Seminars in Oncology Nursing最新文献

{"title":"Using Mobility Tools within Multidimensional Assessments to Increase Prognostic Awareness and Assist in Shared Decision-Making to Enhance Goal Concordant Care","authors":"","doi":"10.1016/j.soncn.2024.151675","DOIUrl":"10.1016/j.soncn.2024.151675","url":null,"abstract":"<div><h3>Objectives</h3><p>The purpose of this practice example from one clinical center is to illustrate the use of interdisciplinary mobility, nutrition, and quality-of-life tools to guide prognostication, which can facilitate discussion on further treatment and goals of care.</p></div><div><h3>Methods</h3><p>Peer-reviewed scientific publications, expert opinions, and a case study are used to illustrate the advantages of using interdisciplinary assessment tools to assist in prognostication, culminating in shared decision-making.</p></div><div><h3>Results</h3><p>This overview includes tools identified for use by interdisciplinary teams to identify high-risk patients appropriate for timely discussions regarding goals of care to maximize the probability that people receive care aligned with their goals and values that are informed by prognostic concordance.</p></div><div><h3>Conclusions</h3><p>Tools assessing mobility, functional status<span>, nutrition, and quality of life can assist the interdisciplinary team in providing whole-person care and in forecasting mortality, thus giving the team valid and reliable information to present to patients and families in the shared decision-making process. Further research is needed to synthesize findings from these tools and share information amongst team members in a cohesive and reliable manner.</span></p></div><div><h3>Implications for Nursing Practice</h3><p>Nurses spend more time at the bedside than any other discipline. Improved knowledge of tools to forecast patients at elevated risk for mortality will empower collaboration with other disciplines to improve prognostic concordance and enhance shared decision-making culminating in optimal patient-centered care.</p></div>","PeriodicalId":54253,"journal":{"name":"Seminars in Oncology Nursing","volume":"40 4","pages":"Article 151675"},"PeriodicalIF":2.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141433358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interprofessional Collaboration in Palliative Care—The Need for an Advanced Practice Nurse: An Ethnographic Study","authors":"","doi":"10.1016/j.soncn.2024.151654","DOIUrl":"10.1016/j.soncn.2024.151654","url":null,"abstract":"<div><h3>Objectives</h3><p>The literature highlights the importance of an interprofessional approach in palliative care to improve the quality of care, favoring an effective use of resources. Members of the interprofessional team include all professionals involved in patient care; in some contexts, the advanced practice nurse (APN) has a clearly defined role. This study aimed to define the possible role of the APN within the interprofessional palliative care team in our context.</p></div><div><h3>Data Sources</h3><p>A focused ethnographic approach was taken involving participant observation and semistructured interviews.</p></div><div><h3>Conclusion</h3><p>From the participant observations, interaction of the participants, discussion content, and styles of meeting management were described. From the thematic analysis of the interviews, 15 themes emerged, grouped into four macro-themes: interprofessional collaboration, the interprofessional meeting, nurse's role, and developments.</p></div><div><h3>Implications for Nursing Practice</h3><p>The study has identified current nursing practice within the interprofessional palliative care team and areas where interprofessional collaboration can be improved. These are both organizational (role definition and team meeting management) and professional (development of nursing culture, expanded nursing role, and introduction of the APN within the team). Nurses must develop advanced skills to ensure more effective care for patients and caregivers. The introduction of an APN could be appropriate to address this need.</p></div>","PeriodicalId":54253,"journal":{"name":"Seminars in Oncology Nursing","volume":"40 4","pages":"Article 151654"},"PeriodicalIF":2.