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Men suffer more complications from diabetes than women despite similar glycaemic control and a better cardiovascular risk profile: the ADCM study 2008 2008年ADCM研究显示,尽管男性的血糖控制相似,心血管风险也较好,但男性患糖尿病的并发症比女性多
IF 0.7 4区 医学 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2012-09-01 DOI: 10.1016/j.jomh.2012.02.004
Chew Boon How MD, MMed (Fam Med) , Cheong Ai-Theng MBBS, MMed (Fam Med) , Zaiton Ahmad MD, MMed (Fam Med) , Mastura Ismail MBBS, MMed (Fam Med)

Background

Gender differences in glycaemic control and diabetes’ complications have been well studied overseas but not locally. Gender is one of the non-modifiable factors for the diabetes patient but it is an important factor for effective personalized diabetes care. This paper examined the gender differences in glycaemic control and diabetes’ complications.

Methods

This was a registry-based observational study from May–December 2008. An online standard case record form was available for site data providers to register their diabetes patients aged 18 years old and above annually. Demographic data, diabetes duration, treatment modalities, as well as various risk factors and diabetes complications were reported. Multivariate analysis was performed.

Results

A total of 20,646 diabetes patients were included. The majority (99.2%) had been diagnosed with type 2 diabetes mellitus (T2D); 42.8% of the sample were men; 57.1% were Malay. The mean age was 58.0 years (standard deviation (SD) = 11.49) with 77.6% of the sample being 50 years old and above. Despite similar diabetes control (HbA1c < 6.5%), females suffered more microvascular complications (estimated glomerular filtration rate (eGFR) <60 mls/min: X2 = 753.54, P = <0.001) while men suffered more from macrovascular complications (ischaemic heart disease (X2 = 57.61, P = <0.001) and stroke (X2 = 13.87, P = <0.001)). Multivariate logistic regression analyses showed that T2D men were more likely to suffer from stroke (odds ratio (OR) = 1.21, 95% confidence interval (CI) = 0.89–1.64), ischaemic heart disease (OR = 1.55, CI = 1.35–1.78) and nephropathy (OR = 1.59, CI = 1.44–1.75).

Conclusion

We observed that men suffered more diabetes-related complications despite similar glycaemic control and better risk factor control. This finding requires further verification from future studies.

背景国外对血糖控制和糖尿病并发症的性别差异研究较多,但本地研究较少。性别是糖尿病患者不可改变的因素之一,但它是有效的个性化糖尿病护理的重要因素。本文探讨了两性在血糖控制和糖尿病并发症方面的差异。方法:这是一项基于注册的观察性研究,时间为2008年5月至12月。网站数据提供者可使用在线标准病例记录表格,每年登记18岁及以上的糖尿病患者。报告了人口统计数据、糖尿病病程、治疗方式以及各种危险因素和糖尿病并发症。进行多变量分析。结果共纳入糖尿病患者20646例。大多数(99.2%)被诊断为2型糖尿病(T2D);42.8%的样本为男性;57.1%是马来人。平均年龄为58.0岁(标准差(SD) = 11.49), 77.6%的样本年龄在50岁及以上。尽管糖尿病控制相似(HbA1c <6.5%),女性有更多微血管并发症(估计肾小球滤过率(eGFR) 60 ml /min: X2 = 753.54, P = <0.001),而男性有更多大血管并发症(缺血性心脏病(X2 = 57.61, P = <0.001)和中风(X2 = 13.87, P = <0.001))。多因素logistic回归分析显示,T2D男性更容易发生中风(优势比(OR) = 1.21, 95%可信区间(CI) = 0.89-1.64)、缺血性心脏病(OR = 1.55, CI = 1.35-1.78)和肾病(OR = 1.59, CI = 1.44-1.75)。结论我们观察到,尽管血糖控制相似,危险因素控制较好,但男性糖尿病相关并发症更多。这一发现需要在未来的研究中进一步验证。
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引用次数: 6
Erectile dysfunction and testosterone deficiency as gender-specific markers of cardiometabolic risk in minority and non-minority men: potential role of social determinants 勃起功能障碍和睾酮缺乏作为少数和非少数男性心脏代谢风险的性别特异性标记:社会决定因素的潜在作用
IF 0.7 4区 医学 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2012-09-01 DOI: 10.1016/j.jomh.2012.03.008
Kevin L. Billups MD

