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[Electrophysiological Effect of Citreoviridin on Human InducedPluripotent Stem Cell-derived Cardiomyocytes]. [黄绿霉素对人多能干细胞源性心肌细胞的电生理影响]。
IF 0.3 4区 农林科学 Q4 FOOD SCIENCE & TECHNOLOGY Pub Date : 2022-01-01 DOI: 10.3358/shokueishi.63.210
Yosuke Uchiyama, Daiju Yamazaki, Naoki Kobayashi, Yasunari Kanda, Yoshiko Sugita-Konishi

Citreoviridin (CTV) is a mycotoxin produced by various fungi, including Penicillium citreonigrum. One of the toxicities reportedly associated with CTV is neurotoxicity. CTV is also suspected to be associated with acute cardiac beriberi (also known as "Shoshin-kakke") and Keshan disease, which can have adverse effects on the heart, so the in vivo and in vitro toxicity of CTV on the heart or cardiomyocytes in experimental animal models have been reported. However, the toxicity of CTV for the human heart, especially its electrophysiological effect, remains poorly understood. Therefore, to investigate the electrophysiological effect of CTV on the human cardiomyocytes, we conducted a multi-electrode array (MEA) using human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). The MEA revealed that 30 μmol/L of CTV stopped the beating of hiPSC-CMs, and the field potential duration and first peak amplitude were shortened at 10 μmol/L. Before the hiPSC-CMs stopped beating, the length of the inter-spike interval varied two- to four-fold. These results demonstrated that CTV induced an electrophysiological disturbance on human cardiomyocytes. This is first paper to elucidate the electrophysiological effect of CTV on human heart directly and may aid in analyzing the risk associated with CTV to ensure food safety.

Citreoviridin (CTV)是一种由多种真菌产生的霉菌毒素,包括citreonigrum青霉。据报道,与CTV相关的毒性之一是神经毒性。CTV还被怀疑与急性心源性脚气(也称为“Shoshin-kakke”)和克山病有关,可对心脏产生不良影响,因此在实验动物模型中,CTV对心脏或心肌细胞的体内和体外毒性已被报道。然而,CTV对人类心脏的毒性,特别是其电生理效应,仍然知之甚少。因此,为了研究CTV对人心肌细胞的电生理影响,我们利用人诱导多能干细胞来源的心肌细胞(hiPSC-CMs)进行了多电极阵列(MEA)研究。MEA结果表明,30 μmol/L CTV能使hiPSC-CMs停止跳动,10 μmol/L时电场电位持续时间和第一峰振幅缩短。在hiPSC-CMs停止跳动之前,峰间间隔的长度变化了2到4倍。这些结果表明,CTV可引起人心肌细胞的电生理紊乱。本文首次直接阐述了CTV对人体心脏电生理的影响,有助于分析CTV的相关风险,确保食品安全。
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引用次数: 0
[Analysis of Ciguatoxins in the Spotted Knifejaw, Oplegnathus punctatus from the Waters of Japan]. [日本水域斑点刀颚鱼(Oplegnathus punctatus)的雪卡毒素分析]。
IF 0.3 4区 农林科学 Q4 FOOD SCIENCE & TECHNOLOGY Pub Date : 2022-01-01 DOI: 10.3358/shokueishi.63.190
Takumi Tomikawa, Kyoko Kuniyoshi, Shiori Ito, Satsuki Sakugawa, Akira Ishikawa, Toshio Saito, Takashi Kojima, Hiroshi Asakura, Tsuyoshi Ikehara, Naomasa Oshiro

