Pub Date : 2020-01-29DOI: 10.20471/lo.2019.47.02-03.12
K. Katić, V. Matković, J. Lešin, Goran Vujić, Pavao Planinić, A. Ćorušić
Epithelial ovarian cancer is the seventh most common cancer among women and the leading cause of gynecological cancer related deaths in Croatia. Approximately 70% of patients are diagnosed at an advanced stage of the disease (FIGO III and IV). The usual approach to treatment involves complete surgical cytoreduction (R0), followed by combined platinumbased chemotherapy. Bevacizumab is recommended to add to paclitaxel/carboplatin chemotherapy in patients diagnosed at FIGO IIIB and IIIC stage with residual disease after surgery and all patients FIGO IV stage of disease, which can extend the time to progression of the disease in these patients.
{"title":"First-line treatment of ovarian cancer FIGO stages IIIB-IV: focus on therapy with bevacizumab - our experience","authors":"K. Katić, V. Matković, J. Lešin, Goran Vujić, Pavao Planinić, A. Ćorušić","doi":"10.20471/lo.2019.47.02-03.12","DOIUrl":"https://doi.org/10.20471/lo.2019.47.02-03.12","url":null,"abstract":"Epithelial ovarian cancer is the seventh most common cancer among women and the leading cause of gynecological cancer related deaths in Croatia. Approximately 70% of patients are diagnosed at an advanced stage of the disease (FIGO III and IV). The usual approach to treatment involves complete surgical cytoreduction (R0), followed by combined platinumbased chemotherapy. Bevacizumab is recommended to add to paclitaxel/carboplatin chemotherapy in patients diagnosed at FIGO IIIB and IIIC stage with residual disease after surgery and all patients FIGO IV stage of disease, which can extend the time to progression of the disease in these patients.","PeriodicalId":53700,"journal":{"name":"Libri Oncologici","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.20471/lo.2019.47.02-03.12","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43426673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-29DOI: 10.20471/lo.2019.47.02-03.18
T. Novosel, P. Jecker, V. Bedeković, D. Boščić, Tomislav Šušnjar, J. Scharpf
Summary Parathyroid glands produce parathyroid hormone (PTH), which regulates calcium level in peripheral circulation by controlling calcium relocation and calcium excretion. Hypoparathyroidism is one of the potential complications that can occur during thyroid surgery. Hypocalcemia, as a result of hypoparathyroidism, can cause severe symptoms, even life-threatening, when not treated properly. In this paper, we would like to focus on how to preserve the function of the parathyroid glands during thyroid surgery and prevent transient and permanent hypoparathyroidism by opting to perform parathyroid autotransplantation. To struc ture our suggestion, we divided the article into why, when, and how to do the parathyroid autotransplantation?
{"title":"Parathyroid glands autotransplantation: why? When? How?","authors":"T. Novosel, P. Jecker, V. Bedeković, D. Boščić, Tomislav Šušnjar, J. Scharpf","doi":"10.20471/lo.2019.47.02-03.18","DOIUrl":"https://doi.org/10.20471/lo.2019.47.02-03.18","url":null,"abstract":"Summary Parathyroid glands produce parathyroid hormone (PTH), which regulates calcium level in peripheral circulation by controlling calcium relocation and calcium excretion. Hypoparathyroidism is one of the potential complications that can occur during thyroid surgery. Hypocalcemia, as a result of hypoparathyroidism, can cause severe symptoms, even life-threatening, when not treated properly. In this paper, we would like to focus on how to preserve the function of the parathyroid glands during thyroid surgery and prevent transient and permanent hypoparathyroidism by opting to perform parathyroid autotransplantation. To struc ture our suggestion, we divided the article into why, when, and how to do the parathyroid autotransplantation?","PeriodicalId":53700,"journal":{"name":"Libri Oncologici","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.20471/lo.2019.47.02-03.18","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67598435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-29DOI: 10.20471/lo.2019.47.02-03.17
F. Cmrečak, Iva Andrašek, Meliha Solak-Mekić, M. Ravlić, L. Beketić-Orešković
Summary The aim of this review article is to present new sophisticated techniques in radiotherapy, which occurred due to the advancement of technology over the past few decades. The paper will provide insight into their advantages and disadvan -tages, the importance of diagnostic imaging modality, precise contouring, treatment planning and control of patients’ posi tion during radiation treatment. The transition from two-dimensional to three-dimensional radiotherapy has allowed con touring of target volume and organs at risk and accurate information on radiation dosage delivered. With a further desire for more precision and protection of healthy tissues, techniques such as intensity modulated radiotherapy (IMRT) and volu metric modulated arc therapy (VMAT) have been developed with the ability to modulate beam intensity. Quality imaging diagnostics is an infallible part of the modern radiotherapy. Image-guided radiotherapy (IGRT) and adaptive radiotherapy enable the delivery of high precision radiation to the target volume and spares organs at risk by correcting interfractional and intrafractional variations. Respiratory gating and tracking technique are useful for tumours that change their position during respiratory cycle. Stereotactic ablative radiotherapy (SABR) is a technique that uses highly conformal high-dose hypofractionated radiation to treat small tumours. In some indication such as the treatment of early stage non-small lung cancer, it competes with radical surgery. SABR is also an important therapeutic modality in the management of oligometa static disease. This paper will briefly discuss proton therapy and its unique physical properties.
