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Proof of Concept: Is Small-scale Production of Diethyl Ether for Anesthetic Use Possible? 概念证明:麻醉用乙醚的小规模生产是否可行?
Sandeep Dhanjal, Katelyn M Kitzinger, Dennis Jarema, Jeffrey S Johnson

Background: Clinicians face numerous challenges when providing effective anesthesia in the setting of humanitarian crisis or armed conflict. Anesthetic supply limitations often stand as a critical gap in these environments. Due to its clinical safety profile and relatively simple production, diethyl ether (Et2O) may offer a solution in such situations.

Methods: The dehydration of ethanol (EtOH) using an acid-catalyzed reaction was conducted twice. Sulfuric acid was added to a solution of ethanol in a glass flask that was heated to approximately 145 °C, promoting the formation of Et2O and water. At this temperature, Et2O was isolated from the solution through fractional distillation and collected in a flask that was cooled in an ice bath. The distillate was analyzed using proton nuclear magnetic resonance (1H NMR) spectroscopy.

Results: Two samples of Et2O were obtained using an acid-promoted dehydration of ethanol. Analysis of the samples using 1H NMR spectroscopy led to the identification of two components, Et2O and EtOH, whose identities were confirmed by comparison of the constituent peaks to known chemical shifts. Integration of the relevant peaks suggested a Et2O purity of approximately 97%.

Conclusion: This proof-of-concept study demonstrates that relatively pure Et2O can feasibly be produced and isolated on a small scale using an acid-catalyzed dehydration reaction with fractional distillation.

背景:临床医生在人道主义危机或武装冲突中提供有效麻醉时面临许多挑战。在这些环境中,麻醉剂供应的限制往往是一个关键的缺口。由于其临床安全性和相对简单的生产,乙醚(Et2O)可能为这种情况提供解决方案。方法:采用酸催化反应对乙醇(EtOH)进行两次脱水。将硫酸加入到玻璃烧瓶中的乙醇溶液中,加热到约145°C,促进Et2O和水的形成。在此温度下,通过分馏从溶液中分离出Et2O,并将其收集在在冰浴中冷却的烧瓶中。采用质子核磁共振(1H NMR)对馏分进行了分析。结果:用酸促乙醇脱水法得到了两个Et2O样品。利用1H NMR对样品进行分析,鉴定出Et2O和EtOH两种成分,通过将其组成峰与已知的化学位移进行比较,证实了它们的身份。相关峰的整合表明Et2O纯度约为97%。结论:这项概念验证研究表明,使用酸催化脱水反应和分馏可以在小范围内生产和分离相对纯净的Et2O。
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引用次数: 0
Ultrasound Use by Special Operations Combat Medics: A Narrative Review Limited to the JSOM. 特种作战医务人员使用超声波:仅限于JSOM的叙述回顾。
Jonathan Curley

Background: Ultrasonography has seen increasing integration into the clinical practice of Special Operations Combat Medics (SOCMs). However, there is limited literature available that describes SOCM use of ultrasonography. This narrative review aims to provide an overview of how SOCMs use ultrasound in clinical practice and explore proposed future applications.

Methods: A PubMed search was conducted for articles discussing ultrasonography in the context of Special Operations medicine. This search initially included a broad PubMed search followed by a targeted search limited to the Journal of Special Operations Medicine. Inclusion criteria for this targeted search encompassed articles describing ultrasound use or advocating for ultrasound use in SOCM clinical practice.

Results: The search was conducted in October 2023 and yielded 120 publications, of which 20 met inclusion criteria and are summarized in this review. Among these articles, 50% focused on cardiovascular applications, 35% on musculoskeletal applications, 20% on abdominal assessments (E-FAST exam), 15% on respiratory applications, and 10% on neurologic applications. Only 40% of the articles described operational use, while 60% advocated for use. Finally, 56.5% of the articles described diagnostic applications, while 43.5% pertained to procedural applications.

Conclusion: SOCM use of ultrasonography likely differs from in-hospital provider use of ultrasonography. To improve ultrasound education for SOCMs, educators should consider customization of the curriculum to align with the unique mission requirements of individual units and an increased emphasis on procedure-based training.