Ciguatera fish poisoning (CFP) is recognized as the most frequent seafood poisoning due to the consumption of fish containing the principal toxins, ciguatoxins (CTXs). In Japan, CFP events have been reported annually from Okinawa and Amami Islands, locating subtropical regions. In addition, there have been reported several outbreaks due to consumption of the fish caught from the Pacific coast of the Mainland and they were often caused by the matured spotted knifejaw, Oplegnathus punctatus. As part of our research on CFP in Japan, we investigated CTXs analysis by LC-MS/MS on 176 individuals of O. punctatus (weight: 100-6,350 g, standard length: 13-60 cm) from the coast of the Mainland (Honshu, Shikoku, and Kyushu), Amami, Okinawa, and Ogasawara (Bonin) Islands. CTXs were detected from only two specimens collected from Okinawa. Total CTXs levels of the two specimens were at 0.014 and 0.040 μg/kg, respectively, exceeding FDA guidance level at 0.01 μg CTX1B equivalent/kg. However, they might be little risk of CFP because consuming over 1.5 kg of flesh is needed to develop intoxication. The toxins consisted of CTX1B analogs including CTX1B, 52-epi-54-deoxyCTX1B, CTX4A, and CTX4B, and no CTX3C analogs, supporting the finding that ciguatoxic fishes in Okinawan Waters containing only CTX1B analogs.

雪卡毒素鱼类中毒(CFP)被认为是最常见的海产品中毒,原因是食用了含有主要毒素雪卡毒素的鱼类。在日本,位于亚热带地区的冲绳和奄美岛每年都有CFP事件的报告。此外,据报有几宗因食用在内地太平洋沿岸捕获的鱼而爆发的个案,通常是由成熟斑点刀颚鱼(Oplegnathus punctatus)引起的。作为日本CFP研究的一部分,我们利用LC-MS/MS对大陆海岸(本州、国、九州)、天美、冲绳和小原(小原)群岛的176只O. punctatus(体重:100-6,350 g,标准长度:13-60 cm)进行了CTXs分析。仅从冲绳采集的两个标本中检测到ctx。两种标本CTXs总含量分别为0.014和0.040 μg/kg,均超过FDA指导水平0.01 μg CTX1B当量/kg。然而,他们患CFP的风险可能很小,因为食用超过1.5公斤的肉才会中毒。毒素由CTX1B类似物组成,包括CTX1B、52-epi-54-脱氧CTX1B、CTX4A和CTX4B,而没有CTX3C类似物,这支持了冲绳水域中有毒鱼类只含有CTX1B类似物的发现。
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引用次数: 2
[Determination of Chlorothalonil Metabolite I in Livestock Products by LC-MS/MS]. 畜产品中百菌清代谢物I的LC-MS/MS测定
IF 0.3 4区 农林科学 Q4 FOOD SCIENCE & TECHNOLOGY Pub Date : 2022-01-01 DOI: 10.3358/shokueishi.63.195
Maki Kobayashi, Naoko Sakai, Yuki Ohmachi, Yuka Morita, Satoru Nemoto, Kenji Ohtsuka

An analytical method based on LC-MS/MS was developed for the determination of chlorothalonil metabolite I in livestock products. Chlorothalonil metabolite I in livestock products was extracted with acetone. The crude extracts were defatted by acetonitrile and n-hexane partitioning. Cleanup was carried out using a combination of ethylene diamine-N-propyl silylation silica gel (PSA) and silica gel (SI) mini columns with acidic condition. The sample solution was subjected to LC-MS/MS using an external solvent calibration curve. The average recovery (n=5) of chlorothalonil metabolite I from five types of livestock products (cattle muscle, cattle fat, cattle liver, milk and egg) spike at the maximum residue limits (MRLs) or at a uniform limit of 0.01 mg/kg was 97.1-102.9%, with a relative standard deviation of 1.4-6.8%. The limit of quantitation of the developed method was calculated to be 0.01 mg/kg.

