Progress in Neuro-Psychopharmacology & Biological Psychiatry最新文献_第8页

Gray matter volumes of the superior temporal gyrus link preterm birth and developmentally disordered eye gazing patterns in toddlers at eighteen months 颞上回灰质体积与早产和18个月大的幼儿眼睛注视模式发育障碍有关。

IF 3.9 2区医学 Q1 CLINICAL NEUROLOGY

Progress in Neuro-Psychopharmacology & Biological Psychiatry

Pub Date : 2025-11-11 DOI: 10.1016/j.pnpbp.2025.111560

Yanan Su , Guangfei Li , Shanmei Wang , Dongmei Hao , Clara S. Li , Yiyao Ye-Lin , Xiaolin Wang , Ruolin Zhang , Lin Yang , Chiang-Shan R. Li

Background

Preterm birth involves structural brain changes and increases the risk of neurodevelopmental disorders, including social cognitive dysfunction as implicated in autism spectrum disorder (ASD). However, it remains unclear whether or how volumetric brain changes may impact the risk of social cognitive dysfunction in toddlers of preterm birth.

Methods

We curated data of 569 toddlers approximately 18 months of age, including 76 with preterm (PB) and 493 with term (TB) birth, from the developing Human Connectome Project. We processed the imaging data, collected at birth, and investigated group differences in gray matter volume (GMV) of the brain and eye-tracking data collected at 18 months as well as the interrelationships amongst birth age, GMVs, and eye-tracking markers of ASD.

Results

In a covariance analysis with age at scan, total intracranial volume, sex, and number of embryos at gestation as covariates, PB demonstrated higher GMV in bilateral superior temporal gyri (STG). Right STG GMV's were negatively correlated with birth age and positively with the proportion of looking at faces and mouths in PB, but not in TB. Further, path analyses suggested right STG GMV at birth as a marker of preferential face and mouth viewing in PB at 18 months.

Conclusions

The findings associate earlier birth age with atypical volumetrics of the right STG and eye gazing patterns in preterm children at 18 months. Longitudinal studies are needed to examine whether these neural and behavioral markers may reflect risks of social cognitive dysfunction in children with neurodevelopmental disorders, including ASD.

背景：早产涉及大脑结构改变，增加神经发育障碍的风险，包括与自闭症谱系障碍（ASD）有关的社会认知功能障碍。然而，目前尚不清楚脑容量变化是否或如何影响早产儿社会认知功能障碍的风险。方法：我们收集了569名年龄约为18 个月的幼儿的数据，包括76名早产儿（PB）和493名足月新生儿（TB），这些数据来自正在发展的人类连接组项目。我们对出生时收集的成像数据进行了处理，并调查了18 个月时收集的大脑灰质体积（GMV）和眼动追踪数据的组间差异，以及出生年龄、GMV和ASD眼动追踪标志物之间的相互关系。结果：在以扫描年龄、颅内总容积、性别和妊娠胚胎数为协方差分析中，PB在双侧颞上回（STG）表现出更高的GMV。右侧STG GMV与出生年龄呈负相关，与注视面孔和嘴巴的比例呈正相关，而与TB无显著相关性。此外，通径分析表明，出生时右侧STG GMV是18 个月大的婴儿优先观看面部和嘴巴的标志。结论：研究结果将早产年龄与18 个月的早产儿右STG的非典型体积和眼睛凝视模式联系起来。需要进行纵向研究，以检查这些神经和行为标志物是否可以反映包括ASD在内的神经发育障碍儿童的社会认知功能障碍风险。

{"title":"Gray matter volumes of the superior temporal gyrus link preterm birth and developmentally disordered eye gazing patterns in toddlers at eighteen months","authors":"Yanan Su , Guangfei Li , Shanmei Wang , Dongmei Hao , Clara S. Li , Yiyao Ye-Lin , Xiaolin Wang , Ruolin Zhang , Lin Yang , Chiang-Shan R. Li","doi":"10.1016/j.pnpbp.2025.111560","DOIUrl":"10.1016/j.pnpbp.2025.111560","url":null,"abstract":"<div><h3>Background</h3><div>Preterm birth involves structural brain changes and increases the risk of neurodevelopmental disorders, including social cognitive dysfunction as implicated in autism spectrum disorder (ASD). However, it remains unclear whether or how volumetric brain changes may impact the risk of social cognitive dysfunction in toddlers of preterm birth.</div></div><div><h3>Methods</h3><div>We curated data of 569 toddlers approximately 18 months of age, including 76 with preterm (PB) and 493 with term (TB) birth, from the developing Human Connectome Project. We processed the imaging data, collected at birth, and investigated group differences in gray matter volume (GMV) of the brain and eye-tracking data collected at 18 months as well as the interrelationships amongst birth age, GMVs, and eye-tracking markers of ASD.</div></div><div><h3>Results</h3><div>In a covariance analysis with age at scan, total intracranial volume, sex, and number of embryos at gestation as covariates, PB demonstrated higher GMV in bilateral superior temporal gyri (STG). Right STG GMV's were negatively correlated with birth age and positively with the proportion of looking at faces and mouths in PB, but not in TB. Further, path analyses suggested right STG GMV at birth as a marker of preferential face and mouth viewing in PB at 18 months.</div></div><div><h3>Conclusions</h3><div>The findings associate earlier birth age with atypical volumetrics of the right STG and eye gazing patterns in preterm children at 18 months. Longitudinal studies are needed to examine whether these neural and behavioral markers may reflect risks of social cognitive dysfunction in children with neurodevelopmental disorders, including ASD.</div></div>","PeriodicalId":54549,"journal":{"name":"Progress in Neuro-Psychopharmacology & Biological Psychiatry","volume":"143 ","pages":"Article 111560"},"PeriodicalIF":3.9,"publicationDate":"2025-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145514507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Social cognition in women with eating disorders: Differences between the restrictive and purgative profiles 饮食失调妇女的社会认知：限制性和泻性特征之间的差异。