背景:超声检查越来越多地融入特种作战医务人员(socm)的临床实践。然而,有有限的文献可用来描述超声检查SOCM的使用。这篇叙述性综述旨在提供socm如何在临床实践中使用超声的概述,并探讨提出的未来应用。方法:在PubMed检索特种作战医学背景下讨论超声检查的文章。这个搜索最初包括一个广泛的PubMed搜索,然后是一个有针对性的搜索,仅限于特种作战医学杂志。该目标搜索的纳入标准包括描述超声使用或倡导超声在SOCM临床实践中的应用的文章。结果:检索于2023年10月进行,共获得120篇出版物,其中20篇符合纳入标准,本文对其进行综述。在这些文章中,50%集中于心血管应用,35%集中于肌肉骨骼应用,20%集中于腹部评估(E-FAST检查),15%集中于呼吸应用,10%集中于神经应用。只有40%的文章描述了操作使用,而60%的文章提倡使用。最后,56.5%的文章描述了诊断应用,而43.5%的文章描述了程序应用。结论:SOCM超声检查的使用可能不同于医院内提供者超声检查的使用。为了提高超声教育的socm,教育工作者应该考虑定制课程,以配合个别单位的独特任务要求,并增加对基于程序的培训的重视。
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引用次数: 0
Performance-Based Differences in Prefrontal Cortex Activation: Assessing Dynamic Marksmanship Performance Using Functional Near-Infrared Spectroscopy. 基于性能的前额皮质激活差异:使用功能近红外光谱评估动态射击性能。
Owen F Salmon, Thomas X Statz, Cierra B Ugale, Matthew D Segovia, Joshua R Thompson, Hunter D Dobbs, Rachel M Rauth, Cory M Smith

Introduction: Marksmanship is a fundamental skill for all servicemembers. However, the underlying neurophysiological differences in performance among marksmen remain unclear. Incorporating neurophysiological tracking such as functional near-infrared spectroscopy (fNIRS) may identify performance-based differences in prefrontal cortex (PFC) activation during dynamic marksmanship scenarios. This study examined cognitive load within the PFC during a simulated dynamic marksmanship scenario in non-proficient and proficient marksmen.

Methods: Twenty-four participants (12 men, 12 women) wore an fNIRS device over their forehead during a simulated stationary pistol marksmanship task (to determine proficiency status) and a dynamic shoot/no-shoot course of fire (COF) (to assess cognitive load). Relative concentrations of oxyhemoglobin (HbO2 ), deoxygenated hemoglobin (deoxygenated Hb), and total hemoglobin (total Hb) were tracked to quantify PFC activation differences in twelve proficient (=80% hit percentage) and twelve non-proficient (<80% hit percentage) marksmen.

Results: No difference in completion time was observed between groups during the dynamic COF (p=.34). However, non-proficient marksmen showed 26.3% higher HbO2 (p=.02) and 42.1% higher total Hb (p<.01) in the PFC compared to proficient marksmen.

Conclusion: Tracking PFC hemodynamic activity identified proficiency-based differences in cognitive load during a dynamic COF. Applying fNIRS during marksmanship-related tasks may be useful in developing stress resilience and mission readiness for servicemembers.

简介:枪法是所有军人的基本技能。然而,神射手在射击表现上潜在的神经生理差异尚不清楚。结合神经生理跟踪,如功能性近红外光谱(fNIRS)可以识别动态射击场景中前额皮质(PFC)激活的性能差异。本研究考察了非熟练和熟练射手在模拟动态射击情景下PFC的认知负荷。方法:24名参与者(12名男性,12名女性)在模拟静止手枪射击任务(以确定熟练程度)和动态射击/不射击过程(COF)(以评估认知负荷)期间在额头上佩戴fNIRS装置。追踪12名熟练患者(=80%命中率)和12名非熟练患者的氧合血红蛋白(HbO2)、脱氧血红蛋白(deoxygenated Hb)和总血红蛋白(total Hb)的相对浓度,以量化PFC激活的差异(结果:在动态COF期间,两组之间完成时间没有差异(p= 0.34)。然而,非熟练射手的HbO2高26.3% (p= 0.02),总Hb高42.1% (p)。结论:追踪PFC血流动力学活动可识别动态COF期间认知负荷的熟练程度差异。在枪法相关任务中应用fNIRS可能有助于发展服务人员的压力恢复能力和任务准备能力。
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引用次数: 0
Severe Rheumatic Heart Disease Requiring Mechanical Valve Placement in a Special Operations Forces Soldier. 特种作战部队士兵需要机械瓣膜植入的严重风湿性心脏病。
Kyler Osborne, Davis Duncan, Angela Curell, Megan Mahowald, Rachel E Bridwell