{"title":"Modern radiotherapy techniques","authors":"F. Cmrečak, Iva Andrašek, Meliha Solak-Mekić, M. Ravlić, L. Beketić-Orešković","doi":"10.20471/lo.2019.47.02-03.17","DOIUrl":"https://doi.org/10.20471/lo.2019.47.02-03.17","url":null,"abstract":"Summary The aim of this review article is to present new sophisticated techniques in radiotherapy, which occurred due to the advancement of technology over the past few decades. The paper will provide insight into their advantages and disadvan -tages, the importance of diagnostic imaging modality, precise contouring, treatment planning and control of patients’ posi tion during radiation treatment. The transition from two-dimensional to three-dimensional radiotherapy has allowed con touring of target volume and organs at risk and accurate information on radiation dosage delivered. With a further desire for more precision and protection of healthy tissues, techniques such as intensity modulated radiotherapy (IMRT) and volu metric modulated arc therapy (VMAT) have been developed with the ability to modulate beam intensity. Quality imaging diagnostics is an infallible part of the modern radiotherapy. Image-guided radiotherapy (IGRT) and adaptive radiotherapy enable the delivery of high precision radiation to the target volume and spares organs at risk by correcting interfractional and intrafractional variations. Respiratory gating and tracking technique are useful for tumours that change their position during respiratory cycle. Stereotactic ablative radiotherapy (SABR) is a technique that uses highly conformal high-dose hypofractionated radiation to treat small tumours. In some indication such as the treatment of early stage non-small lung cancer, it competes with radical surgery. SABR is also an important therapeutic modality in the management of oligometa static disease. This paper will briefly discuss proton therapy and its unique physical properties.","PeriodicalId":53700,"journal":{"name":"Libri Oncologici","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.20471/lo.2019.47.02-03.17","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42482037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-06DOI: 10.20471/lo.2019.47.01.05
P. Vuković, T. Žigman, M. Vučetić, S. Ramić, I. Kirac
{"title":"UGT1A1 polymorphisms as a pharmacogenetic markers for prediction of irinotecan-induced toxicities in metastatic colorectal cancer","authors":"P. Vuković, T. Žigman, M. Vučetić, S. Ramić, I. Kirac","doi":"10.20471/lo.2019.47.01.05","DOIUrl":"https://doi.org/10.20471/lo.2019.47.01.05","url":null,"abstract":"","PeriodicalId":53700,"journal":{"name":"Libri Oncologici","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.20471/lo.2019.47.01.05","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45804814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-06DOI: 10.20471/lo.2019.47.01.03
I. Kirac, J. Fíla, Z. Misir, J. F. Čugura, A. Žaja, I. Benčić, L. Štefančić
1Department of Surgical Oncology, University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, Croatia; 2Division of Diagnostic and Interventional Radiology, Department of Oncological Radiology, University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, Croatia; 3Department of Upper Gastrointestinal Surgery, Sestre milosrdnice University Hospital Center, Zagreb, croatia; 4Department of Anesthesiology, Reanimation and Intensive Care Medicine, University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
{"title":"Nutritional evaluation in the perioperative period of gastric cancer patients using bioelectrical impedance analysis (BIA)","authors":"I. Kirac, J. Fíla, Z. Misir, J. F. Čugura, A. Žaja, I. Benčić, L. Štefančić","doi":"10.20471/lo.2019.47.01.03","DOIUrl":"https://doi.org/10.20471/lo.2019.47.01.03","url":null,"abstract":"1Department of Surgical Oncology, University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, Croatia; 2Division of Diagnostic and Interventional Radiology, Department of Oncological Radiology, University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, Croatia; 3Department of Upper Gastrointestinal Surgery, Sestre milosrdnice University Hospital Center, Zagreb, croatia; 4Department of Anesthesiology, Reanimation and Intensive Care Medicine, University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, Croatia","PeriodicalId":53700,"journal":{"name":"Libri Oncologici","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.20471/lo.2019.47.01.03","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49161558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-06DOI: 10.20471/lo.2019.47.01.01
L. Mayer, S. Langer, Mihaela Gaće, P. Hrabac, Milica Šoštarić, Ines Fijan, Zvjezdana Špacir Prskalo, A. Cvetko, J. Periša, L. Štefančić, Ivan Penavić, Hrvoje Tomasović, G. Brozović, D. Vrdoljak