IF 3.9 2区医学 Q1 CLINICAL NEUROLOGY

Progress in Neuro-Psychopharmacology & Biological Psychiatry

Pub Date : 2025-11-08 DOI: 10.1016/j.pnpbp.2025.111556

P. de la Higuera-Gonzalez , A. Galvez-Merlin , B. Marcos-Diaz , A. Calvo , A. Carrasco-Diaz , W. Ayad-Ahmed , P. Mola-Cardenes , A. de la Torre-Luque , F. Ruiz-Guerrero , F. Polo-Montes , J.L. Carrasco-Perera , L. Beato-Fernandez , A. Gomez-del Barrio , M. Diaz-Marsa

Introduction

Difficulties in interpersonal interactions have been related to Social Cognition (SC) impairments in eating disorders (EDs). However, results do not account for differences between restrictive (rED) and purgative (pED) profiles and are just based on decoding tasks. This study assessed SC by Theory of Mind (ToM) abilities in ToM decoding and inference tasks between rED and pED patients and healthy women and its relationship with clinical variables.

Method

37 rED patients, 42 pED patients and 34 controls were evaluated using the Movie for the Assessment of Social Cognition (MASC) -ToM inference abilities- and the Reading the Mind in the Eyes revised version (RMET-R) - ToM decoding abilities-. Age, body mass index (BMI) and disorder's duration were considered as clinical variables. ANCOVA analyses were carried out to analyse differences between groups, controlling for impulsivity as a covariate. Group relationships between ToM and clinical variables were analysed through linear regression models.

Results

pED showed lower correct MASC responses (p < .01) and more overmentalising errors (p < .05) than controls, and for rED, differences overmentalising errors were close to significance (p = .051). For RMET-R, differences were related to impulsivity. Age (p < .01) and BMI p < .05) were related with correct MASC responses.

Conclusions

Patients with EDs show difficulties in ToM inference abilities, especially those with a purgative profile, with poorer performance related to clinical severity indices such as weight and age. Differences in ToM decoding appear to be related to impulsivity rather than clinical diagnosis.

人际交往困难与进食障碍患者的社会认知障碍有关。然而，结果并没有考虑限制性（rED）和泻性（pED）配置文件之间的差异，而只是基于解码任务。本研究通过心理理论（ToM）在rED和pED患者和健康女性的ToM解码和推理任务中的能力及其与临床变量的关系来评估SC。方法：对37例rED患者、42例pED患者和34例对照患者进行社会认知能力(MASC) -ToM推理能力测评和眼读心术(RMET-R) -ToM解码能力测评。年龄、身体质量指数（BMI）和疾病持续时间作为临床变量。进行ANCOVA分析以分析组间差异，控制冲动性作为协变量。通过线性回归模型分析ToM与临床变量的组间关系。结果：pED患者的正确MASC反应较低（p ）结论：ed患者在ToM推断能力方面存在困难，特别是那些有泻药病史的患者，其在体重和年龄等临床严重程度指标方面的表现较差。ToM解码的差异似乎与冲动有关，而不是与临床诊断有关。