Rheumatic heart disease (RHD) has become exceedingly rare in the United States, but a recent resurgence may place military Servicemembers at increased risk for this diagnosis. Our case describes a 29-year-old U.S.-born Special Operations Forces (SOF) Soldier who presented for recurrent exertional near-syncope and progressive exercise intolerance with subsequent workup remarkable for RHD. Initial electrocardiogram was notable for benign early repolarization and intraventricular conduction delay. Cardiology evaluation with transthoracic and transesophageal echocardiograms revealed severe mitral regurgitation and rheumatic appearing mitral valve leaflets. The patient underwent a successful mechanical mitral valve replacement, requiring lifelong anticoagulation with warfarin. Depending on severity of valvular disease, treatment modalities range from conservative medical therapies to invasive and minimally invasive surgical intervention. This case demonstrates the importance for SOF medics and providers to remain vigilant of this resurging disease process. Additionally, it emphasizes the necessity for a high level of clinical suspicion in those with exertional complaints and decreased exercise tolerance to ensure timely diagnosis and treatment of rare but potentially life-threatening conditions.

风湿性心脏病(RHD)在美国已经变得非常罕见,但最近的死灰复燃可能使军人患这种疾病的风险增加。我们的病例描述了一名29岁的美国出生的特种作战部队(SOF)士兵,他表现为反复的劳累性近晕厥和进行性运动不耐受,随后的检查显示为RHD。初始心电图显示早期良性复极和脑室传导延迟。经胸和经食管超声心动图显示严重的二尖瓣反流和风湿性二尖瓣小叶。患者接受了成功的机械二尖瓣置换术,需要终身使用华法林抗凝。根据瓣膜疾病的严重程度,治疗方式从保守的药物治疗到侵入性和微创性手术干预不等。这个病例说明了特种部队医务人员和医疗服务提供者对这种复发性疾病过程保持警惕的重要性。此外,它强调了对那些有运动抱怨和运动耐受性下降的人进行高度临床怀疑的必要性,以确保及时诊断和治疗罕见但可能危及生命的疾病。
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引用次数: 0
Enhancing Oxygen Therapy and Preserving Oxygen Resources with the Double-Trunk Mask: Literature Review. 双鼻罩加强氧疗和保存氧资源:文献综述。
Frederic Duprez, Rida Cheikh Youssef, Joseph Antoun, Francios Waroquier, Frank Van Trimpont, Jean Baptiste Watelet

Background: The prehospital availability of oxygen resources appears to be a critical limitation in military medicine. The fraction of inspired oxygen (FIO2) provided to patients is frequently lower than their pathophysiological needs. This deficit is due to the difficult mobilization of oxygen reserves and the volatile tactical pressure. Although several oxygen delivery devices are on the market, few effectively achieve optimal FIO2 levels. The double-trunk mask (DTM) represents a revolutionary solution that significantly improves the efficiency of oxygen delivery while conserving oxygen. The DTM is derived from a conventional aerosol mask. It includes two 22mm corrugated tubes secured in the side openings of the mask, each approximately 15 to 20cm in length in adults.

Methods: Following PICO screening, 15 eligible articles (prehospital, real-life settings, published 1990-2023 in English, Dutch, or French) indicated DTM's mechanisms of operation and efficacy.

Results: DTM significantly improves oxygen delivery while minimizing oxygen loss and improving pulmonary diffusion rates. The increase in PaCO2 is minimal despite the increase in material dead space.

Conclusions: This device proves invaluable when oxygen supplies are limited, such as during pandemics or war. Its use maximizes administered FIO2 while minimizing oxygen consumption, optimizing patient care in resource-limited environments.

背景:院前氧气资源的可用性似乎是军事医学的一个关键限制。提供给患者的吸入氧(FIO2)的比例经常低于他们的病理生理需要。这种赤字是由于难以调动氧气储备和不稳定的战术压力。虽然市场上有几种供氧装置,但很少能有效地达到最佳的FIO2水平。双鼻罩(DTM)是一种革命性的解决方案,它在节约氧气的同时显著提高了氧气输送效率。DTM是由传统的气溶胶面罩衍生而来的。它包括两个22毫米的波纹管固定在口罩的侧面开口,每个成人约15至20厘米长。方法:通过PICO筛选,15篇符合条件的文章(院前、现实环境,发表于1990-2023年的英语、荷兰语或法语)表明了DTM的作用机制和疗效。结果:DTM显著改善氧输送,减少氧损失,提高肺弥散速率。尽管材料死区增加,但PaCO2的增加是最小的。结论:在氧气供应有限的情况下,如在流行病或战争期间,这种装置被证明是无价的。它的使用最大限度地提高了FIO2管理,同时最大限度地减少了氧气消耗,在资源有限的环境中优化了患者护理。
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引用次数: 0
Task Analysis Tool to Evaluate Tactical Combat Casualty Care in the Extreme Cold. 任务分析工具在极寒条件下评估战术战斗伤亡护理。
Justin P Bequette, Andres Martinez Murillo, Marcus Caldera, Jack Harris, William D'Angelo