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141065108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Online Group Cognitive Rehabilitation Program for Prostate Cancer Survivors: Development Using Codesign and the Theoretical Domains Framework","authors":"Lorna Pembroke ,&nbsp;Kerry A. Sherman ,&nbsp;Haryana M. Dhillon ,&nbsp;Heather Francis ,&nbsp;David Gillatt ,&nbsp;Howard Gurney","doi":"10.1016/j.soncn.2024.151695","DOIUrl":"10.1016/j.soncn.2024.151695","url":null,"abstract":"<div><h3>Objectives</h3><p>This study aimed to describe the adaptation of a group cognitive rehabilitation program for prostate cancer survivors (PCS) via telehealth delivery using a codesign approach with PCS experiencing cancer-related cognitive impairment. The Theoretical Domains Framework (TDF) also informed the intervention development.</p></div><div><h3>Methods</h3><p>Intervention development consisted of three steps: 1) Adapting an existing cancer-related cognitive rehabilitation program for PCS; 2) Conducting a codesign focus group workshop to gather feedback that was analyzed using a template approach; and 3) Incorporation of consumer feedback to refine the program for future piloting in PCS. Components of the finalized intervention were mapped onto the TDF domains.</p></div><div><h3>Results</h3><p>Six PCS were involved in the codesign focus group workshop, providing feedback on program structure, the topics and its order, and rehabilitation activities. A manualized four-week online group cognitive rehabilitation program titled “Promoting Cognitive Wellbeing in Prostate Cancer Survivors (ProCog)” was developed. Four sessions of 2-hours’ duration were designed exploring: cognitive/brain functions; the impact of cancer treatments and ageing; the relationship between thoughts, feelings and behaviors; values-based goal-setting; and skills/strategies to manage fatigue and improve attention, memory, aspects of executive functioning, and emotional functioning.</p></div><div><h3>Conclusions</h3><p>Consumer input and guidance from the TDF ensures a robust development process for the online ProCog intervention, designed for and with PCS experiencing cognitive difficulties. As an important initial step before piloting, this adaptation and development process ensures that ProCog addresses consumer needs and preferences and targets factors increasing behavior change.</p></div><div><h3>Implications for Nursing Practice</h3><p>This research raises awareness of possible cancer-related cognitive impairments in prostate cancer survivors and strategies for rehabilitation. ProCog is an accessible online intervention that nurses can use to refer patients needing cognitive rehabilitation.</p></div>","PeriodicalId":54253,"journal":{"name":"Seminars in Oncology Nursing","volume":"40 5","pages":"Article 151695"},"PeriodicalIF":2.3,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0749208124001591/pdfft?md5=bade6381218376d24a3cc3b390ff8992&pid=1-s2.0-S0749208124001591-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141762652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Cognitive Rehabilitation on Cognitive and Functional Outcomes in Adult Cancer Survivors: A Systematic Review","authors":"Zev M. Nakamura ,&nbsp;Nadeen T. Ali ,&nbsp;Adele Crouch ,&nbsp;Haryana Dhillon ,&nbsp;Angela Federico ,&nbsp;Priscilla Gates ,&nbsp;Lisa Grech ,&nbsp;Shelli R. Kesler ,&nbsp;Leila Ledbetter ,&nbsp;Elisa Mantovani ,&nbsp;Samantha Mayo ,&nbsp;Ding Quan Ng ,&nbsp;Lorna Pembroke ,&nbsp;Kerryn E. Pike ,&nbsp;Stefano Tamburin ,&nbsp;Chia Jie Tan ,&nbsp;Yi Long Toh ,&nbsp;Yesol Yang ,&nbsp;Diane Von Ah ,&nbsp;Deborah H. Allen","doi":"10.1016/j.soncn.2024.151696","DOIUrl":"10.1016/j.soncn.2024.151696","url":null,"abstract":"<div><h3>Objectives</h3><p>This systematic review (PROSPERO CRD42021275421) synthesized evidence on the efficacy of cognitive rehabilitation on cognitive and functional outcomes in adult cancer survivors.</p></div><div><h3>Methods</h3><p>Articles were identified though PubMed/MEDLINE, EMBASE, PsycINFO, and Web of Science from inception through June 30, 2023. Studies included participants ≥18 years old, diagnosed with cancer. Primary outcomes were validated measures of subjective and objective cognition. Articles were dual reviewed for eligibility and data extraction. Risk of bias was assessed with the Standard Quality Assessment Criteria for Evaluating Primary Research Papers from a Variety of Fields.