{"title":"Social cognition in women with eating disorders: Differences between the restrictive and purgative profiles","authors":"P. de la Higuera-Gonzalez , A. Galvez-Merlin , B. Marcos-Diaz , A. Calvo , A. Carrasco-Diaz , W. Ayad-Ahmed , P. Mola-Cardenes , A. de la Torre-Luque , F. Ruiz-Guerrero , F. Polo-Montes , J.L. Carrasco-Perera , L. Beato-Fernandez , A. Gomez-del Barrio , M. Diaz-Marsa","doi":"10.1016/j.pnpbp.2025.111556","DOIUrl":"10.1016/j.pnpbp.2025.111556","url":null,"abstract":"<div><h3>Introduction</h3><div>Difficulties in interpersonal interactions have been related to Social Cognition (SC) impairments in eating disorders (EDs). However, results do not account for differences between restrictive (rED) and purgative (pED) profiles and are just based on decoding tasks. This study assessed SC by Theory of Mind (ToM) abilities in ToM decoding and inference tasks between rED and pED patients and healthy women and its relationship with clinical variables.</div></div><div><h3>Method</h3><div>37 rED patients, 42 pED patients and 34 controls were evaluated using the Movie for the Assessment of Social Cognition (MASC) -ToM inference abilities- and the Reading the Mind in the Eyes revised version (RMET-R) - ToM decoding abilities-. Age, body mass index (BMI) and disorder's duration were considered as clinical variables. ANCOVA analyses were carried out to analyse differences between groups, controlling for impulsivity as a covariate. Group relationships between ToM and clinical variables were analysed through linear regression models.</div></div><div><h3>Results</h3><div>pED showed lower correct MASC responses (<em>p</em> < .01) and more overmentalising errors (<em>p</em> < .05) than controls, and for rED, differences overmentalising errors were close to significance (<em>p</em> = .051). For RMET-R, differences were related to impulsivity. Age (<em>p</em> < .01) and BMI <em>p</em> < .05) were related with correct MASC responses.</div></div><div><h3>Conclusions</h3><div>Patients with EDs show difficulties in ToM inference abilities, especially those with a purgative profile, with poorer performance related to clinical severity indices such as weight and age. Differences in ToM decoding appear to be related to impulsivity rather than clinical diagnosis.</div></div>","PeriodicalId":54549,"journal":{"name":"Progress in Neuro-Psychopharmacology & Biological Psychiatry","volume":"143 ","pages":"Article 111556"},"PeriodicalIF":3.9,"publicationDate":"2025-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145490899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spinosin ameliorates post-traumatic stress disorder-like behaviors via 5-HT1A receptor in mice Spinosin通过5-HT1A受体改善小鼠创伤后应激障碍样行为。

IF 3.9 2区医学 Q1 CLINICAL NEUROLOGY

Progress in Neuro-Psychopharmacology & Biological Psychiatry

Pub Date : 2025-11-06 DOI: 10.1016/j.pnpbp.2025.111559

Min Seo Kim , Ju Eun Han , Chang Hyeon Kong , Keontae Park , Hoo Sik Min , Yong Seung Lee , Won Hyung Lee , Seo Yun Jung , Soo Kyung Bae , Jae Yeol Lee , Jong Hoon Ryu

Post-traumatic stress disorder (PTSD) is a severe mental illness characterized by increased arousal, intrusion, avoidance, and negative cognitive alterations following exposure to fatal stresses or psychological trauma. In this study, we explored the ameliorating effects of spinosin on PTSD-like behaviors in PTSD model mice induced by single prolonged stress (SPS). A single dose of spinosin (3 mg/kg, p.o.) ameliorated PTSD-like behaviors as assessed using the elevated plus-maze test, marble burying test, Y-maze test, tail suspension test, and fear extinction test. Furthermore, we discovered that spinosin promotes fear extinction through 5-HT_1A receptor activation. We also verified that spinosin normalizes the increased phosphorylation levels of PKA and CREB, which are downstream signaling pathways of the 5-HT_1A receptor, in the amygdala of mice modeling PTSD. Our findings suggest that spinosin could be an effective treatment for PTSD via 5-HT_1A receptor activation, addressing the limitations of current PTSD medications.

创伤后应激障碍（PTSD）是一种严重的精神疾病，其特征是暴露于致命的压力或心理创伤后，唤醒、入侵、逃避和负面认知改变增加。在本研究中，我们探讨了脊髓肽对单次长时间应激（SPS）诱导的PTSD模型小鼠PTSD样行为的改善作用。单剂量spinosin（3 mg/kg, p.o.）改善ptsd样行为，通过升高的正迷宫测试、弹珠掩埋测试、y迷宫测试、悬尾测试和恐惧消除测试进行评估。此外，我们发现spinosin通过5-HT1A受体激活促进恐惧消退。我们还证实，脊髓球蛋白使PKA和CREB磷酸化水平升高正常化，这是5-HT1A受体的下游信号通路，在创伤后应激障碍小鼠的杏仁核中。我们的研究结果表明，spinosin可能通过5-HT1A受体激活有效治疗PTSD，解决了目前PTSD药物的局限性。

