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Research in the Training of Cardiovascular Surgeon 心血管外科医生培训的研究
4区 医学 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2022-03-10 DOI: 10.21470/1678-9741-2021-0612
A. Petroianu
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引用次数: 1
Post Ligation Cardiac Syndrome: an Educational Presentation 结扎术后心脏综合征:教育性报告
4区 医学 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2022-03-10 DOI: 10.21470/1678-9741-2020-0278
Isaac Azevedo Silva, R. B. Corso, Glauco Pina, Marcus Vinícius Nasimento dos Santos, Helmgton José Brito de Souza, Maria Paula Meireles Fenelon, L. J. S. R. Alves, D. L. Vasconcelos, Viviane Bastos Paixão Marques
Although technically simple, surgical correction of patent ductus arteriosus can have serious complications. In this context, acute ventricular failure must be remembered, as its prompt diagnosis and proper management can change clinical outcomes.
尽管技术上很简单,但动脉导管未闭的手术矫正可能会有严重的并发症。在这种情况下,必须记住急性心室衰竭,因为它的及时诊断和正确管理可以改变临床结果。
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引用次数: 0
Indigo Carmine Hemodynamic Studies to Treat Vasoplegia Induced by Compound 48/80 in a Swine Model of Anaphylaxis 靛蓝胭脂红血流动力学研究治疗过敏性猪模型中由化合物48/80诱导的血管麻痹
4区 医学 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2022-03-10 DOI: 10.21470/1678-9741-2020-0622
A. Albuquerque, A. Celotto, C. Becari, Marelaine Prandi, J. M. Barbosa, F. Moreira, M. C. Jordani, P. Evora
Introduction There are many reasons to believe that the nitric oxide/guanosine 3’5’ - cyclic monophosphate (or NO/cGMP) pathway on vasoplegic states is underestimated. To study indigo carmine (IC) as an alternative to methylene blue was the investigation rationale. Methods The IC (3mg/kg intravenous infusion) study protocol included five experimental groups; 1) Control group — saline was injected at 0 and 10 minutes; 2) IC group — IC was injected at 0 and saline at 10 minutes; 3) compound 48/80 (C48/80) group — C48/80 was injected at 0 minute and saline at 10 minutes; 4) C48/80 + IC group — C48/80 was injected at 0 minute and IC at 10 minutes; and 5) IC + C48/80 group — IC was injected at 0 minute and C48/80 at 10 minutes. The studies were carried out by registering and measuring hemodynamic and blood gasometric parameters, including continuous cardiac output. Results 1) The effects of the drugs (IC and C48/80) were more evident in the first 20 minutes of recording; 2) hypotensive responses were more pronounced in the C48/80 groups; 3) IC isolated or applied before C48/80 caused transient pulmonary hypertension; and 4) after the first 20 minutes, the pressure responses showed stability with apparent hypotension more pronounced in the C48/80 groups. Clinical observations showed significant hemodynamic instability and catastrophic anaphylactic reactions (agitation, pulmonary hypertension, severe bronchospasm, urticaria, high-intensity cyanosis, violent gastric hypersecretion, and ascites). Conclusion A global results analysis showed differences between groups only in the first 20 minutes of the experiments.
