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Slow Intravenous Infusion of a Novel Damage Control Cocktail Decreases Blood Loss in a Pig Polytrauma Model. 在猪多发性创伤模型中缓慢静脉输注一种新型损伤控制鸡尾酒可减少失血。
Nathan James White, Chloe Asato, Andrew Wenthe, Xu Wang, Kristyn Ringgold, Alexander St John, Chang Yeop Han, Jennifer C Bennett, Susan A Stern

Background: Our objective was to optimize a novel damage control resuscitation (DCR) cocktail composed of hydroxyethyl starch, vasopressin, and fibrinogen concentrate for the polytraumatized casualty. We hypothesized that slow intravenous infusion of the DCR cocktail in a pig polytrauma model would decrease internal hemorrhage and improve survival compared with bolus administration.

Methods: We induced polytrauma, including traumatic brain injury (TBI), femoral fracture, hemorrhagic shock, and free bleeding from aortic tear injury, in 18 farm pigs. The DCR cocktail consisted of 6% hydroxyethyl starch in Ringer's lactate solution (14mL/kg), vasopressin (0.8U/kg), and fibrinogen concentrate (100mg/kg) in a total fluid volume of 20mL/kg that was either divided in half and given as two boluses separated by 30 minutes as control or given as a continuous slow infusion over 60 minutes. Nine animals were studied per group and monitored for up to 3 hours. Outcomes included internal blood loss, survival, hemodynamics, lactate concentration, and organ blood flow obtained by colored microsphere injection.

Results: Mean internal blood loss was significantly decreased by 11.1mL/kg with infusion compared with the bolus group (p = .038). Survival to 3 hours was 80% with infusion and 40% with bolus, which was not statistically different (Kaplan Meier log-rank test, p = .17). Overall blood pressure was increased (p < .001), and blood lactate concentration was decreased (p < .001) with infusion compared with bolus. There were no differences in organ blood flow (p > .09).

Conclusion: Controlled infusion of a novel DCR cocktail decreased hemorrhage and improved resuscitation in this polytrauma model compared with bolus. The rate of infusion of intravenous fluids should be considered as an important aspect of DCR.

背景:我们的目的是优化一种由羟乙基淀粉、加压素和纤维蛋白原浓缩物组成的新型损伤控制复苏(DCR)混合物,用于多发性创伤伤员。我们假设,在猪多发性创伤模型中缓慢静脉输注DCR混合物与推注相比,可以减少内出血并提高生存率。方法:我们在18头农场猪身上诱导了多发性创伤,包括创伤性脑损伤(TBI)、股骨骨折、失血性休克和主动脉撕裂伤自由出血。DCR混合物由6%羟乙基淀粉的林格乳酸溶液(14mL/kg)、血管加压素(0.8U/kg)和纤维蛋白原浓缩物(100mg/kg)组成,总液体体积为20mL/kg,将其一分为二,分为两次,间隔30分钟作为对照,或在60分钟内连续缓慢输注。每组研究9只动物,并对其进行长达3小时的监测。结果包括通过彩色微球注射获得的内部失血、存活率、血流动力学、乳酸浓度和器官血流量。结果:与推注组相比,输注组的平均内部失血量显著减少了11.1mL/kg(p=.038)。输注组和推注组的3小时生存率分别为80%和40%,这在统计学上没有差异(Kaplan-Meier log秩检验,p=.17)。总血压升高(p<.001),与推注相比,输注后血乳酸浓度降低(p<0.001)。器官血流量没有差异(p>0.05)。结论:与推注相比,在该多发性创伤模型中,控制输注新型DCR混合物可减少出血并改善复苏。静脉输液速率应被视为DCR的一个重要方面。
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引用次数: 0
Altered Sympathoadrenal Activity Following Cold-Water Diving. 冷水潜水后交感肾上腺活动改变。
Karen R Kelly, Carina M Pautz, Laura J Palombo, Andrew E Jensen, Jorgen Melau, Lorraine P Turcotte, Paul A Solberg

Introduction: Little data exist on the effect of extremely cold-water diving on thermo-metabolic hormone secretion. Moreover, the impact of repetitive dives on the stress response is unknown. The purpose of this study was to determine the effects of two daily bouts of cold-water diving on the hormonal and metabolic profile of elite military personnel and to measure the stress response.