{"title":"Spinosin ameliorates post-traumatic stress disorder-like behaviors via 5-HT1A receptor in mice","authors":"Min Seo Kim , Ju Eun Han , Chang Hyeon Kong , Keontae Park , Hoo Sik Min , Yong Seung Lee , Won Hyung Lee , Seo Yun Jung , Soo Kyung Bae , Jae Yeol Lee , Jong Hoon Ryu","doi":"10.1016/j.pnpbp.2025.111559","DOIUrl":"10.1016/j.pnpbp.2025.111559","url":null,"abstract":"<div><div>Post-traumatic stress disorder (PTSD) is a severe mental illness characterized by increased arousal, intrusion, avoidance, and negative cognitive alterations following exposure to fatal stresses or psychological trauma. In this study, we explored the ameliorating effects of spinosin on PTSD-like behaviors in PTSD model mice induced by single prolonged stress (SPS). A single dose of spinosin (3 mg/kg, p.o.) ameliorated PTSD-like behaviors as assessed using the elevated plus-maze test, marble burying test, Y-maze test, tail suspension test, and fear extinction test. Furthermore, we discovered that spinosin promotes fear extinction through 5-HT<sub>1A</sub> receptor activation. We also verified that spinosin normalizes the increased phosphorylation levels of PKA and CREB, which are downstream signaling pathways of the 5-HT<sub>1A</sub> receptor, in the amygdala of mice modeling PTSD. Our findings suggest that spinosin could be an effective treatment for PTSD via 5-HT<sub>1A</sub> receptor activation, addressing the limitations of current PTSD medications.</div></div>","PeriodicalId":54549,"journal":{"name":"Progress in Neuro-Psychopharmacology & Biological Psychiatry","volume":"143 ","pages":"Article 111559"},"PeriodicalIF":3.9,"publicationDate":"2025-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145477365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to Leveraging Language and Cognitive Data for PPA Subtyping: A Systematic Review of AI-Based Approaches’ [Progress in Neuropsychopharmacology & Biological Psychiatry 142 (2025) 1–11/ 111514] 利用语言和认知数据进行PPA亚型分型的勘误表：基于人工智能的方法的系统回顾[神经精神药理学和生物精神病学进展142(2025)1-11/ 111514]。

IF 3.9 2区医学 Q1 CLINICAL NEUROLOGY

Progress in Neuro-Psychopharmacology & Biological Psychiatry

Pub Date : 2025-11-06 DOI: 10.1016/j.pnpbp.2025.111557

Joël Macoir , Fenise Selin Karalı , Samet Tosun

引用次数: 0

Acute DOI treatment evokes dose and species-dependent locomotor effects on the elevated plus maze 急性DOI治疗引起剂量和物种依赖的运动效应升高+迷宫。

IF 3.9 2区医学 Q1 CLINICAL NEUROLOGY

Progress in Neuro-Psychopharmacology & Biological Psychiatry

Pub Date : 2025-11-06 DOI: 10.1016/j.pnpbp.2025.111558

Praachi Tiwari , Vidita A. Vaidya

Recent evidence suggests that psychedelics hold promise in treating a range of neuropsychiatric disorders, highlighting the need to better understand their broader behavioral effects. Many animal-based behavioral assays related to mood, like anxiety and despair-like behavior, highly depend on locomotor activity. However, the influence of psychedelics on movement, especially in emotionally salient contexts, remains underexplored. While general locomotor activity can be monitored in the home cage, assessing movement in novel environments is critical for interpreting behaviors shaped by context and novelty. In this study, we examine the effects of the serotonergic psychedelic, DOI, on locomotor activity using the elevated plus maze (EPM), a conventionally used conflict-based anxiety maze. We find that DOI alters locomotor behavior in rats in a dose-dependent manner, and these changes are closely correlated with changes in anxiety-like behavior on the EPM. Notably, we observe species- and strain-specific differences in the DOI-evoked influence on spontaneous motor activity. While Sprague-Dawley rats and 129S6/SvEv mice exhibit reduced movement in response to 1 mg/kg DOI, C57BL/6J mice show increased movement at the same dose. The modulation of locomotor activity, like the observed anxiety-related effects, appears to be driven by the serotonin 2A receptor (5-HT_2A R), as noted by the absence of DOI-evoked locomotor changes in 5-HT_2A R knockout (KO) mice. These findings highlight the importance of considering the impact of serotonergic psychedelics on both spontaneous and context-dependent locomotion whilst interpreting mood-related behavioral responses in novelty-dependent, conflict-based approach-avoidance tasks.