Evaluation of cardiometabolic risk has become vital in the primary prevention of adverse vascular events (coronary artery disease, heart attack, stroke or congestive heart failure), particularly in younger middle-aged men (aged 40–60 years old). To discern the prevalence of events in these men, clinicians often stratify cardiovascular risk and treat according to traditional Framingham risk criteria. The Framingham Risk Score (FRS) is a useful and often used tool for estimating the 10-year risk for myocardial infarction or coronary death of an individual. It is supported by the 2010 ACCF/AHA guideline for assessment of cardiovascular risk in asymptomatic adults. The FRS is based on data obtained from the Framingham Heart Study and it incorporates age, gender, total and high-density lipoprotein (HDL) cholesterol, smoking, systolic blood pressure (BP), and use of antihypertensive medications. However, it is important to note that the Framingham study includes few data from patients <40 years of age and few minority patients (African American and Hispanic). Thus, the FRS may not adequately estimate risk in younger patients and minorities. The FRS also lacks some important risk factors (e.g., family history, fasting glucose, testosterone) that should be considered when estimating cardiovascular risk in the man with ED. It is evident that the traditional Framingham risk assigned to intermediate and low-risk men will miss several of these individuals deemed at high “cardiometabolic risk”, also known as residual cardiovascular risk. This review will elaborate the definition of cardiometabolic risk, and apply the use of erectile dysfunction and testosterone deficiency as gender-specific surrogate markers for cardiovascular risk stratification in men in addition to the traditional Framingham-based markers. Lastly, it will examine minority men's health, racial differences and the need to include the role of social determinants in future research studies of cardiovascular risk.

心脏代谢风险的评估对于不良血管事件(冠状动脉疾病、心脏病发作、中风或充血性心力衰竭)的初级预防至关重要,特别是在中青年男性(40-60岁)中。为了了解这些男性事件的患病率,临床医生经常根据传统的Framingham风险标准对心血管风险进行分层和治疗。弗雷明汉风险评分(FRS)是一种有用且常用的评估个人10年心肌梗死或冠状动脉死亡风险的工具。它得到了2010年ACCF/AHA无症状成人心血管风险评估指南的支持。FRS基于弗雷明汉心脏研究获得的数据,包括年龄、性别、总胆固醇和高密度脂蛋白(HDL)胆固醇、吸烟、收缩压(BP)和抗高血压药物的使用。然而,值得注意的是,Framingham研究包括的40岁以上患者和少数族裔患者(非裔美国人和西班牙裔)的数据很少。因此,FRS可能不能充分估计年轻患者和少数民族的风险。在评估ED患者的心血管风险时,FRS还缺少一些重要的风险因素(例如家族史、空腹血糖、睾酮)。很明显,传统的Framingham风险分配给中、低风险男性会遗漏一些被认为具有高“心脏代谢风险”的个体,也称为剩余心血管风险。这篇综述将详细阐述心血管代谢风险的定义,并应用勃起功能障碍和睾酮缺乏作为男性心血管风险分层的性别特异性替代标记,除了传统的framingham标记。最后,它将检查少数民族男性的健康、种族差异以及在未来的心血管风险研究中纳入社会决定因素作用的必要性。
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引用次数: 2
Testosterone and abnormal glucose metabolism in an inner-city cohort 市中心人群的睾酮和异常糖代谢
IF 0.7 4区 医学 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2012-09-01 DOI: 10.1016/j.jomh.2012.03.010
Anne K. Monroe MD, MSPH , Adrian S. Dobs MD, MHS , Joseph Cofrancesco Jr MD, MPH , Todd T. Brown MD, PhD

Background

Low testosterone (T) has been associated with insulin resistance and diabetes mellitus (DM) among men in population-based studies. These studies included racially diverse men, but did not target for inclusion individuals with opiate use, Hepatitis C Virus (HCV) infection, or Human Immunodeficiency Virus (HIV) infection, which disproportionately affect inner-city populations and may alter the relationship between T and DM.