1Department of Medical Biochemistry in oncology, University Hospital for tumors, sestre milosrdnice University Hospital center, Zagreb, croatia; 2Department of surgical oncology, University Hospital for tumors, sestre milosrdnice University Hospital center, Zagreb, croatia; 3Departmanet of anaesthesiology, reanimatology and intensive care Medicine, University Hospital for tumors, sestre milosrdnice University Hospital center, Zagreb, croatia; 4croatian institute for Brain research, school of Medicine, University of Zagreb, Zagreb, croatia; 5Department of Biochemistry and Molecular Biology, faculty of pharmacy and Biochemistry, University of Zagreb, Zagreb, croatia; 6Department of oncology and nuclear Medicine, sestre milosrdnice University Hospital center, Zagreb, croatia
{"title":"Prediction score for complications after colorectal cancer surgery based on neutrophils/lymphocytes ratio, percentage of immature granulocytes, IG and IT ratios","authors":"L. Mayer, S. Langer, Mihaela Gaće, P. Hrabac, Milica Šoštarić, Ines Fijan, Zvjezdana Špacir Prskalo, A. Cvetko, J. Periša, L. Štefančić, Ivan Penavić, Hrvoje Tomasović, G. Brozović, D. Vrdoljak","doi":"10.20471/lo.2019.47.01.01","DOIUrl":"https://doi.org/10.20471/lo.2019.47.01.01","url":null,"abstract":"1Department of Medical Biochemistry in oncology, University Hospital for tumors, sestre milosrdnice University Hospital center, Zagreb, croatia; 2Department of surgical oncology, University Hospital for tumors, sestre milosrdnice University Hospital center, Zagreb, croatia; 3Departmanet of anaesthesiology, reanimatology and intensive care Medicine, University Hospital for tumors, sestre milosrdnice University Hospital center, Zagreb, croatia; 4croatian institute for Brain research, school of Medicine, University of Zagreb, Zagreb, croatia; 5Department of Biochemistry and Molecular Biology, faculty of pharmacy and Biochemistry, University of Zagreb, Zagreb, croatia; 6Department of oncology and nuclear Medicine, sestre milosrdnice University Hospital center, Zagreb, croatia","PeriodicalId":53700,"journal":{"name":"Libri Oncologici","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.20471/lo.2019.47.01.01","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45983383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-06DOI: 10.20471/lo.2019.47.01.07
A. Abdelhafeez, Wael Ibrahim, Ahmed Moustafa Wedn, W. Elsherief
{"title":"Total cordectomy in a patient with primary dorso-lumbar glioblastoma multiforme and paraplegia: a case report","authors":"A. Abdelhafeez, Wael Ibrahim, Ahmed Moustafa Wedn, W. Elsherief","doi":"10.20471/lo.2019.47.01.07","DOIUrl":"https://doi.org/10.20471/lo.2019.47.01.07","url":null,"abstract":"","PeriodicalId":53700,"journal":{"name":"Libri Oncologici","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.20471/lo.2019.47.01.07","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49543614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-06DOI: 10.20471/lo.2019.47.01.06
A. Peterko, M. Avirović, D. Mance, P. V. Zujic, I. Lovasić, F. Lovasić
{"title":"Clinical impact of sentinel lymph node biopsy after neoadjuvant systemic treatment in luminal B, HER-2 positive and triple-negative breast cancer patients with initially involved axillary lymph node(s) : Protocol for prospective, non-randomised, observational clinical trial","authors":"A. Peterko, M. Avirović, D. Mance, P. V. Zujic, I. Lovasić, F. Lovasić","doi":"10.20471/lo.2019.47.01.06","DOIUrl":"https://doi.org/10.20471/lo.2019.47.01.06","url":null,"abstract":"","PeriodicalId":53700,"journal":{"name":"Libri Oncologici","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.20471/lo.2019.47.01.06","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42430312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-29DOI: 10.20471/LO.2018.46.02-03.18
I. Kirac, Amir Ibukić, L. Štefančić, Dora Šercar, Vesna Vorih, Dragan Marinic-Korolija
We wanted to assess the distribution of patients and to quantify the travel expenses for specialists’ consultation in cancer care. From 1st to 31st October 2018 specialists consulted 2856 with the malignant disease at University Hospital for Tumors. We looked at rectal cancer (C20) specifi cally and identifi ed 163 rectal cancer patients. Travel expenses are derived from the following:1,35 € per kilometer for patients outside of the city of Zagreb, as denoted by the county they live in, and minimal public transport fee for the patients residing in Zagreb (2,70 €). Cost of their return transport within Zagreb was 313,2 € while 21362,16 € costed the return transport to and from the hospital from outside of Zagreb. The average cost per patient per visit 132,98 €. An estimate for 2856 patients is 379784,22 €. Transport cost for a patient being consulted on cancer care is a substantial part of not recognized costs in system analysis. The process of assessing travel costs display the area of gravitation toward a cancer center. 36% of patients were from Zagreb.