建立了畜产品中百菌清代谢物I的LC-MS/MS分析方法。用丙酮提取畜产品中的百菌清代谢物I。采用乙腈和正己烷分馏法对粗提物进行脱脂。在酸性条件下,使用乙二胺- n -丙基硅基化硅胶(PSA)和硅胶(SI)微型柱的组合进行清理。采用外溶剂校准曲线对样品溶液进行LC-MS/MS分析。5种畜产品(牛肌肉、牛脂肪、牛肝脏、牛奶和鸡蛋)中百菌清代谢产物I在最大残留限量(MRLs)和统一限量为0.01 mg/kg时的平均回收率(n=5)为97.1-102.9%,相对标准偏差为1.4-6.8%。方法的定量限为0.01 mg/kg。
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引用次数: 0
[AFM1 Content Survey in Dairy Products for Infants]. [AFM1婴幼儿乳制品含量调查]。
IF 0.3 4区 农林科学 Q4 FOOD SCIENCE & TECHNOLOGY Pub Date : 2022-01-01 DOI: 10.3358/shokueishi.63.158
Sayaka Teratani, Masami Ki, Taro Murakami, Satoshi Takatori

Infant formula in liquid for childcare can be stored at room temperature for a certain period of time, reducing the burden of childcare and preparing for disasters. Against this background, domestic manufacturing and sales began in March 2019. AFM1 is a metabolite of aflatoxin B1 (AFB1), a carcinogenic mycotoxin, and is contained in the milk of livestock fed a diet contaminated with AFB1. At present, standard values have not been set for infant formula in liquid as well as prepared infant formula in liquid, and infants consume a large amount of dairy products per body weight, so care must be taken in the intake.In this study, we investigated the actual condition of AFM1 content in dairy products with high intake of infants. As a result of the investigation, the AFM1 of the detected dairy products was 0.001 to 0.005 μg/kg, which was extremely small compared to the AFM1 in the dairy products reported so far. Since infant nutrition depends on dairy products, it is undeniable that they may consume more than adults, so continuous research is needed.

保育液型婴幼儿配方奶粉可常温存放一定时间,减轻保育员负担,未雨绸灾。在此背景下,2019年3月开始国内制造和销售。AFM1是黄曲霉毒素B1 (AFB1)的代谢物,AFB1是一种致癌真菌毒素,被AFB1污染的饲料喂养的牲畜的牛奶中含有AFM1。目前,婴儿液体配方奶粉和配制的婴儿液体配方奶粉的标准值尚未确定,而婴儿每体重消耗的乳制品量很大,因此在摄入时必须小心。本研究对婴幼儿高摄入量乳制品中AFM1含量的实际情况进行了调查。调查结果显示,检测到的乳制品中AFM1为0.001 ~ 0.005 μg/kg,与目前报道的乳制品中AFM1相比,这是非常小的。由于婴儿的营养依赖于乳制品,不可否认的是,他们可能比成年人消耗更多,因此需要持续的研究。
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引用次数: 0
[Literature Review on the Type of Fish and Histamine-producing Bacteria Associated with Histamine Poisonings in Japan]. [日本与组胺中毒有关的鱼类和产生组胺的细菌类型的文献综述]。
IF 0.3 4区 农林科学 Q4 FOOD SCIENCE & TECHNOLOGY Pub Date : 2022-01-01 DOI: 10.3358/shokueishi.63.109
Akiko Tomaru, Miou Toda, Yukiko Hara-Kudo

Histamine poisoning has been reported worldwide. Improvements in refrigeration technology have led to a reduction in this food poisoning; however, it continues to occur. Misdiagnosis of fish allergies has compounded this problem and the number of patients subjected to histamine poisoning that are transported to the emergency ward because of anaphylactic shock-like symptoms should not be underestimated. We investigated incidents of histamine food poisoning in Japan from 1998 to 2020, and found that there were a mean 9.7 incidents/year and 195.3 cases/year. Facility-wise occurrence of the incidents per year was the highest in restaurants followed by lunch facilities, and these together accounted for approximately 70% of the incidents. Facility-wise total number of cases was the highest in lunch facilities followed by restaurants, and these together accounted for 80% of the cases. Fish associated with histamine poisoning were mainly tuna, marlin, and mackerel. Based on the current literature review, 23 genera of histamine-producing bacteria were isolated from fish purchased in Japan. The most frequently reported bacteria were Morganella morganii and Photobacterium damselae. Psychrophilic bacteria such as Morganella psychrotolerans and Photobacterium phosphoreum were also isolated. To prevent histamine poisoning, freezing or fast handling of fish and the products during processing and consuming is important because only refrigeration of fish is enough.

