Seminars in Oncology Nursing最新文献

Objectives: Lisocabtagene maraleucel (liso-cel; Breyanzi), an autologous chimeric antigen receptor T-cell therapy, has demonstrated efficacy and safety in relapsed/refractory large B-cell lymphoma, chronic lymphocytic leukemia/small lymphocytic lymphoma, follicular lymphoma, and mantle cell lymphoma. Outpatient monitoring after liso-cel administration has shown lower health care resource utilization and cost and high patient satisfaction. However, outpatient monitoring programs require well-designed processes with collaborations from multiple stakeholders across several facilities. The study objective is to provide learnings and key considerations from nurses and advanced practice providers (APP) with experience setting up and managing liso-cel outpatient monitoring programs.

Data source: Author experience gathered from 3 institutions at 2 workshops.

Results: In the reviewed programs, patients are discharged on the same day after liso-cel infusion and observation. They are required to remain within a short distance of the facility for ≥4 weeks with admission to treatment facilities upon experiencing adverse events (AE). Nurses/APPs report several key features of successful programs: flexibility to carry out essential roles/functions based on institution's resources and staff structure, a phased or hybrid (hospital/clinic) approach to program launch, a core team to run and guide the program, robust training for staff, options to tailor AE monitoring based on institution guidelines, and coordinated transitions between multiple stakeholders and facilities.

Conclusions: Nurses/APPs are critical contributors to liso-cel outpatient monitoring programs. Success in providing appropriate, complex individualized care in these programs can be achieved by using a multistakeholder approach with appropriate staff and patient/caregiver training and careful coordination across multiple functions and facilities.

Implications for nursing practice: The learnings and resources presented may provide insight to considerations around the development of a cell therapy outpatient monitoring program. However, the information provided here should be taken together with other relevant resources and guidelines and should be adapted to align with the institution's own guidelines.

Objectives: Fatigue is a significant challenge among head and neck cancer patients undergoing radiotherapy, impacting their well-being and daily functioning. Exercise-based interventions hold promise in alleviating this fatigue burden. This systematic review aims to evaluate the effectiveness of exercise-based interventions on fatigue among patients with head and neck cancer receiving radiotherapy.

Methods: We systematically searched for the studies in Cumulative Index to Nursing and Allied Health Literature, PubMed, Cochrane Library Database, MEDLINE, and Google Scholar in the English language from 2000 to 2023. Two reviewers independently identified the articles using key thesaurus and free text terms based on the inclusion criteria. The review was guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Statement. Meta-analysis was done by using RevMan 5.3 software.

Results: The systematic review included nine trials encompassing 647 participants, out of which five were randomized control trials and were selected for meta-analysis. Pooled data from randomized control trials showed that exercise-based interventions were effective in reducing few dimensions of fatigue such as general fatigue, physical fatigue, emotional fatigue significantly (P < .001) among Head and Neck Cancer patients receiving radiotherapy.

Conclusion: Preliminary evidence from the review suggests that engaging in exercise-based interventions may reduce fatigue among patients with head and neck cancer receiving radiotherapy. However, future research is necessary, as most of the articles in current review were either pilot studies or feasibility trials.

Implications for nursing practice: This systematic review and meta-analysis protocol was registered in PROSPERO with the register number CRD42023428284.

Objectives: This study was conducted to adapt the Shirom-Melamed Burnout Measure (SMBM) in parents of Turkish pediatric oncology patients.

Methods: This methodological and descriptive study was conducted with 184 parents of pediatric oncology patients from December 2023 to July 2024. Data was collected face to face interviews via an information form and the SMBM. Translation processes, expert opinions, and content validity were meticulously addressed. Data analysis was utilized by IBM SPSS Statistics and AMOS 25.

Results: The mean age of parents was 37.02 ± 8.20, and 94.6% of the parents were mothers. The scale demonstrated high validity (content validity index = 0.97) and excellent internal consistency (Cronbach's alpha = 0.91). The Exploratory Factor Analysis revealed a 4-factor structure, explaining 67.60% of the variance. A modified 4-factor 19-item model of the provided excellent model fit (chi-square/df = 1.946, RMSEA = 0.072, GFI = 0.861, CFI = 0.932, IFI = 0.933, RFI = 0.849, NFI = 0.871, TLI = 0.920).

Conclusions: The Turkish scale with 4-factor 19-item is a valid and reliable tool can be used to determine the burnout level of parents of pediatric oncology patients.

Implications for nursing practice: Healthcare providers should use the SMBM to assess parental burnout, develop targeted support programs, and evaluate the impact of caregiving on parents' well-being.

Objectives: Recruitment of racial/ethnic underserved populations in oncology research is essential to address health disparities. This article presents strategies and lessons learned from community outreach and other approaches for recruiting non-Hispanic Black, Hispanic, and other non-White survivors of cancer into a pilot study that investigated biopsychosocial determinants of health behaviors.

Methods: We critically examined the participant recruitment approaches to explore challenges and successful strategies and develop recommendations for future studies. Direct recruitment strategies included engaging with research staff members' personal community contacts/liaisons and participating in community outreach events (eg, farmers' markets, block parties, library events, cancer awareness events). Indirect recruitment strategies included posting and distribution of study flyers in community centers (eg, LIVESTRONG® at the YMCA, churches, libraries), online platforms (eg, FORCE, Survivor Journey website), and invitation letters sent to individuals identified as eligible through a single state cancer registry.

Results: Between April 2022 and May 2023, among the 64 individuals recruited, 36 were non-Hispanic Black, 25 were Hispanic, and three were American Indian/Alaska Native people. The use of a state cancer registry (64.1%), snowballing/word of mouth (7.8%), and advertisement through an established cancer support organization (ie, FORCE) website (7.8%) were the most effective strategies in this study.

Conclusion: Recruitment of non-Hispanic Black, Hispanic, and other non-White people into biobehavioral studies through community-engaged research is challenging and requires long-term commitment and engagement with partners from target communities and affiliated organizations.

Implication for nursing practice: Registries and community outreach events can build trust for successful enrollment. Using multiple strategies can provide the best opportunities to reach diverse populations and enroll them in cancer-related research studies.