Methods: Healthy, male, Norwegian Special Forces operators (n = 5) volunteered for this study. Physiological and hormone data were analyzed prior to and following twice-daily Arctic dives (3.3°C).

Results: Core temperature was maintained (p > .05), whereas skin temperature was significantly reduced over the course of each dive (p < .01). Pairwise comparisons revealed adrenocorticotropic hormone (ACTH) and cortisol concentration significantly decreased across both dives and days (p < .001). Adrenaline and noradrenaline significantly increased across both time and day (p < .001). Leptin, testosterone, and IGF-1 significantly decreased over time but recovered between days.

Conclusion: The main findings of this effort are that there is a rapid sympathetic-adreno-medullary (SAM/SNS) response to cold-water diving and a suppression of the hypothalamic-pituitary-adrenal (HPA) axis and hormones related to repair and recovery. While the sample size was too small to determine the role of SAM/SNS, HPA, and thyroid hormone effect on thermoregulation, it addresses a gap in our understanding of physiological adaptions that occurs in extreme environments.

引言:关于极冷水潜水对热代谢激素分泌的影响,目前几乎没有数据。此外,重复潜水对压力反应的影响尚不清楚。本研究的目的是确定每天两次冷水潜水对精英军事人员激素和代谢状况的影响,并测量压力反应。方法:健康的男性挪威特种部队操作员(n=5)自愿参加本研究。分析了每天两次北极潜水(3.3°C)前后的生理和激素数据。结果:核心温度保持不变(p>0.05),而皮肤温度在每次潜水过程中都显著降低(p<0.01)。成对比较显示,促肾上腺皮质激素(ACTH)和皮质醇浓度在潜水和潜水天数中都显著下降(p<0.001)。肾上腺素和去甲肾上腺素在潜水和跳伞天数中都显着增加(p<001),IGF-1随着时间的推移显著降低,但在几天之间恢复。结论:该研究的主要发现是对冷水潜水有快速的交感-肾上腺-髓质(SAM/SNS)反应,下丘脑-垂体-肾上腺(HPA)轴和与修复和恢复相关的激素受到抑制。虽然样本量太小,无法确定SAM/SNS、HPA和甲状腺激素对体温调节的作用,但它解决了我们对极端环境中发生的生理适应的理解差距。
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引用次数: 0
Artificial Blood Development Implications for Military Medicine. 人工血液开发对军事医学的启示。
Vanessa R Melanson, Jeremy R Hershfield, Michael Kevin Deegan, Hyeveen Cho, Dion Perinon, Stacey L Bateman, Jason C Barnhill

Massive hemorrhaging remains the most common cause of preventable battlefield deaths. Blood used for trauma care requires a robust donation network, capacity for long-term storage, and extensive and accurate testing. Bioengineering technologies could offer a remedy to these constraints in the form of blood substitutes-fluids that could be transfused into patients to provide oxygen, carry away waste, and aid in coagulation-that would be used in prolonged casualty care and in far-forward settings, overcoming the obstacles of distance and time. The different molecular properties of red blood cells (RBCs), blood substitutes, and platelet replacements contribute to their respective utilities, and each type is currently represented in ongoing clinical trials. Hemoglobin oxygen carriers (HBOCs) are the most advanced RBC replacements, many of which are currently being evaluated in clinical trials in the United States and other countries. Despite recent advancements, challenges remaining in the development of blood alternatives include stability, oxygen capacity, and compatibility. The continued research and investment in new technologies has the potential to significantly benefit the treatment of life-threatening emergency injuries, both on the battlefield and in the civilian sector. In this review, we discuss military blood-management practices and military-specific uses of individual blood components, as well as describe and analyze several artificial blood products that could be options for future battlefield use.