引言有很多理由认为,一氧化氮/鸟苷3'5'-环磷酸(或NO/cGMP)途径在血管麻痹状态下被低估了。研究靛蓝胭脂红(IC)作为亚甲蓝的替代品是研究的基本原理。方法IC(3mg/kg静脉滴注)研究方案包括五个实验组;1) 对照组:0、10分钟注射生理盐水;2) IC组:0时注射IC,10分钟注射生理盐水;3) 化合物48/80(C48/80)组:0分钟注射C48/80,10分钟注射生理盐水;4) C48/80+IC组:0分钟注射C48/80,10分钟注射IC;5)IC+C48/80组,0分钟注射IC,10分钟注射C48/80。这些研究是通过记录和测量血液动力学和血液气体计量参数进行的,包括连续心输出量。结果1)药物(IC和C48/80)的作用在记录的前20分钟更为明显;2) C48/80组的降压反应更为明显;3) 在C48/80引起短暂性肺动脉高压之前分离或应用的IC;和4)在最初的20分钟后,压力反应显示出稳定性,C48/80组的明显低血压更为明显。临床观察显示,血液动力学明显不稳定,并出现灾难性过敏反应(躁动、肺动脉高压、严重支气管痉挛、荨麻疹、高强度发绀、剧烈胃高分泌和腹水)。结论全局结果分析显示,仅在实验的前20分钟,各组之间存在差异。
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引用次数: 1
Evaluation of Ventricular Remodeling and Prognosis in Patients with Aortic Stenosis Who Underwent Surgical or Percutaneous Transcatheter Aortic Valve Replacement 手术或经皮主动脉瓣置换术治疗主动脉狭窄患者的心室重构和预后评估
4区 医学 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2022-03-03 DOI: 10.21470/1678-9741-2021-0175
Rodrigo Joaquim, Tiago Ghislandi Nuernberg, Tammuz Fattah, R. D. da Silva
Introduction Aortic stenosis is the most common heart valve disease in the world, and patients that present with symptoms have a high mortality rate. Aortic valve replacement has the objective of promote left ventricular remodeling, reduce symptoms, and increase overall survival. The objective of this study is to evaluate reverse remodeling of the left ventricle in patients with severe and symptomatic aortic stenosis who underwent surgical or percutaneous transcatheter aortic valve replacement. Methods This is a longitudinal, prospective, non-concurrent, non-randomized unicentric study with patients who underwent aortic valve replacement. Echocardiogram was performed before and after replacement procedure to evaluate several remodeling indexes. Results Of 91 patients, 77 (84.6%) underwent surgical aortic valve replacement, and 14 (15.4%) underwent percutaneous transcatheter aortic valve replacement. Mean age was 68,96±11,98 years, and most patients were male. Remodeling evaluation revealed that patients who decreased left ventricular index mass (53% vs. 38.9%; P=0,019) and those who reduced the mass/volume ratio (30.4% vs. 68.9%; P<0,001) presented with positive left ventricular remodeling. No endpoint difference was found in those with positive remodeling. Conclusion Regarding the left ventricular remodeling in patients with severe and symptomatic aortic valve stenosis who underwent percutaneous transcatheter or surgical valve replacement, there is a positive increment in remodeling, however it remains in concentric hypertrophic shape. Implication of these findings remains uncertain and to be studied in large dedicated trials with clinical endpoints.
引言主动脉瓣狭窄是世界上最常见的心脏瓣膜疾病,出现症状的患者死亡率很高。主动脉瓣置换术的目的是促进左心室重构,减轻症状,提高总生存率。本研究的目的是评估接受手术或经皮经导管主动脉瓣置换术的严重和症状性主动脉瓣狭窄患者的左心室反向重构。方法这是一项针对主动脉瓣置换术患者的纵向、前瞻性、非并发、非随机单中心研究。在置换手术前后进行超声心动图检查,以评估几个重塑指标。结果91例患者中,77例(84.6%)接受了外科主动脉瓣置换术,14例(15.4%)接受了经皮经导管主动脉瓣置换。平均年龄为68,96±11,98岁,大多数患者为男性。重塑评估显示,左心室指数质量降低的患者(53%对38.9%;P=0.019)和质量/体积比降低的患者的左心室重塑呈阳性(30.4%对68.9%;P<0.0001)。在那些具有阳性重塑的患者中没有发现终点差异。结论对于接受经皮经导管或外科瓣膜置换术的严重和症状性主动脉瓣狭窄患者的左心室重构,重构有正增加,但仍呈同心肥大形状。这些发现的含义仍不确定,有待于具有临床终点的大型专门试验进行研究。
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引用次数: 0
Preoperative Left Ventricular Global Longitudinal Strain Identifies Aortic Stenosis Patients with Improved Postoperative Recovery of Left Ventricular Geometry: A Prospective Cohort Study 术前左心室整体纵向应变识别主动脉瓣狭窄患者改善术后左心室几何恢复:一项前瞻性队列研究
4区 医学 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2022-03-03 DOI: 10.21470/1678-9741-2020-0529
P. Zafirovska, Rodney A. Rosalia, Ljubica Georgievska Ismail, N. Matveeva, Z. Mitrev
Introduction The left ventricular ejection fraction (LVEF) is commonly used as a marker of aortic stenosis (AS) disease severity and to indicate surgical intervention. However, an LVEF <50% identifies mainly advanced disease. Hence, earlier detection of subclinical LV systolic dysfunction may improve clinical decision-making. The global longitudinal strain (GLS) can identify subclinical systolic dysfunction at earlier stages of AS progression even in the presence of preserved LVEF. To this end, we evaluated the preoperative prognostic significance of the LVGLS to identify patients who will undergo a more extensive postoperative LV reverse remodeling as a surrogate marker for clinical recovery. Methods We performed a prospective observational study based on detailed pre- and postoperative 2D transthoracic echocardiographic examinations, including strain analysis with speckle tracking. We screened 60 consecutive patients with severe AS and a preoperative LVEF ≥50% indicated for surgery; 39 patients met the study entry criteria and consented to their participation. Results The median age was 67 (range 30-79) years; 56.4% were female. At baseline, the GLS was 61.64±7.22%. Surgery led to an improvement in the GLS; the mean difference was 3.23% [95% CI=1.96 to 4.49%] during a median follow up time of 5 (interquartile range 4-6) months. The preoperative GLS correlated with the postoperative LV mass index (LVMI) r=0.526, P=0.001 and the intraventricular septal thickness in diastole (IVSd) r=0.462, P=0.003. Furthermore, patients with a normal GLS (≤-18.9%) at baseline experienced a better recovery of their LV morphology and systolic function during the postoperative course compared to those with an abnormal GLS (>-18.9%). The effect size, hedges g, was at least >0.75 for the LVMI, IVSd, intraventricular septal thickness in systole (IVSs), left ventricular posterior wall thickness in diastole (LVPWd) and LVEF, suggesting a clinically significant difference between subgroups at follow-up. Conclusion A normal preoperative left ventricular global longitudinal strain is associated with an improved left ventricular reverse remodeling and systolic function following surgery to resolve aortic stenosis.
