Quantitative Imaging in Medicine and Surgery最新文献

Background: The American Society of Spine Radiology (ASSR), American Society of Neuroradiology (ASNR), and North American Spine Society (NASS) published a consensus paper with recommendations for lumbar disc nomenclature reports in 2014. We aimed to evaluate the degree of adoption in our radiology department of the ASSR, ASNR, and NASS 2.0 lumbar spine consensus paper using natural language processing (NLP).

Methods: In March 2015 we gave in our radiology department, at HT Medica in Jaén (Spain) a lecture detailing the changes proposed in the ASSR, ASNR, and NASS consensus about lumbar disc nomenclature, version 2.0. We analyzed 34,064 lumbar spine magnetic resonance imaging (MRI) reports from three different expert radiologists (A, B, and C) performed from May 2010 to February 2015 (15,813 studies) and from March 2015 to February 2022 (18,251 studies). Using an NLP algorithm, we evaluated 29 old and new terms related to 4 different categories: disc with fissures of the annulus, degenerated disc, herniated disc, and location of the disc.

Results: A relevant decrease in the percentage of use of old terms was found for degenerated disc category (44.63% for radiologist B and 18.95% for radiologist C) and disc localization (18.86% for radiologist A and 27.73% for radiologist C). Relevant increments in the percentage of use of new lexicon were depicted for terms related to degenerated disc (32.48% for radiologist C), herniated disc (7.27% for radiologist A) and disc localization (36.53% for radiologist C).

Conclusions: NLP algorithms may help to manage large radiological report datasets to evaluate the impact and degree of adherence of radiologists to recommendations for the use of ASSR, ASNR and NASS lumbar disc nomenclature version 2.0.

Background and objective: Traditionally, literature on thoracic ultrasound has focused on the study of pleural and pulmonary pathology. However, given the superficial location of thoracic wall structures, ultrasound proves to be an excellent technique for their examination. This study aims to evaluate the clinical utility of thoracic ultrasound in diagnosing various thoracic wall pathologies and to illustrate the primary diagnoses that can be achieved.

Methods: We performed a literature search in January 2024 in PubMed and Google Scholar for articles on thoracic ultrasound. Relevant articles were selected and synthesized in a narrative form.

Key content and findings: Thoracic ultrasound has emerged as a powerful diagnostic tool, especially when combined with a thorough clinical history. It allows for rapid, inexpensive, and safe resolution of a wide range of common clinical uncertainties across all levels of healthcare. In emergency contexts, it excels in the detection of rib fractures, demonstrating superior capability compared to traditional chest X-rays and similar efficacy to computed tomography (CT) scans. Additionally, thoracic ultrasound is highly effective in evaluating tumors, often providing accurate diagnoses without the need for further studies. It also aids in differentiating pathologies that may require more advanced imaging such as CT or magnetic resonance imaging (MRI). Moreover, thoracic ultrasound plays a valuable role in the initial assessment of infectious and degenerative conditions.

Conclusions: Thoracic ultrasound is a versatile and efficient diagnostic tool for examining thoracic wall structures. Its applications are particularly valuable in trauma assessment, tumor evaluation, and the differentiation of various pathologies. The rapid, cost-effective, and safe nature of this technique highlights its potential as a primary diagnostic tool in a wide variety of clinical settings.

Calf muscle injuries are common among athletes and occupational populations, with highly variable recovery times that are challenging to be predicted at the initial clinical evaluation. Specifically, in distal gastrocnemius muscle injuries, an ultrasound-based severity classification has shown to be useful for estimating the recovery time. According to the location of lesions and the recognition of some US signs, four types of injuries of the distal gastrocnemius muscle were described. Since magnetic resonance imaging (MRI) has proven to be useful in diagnosing and prognosticating muscle injuries by assessing the extent of affected connective tissue, a specific MRI protocol involving T1-weighted and fluid-sensitive static and dynamic acquisitions has been developed aimed to characterize the four types of injuries. We here describe the characteristics of this new MRI protocol and the interpretation of images, which will be useful to improve the recognition of acute and delayed distal gastrocnemius muscle injuries. The proposed classification includes: myoaponeurotic muscle injury without aponeurotic discontinuities (type 1), myoaponeurotic muscle injury with aponeurotic discontinuities (type 2), isolated free aponeurosis discontinuity (type 3), and a mixed myoaponeurotic-aponeurotic injury pattern (type 4). A comprehensive understanding of the MRI features associated with each injury type, in conjunction with multidisciplinary team collaboration, is essential for optimizing the athlete's recovery and return to play.

