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Analyzing the efficacy of a new natural compound made of the alga Ecklonia bicyclis, Tribulus terrestris and BIOVIS® in order to improve male sexual function 分析由绿藻Ecklonia bicyclis、蒺藜和BIOVIS®合成的一种新型天然化合物对改善男性性功能的功效
IF 0.7 4区 医学 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2011-12-01 DOI: 10.1016/j.jomh.2011.10.001
F. Iacono MD , D. Prezioso MD , A. Ruffo MD , G. Di Lauro MD , L. Romis MD , E. Illiano MD
<div><h3>Background</h3><p><span>We investigated the therapeutic efficacy of a new composite natural drug based on </span><span><em>Tribulus terrestris</em></span>, BIOVIS<sup>®</sup> and the alga <em>Ecklonia bicyclis</em><span><span> in order to improve male sexual function, selecting patients using the International Index of Erectile Function (IIEF), </span>Nocturnal Penile Tumescence and Rigidity Testing (NPTR) using the RigiScan</span><sup>®</sup> device and hormonal levels.</p></div><div><h3>Materials and methods</h3><p><span>A total of 164 patients with erectile dysfunction (ED) were enrolled between September 2009 and January 2010. Patients were classified as having mild (</span><em>n</em> <!-->=<!--> <!-->64), moderate (<em>n</em> <!-->=<!--> <!-->62) or severe (I<!--> <!-->=<!--> <!-->38) ED. Mean age was 53.1 years. A new compound (150<!--> <!-->mg of the alga <em>Ecklonia bicyclis</em>, 396<!--> <!-->mg of <em>Tribulus terrestris</em> and 144<!--> <!-->mg of BIOVIS<sup>®</sup>) was administered to all patients twice a day for 60 days. The IIEF questionnaire was administered and NPTR testing was carried out using the Rigiscan<sup>®</sup> device both pre and post-treatment with all patients.</p></div><div><h3>Results</h3><p><span>150 patients were evaluable, and their IIEF scores were all significantly improved, with an increase of 78% in the mild ED group, an 80% improvement in the moderate ED group, and an improvement of 108% in the severe ED group compared with the baseline. The mean IIEF scores for all the patients showed significant improvement after 8 weeks of treatment with this new composite drug (baseline 14.3</span> <!-->±<!--> <!-->1.5 to 26.2<!--> <!-->±<!--> <!-->3.2; <em>P</em> <!-->=<!--> <!-->0.01). Among other parameters penile rigidity and tumescence, as tested using the RigiScan<sup>®</sup> showed significant improvement for treated patients. Furthermore, no significant side effects were claimed.</p></div><div><h3>Conclusion</h3><p><span>The active components of these three natural compounds (namely protodioscin, a steroidal saponin, contained in </span><em>Tribulus terrestris</em>; the polyphenols, dieckol, florofucofuroeckol and bieckol, contained in the alga <em>Ecklonia bicyclis</em>; and the polymers of <em>d</em>-glucosamine and <em>n</em>-acetyl-<em>d</em>-glucosamine contained in BIOVIS<sup>®</sup>) when combined, seem to work in synergy not only improving erectile function but also stimulating testosterone-dependent sexual desire. Protodioscin is able to stimulate testosterone production and it also has an androgen-mimetic action, binding and activating the testosterone receptors. Polyphenols play an anti-nflammatory role, modulating the cytokines (lipopolisaccarids, TNF-alpha, IFN-gamma) with a potent antioxidant and antifibrotic effect. BIOVIS<sup>®</sup><span><span> acts on both the non-adrenergic and non-cholinergic system (NANC) and on the endothelial cell system as a strong </span>nitric oxide synthetas
本研究采用国际勃起功能指数(IIEF)、使用RigiScan®装置的夜间阴茎肿胀和硬度测试(NPTR)和激素水平,研究了一种基于蒺藜、BIOVIS®和藻类Ecklonia bicyclis的新型天然复合药物对男性性功能的改善效果。材料与方法2009年9月至2010年1月共纳入164例勃起功能障碍(ED)患者。患者分为轻度ED (n = 64)、中度ED (n = 62)和重度ED (I = 38),平均年龄53.1岁。一种新的化合物(150毫克环Ecklonia bicyclis藻类,396毫克蒺藜和144毫克BIOVIS®)每天两次给予所有患者,持续60天。所有患者在治疗前后均使用Rigiscan®设备进行IIEF问卷调查和NPTR测试。结果150例患者可评估,他们的IIEF评分均有显著改善,与基线相比,轻度ED组提高78%,中度ED组提高80%,重度ED组提高108%。治疗8周后,所有患者的平均IIEF评分均有显著改善(基线14.3±1.5至26.2±3.2;p = 0.01)。在其他参数中,使用RigiScan®测试的阴茎刚性和肿胀显示出治疗患者的显着改善。此外,没有明显的副作用。结论蒺藜中含有三种天然化合物的有效成分,即甾体皂苷原薯蓣皂苷;藻Ecklonia bicyclis中所含的多酚、二酚、氟化氟酚和二酚;以及BIOVIS®中含有的d-氨基葡萄糖胺和n-乙酰-d-氨基葡萄糖胺的聚合物),当它们结合在一起时,似乎不仅可以改善勃起功能,还可以刺激睾丸激素依赖性的性欲。原薯蓣皂苷能够刺激睾丸激素的产生,它也有一种模拟雄激素的作用,结合并激活睾丸激素受体。多酚具有抗炎作用,调节细胞因子(脂质体、tnf - α、ifn - γ),具有有效的抗氧化和抗纤维化作用。BIOVIS®同时作用于非肾上腺素能和非胆碱能系统(NANC)和内皮细胞系统,作为一种强的一氧化氮合成酶(NOS)刺激剂。我们的研究表明,这种新的复合药物口服治疗ED是有效的。
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引用次数: 10
Factors influencing children's knowledge and attitudes toward medicines in Malaysia 影响马来西亚儿童对药物的知识和态度的因素
IF 0.7 4区 医学 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2011-12-01 DOI: 10.1016/j.jomh.2011.04.005
Omar Thanoon Dawood M.Sc , Mohamed Izham Mohamed Ibrahim Ph.D , Anna Christina Abdullah Ph.D