Methods

The association between free T (FT) and abnormal glucose metabolism was studied among male participants in the Study of HIV, Injection Drug Use, Nutrition, and Endocrinology (SHINE). Logistic regression was used to examine the relationship between log FT and both insulin resistance and prediabetes/DM.

Results

Of 175 men, 43 (24.6%) had low levels of FT (< 52 pg/ml). There were more men in the low FT group on methadone maintenance (39.5% vs. 15.2%, P = 0.001), but there was no difference in FT by HIV or HCV status. Overall, 23 men (13.1%) had prediabetes/DM, which was unrelated to FT (odds ratio (OR) of prediabetes/DM for each log increase in FT = 0.56, 95% Confidence Interval (CI) = 0.13–2.41). FT was also not related to insulin resistance.

Conclusions

The prevalence of hypogonadism was high in this inner-city cohort and was associated with methadone use. However, low FT was not related to insulin resistance or prediabetes/DM. Continued work to identify diabetes risk factors among inner-city populations will help determine targets for intervention to reduce diabetes incidence. Treatment trials of testosterone to reduce diabetes among hypogonadal men may be of particular relevance to opiate users, many of whom are hypogonadal.

背景:在以人群为基础的研究中,低睾酮(T)与男性胰岛素抵抗和糖尿病(DM)有关。这些研究纳入了不同种族的男性,但没有纳入阿片类药物使用、丙型肝炎病毒(HCV)感染或人类免疫缺陷病毒(HIV)感染的个体,这些个体对市中心人群的影响不成比例,可能会改变T和dm之间的关系。方法在HIV、注射药物使用、营养和内分泌学(SHINE)研究中,研究了游离T (FT)和异常糖代谢之间的关系。采用Logistic回归检验log FT与胰岛素抵抗和糖尿病前期/糖尿病之间的关系。结果175例男性中,43例(24.6%)有低水平的FT (<52个pg / ml)。低FT组中有更多的男性接受美沙酮维持治疗(39.5%比15.2%,P = 0.001),但FT与HIV或HCV状态没有差异。总体而言,23名男性(13.1%)患有前驱糖尿病/糖尿病,与FT无关(FT每增加log,前驱糖尿病/糖尿病的比值比(OR) = 0.56, 95%可信区间(CI) = 0.13-2.41)。FT也与胰岛素抵抗无关。结论性腺功能减退的患病率在这一市中心队列中较高,且与美沙酮的使用有关。然而,低FT与胰岛素抵抗或糖尿病前期/糖尿病无关。继续在市中心人群中确定糖尿病危险因素的工作将有助于确定减少糖尿病发病率的干预目标。在性腺功能低下的男性中使用睾酮降低糖尿病的治疗试验可能与阿片类药物使用者特别相关,其中许多人是性腺功能低下的。
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引用次数: 5
Male breast cancer 男性乳腺癌
IF 0.7 4区 医学 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2012-09-01 DOI: 10.1016/j.jomh.2012.03.013
Nicole P. Sandhu MD, PhD , Marie Brid Mac Bride MB, BCh , Christina A. Dilaveri MD , Lonzetta Neal MD , David R. Farley MD , Charles L. Loprinzi MD , Dietlind L. Wahner-Roedler MD , Karthik Ghosh MD, MS