{"title":"An argument for one day follow-up in cancer care","authors":"I. Kirac, Amir Ibukić, L. Štefančić, Dora Šercar, Vesna Vorih, Dragan Marinic-Korolija","doi":"10.20471/LO.2018.46.02-03.18","DOIUrl":"https://doi.org/10.20471/LO.2018.46.02-03.18","url":null,"abstract":"We wanted to assess the distribution of patients and to quantify the travel expenses for specialists’ consultation in cancer care. From 1st to 31st October 2018 specialists consulted 2856 with the malignant disease at University Hospital for Tumors. We looked at rectal cancer (C20) specifi cally and identifi ed 163 rectal cancer patients. Travel expenses are derived from the following:1,35 € per kilometer for patients outside of the city of Zagreb, as denoted by the county they live in, and minimal public transport fee for the patients residing in Zagreb (2,70 €). Cost of their return transport within Zagreb was 313,2 € while 21362,16 € costed the return transport to and from the hospital from outside of Zagreb. The average cost per patient per visit 132,98 €. An estimate for 2856 patients is 379784,22 €. Transport cost for a patient being consulted on cancer care is a substantial part of not recognized costs in system analysis. The process of assessing travel costs display the area of gravitation toward a cancer center. 36% of patients were from Zagreb.","PeriodicalId":53700,"journal":{"name":"Libri Oncologici","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44907748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-29DOI: 10.20471/LO.2018.46.02-03.14
Iva Andrašek, I. Alvir, L. Beketić-Orešković
Pregnancy-associated breast cancer is a diffi cult psychosocial and health problem for the patient, demanding an individual multidisciplinary treatment approach. Due to the need for aggressive oncological treatment with minimal adverse eff ects on the growing fetus, numerous studies are carried out to fi nd an optimal protocol, concerning the interest of both the mother and the child. Due to the physiological changes in the breasts in pregnancy, the diagnosis of breast cancer can be delayed and therefore patients have often higher clinical stage of the disease at initial presentation comparing to non-pregnant patients. Pregnancy termination due to breast cancer diagnosis had no eff ect on the prognosis of the patient, and longterm studies did not fi nd a higher incidence of malignant disease in children who were exposed to chemotherapy in utero compared to the general population. Although prognosis data of those patients is controversial, recent studies have not found a worse outcome compared to breast cancer unrelated to pregnancy.
{"title":"Pregnancy associated breast cancer","authors":"Iva Andrašek, I. Alvir, L. Beketić-Orešković","doi":"10.20471/LO.2018.46.02-03.14","DOIUrl":"https://doi.org/10.20471/LO.2018.46.02-03.14","url":null,"abstract":"Pregnancy-associated breast cancer is a diffi cult psychosocial and health problem for the patient, demanding an individual multidisciplinary treatment approach. Due to the need for aggressive oncological treatment with minimal adverse eff ects on the growing fetus, numerous studies are carried out to fi nd an optimal protocol, concerning the interest of both the mother and the child. Due to the physiological changes in the breasts in pregnancy, the diagnosis of breast cancer can be delayed and therefore patients have often higher clinical stage of the disease at initial presentation comparing to non-pregnant patients. Pregnancy termination due to breast cancer diagnosis had no eff ect on the prognosis of the patient, and longterm studies did not fi nd a higher incidence of malignant disease in children who were exposed to chemotherapy in utero compared to the general population. Although prognosis data of those patients is controversial, recent studies have not found a worse outcome compared to breast cancer unrelated to pregnancy.","PeriodicalId":53700,"journal":{"name":"Libri Oncologici","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.20471/LO.2018.46.02-03.14","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44014686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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