</p></div><div><h3>Results</h3><p>The search yielded 3,811 articles; 65 full-text articles were reviewed; 53 articles (15 cognitive training, 14 strategy-based, 21 combinations, three inpatient rehabilitation), representing 52 unique studies, were included. Positive effects were observed in at least one objective cognitive measure in 93% of strategy training, 81% of cognitive training, 79% of combination rehabilitation interventions. Positive effects were observed in subjective cognition in 100% of strategy training, 55% of cognitive training, and 92% of combination interventions. Among studies with comparator groups, processing speed improved in 60% of cognitive training studies, while strategy training did not improve processing speed; otherwise, cognitive domain effects were similar between intervention types. Impact on functional outcomes was inconclusive.</p></div><div><h3>Conclusions</h3><p>Cognitive rehabilitation appear beneficial for cancer-related cognitive impairment (CRCI). Differential effects on specific cognitive domains (eg, processing speed) and subjective cognition may exist between intervention types.</p></div><div><h3>Implications for Nursing Practice</h3><p>Nurses should increase patient and provider awareness of the benefits of cognitive rehabilitation for CRCI.</p></div>","PeriodicalId":54253,"journal":{"name":"Seminars in Oncology Nursing","volume":"40 5","pages":"Article 151696"},"PeriodicalIF":2.3,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141762651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using Data to Improve Healthcare: A Case Study of Pancreatic Enzyme Replacement in Pancreatic Cancer","authors":"Teena S Varghese ,&nbsp;Colm Andrews ,&nbsp;Louis Fisher ,&nbsp;Ben Goldacre ,&nbsp;Amir Mehrkar ,&nbsp;Rupaly Pande ,&nbsp;Nadia A S Smith ,&nbsp;Alex J Walker ,&nbsp;Keith J Roberts ,&nbsp;Asma Sultana ,&nbsp;Brian MacKenna ,&nbsp;Agnieszka Lemanska","doi":"10.1016/j.soncn.2024.151688","DOIUrl":"10.1016/j.soncn.2024.151688","url":null,"abstract":"<div><h3>Objectives</h3><p><span>In the UK, guidelines recommend pancreatic enzyme replacement therapy (PERT) to all people with unresectable </span>pancreatic cancer. In 2023, we published a national audit of PERT which showed suboptimal prescribing and wide regional variation in England. The aim of this manuscript was to describe how we used the PERT audit to drive improvements in healthcare.</p></div><div><h3>Methods</h3><p>Building on the PERT audit, we deployed an online dashboard which will deliver ongoing updates of the PERT audit. We developed a collaborative intervention with cancer nurse specialists (CNS) to improve care delivered to people with pancreatic cancer. The intervention called Creating a natiOnAL CNS pancrEatic cancer network to Standardise and improve CarE (COALESCE) will use the dashboard to evaluate improvements in prescribing of PERT.</p></div><div><h3>Results</h3><p>We demonstrated how large databases of electronic healthcare records (EHRs) can be used to improve cancer care. The PERT audit was implemented into a dashboard for tracking the progress of COALESCE. We will measure improvements in PERT prescribing as the intervention with CNS progresses.</p></div><div><h3>Conclusions</h3><p>Improving healthcare is an ongoing and iterative process. By implementing the PERT dashboard, we created a resource-efficient, automated evaluation method enabling COALESCE to deliver a sustainable change. National-scale databases of EHRs enable rapid cycles of audits, providing regular feedback to interventions, working systematically to deliver change. Here, the focus is on pancreatic cancer. However, this methodology is transferable to other areas of healthcare.</p></div><div><h3>Implications for Nursing Practice</h3><p>Nurses play a key role in collecting good quality data which are needed in clinical audits to identify shortcomings in healthcare. Nurse-driven interventions can be designed to improve healthcare. In this study, we capitalize on the unique role of CNS coordinating care for every patient with cancer. COALESCE is the first national collaborative study which uses CNS as researchers and change agents.</p></div>","PeriodicalId":54253,"journal":{"name":"Seminars in Oncology Nursing","volume":"40 5","pages":"Article 151688"},"PeriodicalIF":2.3,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141753384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Education and Monitoring via Tele-Nursing to Elderly Cancer Patients Using Oral Anticancer Agents on Self-efficacy and Medication Adherence: A Randomized Controlled Trial","authors":"Sümeyye Başoğlu ,&nbsp;Ülkü Polat","doi":"10.1016/j.soncn.2024.151692","DOIUrl":"10.1016/j.soncn.2024.151692","url":null,"abstract":"<div><h3>Objectives</h3><p>This study was conducted as a randomized controlled trial<span> to determine the effect of the education and monitoring provided via tele-nursing to elderly cancer patients using oral anticancer agents on their medication treatment adherence self-efficacy and medication adherence.