最近的证据表明，致幻剂有望治疗一系列神经精神疾病，这凸显了更好地了解其更广泛的行为影响的必要性。许多与情绪相关的动物行为分析，如焦虑和绝望行为，高度依赖于运动活动。然而，迷幻药对运动的影响，特别是在情绪突出的情况下，仍然没有得到充分的研究。虽然一般的运动活动可以在家庭笼子中监测，但评估新环境中的运动对于解释由环境和新颖性形成的行为至关重要。在本研究中，我们使用升高正迷宫（EPM）（一种常规使用的基于冲突的焦虑迷宫）研究了5 -羟色胺能致幻剂DOI对运动活动的影响。我们发现DOI以剂量依赖的方式改变大鼠的运动行为，这些变化与EPM上焦虑样行为的变化密切相关。值得注意的是，我们观察到doi对自发运动活动的影响在物种和品系上的差异。Sprague-Dawley大鼠和129S6/SvEv小鼠对1 mg/kg DOI的反应是运动减少，而C57BL/6 J小鼠在相同剂量下运动增加。运动活动的调节，就像观察到的焦虑相关效应一样，似乎是由5-羟色胺2A受体（5-HT2A R）驱动的，正如在5-HT2A R敲除（KO）小鼠中没有doi引起的运动变化所指出的那样。这些发现强调了考虑血清素能致幻剂对自发运动和情境依赖运动的影响的重要性，同时解释了在新奇依赖、基于冲突的方法回避任务中与情绪相关的行为反应。

{"title":"Acute DOI treatment evokes dose and species-dependent locomotor effects on the elevated plus maze","authors":"Praachi Tiwari , Vidita A. Vaidya","doi":"10.1016/j.pnpbp.2025.111558","DOIUrl":"10.1016/j.pnpbp.2025.111558","url":null,"abstract":"<div><div>Recent evidence suggests that psychedelics hold promise in treating a range of neuropsychiatric disorders, highlighting the need to better understand their broader behavioral effects. Many animal-based behavioral assays related to mood, like anxiety and despair-like behavior, highly depend on locomotor activity. However, the influence of psychedelics on movement, especially in emotionally salient contexts, remains underexplored. While general locomotor activity can be monitored in the home cage, assessing movement in novel environments is critical for interpreting behaviors shaped by context and novelty. In this study, we examine the effects of the serotonergic psychedelic, DOI, on locomotor activity using the elevated plus maze (EPM), a conventionally used conflict-based anxiety maze. We find that DOI alters locomotor behavior in rats in a dose-dependent manner, and these changes are closely correlated with changes in anxiety-like behavior on the EPM. Notably, we observe species- and strain-specific differences in the DOI-evoked influence on spontaneous motor activity. While Sprague-Dawley rats and 129S6/SvEv mice exhibit reduced movement in response to 1 mg/kg DOI, C57BL/6J mice show increased movement at the same dose. The modulation of locomotor activity, like the observed anxiety-related effects, appears to be driven by the serotonin 2A receptor (5-HT<sub>2A</sub> R), as noted by the absence of DOI-evoked locomotor changes in 5-HT<sub>2A</sub> R knockout (KO) mice. These findings highlight the importance of considering the impact of serotonergic psychedelics on both spontaneous and context-dependent locomotion whilst interpreting mood-related behavioral responses in novelty-dependent, conflict-based approach-avoidance tasks.</div></div>","PeriodicalId":54549,"journal":{"name":"Progress in Neuro-Psychopharmacology & Biological Psychiatry","volume":"143 ","pages":"Article 111558"},"PeriodicalIF":3.9,"publicationDate":"2025-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145477287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The cognitive and neural pathways linking psychological resilience to procrastination 将心理弹性与拖延症联系起来的认知和神经通路。

IF 3.9 2区医学 Q1 CLINICAL NEUROLOGY

Progress in Neuro-Psychopharmacology & Biological Psychiatry

Pub Date : 2025-11-03 DOI: 10.1016/j.pnpbp.2025.111549

Biying Zhang , Rong Zhang , Tingyong Feng

Procrastination is a problematic behavior that negatively affects both physical and mental well-being. While extant research has established a negative association between psychological resilience and procrastination, the cognitive and neural basis underlying this relationship remain poorly characterized. To address this issue, current study asked college student participants (n = 430, M_age = 19.288 years, SD = 1.675) to undergo the MRI scanning and complete the Resilience Scale for Chinese Adolescents (RSCA) and General Procrastination Scale (GPS). The network model found that the negative relationship between psychological resilience and procrastination was primarily driven by goal planning and affect control which were two subcomponents of psychological resilience. VBM results showed that the gray matter volume (GMV) of the left Inferior Frontal Gyrus (IFG) and right Middle Frontal Gyrus (MFG) were positively correlated with goal planning, while the GMV of the right Inferior Temporal Gyrus (ITG) was positively correlated with the affect control. Importantly, the structural equation modeling (SEM) results indicated that the left IFG and the right ITG were associated with procrastination via goal planning and affect control, respectively. Taken together, these findings suggest that high psychological resilience reduces procrastination primarily through brain regions supporting goal planning and affect control.