Due to the evolving geopolitical strategy of near-peer nations, there has been a growing national interest in the Arctic region. However, Tactical Combat Casualty Care (TCCC) assessments and interventions have been shaped based on input from conflicts such as Iraq and Afghanistan. They do not consider the unique factors seen in extreme cold environments. Naval Medical Research Unit San Antonio has developed a task analysis tool, the Task Step Analysis Tool-Binary (TSAT-B), to evaluate the effects of extreme cold on tasks within the current TCCC protocols. The tool was pilot-tested using a trauma manikin in field environments in Alaska, with temperatures ranging from -2 to -35°C. As part of the TSAT-B, task steps are graded into three categories (provider, casualty, and procedure). Steps are timed, and hand temperature is measured before and after a task. Written and verbal feedback is used to enhance the binary (go/nogo) two-alternative forced-choice. The TSAT-B has proven to be a useful evaluation tool and is being offered to standardize how current TCCC protocols and proposed changes are evaluated.

由于邻近国家不断演变的地缘政治战略,各国对北极地区的兴趣日益浓厚。然而,战术战斗伤亡护理(TCCC)评估和干预措施是基于伊拉克和阿富汗等冲突的投入而形成的。他们没有考虑极端寒冷环境中的独特因素。圣安东尼奥海军医学研究单位开发了一种任务分析工具,即任务步骤分析工具-二进制(TSAT-B),以评估当前TCCC协议中极端寒冷对任务的影响。该工具在阿拉斯加的野外环境中使用创伤模型进行了试点测试,温度范围为-2至-35°C。作为TSAT-B的一部分,任务步骤分为三类(提供者、伤亡人员和程序)。步数是定时的,并且在任务前后测量手的温度。书面和口头反馈用于增强二元(go/nogo)两种选择的强制选择。TSAT-B已被证明是一个有用的评估工具,并被提供用于标准化如何评估当前TCCC协议和拟议的变更。
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引用次数: 0
Committee on Tactical Combat Casualty Care (CoTCCC) Update. 战术战斗伤亡护理委员会(CoTCCC)更新。
Harold R Montgomery
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引用次数: 0
Traumatic Hyphema with Commotio Retinae in a Special Operations Environment. 特种作战环境下外伤性前房积血伴视网膜震颤。
Scott R Bird, Kaytlin Hack, John W Kircher, Rachel E Bridwell

Traumatic ocular injuries from both combat- and noncombat-related activity remain a significant burden in active duty Ser- vicemembers and present a diagnostic and therapeutic challenge to Special Operations medics with limited resources in far forward and remote areas. Blunt ocular injury, whether from sports or battlefield engagement, can result in a variety of eyesight-threatening injuries, including hyphema, commotio retinae, iritis, uveitis, and open globe injury. The management of these conditions often requires teleconsultation with ophthalmology and potential evacuation, which is tailored to the resources available for the Special Operations Forces medic. The authors present a case of sports-related traumatic hyphema complicated by commotio retinae in a Special Operations unmanned aircraft systems (UAS) operator, requiring teleconsultation and evacuation to specialty care. The authors additionally provide tailored prehospital strategies for the management of these unique but imperative injuries.

战斗和非战斗相关活动造成的创伤性眼部损伤仍然是现役军人的一个重大负担,对在遥远的前沿和偏远地区资源有限的特种作战医务人员提出了诊断和治疗方面的挑战。钝性眼损伤,无论是运动还是战场,都可能导致各种威胁视力的损伤,包括前房积血、视网膜震颤、虹膜炎、葡萄膜炎和开放性眼球损伤。这些情况的处理通常需要眼科远程会诊和可能的后送,这是根据特种作战部队医务人员的可用资源量身定制的。作者提出了一例运动相关的创伤性前房积血并发视网膜紊乱的情况下,在特种作战无人机系统(UAS)操作员,需要远程咨询和疏散到专科护理。此外,作者提供量身定制的院前策略管理这些独特的,但势在必行的伤害。
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引用次数: 0
On Saving - The Psychosocial Benefit of Saving Lives in War and Society. 论拯救——在战争和社会中拯救生命的社会心理利益。
Russ S Kotwal, Robert L Mabry, Jeffrey T Howard

Posttraumatic stress can result from combat and noncombat-related experiences. Conditioning military forces to be lethal or to save lives may influence responses to stress. Training to respond to casualties and to save lives should be a universal practice among medical and non-medical personnel when preparing for combat operations and battlefield casualties. National security requires a strong military. A strong military is reliant on a strong society that is cohesive as well as economically and spiritually intact. Cohesion is vital to the overall health and development of a society. A lack of cohesion can result in excess mortality and a reduction in life expectancy. Cohesion expands social networks and increases social capital that provides support for its military and overall population. Cohesion and leadership are needed to defend our nation, preserve national security, improve societal health, and save lives.