</span></p></div><div><h3>Methods</h3><p>The sample of the study consisted of 60 elderly cancer patients who presented to the oncology outpatient clinics of a medical faculty hospital in Turkey. An Elderly Information Form, the Oral Chemotherapy Adherence Scale, the Medication Adherence Self-Efficacy Scale, a Tele-nursing Evaluation Form, and a Telephone Monitoring Form were used to collect data. Patients in the intervention group were sent text messages and educational videos via WhatsApp® for the first four weeks, and after the fifth week, they were monitored by phone for eight weeks. Data collection tools were applied to the control and intervention groups at weeks 1, 8, and 12. Independent samples t-test, Repeated measurements analysis of variance chi-square test, and Pearson correlation test were used to analyze the data.</p></div><div><h3>Results</h3><p>In the study, while there was no significant difference between the mean scores of the intervention and control groups on the pretest application of the Oral Chemotherapy Adherence Scale and the Medication Adherence Self-Efficacy Scale (<em>p</em> &gt; .05), a significant difference was found between the mean posttest scores of the groups (<em>p</em> &lt; .05).</p></div><div><h3>Conclusions</h3><p>In this study, it was determined that the education and monitoring provided to elderly cancer patients via tele-nursing positively affected their self-efficacy and medication adherence.</p></div><div><h3>Implications for nursing practice</h3><p>In line with the research results, it is recommended that nurses use tele-nursing applications in the care of elderly cancer patients using oral anticancer agents.</p></div>","PeriodicalId":54253,"journal":{"name":"Seminars in Oncology Nursing","volume":"40 5","pages":"Article 151692"},"PeriodicalIF":2.3,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141728298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pain and Cognition of Breast Cancer Survivors Treated with Chemotherapy: The Mediating Role of Depression","authors":"Yesol Yang ,&nbsp;Jeehee Han ,&nbsp;Todd B. Monroe ,&nbsp;Sue Kim","doi":"10.1016/j.soncn.2024.151693","DOIUrl":"10.1016/j.soncn.2024.151693","url":null,"abstract":"<div><h3>Objectives</h3><p>While chemotherapy is the primary contributor to cancer-related cognitive impairment (CRCI), interindividual differences in CRCI are not well-understood. Studies suggest that breast cancer (BC) survivors who are in pain are more likely to experience depression, which in turn contributes to CRCI, although this hypothesis is not yet tested. Therefore, this study aimed to investigate the relationship between pain and CRCI among BC survivors and the mediation effect of depression on this relationship.</p></div><div><h3>Methods</h3><p>As a secondary analysis of a descriptive cross-sectional study investigating fatigue and preferred types of fatigue self-management in BC survivors recruited from five tertiary hospitals<span><span><span> in South Korea; of the 229 participants, data on 186 who received chemotherapy were analyzed. Study participants were aged between 20 and 69 years, diagnosed with stage I to III, and treated with chemotherapy and/or radiation therapy. Measurement was done with Korean versions of the </span>Cognitive Failure Questionnaire<span> (to assess CRCI), Brief Pain Inventory<span> (for pain severity and interference on daily functioning), and C-ESD (for depression). To assess bivariate relationships between pain, depression, and CRCI, Pearson correlation was used. A </span></span></span>mediation analysis was used to examine the effect of depression on CRCI.</span></p></div><div><h3>Results</h3><p>Significant associations were found among pain, depression, and CRCI (all <em>P</em> &lt; 0.01). Furthermore, a mediation effect of depression was found on the association between pain and CRCI (severity, β = 1.26, SE = 0.38, 95% confidence intervals [0.60, 2.08]; interference, β = 1.53, SE = 0.32, 95% confidence intervals [0.95, 2.20]).</p></div><div><h3>Conclusion</h3><p>Findings indicate that among BC survivors, those with higher pain tend to show higher depression and consequently had lower cognitive function.