicalId":53607,"journal":{"name":"Plasma Medicine","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134891176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.1615/plasmamed.2023050280
Katrinne Clea Pinca, Aian Ontoria, Magdaleno Jr Vasquez
Surgical tools are used in many medical treatments and procedures that expose them to a wide range of biological conditions that induce corrosion, abrasion, and wear. A protective layer is often needed to prolong its service life. Thus, it is essential to use appropriate coating techniques to improve the mechanical properties and chemical stability of the substrate. This work developed a custom-built radio frequency magnetron sputtering system for the deposition of titanium (Ti)-based coatings, which were selected because of their reported biocompatibility and superior mechanical qualities. Titanium nitride (TiN), and titanium aluminum nitride (TiAlN) thin films were deposited on AISI 304 stainless steel substrates and on INDOPLAS{texttrademark} sterile scalpel blades. TiN was grown using a Ti target while TiAlN used a Ti-Al combinatorial target. Both films were deposited using a 90:10 admixture of argon (Ar) and nitrogen (N) gases. The substrate bias was varied into three different potentials: 0, -100, and -200 V. Substrate heating of 200C was applied and the deposition time was set at 2 hours. The optimal parameters and material for surgical tools are found to be TiN deposited at -100 V and TiAlN deposited at -200 V substrate bias as they show the highest resistance to abrasion and corrosion, respectively, and without reducing the sharpness of the blades. This work aims to offer the medical community a practical and inexpensive method of protecting surgical instruments while extending service life.
{"title":"Properties of Nitride-coated surgical scalpel blades","authors":"Katrinne Clea Pinca, Aian Ontoria, Magdaleno Jr Vasquez","doi":"10.1615/plasmamed.2023050280","DOIUrl":"https://doi.org/10.1615/plasmamed.2023050280","url":null,"abstract":"Surgical tools are used in many medical treatments and procedures that expose them to a wide range of biological conditions that induce corrosion, abrasion, and wear. A protective layer is often needed to prolong its service life. Thus, it is essential to use appropriate coating techniques to improve the mechanical properties and chemical stability of the substrate. This work developed a custom-built radio frequency magnetron sputtering system for the deposition of titanium (Ti)-based coatings, which were selected because of their reported biocompatibility and superior mechanical qualities. Titanium nitride (TiN), and titanium aluminum nitride (TiAlN) thin films were deposited on AISI 304 stainless steel substrates and on INDOPLAS{texttrademark} sterile scalpel blades. TiN was grown using a Ti target while TiAlN used a Ti-Al combinatorial target. Both films were deposited using a 90:10 admixture of argon (Ar) and nitrogen (N) gases. The substrate bias was varied into three different potentials: 0, -100, and -200 V. Substrate heating of 200C was applied and the deposition time was set at 2 hours. The optimal parameters and material for surgical tools are found to be TiN deposited at -100 V and TiAlN deposited at -200 V substrate bias as they show the highest resistance to abrasion and corrosion, respectively, and without reducing the sharpness of the blades. This work aims to offer the medical community a practical and inexpensive method of protecting surgical instruments while extending service life.","PeriodicalId":53607,"journal":{"name":"Plasma Medicine","volume":"83 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135953184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.1615/plasmamed.2023047179
A. Benmoussa
{"title":"Gas temperature effect in methane DBD reactor for hydrogen production","authors":"A. Benmoussa","doi":"10.1615/plasmamed.2023047179","DOIUrl":"https://doi.org/10.1615/plasmamed.2023047179","url":null,"abstract":"","PeriodicalId":53607,"journal":{"name":"Plasma Medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67349250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.1615/plasmamed.2023049445
Doaa Rifaat jassim, Ramiz Ahmed Al-ansari, Ban.H Adil
Cu:Se core shell nanomaterials were created using atmospheric cold plasma in order to treat parasite leishmaniasis. In this investigation, leishmania parasite treatment was examined experimentally (L. tropica). Specifically, a 1mm diameter high-voltage electrode was used to produce atmospheric pressure non-thermal plasma. Cu:Se NPs were made using copper and selenium salts in aqueous solution as a precursor. The nanoparticles were examined using X-ray diffraction ,UV spectroscopy and FESEM, respectively. The ideal concentration (3:7) yields grains with a diameter of 17 nm . Morphology of the Cu:Se NPs were carried out using FESEM. Observations show that the NPs synthesized were spherical(Cluster) in shape. with diameters of was 15-50 nm. Thus, utilizing the aforementioned diameter, nanoparticles for the treatment of parasitic leishmaniasis were created. After 48 hours of exposure, the percentage of L. tropica parasites for the parasites at a molar concentration of 3:7, 30 min of Cu salt exposure, and 10 min of Se salt exposure, was equal to 78.8%. The core-shell nanoparticles are a viable method for treating the parasite leishmaniasis that threatens people all over the world, according to the results.
{"title":"Synthesis core-shell nanoparticles (Cu: Se) by plasma jet scheme for parasitic leishmaniasis treatment","authors":"Doaa Rifaat jassim, Ramiz Ahmed Al-ansari, Ban.H Adil","doi":"10.1615/plasmamed.2023049445","DOIUrl":"https://doi.org/10.1615/plasmamed.2023049445","url":null,"abstract":"Cu:Se core shell nanomaterials were created using atmospheric cold plasma in order to treat parasite leishmaniasis. In this investigation, leishmania parasite treatment was examined experimentally (L. tropica). Specifically, a 1mm diameter high-voltage electrode was used to produce atmospheric pressure non-thermal plasma. Cu:Se NPs were made using copper and selenium salts in aqueous solution as a precursor. The nanoparticles were examined using X-ray diffraction ,UV spectroscopy and FESEM, respectively. The ideal concentration (3:7) yields grains with a diameter of 17 nm . Morphology of the Cu:Se NPs were carried out using FESEM. Observations show that the NPs synthesized were spherical(Cluster) in shape. with diameters of was 15-50 nm. Thus, utilizing the aforementioned diameter, nanoparticles for the treatment of parasitic leishmaniasis were created. After 48 hours of exposure, the percentage of L. tropica parasites for the parasites at a molar concentration of 3:7, 30 min of Cu salt exposure, and 10 min of Se salt exposure, was equal to 78.8%. The core-shell nanoparticles are a viable method for treating the parasite leishmaniasis that threatens people all over the world, according to the results.","PeriodicalId":53607,"journal":{"name":"Plasma Medicine","volume":"155 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134887631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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