Background

The use of medicine for the treatment of health problems is a common practice among children. Most children form attitudes, beliefs and expectations about medicines through their past experience with medicines, and through observing their parents or family members taking medicines.

Objectives

This study aimed to evaluate knowledge and attitudes toward medicines among primary schoolchildren and to evaluate the factors that may be associated with such knowledge and attitudes.

Method

A cross-sectional survey was conducted among schoolchildren from the fifth and sixth grades (aged 11–12 years) in four conveniently selected primary schools in Penang Island. Self-administered questionnaires were used to collect data from the children and their parents. All schoolchildren from grades 5 and 6 in the four schools were recruited into the survey. The total sample size was 1000 children and 1000 of those children's parents.

Results

The findings indicated that the average knowledge score was 7.36 ± 2.38 for 11-year olds and 8.09 ± 2.08 for 12-year olds, out of a maximum point score of 12. However, there was a significant difference between children related to their age and race (P < 0.05). Older children were more knowledgeable about medicines. Furthermore, the education level of the parents and their socioeconomic status influenced children's knowledge and attitude scores regarding medicines.

Conclusion

This study indicated that children have limited knowledge about medicines and some negative attitudes toward medicines. This suggests that a plan for school-based health education is needed especially on the topic of medicine education.

使用药物治疗健康问题在儿童中是一种常见的做法。大多数儿童通过其过去的用药经验以及观察其父母或家庭成员服药,形成对药物的态度、信念和期望。目的了解小学生的药物知识和态度,探讨影响小学生药物知识和态度的因素。方法采用横断面调查的方法,选取槟城岛四所小学的五、六年级(11-12岁)学生进行调查。使用自我管理的问卷从儿童及其父母那里收集数据。四所学校五年级和六年级的所有学生都被招募到调查中。总样本量是1000个孩子和1000个孩子的父母。结果11岁学生平均知识得分为7.36±2.38分,12岁学生平均知识得分为8.09±2.08分,满分为12分。然而,与年龄和种族相关的儿童之间存在显著差异(P <0.05)。年龄较大的儿童对药物的了解更多。此外,父母的受教育程度和社会经济地位对儿童的药物知识和态度得分有影响。结论本研究表明,儿童对药物的认知有限,对药物的态度较为消极。这表明,需要制定一项以学校为基础的健康教育计划,特别是关于医学教育的计划。
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引用次数: 8
Testosterone replacement therapy in males with hypogonadism in Sweden: a cost-effectiveness analysis 瑞典男性性腺功能减退患者的睾酮替代疗法:成本-效果分析
IF 0.7 4区 医学 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2011-12-01 DOI: 10.1016/j.jomh.2011.09.002
Stefan Arver , Anina Fraschke , Ba Luong , Ola Ghatnekar , Sanja Stanisic , Elvira Müller
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引用次数: 0
Editor's Comments 编辑的评论
IF 0.7 4区 医学 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2011-12-01 DOI: 10.1016/j.jomh.2011.10.003
Ajay Nehra MD
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引用次数: 0
The Invisible Men: finding and engaging with the male partners of street sex workers 看不见的男人:寻找和接触街头性工作者的男性伴侣
IF 0.7 4区 医学 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2011-10-01 DOI: 10.1016/j.jomh.2011.03.008
Susan Collinson PhD , Reg Straub , Georgina Perry BA

Men, in general, remain less likely than women to seek medical care, and are only half as likely as women to undertake preventive health visits and/or screening tests. There is a great need to increase men's health awareness and reduce this significant gender disparity. Furthermore, marginalised and socially excluded men rarely access health services, even though the reasons for their social exclusion, particularly drug and alcohol dependency, invariably mean that their need for health interventions is greater than in the normal population.