拖延症是一种有问题的行为，对身体和精神健康都有负面影响。虽然现有的研究已经建立了心理弹性和拖延症之间的负相关关系，但这种关系背后的认知和神经基础仍然缺乏特征。为了解决这一问题，本研究要求被试大学生（n = 430,Mage = 19.288 years, SD = 1.675）接受MRI扫描并完成中国青少年弹性量表（RSCA）和一般拖延量表（GPS）。网络模型发现心理弹性与拖延之间的负向关系主要由心理弹性的两个子成分目标规划和情绪控制驱动。VBM结果显示，左侧额下回（IFG）和右侧额中回（MFG）的灰质体积（GMV）与目标规划呈正相关，右侧颞下回（ITG）的GMV与情绪控制呈正相关。重要的是，结构方程模型（SEM）结果表明，左侧IFG和右侧ITG分别通过目标规划和影响控制与拖延相关。综上所述，这些发现表明，高心理弹性主要通过支持目标规划和情绪控制的大脑区域减少拖延症。

{"title":"The cognitive and neural pathways linking psychological resilience to procrastination","authors":"Biying Zhang , Rong Zhang , Tingyong Feng","doi":"10.1016/j.pnpbp.2025.111549","DOIUrl":"10.1016/j.pnpbp.2025.111549","url":null,"abstract":"<div><div>Procrastination is a problematic behavior that negatively affects both physical and mental well-being. While extant research has established a negative association between psychological resilience and procrastination, the cognitive and neural basis underlying this relationship remain poorly characterized. To address this issue, current study asked college student participants (<em>n</em> = 430, <em>M</em><sub><em>age</em></sub> = 19.288 years, <em>SD</em> = 1.675) to undergo the MRI scanning and complete the Resilience Scale for Chinese Adolescents (RSCA) and General Procrastination Scale (GPS). The network model found that the negative relationship between psychological resilience and procrastination was primarily driven by goal planning and affect control which were two subcomponents of psychological resilience. VBM results showed that the gray matter volume (GMV) of the left Inferior Frontal Gyrus (IFG) and right Middle Frontal Gyrus (MFG) were positively correlated with goal planning, while the GMV of the right Inferior Temporal Gyrus (ITG) was positively correlated with the affect control. Importantly, the structural equation modeling (SEM) results indicated that the left IFG and the right ITG were associated with procrastination via goal planning and affect control, respectively. Taken together, these findings suggest that high psychological resilience reduces procrastination primarily through brain regions supporting goal planning and affect control.</div></div>","PeriodicalId":54549,"journal":{"name":"Progress in Neuro-Psychopharmacology & Biological Psychiatry","volume":"143 ","pages":"Article 111549"},"PeriodicalIF":3.9,"publicationDate":"2025-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145453967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pre-Reproductive Excessive Alcohol and Maternal Immune Activation Differentially Affect Offspring Behavior, Neurobiology, and Brain Volume in a Sex-Dependent Manner 生殖前过量酒精和母体免疫激活以性别依赖的方式对后代行为、神经生物学和脑容量产生不同的影响。

IF 3.9 2区医学 Q1 CLINICAL NEUROLOGY

Progress in Neuro-Psychopharmacology & Biological Psychiatry

Pub Date : 2025-11-03 DOI: 10.1016/j.pnpbp.2025.111550

Alexandra Ott , Octavio Ghirardello , Kaloyan. Tanev , Jennifer Altschüler , Asude Zülal Gül , Zoë Kruschke , Susanne Mueller , Stefan Paul Koch , Philipp Boehm-Sturm , Christine Winter , Ravit Hadar

While the harmful effects of alcohol use during pregnancy are well recognized, less is understood about how maternal alcohol consumption during adolescence, prior to reproduction, may affect offspring. This is especially concerning given the high prevalence of adolescent alcohol use, particularly in females. This study investigates how maternal pre-reproductive alcohol exposure, combined with a maternal immune activation (MIA) during pregnancy, a well-established neurodevelopmental risk factor, affects offspring. Female Wistar rats were subjected to intermittent binge-like alcohol consumption during adolescence and later mated with naïve males. On gestational day 15, dams received either saline or a mild dose of the viral mimic Poly I:C. Maternal care was monitored, and stress axis components were analyzed in both dams and their offspring. Adult offspring underwent behavioral testing, MRI, neurochemical and neuroimmune analyses, metabolic profiling, and voluntary alcohol consumption assessments. Maternal alcohol exposure prior to reproduction led to increased offspring body weight, memory impairments, altered HPA axis function, microglial reductions, and enlarged cerebellar volumes, with most outcomes showing sex-specific differences, including opposing neurochemical responses. Interestingly, MIA, but not maternal alcohol, induced elevated alcohol intake in offspring and disrupted sensorimotor gating. MIA-exposed dams also showed impaired maternal care and reproductive HPA axis dysregulation. These findings demonstrate that adolescent alcohol use before reproduction has significant intergenerational consequences and that even mild immune challenges during pregnancy can independently disrupt offspring development. Results underscore the importance of sex as a biological variable and call for targeted preventive strategies.