Male breast cancer is rare, and many patients and health care providers are not familiar with this entity. Although the underlying causes are not well understood, certain populations are at higher risk, including certain gene mutation carriers, men with Klinefelter syndrome, and certain ethnic groups. Male breast cancer typically presents at a later stage than female breast cancer. A palpable mass is the most common presentation, but nipple discharge or other nipple changes may be seen. Because the number of affected individuals is small, prospective trials have not been conducted; thus, treatment recommendations are typically taken from large trials involving female breast cancer populations. Although outcomes in male breast cancer were previously thought to be worse than female breast cancer outcomes, it appears that they are similar. Questions regarding the most effective surgical and adjuvant therapies remain. Mastectomy with axillary lymph node evaluation, adjuvant hormonal therapy, and chemotherapy are commonly used. Providers of health care to male patients must be aware of the possibility of breast cancer and appropriately evaluate any suspicious changes.

男性乳腺癌是罕见的,许多患者和卫生保健提供者不熟悉这个实体。虽然根本原因尚不清楚,但某些人群的风险更高,包括某些基因突变携带者、患有克兰费尔特综合征的男性和某些种族群体。男性乳腺癌通常比女性乳腺癌出现得晚。可触及的肿块是最常见的表现,但乳头溢液或其他乳头变化也可能被看到。由于受影响的个体数量很少,因此尚未进行前瞻性试验;因此,治疗建议通常来自涉及女性乳腺癌人群的大型试验。虽然以前认为男性乳腺癌的结果比女性乳腺癌的结果更差,但现在看来它们是相似的。关于最有效的手术和辅助治疗的问题仍然存在。乳房切除术伴腋窝淋巴结评估,辅助激素治疗和化疗是常用的。男性患者的医疗保健提供者必须意识到患乳腺癌的可能性,并适当评估任何可疑的变化。
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引用次数: 3
Editor's Comments 编辑的评论
IF 0.7 4区 医学 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2012-09-01 DOI: 10.1016/j.jomh.2012.07.001
Ajay Nehra MD (Editor-in-Chief)
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引用次数: 0
Psychosocial, socio-cultural, and environmental influences on mental health help-seeking among African-American men 心理社会、社会文化和环境对非裔美国男性心理健康求助的影响
IF 0.7 4区 医学 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2012-06-01 DOI: 10.1016/j.jomh.2012.03.002
Kisha B. Holden PhD , Brian S. McGregor PhD , Starla H. Blanks MBA , Carlos Mahaffey PharmD, MPH

The social determinants unique to African-American men's health contribute to limited access and utilization of health and mental health care services and can have a deleterious effect on their overall health and well-being. There is a need to examine the complex issues concerning African-American men's help-seeking behaviors relative to mental health concerns. Current research estimates that African-American men are approximately 30% more likely to report having a mental illness compared to non-Hispanic Whites and are less likely to receive proper diagnosis and treatment. There is an extensive body of research that supports the view that women are more likely to seek help for psychological problems than African-American men. This review explores the psychosocial, environmental and socio-cultural factors that influence mental health help-seeking behavior among African-American men and explains the urgency to engage various stakeholders to pursue effective behavioral strategies. Research literature concerning the relationships between social determinants of health and their mental health help-seeking behaviors is reviewed and discussed in this paper. The article illustrates the need for mental health providers and researchers to establish feasible, culturally competent prevention and intervention strategies to increase help seeking behavior among African-American men, thereby contributing to the reduction of mental health disparities.