世界各地都有组胺中毒的报道。制冷技术的改进减少了这种食物中毒;然而,这种情况仍在发生。鱼类过敏的误诊加剧了这一问题,由于过敏性休克样症状而被送往急诊室的组胺中毒患者的数量不应被低估。我们调查了1998 ~ 2020年日本的组胺类食物中毒事件,发现平均9.7例/年,195.3例/年。从设施的角度来看,每年的事故发生率最高的是餐馆,其次是午餐设施,这些设施加起来约占事故的70%。从设施的角度来看,午餐设施的病例总数最高,其次是餐馆,这些设施合计占病例的80%。与组胺中毒有关的鱼类主要是金枪鱼、马林鱼和鲭鱼。根据目前的文献综述,从日本购买的鱼中分离出23属产生组胺的细菌。报告最多的细菌是摩根氏摩根氏菌和少女光杆菌。还分离到了耐冷摩根菌和磷光杆菌等嗜冷细菌。为了防止组胺中毒,在加工和食用过程中冷冻或快速处理鱼及其产品是很重要的,因为只有冷藏鱼就足够了。
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引用次数: 0
[Collaborative Study of an LC-MS/MS Method for Determination of Chlorpropham in Feeds]. hplc -MS/MS法测定饲料中氯苯胺的协同研究
IF 0.3 4区 农林科学 Q4 FOOD SCIENCE & TECHNOLOGY Pub Date : 2022-01-01 DOI: 10.3358/shokueishi.63.122
Zenya Takeda, Chinami Kurashima, Yasutoshi Sugimoto, Yoshihiro Sekiguchi

A collaborative study for validating the determination method of chlorpropham in feeds by LC-MS/MS was conducted in 13 laboratories using 2 kinds of formula feeds, oats, barley, wheat, and corn. The resulting trueness ranged from 75.3 to 87.0%, repeatability and reproducibility in terms of relative standard deviation (RSDr and RSDR) were within 7.3% and 33% respectively, and the HorRat values ranged from 0.39 to 1.5. The limit of detection and limit of quantitation of chlorpropham in feed ware 0.008 mg/kg and 0.003 mg/kg, respectively. This method was thus validated as useful for inspections of chlorpropham in feed.

以燕麦、大麦、小麦、玉米2种配方饲料为研究对象,在13个实验室开展了hplc -MS/MS法测定饲料中氯苯胺的合作研究。准确度为75.3 ~ 87.0%,重复性和再现性相对标准偏差(RSDr和RSDr)分别在7.3%和33%以内,HorRat值为0.39 ~ 1.5。饲料中氯苯胺的检出限为0.008 mg/kg,定量限为0.003 mg/kg。该方法可用于饲料中氯苯胺的检测。
{"title":"[Collaborative Study of an LC-MS/MS Method for Determination of Chlorpropham in Feeds].","authors":"Zenya Takeda,&nbsp;Chinami Kurashima,&nbsp;Yasutoshi Sugimoto,&nbsp;Yoshihiro Sekiguchi","doi":"10.3358/shokueishi.63.122","DOIUrl":"https://doi.org/10.3358/shokueishi.63.122","url":null,"abstract":"<p><p>A collaborative study for validating the determination method of chlorpropham in feeds by LC-MS/MS was conducted in 13 laboratories using 2 kinds of formula feeds, oats, barley, wheat, and corn. The resulting trueness ranged from 75.3 to 87.0%, repeatability and reproducibility in terms of relative standard deviation (RSD<sub>r</sub> and RSD<sub>R</sub>) were within 7.3% and 33% respectively, and the HorRat values ranged from 0.39 to 1.5. The limit of detection and limit of quantitation of chlorpropham in feed ware 0.008 mg/kg and 0.003 mg/kg, respectively. This method was thus validated as useful for inspections of chlorpropham in feed.</p>","PeriodicalId":54373,"journal":{"name":"Food Hygiene and Safety Science","volume":"63 3","pages":"122-127"},"PeriodicalIF":0.3,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40524436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Frequency of Worsening Clinical Test Values Related to Supplement Use: Estimation by Using Nationwide Online Survey]. [与服用补充剂相关的临床试验值恶化的频率:使用全国在线调查的估计]。
IF 0.3 4区 农林科学 Q4 FOOD SCIENCE & TECHNOLOGY Pub Date : 2022-01-01 DOI: 10.3358/shokueishi.63.169
Chiharu Nishijima, Tsuyoshi Chiba, Keizo Umegaki