大规模出血仍然是可预防的战场死亡的最常见原因。用于创伤护理的血液需要强大的捐赠网络、长期储存能力以及广泛准确的检测。生物工程技术可以以血液替代液的形式为这些限制提供补救措施,血液替代液可以输注到患者体内,提供氧气,带走废物,并有助于凝血,用于长期伤员护理和远期环境,克服距离和时间的障碍。红细胞(RBCs)、血液替代品和血小板替代品的不同分子特性有助于它们各自的用途,目前每种类型都在正在进行的临床试验中有代表性。血红蛋白氧载体(HBOC)是最先进的红细胞替代品,其中许多目前正在美国和其他国家的临床试验中进行评估。尽管最近取得了进展,但血液替代品的开发仍面临挑战,包括稳定性、氧气容量和兼容性。对新技术的持续研究和投资有可能大大有利于在战场和民用部门治疗危及生命的紧急伤害。在这篇综述中,我们讨论了军事血液管理实践和个别血液成分的军事特定用途,并描述和分析了几种可供未来战场使用的人造血液产品。
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引用次数: 0
Proceedings of the 2023 Spring/Summer Meeting of the Committee for Tactical Emergency Casualty Care (C-TECC) and Committee Updates. 战术紧急伤亡护理委员会(C-TECC)2023年春季/夏季会议记录和委员会更新。
Geoffrey L Shapiro, Michael J Marino, David W Callaway, Richard Kamin, Allen Yee, Carol Cunningham, James Schwartz, Claire Park, Reed Smith, Nelson Tang
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引用次数: 0
Use of Intranasal Analgesia in French Armed Forces: A Cross-Sectional Survey. 法国武装部队使用鼻内镇痛:横断面调查。
Romain Montagnon, Pierre-Julien Cungi, Olivier Aoun, Gabriel Morand, Jerome Desmottes, Pierre Pasquier, Stephane Travers, Luc Aigle, Christophe Dubecq

Background: Pain management is essential in military medicine, particularly in Tactical Combat Casualty Care (TCCC) during deployments in remote and austere settings. The few previously published studies on intranasal analgesia (INA) focused only on the efficacy and onset of action of the medications used (ketamine, sufentanil, and fentanyl). Side-effects were rarely reported. The aim of our study was to evaluate the use of intranasal analgesia by French military physicians.

Methods: We carried out a multicentric survey between 15 January and 14 April 2020. The survey population included all French military physicians in primary-care centers (n = 727) or emergency departments (n = 55) regardless of being stationed in mainland France or French overseas departments and territories.

Results: We collected 259 responses (33% responsiveness rate), of which 201 (77.6%) physicians reported being familiar with INA. However, regarding its use, of the 256 physicians with completed surveys, only 47 (18.3%) had already administered it. Emergency medicine physicians supporting highly operational units (e.g., Special Forces) were more familiar with this route of administration and used it more frequently. Ketamine was the most common medication used (n = 32; 57.1%). Finally, 234 (90%) respondents expressed an interest in further education on INA.

Conclusion: Although a majority of French military physicians who replied to the survey were familiar with INA, few used it in practice. This route of administration seems to be a promising medication for remote and austere environments. Specific training should, therefore, be recommended to spread and standardize its use.

背景:疼痛管理在军事医学中至关重要,尤其是在偏远和艰苦环境中部署的战术战斗伤亡护理(TCCC)中。先前发表的少数关于鼻内镇痛(INA)的研究仅关注所用药物(氯胺酮、舒芬太尼和芬太尼)的疗效和起效情况。副作用很少报道。我们研究的目的是评估法国军医使用鼻内镇痛的情况。方法:我们在2020年1月15日至4月14日期间进行了一项多中心调查。调查人群包括初级保健中心(n=727)或急诊科(n=55)的所有法国军医,无论他们驻扎在法国本土或法国海外部门和地区。结果:我们收集了259份回复(33%的回复率),其中201名(77.6%)医生报告熟悉INA。然而,关于它的使用,在完成调查的256名医生中,只有47人(18.3%)已经使用过它。支持高作战部队(如特种部队)的急诊医生更熟悉这种给药途径,使用频率也更高。氯胺酮是最常用的药物(n=32;57.1%)。最后,234名(90%)受访者表示有兴趣继续接受INA的教育。结论:尽管大多数接受调查的法国军医都熟悉INA,但很少有人在实践中使用它。这种给药途径似乎是一种很有前途的药物,适用于偏远和艰苦的环境。因此,应建议进行具体培训,以推广和规范其使用。
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引用次数: 0
Combat Vascular Access: A Scoping Review. 作战血管通路:范围界定综述。
Shane Smith, John White, Tabitha McGuire, Bethann Meunier, Ian Ball, Richard Hilsden

Medical leadership must decide how to obtain vascular access in a combat environment. Adequate combat trauma resuscitation requires efficient vascular access. A search of the Medline and EMBASE databases was conducted to find articles on combat vascular access. The primary dataset of interest was the type of vascular access obtained. Other data reviewed included who performed the intervention and the success rate of the intervention. The search strategy produced 1,339 results, of which 24 were included in the final analysis. Intravenous (IV), intraosseous (IO), and central venous access have all been used in the prehospital combat environment. This review summarizes the available combat literature to help commanders make an evidence-based decision about their prehospital vascular access strategy.