左心室射血分数(LVEF)通常被用作主动脉狭窄(as)疾病严重程度的标志,并指示手术干预。然而,LVEF(18.9%)。LVMI、IVSd、收缩期室间隔厚度(IVSs)、舒张期左室后壁厚度(LVPWd)和LVEF的效应量(hedges g)至少为>0.75,表明随访时亚组间存在临床显著差异。结论术前左心室整体纵向应变正常与主动脉瓣狭窄手术后左心室反向重构和收缩功能改善相关。
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引用次数: 1
Custodiol versus Blood Cardioplegia: Comparison of Myocardial Immunohistochemical Analysis and Clinical Outcomes 库斯托二醇与血液心脏骤停:心肌免疫组化分析和临床结果的比较
4区 医学 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2022-03-03 DOI: 10.21470/1678-9741-2020-0662
Onur Şen, U. Aydin, Ersin Kadiroğulları, Salih Güler, S. Gonca, S. Solakoğlu, M. Karaçalılar, B. Timur, B. Onan
Introduction Custodiol (histidine-tryptophan-ketoglutarate) and repetitive blood cardioplegia are the solutions for myocardial protection and cardiac arrest. In this study, we aimed to compare immunohistochemical analysis, clinical outcomes, and cardiac enzyme values of Custodiol and blood cardioplegia groups. Methods This was a randomized prospective study consisting of 2 groups and 20 patients, 10 patients for each group, who underwent mitral and mitral/tricuspid valve surgery. Group 1 was formed for Custodiol cardioplegia and group 2 for blood cardioplegia. Perioperative and postoperative cardiac events were recorded, cardiac enzymes were analyzed with intervals, and myocardial samples were taken for immunohistochemical analysis. Recorded data were statistically evaluated. Results There was no significant difference for the Custodiol and blood cardioplegia groups in perioperative and postoperative cardiac performance and adverse events. Cardiac enzyme analysis showed no significant difference between groups. However, two parameters (eNOS, Bcl-2) were in favor of the Custodiol group in immunohistochemical studies. Custodiol performed better in cellular oxidative stress resistance and cellular viability. Conclusion Clinical outcomes and cardiac enzyme analysis results were similar regarding myocardial protection. However, Custodiol performed better in the immunohistochemical analysis.