</p></div><div><h3>Implication for Nursing Practice</h3><p>Oncology nurses may need to identify BC survivors with higher pain, and screening those survivors could be a strategy to identify those at higher risk for CRCI. Also, nurses should focus on managing depression to prevent and/or treat CRCI in BC survivors.</p></div>","PeriodicalId":54253,"journal":{"name":"Seminars in Oncology Nursing","volume":"40 5","pages":"Article 151693"},"PeriodicalIF":2.3,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141635737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationships Between Chemotherapy-Related Cognitive Impairment, Self-Care Ability, and Quality of Life in Breast Cancer Survivors: A Cross-Sectional Study","authors":"","doi":"10.1016/j.soncn.2024.151690","DOIUrl":"10.1016/j.soncn.2024.151690","url":null,"abstract":"<div><h3>Objectives</h3><p>It is not clear how chemotherapy-related cognitive impairment<span><span> and self-care ability affect the quality of life of women with breast cancer. The purpose of this study was to explore the relationships between chemotherapy-related </span>cognitive impairment<span><span>, self-care ability, and quality of life in breast cancer patients, and test whether self-care ability plays a mediating role in the association between </span>cognitive impairment and quality of life.</span></span></p></div><div><h3>Methods</h3><p>This study was a cross-sectional study, conducted in China in 2022. Self-reported scales were used to assess cognitive function, self-care ability, and quality of life. Data were analyzed using descriptive statistics, spearman correlation analysis and hierarchical multiple regression analyses, the SPSS Process program was used to explore the mediating effect of self-care ability.</p></div><div><h3>Results</h3><p>A total of 218 participants were investigated, and approximately 79.3% of patients experienced mild chemotherapy-related cognitive impairment, the mean quality of life score was 59.96 ± 14.15, and the mean self-care ability score was 107.4 ± 24.09. Significant correlations among cognitive impairment, self-care ability, and quality of life were observed (<em>P</em> &lt; .05). Additionally, self-care ability played a partial mediating role between cognitive impairment and quality of life (<em>P</em> &lt; .05), accounting for 24.3% and 22.3%, respectively.</p></div><div><h3>Conclusions</h3><p>Chemotherapy-related cognitive impairment and self-care ability are factors affecting the quality of life of breast cancer survivors. Self-care ability mediates the relationship between cognitive impairment and quality of life. Enhancing patients' self-care ability can improve the quality of life of patients with cognitive impairment.</p></div><div><h3>Implications for Nursing Practice</h3><p>In the future, oncology nurses should not only pay attention to the severity of cognitive impairment, but also assess the level of patients’ self-care ability, provide relevant medical and healthcare guidance, train self-management behavior and strengthen self-care ability by integrating multidisciplinary forces to improve the quality of life of breast cancer patients effectively.</p></div>","PeriodicalId":54253,"journal":{"name":"Seminars in Oncology Nursing","volume":"40 5","pages":"Article 151690"},"PeriodicalIF":2.3,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141545549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring Chemotherapy-Induced Peripheral Neuropathy Management Practice Patterns Among Oncology Clinicians","authors":"","doi":"10.1016/j.soncn.2024.151685","DOIUrl":"10.1016/j.soncn.2024.151685","url":null,"abstract":"<div><h3>Objectives</h3><p>Approximately 60% of cancer survivors receiving neurotoxic chemotherapy experience chemotherapy-induced peripheral neuropathy (CIPN) (eg, hand and foot numbness, tingling, or pain). There is only one recommended pharmacological treatment (duloxetine) and one modestly beneficial nonpharmacological treatment (exercise) for CIPN. However, data suggest national guideline recommendations are not routinely practiced. Further, less is known about nurses’ CIPN management practices. The purpose of this convergent mixed methods study was to explore oncology clinicians’ self-reported practices and perceptions regarding CIPN prevention and management.