This study examined the frequency of worsening clinical test values related to supplement use using a nationwide online survey, with a focus on liver function markers, and clarified the differences between outcome indices of diarrhea or skin manifestations. A nationwide online survey was conducted with 73,010 supplement users from the previous year. Of these, 221 individuals with worsening clinical test values responded to the full-scale survey. To compare surveys with different outcome indices, we used previously reported data from similar surveys.Only 0.5% of individuals who self-reported worsening of clinical test values caused by supplement use recognized an almost certain causal relationship. Among the test items, blood lipids were the most frequently reported. The frequency of worsening liver function markers was 0.2% in supplement users. Among those who experienced worsening clinical test values, 56.1% received no treatment and 82.4% did not report the incidence of worsening clinical test values anywhere. The ingredient-based classification of products revealed more "Peptides or animal by-products" and "Combination products/not classifiable products" than those associated with other categories. Compared to the results of the survey about the experience of diarrhea or skin manifestations, those who experienced worsening clinical test values were predominantly men, frequent and long-term users, and individuals whose products could not be identified.Few supplement users experience worsening of liver function markers, which does not seem serious. However, it is difficult for supplement users to recognize abnormal changes by themselves. Thus, it is important to record product information, usage, and changes in physical condition.

本研究通过一项全国性的在线调查,研究了与补充剂使用相关的临床测试值恶化的频率,重点关注肝功能指标,并澄清了腹泻或皮肤表现的结局指标之间的差异。一项全国范围内的在线调查对前一年的73010名补充剂使用者进行了调查。其中,221名临床测试值恶化的个体对全面调查做出了回应。为了比较具有不同结果指数的调查,我们使用了以前报道的类似调查的数据。只有0.5%的自我报告因服用补充剂而导致临床测试值恶化的个体承认两者之间存在几乎确定的因果关系。在测试项目中,血脂是最常被报道的。食用者肝功能指标恶化的频率为0.2%。在临床试验值恶化的患者中,56.1%的患者未接受治疗,82.4%的患者未报告临床试验值恶化的发生率。基于成分的产品分类显示“多肽或动物副产品”和“组合产品/不可分类产品”比与其他类别相关的产品更多。与腹泻或皮肤表现的调查结果相比,临床测试值恶化的主要是男性、频繁和长期使用者以及产品无法识别的个人。很少有补充剂使用者经历肝功能指标的恶化,这似乎并不严重。然而,补充剂使用者很难自行识别异常变化。因此,记录产品信息、使用情况和物理状态的变化是很重要的。
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引用次数: 0
[Tetrodotoxin Intoxications in Nagasaki, Japan: Symptoms of Patients, Tetrodotoxin Levels in Leftover Food and Clinical Urine and Serum Samples]. [日本长崎河豚毒素中毒:患者症状、剩余食物中的河豚毒素水平以及临床尿液和血清样本]。
IF 0.3 4区 农林科学 Q4 FOOD SCIENCE & TECHNOLOGY Pub Date : 2022-01-01 DOI: 10.3358/shokueishi.63.182
Kazunari Tsujimura, Hironobu Matsuo, Kaori Taniguchi, Hiroki Yoshimura