Historically, musculoskeletal (MSK) tumors, which include both bone and soft tissue tumors, have been managed as distinct entities. The incidence of metastases, particularly bone metastasis, in patients with MSK tumors can result in the emergence of significant complications such as pain, impairment of vital anatomical structures, or pathological fractures. Given these issues, a diverse team of experts is typically engaged in intricate treatment decision-making concerning the necessity of surgery, radiation, chemotherapy, or a mix of these methodologies. Nevertheless, percutaneous image-guided minimally invasive interventional therapy for MSK tumors represent a promising approach for treating such tumors. Over the past decade, significant progress has been made in this technique, leading to its growing acceptance in ordinary clinical practice. MSK tumors can be effectively treated by the use of ablation techniques, either as standalone procedures or in conjunction with other percutaneous treatments. Various image-guided techniques have been employed to observe the ablation zone and nearby structures, such as fluoroscopy, ultrasonography (US), computed tomography (CT), and magnetic resonance imaging (MRI). However, CT is the favored method due to its widespread availability and ability to visualize the tumor and its environs. The procedures employed include ethanol injection, radiofrequency ablation, microwave ablation, cryoablation, and magnetic resonance (MR)-guided high-intensity focused ultrasound (HIFU). The technique can be performed in combination with cementation, with or without additional metallic stabilizing devices, depending on the location of the lesion. Improved local tumor control can be attained by combining ablation with bland embolization or transarterial chemoembolization. This article provides an overview of the fundamental elements of minimally invasive interventional guided imaging therapy for MSK malignancies.

Background: The hybrid imaging positron emission tomography/magnetic resonance (PET/MR) is an important tool in the management of pediatric oncology patients, particularly in malignant musculoskeletal pathologies, because it combines the functional and metabolic information of tumor provided by PET with the high soft-tissue contrast and the functional information offered by magnetic resonance imaging (MRI).

Methods: We performed an observational retrospective study that included pediatric patients diagnosed with primary bone or soft-tissue sarcomas in the Pediatric Hematology and Oncology Unit at the HM Montepríncipe University Hospital, Boadilla del Monte, Madrid (Spain) who underwent whole-body ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG) PET/MRI as a staging study and for follow-up evaluation for treatment response from September 2017 to January 2023. This study explores the protocols, the practical application of the PET/MRI technique and our clinical experience at our center in the diagnosis and follow-up of primary bone tumors and soft-tissue sarcomas in children.

Results: Seventy-one ¹⁸F-PET/MR studies were performed on 39 patients. Most of them (55%) were initial extension studies and (45%) were follow-up studies. Most of the patients studied were male (74.4%) with a median age of 15 years. Of the 39 cases, 51% were primary bone tumors while 18% were Langerhans cell histiocytosis and 21% soft tissue tumors. Of the 71 studies, five showed metastases at the initial diagnosis, three presented lymph node involvement, one with local infiltration, and one with pulmonary metastasis.

Conclusions: PET/MR has represented a significant advancement in the evaluation of pediatric malignant neoplasms, with specific applications in musculoskeletal tumors showing clear benefits over PET/CT. The primary advantage is the reduction in ionizing radiation doses and the assessment of soft tissues, making it an excellent option for malignant musculoskeletal pathologies in pediatric patients who often require long-term follow-up. It is particularly useful for early tumor detection and functional therapy monitoring in oncology. The development of new protocols is making studies increasingly faster and better tolerated, even without the need for anesthesia. PET/MRI has shown to increase diagnostic accuracy in primary bone and soft tissue tumors, as it allows for the comprehensive evaluation of their morpho-metabolic characteristics, locoregional, and distant involvement in a single study. It is also useful in surgical planning and post-treatment follow-up.

Background: Contraceptive arm implants, such as Implanon NXT^®/Nexplanon^®, are reversible methods of birth control that have gained global popularity, with over 20 million worldwide users. While palpable implants can be easily removed, deep or non-palpable implants pose complications during extraction, often requiring open surgery. This ultrasound-guided removal technique offers a minimally invasive, safe, and effective alternative, providing real-time control over the implant and neurovascular structures. Our study aims to evaluate the effectiveness and challenges of this implant removal method.