The Open Doors Sexual Health Service has been working with female street sex workers (SSWs) in the London Borough of Hackney since 2006, in order to help them address their physical, psychological and social needs. Open Doors is based in, and partly funded by, City and Hackney Primary Care Trust. As Open Doors’ staff's relationships with the women grew and the team developed an understanding of the lives of the women and their networks, it became clear that their relationships with the men in their lives (historically characterised as “pimps”) were more significant and enduring than had previously been assumed, and that working with couples had the potential to be of greater benefit than working with the women only.

In July 2008, a male worker joined the Open Doors team, in order to work exclusively with the male partners of women using the service, and to develop access to clinical and social services for this shadowy group. During the first 12 months, the male partners’ coordinator (MPC) engaged with 23 men, each one of whom has needed intensive case management, as illustrated by a Case Study. The MPC's contract has been renewed for a further year, and the scope of the post widened to include other marginalised men, such as street drinkers, squatters and undocumented migrants, achieved by close collaboration with key services, especially the TB service, the Department of Sexual Health (DoSH) and the Specialist Addictions Unit (SAU) in Hackney's local hospital, the Homerton.

This paper will describe the work done by the MPC during the first 12 months of his tenure.

总的来说,男子寻求医疗保健的可能性仍然低于妇女,进行预防性保健检查和/或筛查检查的可能性只有妇女的一半。亟需提高男子的健康意识,缩小这一巨大的性别差距。此外,被边缘化和被社会排斥的男子很少获得保健服务,尽管他们被社会排斥的原因,特别是吸毒和酗酒,总是意味着他们比正常人口更需要保健干预。自2006年以来,“敞开的门”性健康服务机构一直与伦敦哈克尼区的女性街头性工作者(ssw)合作,帮助她们解决生理、心理和社会需求。“敞开的门”的总部设在城市和哈克尼初级保健信托基金,其部分资金由该基金提供。随着敞开的门的工作人员与女性的关系的发展,以及团队对女性的生活和她们的网络的了解,很明显,她们与生活中的男性(历史上被描述为“皮条客”)的关系比以前想象的更重要和持久,与夫妇合作比只与女性合作有更大的好处。2008年7月,一名男性工作人员加入了“敞开的门”团队,以便专门与使用该服务的妇女的男性伴侣合作,并为这一阴暗群体提供获得临床和社会服务的机会。在头12个月期间,男性伴侣协调员与23名男性进行了接触,如案例研究所示,每名男性都需要强化病例管理。MPC的合同又延长了一年,该职位的范围扩大到包括其他被边缘化的男性,如街头酗酒者、非法居留者和无证移民,这是通过与主要服务部门,特别是结核病服务部门、性健康部门(DoSH)和哈克尼当地医院的专家戒毒部门(SAU)的密切合作实现的。本文将描述货币政策委员会在他任职的前12个月所做的工作。
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引用次数: 2
Varicose disease of the pelvis as the cause of LUTS in men 骨盆静脉曲张疾病是男性LUTS的病因
IF 0.7 4区 医学 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2011-10-01 DOI: 10.1016/j.jomh.2011.08.004
A. Tsukanov
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引用次数: 1
Phytotherapy for erectile dysfunction in men 植物疗法治疗男性勃起功能障碍
IF 0.7 4区 医学 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2011-10-01 DOI: 10.1016/j.jomh.2011.08.042
C.C.K. Ho , H.M. Tan
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引用次数: 0
Initial experience of low energy shockwaves for the treatment of erectile dysfunction in Teikyo University Hospital, Japan 低能冲击波治疗日本帝京大学医院勃起功能障碍的初步经验
IF 0.7 4区 医学 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2011-10-01 DOI: 10.1016/j.jomh.2011.08.014
S.-I. Hisasue, H. Ide, T. China, S. Isotani, S. Muto, R. Yamaguchi, S. Horie
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引用次数: 1
Erectile dysfunction shock wave therapy. A new modality in the management of erectile dysfunction: Does it improve the outcome? 勃起功能障碍冲击波疗法。一种治疗勃起功能障碍的新模式:它能改善结果吗?
IF 0.7 4区 医学 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2011-10-01 DOI: 10.1016/j.jomh.2011.08.021
V. Satya Srini , S. Belur Veerachari
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引用次数: 1
Obesity adversely impacts disease specific outcomes in urothelial carcinoma of the urinary bladder 肥胖对膀胱尿路上皮癌的疾病特异性结局有不利影响
IF 0.7 4区 医学 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2011-10-01 DOI: 10.1016/j.jomh.2011.08.025
T. Chromecki , E.K. Cha , H. Fajkovic , S.F. Shariat
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引用次数: 0
期刊
Journal of Mens Health
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