库斯托二醇(组氨酸-色氨酸-酮戊二酸)和重复血停搏是心肌保护和心脏骤停的解决方案。在这项研究中,我们的目的是比较免疫组织化学分析、临床结果和心脏酶值的库斯托二醇和血液心脏骤停组。方法采用随机前瞻性研究,随机分为两组,每组10例,共20例患者行二尖瓣及二尖瓣/三尖瓣手术。1组为固二醇心脏骤停,2组为血液心脏骤停。记录围术期和术后心脏事件,每隔一段时间分析心肌酶,并取心肌样本进行免疫组织化学分析。对记录的数据进行统计学评价。结果两组患者围手术期和术后心脏功能及不良事件无显著性差异。心肌酶分析结果显示各组间差异无统计学意义。然而,在免疫组织化学研究中,两个参数(eNOS, Bcl-2)有利于Custodiol组。固二醇在细胞抗氧化应激和细胞活力方面表现较好。结论心肌保护的临床效果与心肌酶分析结果相似。然而,在免疫组织化学分析中,固二醇表现更好。
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引用次数: 0
Clinical Significance of HSCARG for Atherosclerotic Coronary Heart Disease and Reduced ROS-Oxidative Stress in in Vivo and in Vitro Models via p47phox by NF-κB Activity HSCARG对动脉粥样硬化性冠心病的临床意义以及通过NF-κB活性的p47phox降低体内外ROS氧化应激
4区 医学 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2022-03-03 DOI: 10.21470/1678-9741-2021-0183
Xiaofang Zhou, Siwei Zhou, Yuan-Fang Li, Z. Qian, Chao Zeng, Y. Li
Introduction Coronary heart disease (CHD) is a dynamic process in which there are interactions between endothelial dysfunction, oxidative stress, and inflammatory responses. The aim of the present study was to investigate the function and mechanism of HSCARG in the treatment of CHD. Methods Male apolipoprotein E/low-density lipoprotein receptor-deficient mice were given a high-fat diet with 21% fat and 0.15% cholesterol for the in vivo model. Human umbilical vein endothelial cells were incubated with angiotensin II for the in vitro model. HSCARG expression was inhibited in patients or mice with CHD. Results HSCARG reduced oxidative stress in mice with CHD. HSCARG also reduced reactive oxygen species (ROS)-oxidative stress in the in vitro model. HSCARG induced p47phox expression in the in vitro model by NF-κB activity. The regulation of nuclear factor kappa B (NF-κB) activity or p47phox expression participates in the effects of HSCARG in CHD. Conclusion Altogether, our data indicate that HSCARG reduced ROS-oxidative stress in in vivo and in vitro models of CHD via p47phox by NF-κB activity and may be a clinical target for CHD.
引言冠心病是一个内皮功能障碍、氧化应激和炎症反应相互作用的动态过程。本研究旨在探讨HSCARG在冠心病治疗中的作用及其机制。方法雄性载脂蛋白E/低密度脂蛋白受体缺陷小鼠采用含21%脂肪和0.15%胆固醇的高脂饮食作为体内模型。将人脐静脉内皮细胞与血管紧张素II一起孵育用于体外模型。HSCARG在CHD患者或小鼠中的表达受到抑制。结果HSCARG可降低CHD小鼠的氧化应激。HSCARG还降低了体外模型中活性氧(ROS)的氧化应激。HSCARG通过NF-κB活性在体外模型中诱导p47phox表达。核因子κB(NF-κB)活性或p47phox表达的调节参与了HSCARG在CHD中的作用。结论总之,我们的数据表明,HSCARG通过NF-κB活性的p47phox降低了体内外CHD模型中ROS的氧化应激,可能是CHD的临床靶点。
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引用次数: 0
Aortic Valve Repair as a Subspecialty: Still an Institutional Practice or Open for All? 主动脉瓣修复作为亚专业:仍是机构实践还是开放给所有人?
4区 医学 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2022-03-03 DOI: 10.21470/1678-9741-2021-0160
K. Rathore
Aortic valve repair combined with root stabilization procedures have been reported to have reliable mid to long-term outcomes, and this is one of the reasons that various surgical units are accepting these techniques as an option in selected cases. Aortic valve replacement is a standard procedure with established results, but to master its techniques there is a major uphill learning curve. A brief communication is presented on the aortic valve repair focusing on the lesser discussed aspects like global variability of the pathology and outcomes, variable referral patterns, and effect of ethnicity.
据报道,主动脉瓣修复结合根部稳定手术具有可靠的中长期结果,这也是各种手术单位在选定病例中接受这些技术作为选择的原因之一。主动脉瓣置换术是一种标准的手术,已经取得了一定的效果,但要掌握其技术,还需要一个主要的上坡学习曲线。简要介绍了主动脉瓣修复,重点介绍了较少讨论的方面,如病理学和结果的全球变异性、可变的转诊模式和种族影响。
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引用次数: 0
Early Mobilization Prescription in Patients Undergoing Cardiac Surgery: Systematic Review 心脏手术患者早期动员处方的系统评价
4区 医学 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2022-03-03 DOI: 10.21470/1678-9741-2021-0140
M. Borges, D. Borges, M. Ribeiro, Lara Susan Silva Lima, Karolina Carneiro Morais Macedo, Vinícius José da Silva Nina
Introduction Early mobilization of patients in the postoperative period of cardiac surgery who are hospitalized in the intensive care unit (ICU) is a practice that has a positive impact. Methods This is a systematic review of studies published until September 2020 in the Medical Literature Analysis and Retrieval System Online (or MEDLINE®), Embase, Physiotherapy Evidence Database (or PEDro), Scientific Electronic Library Online (or SciELO), and Latin American and Caribbean Health Sciences Literature (or LILACS) databases. Randomized clinical trials describing mobilization protocols performed early in ICU patients after cardiac surgery were included. Results According to the eligibility criteria, only 14 of the 1,128 articles found were included in the analysis. Early mobilization protocols were initiated in the immediate postoperative period or first postoperative day. The resources and technics used were progressive mobilization, cycle ergometer, early bed activities, walking protocols, resistance exercise, and virtual reality. Intensity of the mobilization activities was determined using the Borg scale and heart rate. Conclusion Early mobilization protocols are generalist (not individual), and low-intensity exercises are used, through progressive mobilization, with two daily physical therapy sessions, during 10 to 30 minutes.