Methods: In this retrospective observational study, all cases referred to our institution for ultrasound-guided removal of contraceptive implants, from June 2022 to December 2023, were reviewed. Our facility serves as a referral center for handling challenging implants. Twenty-nine women with contraceptive implants were referred for implant removal in this period of time. Thirty implants were sent for removal in total (one patient had a double implant). Data specific to the patients were collected: age and body mass index (BMI). Data specific to the implant were also collected: time since implant insertion (months), history of a previous removal attempt, type of implant (single or double rod), implant palpability, laterality of the implant, supra or subfascial location, success or failure of the ultrasound-guided removal procedure and presence of complications in the post-procedure. Statistical analysis was conducted to determine the relationship between the procedure success rate and these variables, and also between these variables and the supra or subfascial location of the implant.

Results: Twenty-six of the 30 implants (86.67%) were successfully removed with this fully ultrasound-guided technique. In cases where the implant could not be removed, there was a higher rate of subfascial implant location (75%), while in cases where the removal was successful, the rate of subfascial implant location was significantly lower at 19.23% (P=0.048). Patients whose implants could be removed had a median BMI of 23.71 kg/m², which was higher than the BMI of patients whose implants could not be removed (20.82 kg/m²), with a P=0.022. No complications were registered.

Conclusions: Percutaneous real-time ultrasound-guided implant removal is effective, safe and offers a minimally-invasive alternative to open surgery. The removal of subfascial implants is also feasible but more challenging, leading to a reduction of success rate in this group. These positive outcomes suggest its potential as a standard initial approach for deep contraceptive implant removal.

Background: Osteoporotic vertebral fractures (OVFs) significantly impact morbidity, mortality, functionality, and quality of life. Vertebroplasty, a widely utilized treatment for OVFs, has its efficacy and safety debated due to varying outcomes reported across clinical trials and meta-analyses. This study aims to critically review and conduct a meta-analysis of randomized controlled trials (RCTs) focusing on the safety of vertebroplasty, specifically its association with serious adverse effects and the development of new vertebral fractures, while exploring potential confounders.

Methods: We conducted a systematic review and meta-analysis by searching PubMed, Web of Science, and EMBASE. The search was updated to February 23, 2024. We included published RCTs comparing vertebroplasty to conservative treatment (CT) or placebo/active control, focusing on new fractures and serious adverse effects. The primary outcomes were "incidence of new fractures" and "serious adverse effects". We applied the Dersimonian-Laird method with a random effects model to estimate risk ratios (RRs) of the primary outcomes, using the I² statistic to assess heterogeneity among studies. Sensitivity analyses were conducted when significant heterogeneity was detected. Subgroup analyses were performed based on the characteristics of the control groups, risk of bias based on The Cochrane Risk of Bias Tool 2, time from fracture onset, and multicentric versus single-center trials.

Results: In total, 14 RCTs encompassing 1,413 patients were analyzed. High and unclear risk of bias were observed in 15 and 25 items, respectively. No significant difference was observed in the incidence of new vertebral fractures between vertebroplasty and the control groups [RR =1.05, 95% confidence interval (CI): 0.71-1.56; I²=55%; P<0.01]. However, vertebroplasty was associated with a significantly lower incidence of serious adverse effects (RR =0.53, 95% CI: 0.31-0.91; I²=0%; P=0.93). Subgroup analyses revealed no significant differences based on control types, risk of bias, or number of institutions involved. Notably, early vertebroplasty (within 6 weeks of symptom onset) showed a protective effect against new vertebral fractures (RR =0.60, 95% CI: 0.38-0.92; I²=0%; P=0.53). The sensitivity analysis showed that one study influenced the observed heterogeneity but did not significantly modify the pooled estimate.

Conclusions: Vertebroplasty is not associated with an increased risk of developing new vertebral fractures and may reduce the risk of serious adverse effects compared to placebo or CT. Early intervention post-fracture appears beneficial. However, the limited number and quality of RCTs call for further high-quality studies.

Background: In recent years, significant progress in the diagnosis of knee osteoarthritis (OA) has been made due to advancements in imaging techniques, especially magnetic resonance imaging (MRI). However, the diagnostic accuracy of MRI for knee OA lacks agreement in the literature due to limitations such as heterogeneous reference standards and suboptimal methodological assessment tools. This scoping review systematically collated the literature on the accuracy of MRI in diagnosing symptomatic knee OA and evaluated its methodological quality using a novel tool.

Methods: A comprehensive search was conducted across seven electronic databases to identify systematic reviews, with or without meta-analyses, published until May 30, 2024. Selected articles were systematic reviews on test accuracy of MRI for knee OA, whose methodological quality was assessed using a tailored version of the A Measurement Tool to Assess Systematic Reviews (AMSTAR) 2 tool, and the test accuracy performance summarized.