Incidents of food poisoning associated with tetrodotoxin (TTX) contamination occur every year throughout Japan. Here, we determined TTX levels in leftover foods and serum and urine samples from eight food poisoning incidents associated with TTX contamination in Nagasaki, Japan, from 2011 to 2017.Seven food samples associated with four of these food poisoning incidents were classified as weakly toxic (four samples), moderate-to-strongly toxic (two samples), and strongly toxic (one sample).In comparison with previous reports, TTX was detected at harmful levels in the urine samples, but the grade of poisoning symptoms varied.The patients' time to maximum serum TTX levels (Tmax) was estimated to be 12-24 h after ingestion of TTX-containing foods. Additionally, serum TTX levels of 19.5 ng/mL or higher within 24 h after ingestion indicated Grade 3 poisoning associated with respiratory abnormalities.These conditions were considered indicators of severe symptoms, while TTX levels of 1-3 ng/mL relate to the onset and disappearance of symptoms. A negative correlation was found between the logarithm of serum TTX concentration and the time after ingestion for two patients, indicating that the TTX serum levels decreased logarithmically. Furthermore, the TTX serum half-lives (T1/2) were 17.5 and 23.7 h.The results of this study enhance our understanding of TTX food safety and contribute to TTX risk assessment.

日本每年都会发生与河豚毒素(TTX)污染有关的食物中毒事件。在这里,我们测定了2011年至2017年日本长崎8起与TTX污染有关的食物中毒事件中剩余食物、血清和尿液样本中的TTX水平。与其中4起食物中毒事件相关的7个食物样本被分为弱毒性(4个样本)、中毒性至强毒性(2个样本)和强毒性(1个样本)。与以前的报告相比,在尿样中检测到有害水平的TTX,但中毒症状的等级各不相同。估计患者在摄入含TTX的食物后12-24小时达到最高血清TTX水平(Tmax)。此外,摄入后24小时内血清TTX水平为19.5 ng/mL或更高,表明3级中毒与呼吸异常有关。这些情况被认为是严重症状的指标,而1-3 ng/mL的TTX水平与症状的发生和消失有关。两例患者血清TTX浓度的对数与摄入后时间呈负相关,表明TTX血清水平呈对数下降。TTX的血清半衰期(T1/2)分别为17.5 h和23.7 h。本研究结果有助于对TTX食品安全性的认识,并有助于TTX的风险评估。
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引用次数: 0
[Internal Quality Control of Residual Pesticides Analysis Using Multiple Stable Isotope Labeled Compounds]. [多种稳定同位素标记化合物在农药残留分析中的内部质量控制]。
IF 0.3 4区 农林科学 Q4 FOOD SCIENCE & TECHNOLOGY Pub Date : 2022-01-01 DOI: 10.3358/shokueishi.63.163
Kosuke Fukatsu, Tomoyuki Tsuchiyama, Masaru Taniguchi, Kazumasa Niwa, Jun Sugiura, Hitoshi Miyazaki

Internal quality control (IQC) is essential to ensure the reliability of the results of chemical analysis. In this study, we propose a novel method of IQC for multiresidue analysis of pesticides. A total of seven stable isotope labeled compounds (SILC) were added to analytical samples and were used to monitor and evaluate the quality of analytical results. In contrast to conventional IQC method in which only a limited number of control materials were analyzed to ensure the reliability of the results for an entire batch, the developed method can monitor the analytical quality of all the samples in the batch. It was shown that the developed method could achieve better performance than that of conventional method. Therefore, the developed method is considered to be promising for practical applications.(Received January 27, 2022; Accepted July 4, 2022).