创伤后压力可能源于战斗和非战斗相关的经历。将军事力量训练成致命的或拯救生命的可能会影响对压力的反应。在为作战行动和战场伤亡做准备时,医务人员和非医务人员应普遍接受应对伤亡和拯救生命的培训。国家安全需要一支强大的军队。一支强大的军队依赖于一个强大的社会,一个凝聚力强、经济和精神完整的社会。凝聚力对社会的整体健康和发展至关重要。缺乏凝聚力会导致死亡率过高和预期寿命缩短。凝聚力扩大了社会网络,增加了社会资本,为军队和全体人口提供了支持。保卫我们的国家、维护国家安全、改善社会健康和拯救生命需要凝聚力和领导力。
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引用次数: 0
Chronicity of Posttraumatic Stress Disorder Symptoms Following Traumatic Brain Injury: A Comparison of Special Operators and Conventional Forces. 创伤性脑损伤后创伤后应激障碍症状的慢性:特种部队与常规部队的比较
Shannon Miles, Daniel Klyce, Amanda Garcia, Alexandra R Thelan, Xinyu Tang, Rachel Wallace, Raj G Kumar, Risa Nakase-Richardson

Background: Special Operations Forces (SOF) have become the solution to many of the United States military challenges due to their ability to conduct time sensitive, clandestine, and high-risk missions. Historically, SOF were assumed to be resilient to the psychological sequelae of war, including posttraumatic stress disorder (PTSD). However, the objective burden of PTSD in SOF, particularly after traumatic brain injury (TBI), remains unknown. This study compared average PTSD symptoms over time between SOF and Conventional Forces (CF) who had sustained a TBI.

Methods: This prospective cohort study examined Servicemembers and Veterans admitted to one of five Veterans Affairs Polytrauma Rehabilitation Centers for TBI. Propensity score matching created matched samples of 205 SOF and 205 CF. The PTSD Checklist-Civilian version (PCL-C) measured PTSD symptoms at admission and 1, 2, 5, and 10 years post TBI.

Results: In a longitudinal mixed-effects model of PTSD symptoms over time grouped by TBI severity, SOF and CF had similar severity and patterns of PTSD symptoms. SOF and CF with mild TBI had more PTSD symptoms across all time points compared to those with moderate and severe TBI.

Conclusion: The evolution and severity of PTSD symptoms after TBI in SOF and CF were similar. While SOFs had higher resilience compared to CFs in previous work, SOFs are not impervious to trauma exposure and PTSD. Increasing awareness of PTSD prevalence and consequences is needed to serve SOF. Identifying those needing care and providing evidence-based PTSD treatments can have the downstream effects of reducing attrition from the service and maintaining military readiness.

背景:特种作战部队(SOF)由于其执行时间敏感、秘密和高风险任务的能力,已经成为美国许多军事挑战的解决方案。从历史上看,特种部队被认为能够适应战争的心理后遗症,包括创伤后应激障碍(PTSD)。然而,创伤后应激障碍的客观负担,特别是在创伤性脑损伤(TBI)后,仍然是未知的。本研究比较了特种部队和常规部队(CF)遭受创伤性脑损伤后的平均PTSD症状。方法:这项前瞻性队列研究调查了在五个退伍军人事务多创伤康复中心之一接受TBI治疗的军人和退伍军人。倾向评分匹配产生205个SOF和205个CF的匹配样本。PTSD检查表-平民版(PCL-C)测量入院时以及创伤后1、2、5和10年的PTSD症状。结果:在创伤性脑损伤严重程度分组的PTSD症状随时间的纵向混合效应模型中,SOF和CF具有相似的PTSD症状严重程度和模式。与中度和重度TBI患者相比,轻度TBI患者在所有时间点上都有更多的PTSD症状。结论:SOF和CF患者创伤后应激障碍症状的演变和严重程度相似。虽然在之前的研究中,SOFs比CFs具有更高的弹性,但SOFs并非不受创伤暴露和创伤后应激障碍的影响。为特种部队服务,需要提高对PTSD患病率和后果的认识。确定那些需要护理的人,并提供基于证据的创伤后应激障碍治疗,可以减少服役人员的减员,保持军事准备状态。
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引用次数: 0
期刊
Journal of special operations medicine : a peer reviewed journal for SOF medical professionals
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