Results: The search yielded 8,586 records of which 73 full-text articles were assessed for eligibility. We included 3 systematic reviews with a total of 99 original studies (7,530 participants). The methodological quality assessment of the reviews revealed common deficiencies in research questions and inclusion criteria components (2/3, 66.7%), protocol registration (2/3, 66.7%), use of statistical methods (1/3, 33.3%), and risk of bias assessment (2/3, 66.7%). The reference standards used were histology (1/3, 33.3%), radiography (1/3, 33.3%), computed tomography (1/3, 33.3%), clinical evaluation (1/3, 33.3%) and direct visual inspection (1/3, 33.3%), open surgery (1/3, 33.3%) and arthroscopy (3/3, 100%). In two reviews with meta-analysis the accuracy of MRI was: sensitivity 61% [95% confidence interval (CI), 53-68%] and specificity 82% (95% CI, 77-87%) (low methodological quality); and sensitivity 74% (95% CI, 71-77%) and specificity 95% (95% CI, 94-95%) (high methodological quality). In the third systematic review, without meta-analysis, the MRI sensitivity and specificity ranged from 26% to 96% and from 50% to 100%, respectively (critically low methodological quality).

Conclusions: This scoping review highlights the heterogeneity and gaps in methodological quality of the literature regarding the accuracy of MRI in diagnosing knee OA. Our adaptation of AMSTAR 2 will help to ensure systematic reviews of diagnostic tests are assessed more effectively and reliably. There is a need for standardization in future studies and reviews to strengthen the evidence base for the use of MRI as a diagnostic tool for knee OA.

Background and objective: Ultrasound guidance plays a pivotal role in percutaneous procedures for diagnosing and managing musculoskeletal disorders. Such procedures encompass biopsies for tumor, diagnostic aspiration and therapeutic drainage of abscesses, hematomas, cysts and fluid collections, therapeutic injections into joints, nerves, and tendons, as well as aspirations of calcium deposits and extraction of foreign bodies. This review aims to compile the most frequent ultrasound-guided procedures in the musculoskeletal system and present the state-of-the-art in current advances and evidence.

Methods: We performed a literature review on interventional ultrasound in the musculoskeletal system, and included reviews, systematic reviews, meta-analysis, and clinical trials published during the last 10 years. Articles related to imaging techniques different from ultrasound, or spinal, thoracoabdominal and facial procedures were excluded. A total of 120 articles were selected and included in this review. We qualitatively synthesized the main findings and complemented the review with illustrative images from our daily practice.

Key content and findings: Most of the reviewed studies found superiority of ultrasound-guided versus landmark-guided procedures. Ultrasound was generally considered as a valuable tool for many specialists in diagnosing and treating many musculoskeletal pathologies, but some disparities in needle approaches, techniques, medication, and doses make it difficult to draw strong evidence in different clinical scenarios.

Conclusions: Advances in ultrasound-guided procedures in the musculoskeletal system have enabled radiologists and other specialists to achieve high accuracy in diagnosing and treating various musculoskeletal conditions, including tumors, inflammatory and degenerative arthritis, tendinopathies, and bursal pathologies.

Background: Vascular leiomyoma or angioleiomyoma is a rare benign tumor which belongs to the group of benign smooth muscle tumors. They are commonly located at the extremities, usually presented as a painful solitary lesion in the subcutaneous tissue. To date, very few reports describe its characteristics from an imaging point of view, especially their ultrasound characteristics, making it difficult to do a pre-surgical diagnosis. Our purpose is to describe the clinical, pathologic and imaging features of angioleiomyoma [ultrasound, Doppler ultrasound and magnetic resonance imaging (MRI) findings].

Methods: We retrospectively reviewed from the pathology database from Hospital Universitario Fundación Alcorcón, Madrid, Spain, the clinical histories of 139 patients who had surgical excision and histologic diagnosis of angioleiomyoma during the last 17 years, from May 31^st 2006 to April 17^th 2023. Of those patients, we focused on 50 who had soft tissue angioleiomyoma with imaging study [ultrasonography (US) and/or MRI] performed in our institution, making a descriptive cross-sectional study.

Results: In our series, a very characteristic ultrasonographic and US Doppler pattern was found. It consists in the presence of a well defined, homogeneous and highly vascularized soft tissue tumor, sometimes with the presence of a feeding vessel.

Conclusions: When the described US features appear in a mobile and elastic subcutaneous slow growing tumor on an extremity, the diagnosis of angioleiomyoma should be considered as highly probable.