非裔美国男子健康所特有的社会决定因素导致获得和利用保健和精神保健服务的机会有限,并可能对他们的整体健康和福祉产生有害影响。有必要研究有关非裔美国人寻求帮助行为与心理健康问题的复杂问题。目前的研究估计,与非西班牙裔白人相比,非洲裔美国男性报告患有精神疾病的可能性大约高出30%,而且接受适当诊断和治疗的可能性较小。有大量的研究支持这样一种观点,即女性比非裔美国男性更有可能寻求心理问题的帮助。本综述探讨了影响非裔美国男性心理健康求助行为的社会心理、环境和社会文化因素,并解释了让各利益相关者参与追求有效行为策略的紧迫性。本文对健康社会决定因素与心理健康求助行为之间关系的研究文献进行了综述和讨论。这篇文章说明了心理健康提供者和研究人员需要建立可行的、文化上合适的预防和干预策略,以增加非裔美国男性的寻求帮助行为,从而有助于减少心理健康差异。
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引用次数: 56
Sexual and reproductive health issues among rural and urban adolescent boys of eastern India 印度东部农村和城市青少年男孩的性健康和生殖健康问题
IF 0.7 4区 医学 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2012-06-01 DOI: 10.1016/j.jomh.2012.01.004
Subha Ray PhD , Shailendra Kumar Mishra PhD , Bhubon Mohan Das MSc

Background

Adolescent boys in India constitute a large group with unmet sexual and reproductive health (SRH) needs. However, their problems and needs are poorly addressed by researchers and policy makers. Socio-demographic factors are considered to enrich the SRH knowledge and awareness of adolescents and to shape their behaviours. The present study investigated SRH awareness, attitudes and practices among adolescent males by place of residence and age. Furthermore, the study aimed to understand the socio-demographic correlates of SRH awareness and behaviours among them.

Methods

The study sample constituted 220 adolescent boys from rural (101) and urban (119) areas. These boys all belonged to a Bengali-speaking Hindu ethnic group. Data on socio-demographic characteristics, SRH awareness, attitudes and practices were collected using pretested questionnaires.

Results

Rural and urban boys differed significantly (P < 0.05) in their sexual attitudes and practices. Place of residence and exposure to media were found to be significant predictors of sexual activity among adolescents. Urban boys were significantly less likely to be involved in penetrative sexual activity (OR = 0.42) compared to rural ones.

Conclusion

Awareness of SRH issues was found to be associated with responsible sexual behaviours among adolescents. Media, along with schools, had an important role in educating adolescent boys on SRH issues and in promoting healthy sexual behaviours among them.

背景:印度的青春期男孩构成了一个未满足性健康和生殖健康(SRH)需求的庞大群体。然而,他们的问题和需求没有得到科学家和决策者的重视。社会人口因素被认为可以丰富青少年的性健康和生殖健康知识和意识,并影响他们的行为。本研究调查了不同居住地和年龄的青少年男性对性生殖健康的认识、态度和行为。此外,本研究旨在了解他们的性健康意识和行为的社会人口学相关性。方法选取农村(101)和城市(119)地区的220名青春期男孩作为研究对象。这些男孩都属于说孟加拉语的印度教族群。使用预测问卷收集社会人口特征、性健康和生殖健康意识、态度和做法的数据。结果农村和城市男孩差异显著(P <0.05)在性态度和性行为方面的差异。居住地和接触媒体是青少年性行为的重要预测因素。城市男孩参与插入性行为的可能性明显低于农村男孩(OR = 0.42)。结论青少年性健康与生殖健康意识与负责任的性行为相关。媒体与学校一道,在教育青春期男孩了解性健康和生殖健康问题以及在他们中间促进健康的性行为方面发挥了重要作用。
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引用次数: 2
The potential influence of masculine identity on health-improving behavior in midlife and older African American men 男性身份对中年和老年非裔美国男性健康改善行为的潜在影响
IF 0.7 4区 医学 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2012-06-01 DOI: 10.1016/j.jomh.2012.02.001
Steven P. Hooker PhD, FACSM , Sara Wilcox PhD , Ericka L. Burroughs MPH , Carol E. Rheaume MSPH , Will Courtenay PhD

Objective

To gain a greater understanding of masculinity and its potential influence on health-improving behavior in midlife and older African American (AA) men.