内部质量控制(IQC)是保证化学分析结果可靠性的关键。本研究提出了一种用于农药多残留分析的IQC新方法。在分析样品中添加了7种稳定同位素标记化合物(SILC),用于监测和评价分析结果的质量。传统的IQC方法只分析有限数量的对照物质以确保整个批次结果的可靠性,而该方法可以监控批次中所有样品的分析质量。结果表明,该方法比传统方法具有更好的性能。因此,该方法具有较好的实际应用前景。(2022年1月27日收稿;接受于2022年7月4日)。
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引用次数: 0
[Evaluation of the Capacity to Produce Histamine by Histamine-Producing Bacteria during Storage at 10℃]. [评估组胺产生细菌在 10℃储存期间产生组胺的能力]。
IF 0.2 4区 农林科学 Q4 FOOD SCIENCE & TECHNOLOGY Pub Date : 2022-01-01 DOI: 10.3358/shokueishi.63.129
Yusuke Chiba, Akane Fujiwara, Noritaka Yoshino, Misa Ohsaka, Mika Sato, Saeko Takase, Rie Doi, Kayoko Ohtsuka, Shinichi Shimada, Rie Ishii

Histamine is produced from histidine using histidine decarboxylase of histamine-producing bacteria. However, associated histamine food poisoning demands microbiological controls. Furthermore, studies reported that histamine production by histamine-producing bacteria is affected by temperature. Therefore, to prevent histamine food poisoning, it is desirable to store foods below 4℃. However, it is challenging to maintain the storage temperature of food substances in refrigerators constantly below 4℃. Thus, we investigated histamine production capacity using seven histamine-producing bacterial strains under storage at 10℃, a more reasonable cold storage condition. Subsequently, we examined the variation of histamine production in buffers, the correlation between bacterial density and histamine production quantities, and the growth rate in broths. Results showed that similar levels of histamine were produced in buffers even after 5 days of storage under certain conditions in which histamine-producing bacteria did not grow. Moreover, bacterial density was proportional to histamine production, and the coefficient of determination was more than 0.97, and the bacterial density required to produce 200 μg/mL of histamine during storage at 10℃ was calculated to be 4×107-4×108 CFU/mL. When the initial bacterial density was 102-103 CFU/mL, psychrophilic bacteria required 2 or 3 days and mesophilic bacteria required more than 4 days to grow above 107 CFU/mL. The above results suggest that understanding the capacity of histamine-producing bacteria to produce histamine and its growth rate in foods is important for the prevention of histamine food poisoning.

组胺是利用产组胺细菌的组氨酸脱羧酶从组氨酸中产生的。然而,与组胺有关的食物中毒需要微生物控制。此外,有研究报告指出,组胺产生菌产生组胺的情况受温度影响。因此,为防止组胺食物中毒,最好将食物储存在 4℃以下。然而,要将冰箱中食品的储存温度始终保持在 4℃以下却很困难。因此,我们利用七种产组胺的细菌菌株,研究了在 10℃(一种更合理的冷藏条件)条件下储存组胺的能力。随后,我们研究了缓冲液中组胺产生量的变化、细菌密度与组胺产生量的相关性以及肉汤中的生长速度。结果表明,在某些条件下,即使缓冲液储存了 5 天,组胺产生菌也不会生长,但缓冲液中组胺的产生量却相差无几。此外,细菌密度与组胺产量成正比,测定系数大于 0.97,经计算,在 10℃储存期间产生 200 μg/mL 组胺所需的细菌密度为 4×107-4×108 CFU/mL。当初始细菌密度为 102-103 CFU/mL 时,嗜心理细菌需要 2 或 3 天才能生长到 107 CFU/mL 以上,而嗜中性细菌需要 4 天以上才能生长到 107 CFU/mL 以上。上述结果表明,了解产生组胺的细菌产生组胺的能力及其在食品中的生长速度对预防组胺食物中毒非常重要。
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引用次数: 0
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