虽然怀孕期间饮酒的有害影响已得到充分认识，但对于母亲在生育前的青春期饮酒可能如何影响后代，了解较少。鉴于青少年、特别是女性酗酒的高发率，这一点尤其令人担忧。本研究调查了孕妇生殖前酒精暴露，结合怀孕期间孕妇免疫激活（MIA），这是一个公认的神经发育风险因素，如何影响后代。雌性Wistar大鼠在青春期间歇性狂饮，随后与naïve雄性交配。在妊娠第15天，母鼠接受生理盐水或轻度剂量的病毒模拟物Poly I:C。监测母代护理，分析母代及其后代的应力轴分量。成年后代进行了行为测试、核磁共振成像、神经化学和神经免疫分析、代谢谱分析和自愿饮酒评估。母亲在生育前的酒精暴露导致后代体重增加、记忆障碍、下丘脑轴功能改变、小胶质细胞减少和小脑体积增大，大多数结果显示性别特异性差异，包括相反的神经化学反应。有趣的是，MIA，而不是母体酒精，诱导后代酒精摄入量升高并破坏感觉运动门控。暴露于mia的水坝也表现出母性保健受损和生殖HPA轴失调。这些发现表明，青少年在生育前饮酒会产生显著的代际影响，怀孕期间即使是轻微的免疫挑战也会独立地破坏后代的发育。结果强调了性别作为一个生物学变量的重要性，并呼吁采取有针对性的预防策略。

{"title":"Pre-Reproductive Excessive Alcohol and Maternal Immune Activation Differentially Affect Offspring Behavior, Neurobiology, and Brain Volume in a Sex-Dependent Manner","authors":"Alexandra Ott , Octavio Ghirardello , Kaloyan. Tanev , Jennifer Altschüler , Asude Zülal Gül , Zoë Kruschke , Susanne Mueller , Stefan Paul Koch , Philipp Boehm-Sturm , Christine Winter , Ravit Hadar","doi":"10.1016/j.pnpbp.2025.111550","DOIUrl":"10.1016/j.pnpbp.2025.111550","url":null,"abstract":"<div><div>While the harmful effects of alcohol use during pregnancy are well recognized, less is understood about how maternal alcohol consumption during adolescence, prior to reproduction, may affect offspring. This is especially concerning given the high prevalence of adolescent alcohol use, particularly in females. This study investigates how maternal pre-reproductive alcohol exposure, combined with a maternal immune activation (MIA) during pregnancy, a well-established neurodevelopmental risk factor, affects offspring. Female Wistar rats were subjected to intermittent binge-like alcohol consumption during adolescence and later mated with naïve males. On gestational day 15, dams received either saline or a mild dose of the viral mimic Poly I:C. Maternal care was monitored, and stress axis components were analyzed in both dams and their offspring. Adult offspring underwent behavioral testing, MRI, neurochemical and neuroimmune analyses, metabolic profiling, and voluntary alcohol consumption assessments. Maternal alcohol exposure prior to reproduction led to increased offspring body weight, memory impairments, altered HPA axis function, microglial reductions, and enlarged cerebellar volumes, with most outcomes showing sex-specific differences, including opposing neurochemical responses. Interestingly, MIA, but not maternal alcohol, induced elevated alcohol intake in offspring and disrupted sensorimotor gating. MIA-exposed dams also showed impaired maternal care and reproductive HPA axis dysregulation. These findings demonstrate that adolescent alcohol use before reproduction has significant intergenerational consequences and that even mild immune challenges during pregnancy can independently disrupt offspring development. Results underscore the importance of sex as a biological variable and call for targeted preventive strategies.</div></div>","PeriodicalId":54549,"journal":{"name":"Progress in Neuro-Psychopharmacology & Biological Psychiatry","volume":"143 ","pages":"Article 111550"},"PeriodicalIF":3.9,"publicationDate":"2025-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145453970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation of auditory network hyperconnectivity with P3a amplitude and set-shifting in individuals with autism spectrum disorder 自闭症谱系障碍患者听觉网络超连通性与P3a振幅和集移位的相关性

IF 3.9 2区医学 Q1 CLINICAL NEUROLOGY

Progress in Neuro-Psychopharmacology & Biological Psychiatry

Pub Date : 2025-11-03 DOI: 10.1016/j.pnpbp.2025.111552

Yi-Ling Chien , Chi Chen , Ming Hsien Hsieh , Susan Shur-Fen Gau

Backgrounds

Individuals with autism spectrum disorder (ASD) exhibit aberrant intrinsic connectivity and altered mismatch negativity responses. Both mismatch negativity and intrinsic connectivity are associated with pre-attentive mechanisms. However, the potential link between mismatch negativity and alterations in intrinsic connectivity in ASD has not been thoroughly explored. This study aimed to investigate the resting-state functional connectivity of the auditory network in ASD and examine its association with mismatch negativity and set-shifting performance.