医疗领导层必须决定如何在作战环境中获得血管通路。充分的战斗创伤复苏需要有效的血管通路。对Medline和EMBASE数据库进行了搜索,以查找关于对抗血管通路的文章。感兴趣的主要数据集是获得的血管通路类型。审查的其他数据包括谁进行了干预以及干预的成功率。搜索策略产生了1339个结果,其中24个包含在最终分析中。静脉(IV)、骨内(IO)和中心静脉通路都已用于院前作战环境。这篇综述总结了现有的作战文献,以帮助指挥官对院前血管通路策略做出循证决策。
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引用次数: 0
Yugoslav Guerrilla Hospital Design Features and Operation in World War II. 南斯拉夫游击队医院在第二次世界大战中的设计特点和运作。
M Tyler Colesar, Jay B Baker

In the most austere combat conditions, Yugoslav guerillas of World War II (WWII) demonstrated an innovative and effective hospitalization system that saved countless lives. Yugoslav Partisans faced extreme medical and logistical challenges that spurred innovation while waging a guerrilla war against the Nazis. Partisans used concealed hospitals ranging between 25 to 215 beds throughout the country with wards that were often subterranean. Concealment and secrecy prevented discovery of many wards, which prototypically contained two bunk levels and held 30 patients in a 3.5 × 10.5-meter space that included storage and ventilation. Backup storage and treatment facilities provided critical redundancy. Intra-theater evacuation relied on pack animals and litter bearers while partisans relied on Allied fixed wing aircraft for inter-theater evacuation.

在最严峻的战斗条件下,第二次世界大战的南斯拉夫游击队展示了一种创新有效的住院系统,挽救了无数人的生命。南斯拉夫游击队在对纳粹发动游击战争的同时,面临着极端的医疗和后勤挑战,这激发了创新。游击队在全国各地使用25至215张床位的隐蔽医院,病房通常在地下。隐蔽性和保密性阻止了许多病房的发现,这些病房通常有两层双层,在3.5×10.5米的空间里容纳了30名患者,包括储藏室和通风室。备用储存和处理设施提供了关键的冗余。战区内疏散依靠驮畜和担架手,而游击队则依靠盟军固定翼飞机进行战区间疏散。
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引用次数: 0
Phosphorus Burn Management with Multimodal Analgesia. 磷烧伤多模式镇痛治疗。
Luc Saint-Jean, Simon-Pierre Corcostegui, Julien Galant, Clement Derkenne

We report the case of a patient suffering from a chemical burn caused by white phosphorus, for whom initial management required decontamination using multimodal analgesia. This case report should be familiar to other military emergency physicians and Tactical Emergency Medical Support for two reasons: 1) A phosphorus burn occurs from a chemical agent rarely encountered, with minimal research available in the medical literature, despite the use of this weapon in the recent Ukrainian conflict, and 2) We discuss the use of multimodal analgesia, combining loco-regional anesthesia (LRA) and an intranasal pathway, which can be used in a remote and austere environment.

我们报告了一例患者因白磷引起的化学烧伤,其初始治疗需要使用多模式镇痛进行去污。其他军事急诊医生和战术紧急医疗支持人员应该熟悉这份病例报告,原因有两个:1)磷烧伤是由很少遇到的化学制剂引起的,尽管在最近的乌克兰冲突中使用了这种武器,但医学文献中的研究很少;2)我们讨论了多模式镇痛的使用,结合局部区域麻醉(LRA)和鼻内途径,可在偏远和艰苦的环境中使用。
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引用次数: 0
Unconventional Resilience: A Strategic Framework. 非常规弹性:一个战略框架。
Erika Ann Jeschke, Jay B Baker, Jared Wyma-Bradley, John Dorsch, Sarah L Huffman