引言在重症监护室(ICU)住院的心脏手术术后患者的早期动员是一种具有积极影响的做法。方法这是对截至2020年9月在医学文献分析和检索系统在线(或MEDLINE®)、Embase、物理治疗证据数据库(或PEDro)、科学电子图书馆在线(或SciELO)和拉丁美洲和加勒比健康科学文献(或LILACS)数据库中发表的研究的系统综述。包括描述心脏手术后ICU患者早期进行的动员方案的随机临床试验。结果根据合格标准,1128篇文章中只有14篇被纳入分析。早期动员方案在术后即刻或术后第一天开始。所使用的资源和技术包括渐进动员、自行车测力计、早床活动、步行协议、阻力练习和虚拟现实。动员活动的强度使用博格量表和心率来确定。结论早期动员方案是通用的(而不是个体的),通过渐进式动员使用低强度运动,每天两次物理治疗,时间为10-30分钟。
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引用次数: 3
Predictive Value of QT Interval for Postoperative Atrial Fibrillation in Patients Undergoing Off-Pump Coronary Artery Bypass Surgery QT间期对非体外循环冠状动脉搭桥术后心房颤动的预测价值
4区 医学 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2022-03-03 DOI: 10.21470/1678-9741-2020-0571
Gencehan Kumtepe, E. Uçaroğlu
Introduction Postoperative atrial fibrillation (poAF) is a common complication of coronary artery bypass grafting, and its reasons are still the subject of research. The aim of this study was to evaluate whether QT interval is related to new onset of poAF occurrence. Methods This study included 167 patients undergoing elective isolated off-pump coronary artery bypass grafting (OPCAB) surgery. Patients were divided into two groups as poAF (+) and poAF (-), according to the development of poAF, and the results of the measurements were compared between the groups. Results PoAF was detected in 37 (22.1%) of 167 patients who underwent OPCAB surgery. When QT interval measurements were compared, preoperative and postoperative QT and corrected QT interval (QTc) values were significantly longer in the group with atrial fibrillation. Mean values of preoperative QT were 407.5±27.1 in the poAF (-) group vs. 438.5±48.5 in the poAF (+) group (P<0.001). Mean values of preoperative QTc were 419.1±14.5 in the poAF (-) group vs. 448.5±26.6 in the poAF (+) group (P<0.001). Mean values of postoperative QT were 416.3±48.3 in the poAF (-) group vs. 439.2±45.8 in the poAF (+) group (P=0.005). And mean values of postoperative QTc were 419.8±12.5 in the poAF (-) group vs. 452.0±23.3 in the poAF (+) group (P<0.001). Conclusion QT interval measurement may be a new parameter in predicting poAF development after OPCAB surgery.
引言术后心房颤动(poAF)是冠状动脉搭桥术中常见的并发症,其原因至今仍在研究中。本研究的目的是评估QT间期是否与新发poAF的发生有关。方法本研究包括167例接受选择性孤立性非体外循环冠状动脉旁路移植术(OPCAB)的患者。根据poAF的发展,患者被分为poAF(+)和poAF(-)两组,并比较两组之间的测量结果。结果在167例接受OPCAB手术的患者中,37例(22.1%)检测到房颤。当比较QT间期测量值时,心房颤动组术前和术后QT和校正QT间期(QTc)值明显更长。poAF(-)组术前QT平均值为407.5±27.1,而poAF(+)组为438.5±48.5(P<0.001)poAF(-)组为419.8±12.5,而poAF(+)组为452.0±23.3(P<0.001)。
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引用次数: 1
期刊
Revista Brasileira De Cirurgia Cardiovascular
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