</p></div><div><h3>Methods</h3><p>Oncology clinicians at three cancer centers completed a survey about their recommendations for CIPN prevention and management in practice. A subset of clinicians also participated in a semi-structured interview to explore their perspectives of and motivations for implementing CIPN assessment, prevention, and management in practice. Quantitative data were described (eg, frequency or median) and qualitative data were analyzed using inductive content analysis.</p></div><div><h3>Results</h3><p><span>This study (N = 44 survey responses; n = 9 interviews) resulted in four themes: (1) clinicians primarily recommend gabapentin for CIPN management and often observe </span>cryotherapy<span> used for CIPN prevention, but these interventions are complicated by discomfort, intolerable side effects, and efficacy concerns; (2) clinicians perceive CIPN as troublesome and desire additional information and resources regarding CIPN prevention and management; (3) CIPN-related education provided by clinicians may be limited by patient retention of the amount of education received about cancer treatment and other factors; (4) clinicians use subjective CIPN assessment to screen at each visit for common CIPN symptoms (eg, numbness or tingling) and the impact of symptoms on day-to-day activities.</span></p></div><div><h3>Conclusions</h3><p>Discrepancies persist between evidence-based guidelines on CIPN management and current oncology clinician practices.</p></div><div><h3>Implications for Nursing Practice</h3><p>Clinician involvement is needed when developing education and resources to help oncology clinicians provide the most evidence-based care to potentially prevent and manage their patients’ CIPN.</p></div>","PeriodicalId":54253,"journal":{"name":"Seminars in Oncology Nursing","volume":"40 5","pages":"Article 151685"},"PeriodicalIF":2.3,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141472516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prazosin as an Adjuvant to Increase Effectiveness of Duloxetine in a Rat Model of Oxaliplatin-Induced Peripheral Neuropathy","authors":"","doi":"10.1016/j.soncn.2024.151686","DOIUrl":"10.1016/j.soncn.2024.151686","url":null,"abstract":"<div><h3>Objectives</h3><p>Duloxetine, the only American Society of Clinical Oncology (ASCO) treatment recommended for chemotherapy-induced peripheral neuropathy (CIPN) in cancer survivors, is not effective for 40% of survivors. This study examined the ability of a duloxetine-prazosin combination to prevent the development of allodynia and hyperalgesia in a rat model of oxaliplatin-induced peripheral neuropathy (OPIN).</p></div><div><h3>Methods</h3><p>Female (n = 24) and male (n = 41) rats were started on duloxetine (15 mg), prazosin (2 mg), or a duloxetine-prazosin combination one week prior to administration of the chemotherapy drug, oxaliplatin, and continued the duloxetine-prazosin combination for 32 days. Behavioral testing for mechanical allodynia and mechanical hyperalgesia was done with selected von Frey filaments over the course of the study.</p></div><div><h3>Results</h3><p>Overall percent paw withdrawal for rats that received the duloxetine-prazosin combination was significantly lower in female (<em>p</em> &lt; .001 for both conditions) and male (<em>p</em> = .029 for allodynia; <em>p</em> &lt; .001 for hyperalgesia) than those that received water. No significant posttreatment differences were found for allodynia or hyperalgesia between rats treated with duloxetine and rats that received the duloxetine-prazosin combination in either sex.</p></div><div><h3>Conclusions</h3><p>These finding provide preliminary evidence that a duloxetine-prazosin combination can prevent the posttreatment development of allodynia and hyperalgesia in both male and female rats; however, the results suggest that the duloxetine-prazosin combination is no more efficacious than duloxetine alone in <em>preventing</em> chronic OIPN.</p></div><div><h3>Implications for Nursing Practice</h3><p>The profession of nursing is built on clinical practice supported by scientific research. The current study addressed the clinical practice problem of prevention and management of painful OIPN, which is a priority area in oncology nursing.</p></div>","PeriodicalId":54253,"journal":{"name":"Seminars in Oncology Nursing","volume":"40 5","pages":"Article 151686"},"PeriodicalIF":2.3,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0749208124001487/pdfft?md5=387bb1e47b02c309cebc352bc742e62f&pid=1-s2.0-S0749208124001487-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141428233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}