Methods

Forty-nine AA men aged 45–88 years completed in-depth interviews to ascertain their perspectives on masculinity, how masculine identity in this population might be influenced by age and physical activity level, or how it might impact health. Taped interviews were transcribed and organized for analysis with common themes identified by multiple researchers.

Results

Most often cited attributes of someone considered “manly” included a leader of a family/household, provider, strong work ethic, and masculine physique. Terms such as responsible, principled, and man of character also described the typical man. Potential negative and positive influences of manhood on health included avoiding health care appointments and being a good example to children/others, respectively. Themes associated with age-related changes in manhood were acceptance and being more health conscious. Elements associated with how manhood was influenced by AA race included stress and perseverance.

Conclusions

Midlife and older AA men in this study primarily expressed views of masculinity that fit the traditional perception of manhood. However, the attributes revealed, such as family provider, responsibility, self-reliance, and perseverance, were viewed as having potential for both negative and positive impacts on health and health-improving behaviors. It will be essential to integrate these prevalent attributes of masculine identity into health promotion interventions such that they facilitate positive behavior change while not competing with gender role norms among this vulnerable group of men.

目的了解非洲裔中老年男性的阳刚之气及其对健康改善行为的潜在影响。方法49名年龄在45-88岁之间的AA男性完成了深度访谈,以确定他们对男子气概的看法,男性身份在这一人群中如何受到年龄和体育活动水平的影响,以及它如何影响健康。录音访谈被转录和组织,以分析由多位研究人员确定的共同主题。结果:被认为“有男子气概”的人最常被提及的特征包括:家庭/家庭的领导者、养家糊口者、强烈的职业道德和男性化的体格。诸如负责任的、有原则的、有个性的人等术语也用来描述典型的男人。男子气概对健康的潜在消极和积极影响分别包括避免就医和成为儿童/他人的好榜样。与年龄相关的男性变化的主题是接受和更有健康意识。与AA种族对男子气概的影响有关的因素包括压力和毅力。结论本研究中老年AA男性对男子气概的看法主要符合传统的男子气概观念。然而,所揭示的特征,如家庭提供者、责任、自力更生和毅力,被认为对健康和改善健康的行为既有消极影响,也有积极影响。必须将这些男性身份的普遍特征纳入促进健康的干预措施,以便促进积极的行为改变,同时不与这一弱势男子群体的性别角色规范相竞争。
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引用次数: 41
Social determinants of oral health and disease in U.S. men 美国男性口腔健康和疾病的社会决定因素
IF 0.7 4区 医学 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2012-06-01 DOI: 10.1016/j.jomh.2012.03.001
Scott L. Tomar DMD, DrPH

Oral diseases are among the most prevalent chronic diseases in the United States (U.S.), disproportionately affect males, and exhibit profound disparities among socioeconomic and ethnic groups. The potentially modifiable proximal risk factors for these diseases are relatively small in number though difficult to modify at the individual level, and largely are the same as those associated with increased risk for the major chronic diseases affecting Americans. This paper gives a brief overview of disparities in oral health in the U.S., presents a conceptual model of social determinants involved in one of the most common oral diseases, and discusses the implications of a social determinant perspective for oral health policy and research.

口腔疾病是美国最普遍的慢性疾病之一,对男性的影响不成比例,并且在社会经济和种族群体中表现出深刻的差异。这些疾病的潜在可改变的近端危险因素数量相对较少,尽管在个人水平上很难改变,但与影响美国人的主要慢性疾病风险增加相关的因素在很大程度上是相同的。本文简要概述了美国口腔健康的差异,提出了一个涉及最常见口腔疾病之一的社会决定因素的概念模型,并讨论了社会决定因素视角对口腔健康政策和研究的影响。
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引用次数: 5
Editor's Comments 编辑的评论
IF 0.7 4区 医学 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2012-06-01 DOI: 10.1016/j.jomh.2012.04.001
Ajay Nehra MD
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引用次数: 0
期刊
Journal of Mens Health
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