This will be the second in a series of nine articles in which we discuss findings from our ethnographic study entitled "The Impact of Catastrophic Injury Exposure on Resilience in Special Operations Surgical Teams." Our goal in this article is to establish the practical importance of redefining resilience within a strategic framework. Our bottom-up approach to strategy development explores unconventional resilience as an integrated transformational process that promotes change-agency through the force of movement. Synthesis of empirical data derived from participant interviews and focus groups highlights conceptual attributes that make up the essential components of this framework. To achieve our goal, the authors (1) briefly remind readers how we have problematized conventional resilience; (2) explain how we analyzed qualitative quotes to extrapolate our definition of unconventional resilience; and (3) describe in detail our strategic framework. We conclude by gesturing to why this strategic framework is applicable to practical performance of all Special Operation Forces (SOF) medics.

这将是我们在一系列九篇文章中的第二篇,在这些文章中,我们讨论了民族志研究的结果,题为“灾难性伤害暴露对特种外科团队复原力的影响”。我们在这篇文章中旨在确定在战略框架内重新定义复原力的实际重要性。我们自下而上的战略制定方法探索了非传统的韧性,将其作为一个综合转型过程,通过运动的力量促进变革。综合来自参与者访谈和焦点小组的经验数据,突出了构成该框架基本组成部分的概念属性。为了实现我们的目标,作者(1)简要地提醒读者,我们是如何将传统的韧性问题化的;(2) 解释我们如何分析定性报价,以推断我们对非常规弹性的定义;以及(3)详细描述我们的战略框架。最后,我们指出了为什么这一战略框架适用于所有特种作战部队(SOF)医务人员的实际表现。
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引用次数: 0
A Novel Scale to Assess Psychological Strategies in Explosive Ordnance Disposal Technicians. 一种新的评估爆炸物处理技术人员心理策略的量表。
Marcus Keene Taylor, Nikki E Barczak-Scarboro, Lisa Mercedes Hernandez

Purpose: This report describes the development and validation of the U.S. Navy Explosive Ordnance Disposal (EOD) Combat Mindset Scale-Training (CMS-T), a population-specific measure of psychological strategy use in EOD training environments.

Methods: Scale items were developed by a working group composed of active-duty technicians from EOD Training and Evaluation Unit 1, Naval Health Research Center scientists, and a psychometrician. The working group developed 30 candidate items, which were administered to EOD accessions (new recruits), advanced students, and technicians (N = 164). Factor structure was explored with principal axis factoring and Varimax rotation with Kaiser normalization. Internal consistencies were established via Cronbach alpha, and convergent validity was evaluated with correlational and ANOVA models.

Results: Five internally stable subscales were derived from 19 essential items, explaining 65% of total variance. The subscales were named relaxation, attentional-emotional control (AEC), goal setting-visualization (GSV), internal dialogue (ID), and automaticity. The most frequently used strategies were GSV and ID. Expected relationships emerged between strategies, most notably AEC and mental health. The scale also differentiated between subgroups.

Conclusion: The EOD CMS-T demonstrates a stable factor structure, internal reliability, and convergent validity. This study yields a valid, practical, and easily administered instrument to support EOD training and evaluation.

目的:本报告描述了美国海军爆炸物处理(EOD)战斗心态规模训练(CMS-T)的开发和验证,这是一种针对特定人群的EOD训练环境中心理策略使用的衡量标准。方法:量表项目由一个工作组开发,该工作组由第一单元EOD培训和评估的现役技术人员、海军健康研究中心的科学家和一名心理测量师组成。工作组开发了30个候选项目,对EOD加入者(新招募人员)、高级学生和技术人员进行管理(N=164)。因子结构采用主轴因子分解和Kaiser归一化的Varimax旋转进行了探索。通过Cronbachα建立内部一致性,并通过相关和方差分析模型评估收敛有效性。结果:5个内部稳定的分量表来自19个基本项目,解释了65%的总方差。分量表被命名为放松、注意情绪控制(AEC)、目标设定可视化(GSV)、内部对话(ID)和自动性。最常用的策略是GSV和ID。策略之间出现了预期的关系,最显著的是AEC和心理健康。该量表还区分了不同的亚组。结论:EOD CMS-T具有稳定的因子结构、内部信度和收敛有效性。这项研究提供了一种有效、实用且易于管理的工具来支持EOD培训和评估。
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引用次数: 0
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Journal of special operations medicine : a peer reviewed journal for SOF medical professionals
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