Methods

This study recruited 75 ASD participants and 50 neurotypical controls (NAC). All participants underwent clinical assessments, mismatch negativity on the oddball paradigm, and resting-state functional MRI. We compared the resting-state brain connectivity of the auditory network between ASD and NAC using independent component analysis. We then examined correlations between this connectivity, mismatch negativity, and executive function measured by the Intra-Extra Dimensional Set Shift task (IED).

Results

The ASD group demonstrated resting-state hyperconnectivity between the auditory network and the regions of the posterior cingulate gyrus, left inferior frontal gyrus, right angular gyrus, and right caudate/thalamus. In ASD, the connectivity between the auditory network and the left inferior frontal gyrus was positively correlated with higher P3a amplitude and a greater number of completed stages on the IED task, indicating enhanced cognitive flexibility.

Conclusion

Findings suggest heightened functional connectivity between the auditory network and various brain regions in ASD. Specifically, connectivity to the left inferior frontal gyrus at rest may predict enhanced attention reorientation and cognitive flexibility in autistic individuals. Further research is warranted to elucidate these relationships.

背景：自闭症谱系障碍（ASD）个体表现出异常的内在连通性和改变的错配负性反应。失配消极性和内在连通性都与注意前机制有关。然而，失配负性与ASD内在连通性改变之间的潜在联系尚未得到充分探讨。本研究旨在探讨ASD患者静息状态听觉网络的功能连通性，并探讨其与失配负性和集移表现的关系。方法：本研究招募75名ASD参与者和50名神经正常对照组（NAC）。所有参与者都进行了临床评估，在古怪范式上进行了失配阴性，并进行了静息状态功能MRI。我们使用独立分量分析比较了ASD和NAC的静息状态听觉网络连接。然后，我们研究了这种连通性、错配负性和执行功能之间的相关性，这些关系是通过内部额外维度集合转移任务（IED）测量的。结果：ASD组静息状态下听觉网络与扣带回后区、左侧额下回、右侧角回和右侧尾状/丘脑区域之间存在超连通性。在ASD中，听觉网络与左侧额下回之间的连通性与更高的P3a振幅和更多的IED任务完成阶段呈正相关，表明认知灵活性增强。结论：研究结果表明，ASD患者听觉网络与大脑各区域之间的功能连通性增强。具体来说，休息时与左额下回的连通性可能预示着自闭症患者注意力重新定向和认知灵活性的增强。需要进一步的研究来阐明这些关系。

{"title":"Correlation of auditory network hyperconnectivity with P3a amplitude and set-shifting in individuals with autism spectrum disorder","authors":"Yi-Ling Chien , Chi Chen , Ming Hsien Hsieh , Susan Shur-Fen Gau","doi":"10.1016/j.pnpbp.2025.111552","DOIUrl":"10.1016/j.pnpbp.2025.111552","url":null,"abstract":"<div><h3>Backgrounds</h3><div>Individuals with autism spectrum disorder (ASD) exhibit aberrant intrinsic connectivity and altered mismatch negativity responses. Both mismatch negativity and intrinsic connectivity are associated with pre-attentive mechanisms. However, the potential link between mismatch negativity and alterations in intrinsic connectivity in ASD has not been thoroughly explored. This study aimed to investigate the resting-state functional connectivity of the auditory network in ASD and examine its association with mismatch negativity and set-shifting performance.</div></div><div><h3>Methods</h3><div>This study recruited 75 ASD participants and 50 neurotypical controls (NAC). All participants underwent clinical assessments, mismatch negativity on the oddball paradigm, and resting-state functional MRI. We compared the resting-state brain connectivity of the auditory network between ASD and NAC using independent component analysis. We then examined correlations between this connectivity, mismatch negativity, and executive function measured by the Intra-Extra Dimensional Set Shift task (IED).</div></div><div><h3>Results</h3><div>The ASD group demonstrated resting-state hyperconnectivity between the auditory network and the regions of the posterior cingulate gyrus, left inferior frontal gyrus, right angular gyrus, and right caudate/thalamus. In ASD, the connectivity between the auditory network and the left inferior frontal gyrus was positively correlated with higher P3a amplitude and a greater number of completed stages on the IED task, indicating enhanced cognitive flexibility.</div></div><div><h3>Conclusion</h3><div>Findings suggest heightened functional connectivity between the auditory network and various brain regions in ASD. Specifically, connectivity to the left inferior frontal gyrus at rest may predict enhanced attention reorientation and cognitive flexibility in autistic individuals. Further research is warranted to elucidate these relationships.</div></div>","PeriodicalId":54549,"journal":{"name":"Progress in Neuro-Psychopharmacology & Biological Psychiatry","volume":"143 ","pages":"Article 111552"},"PeriodicalIF":3.9,"publicationDate":"2025-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145453959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Global and regional morphometric similarity in insomnia with objective short sleep duration 客观睡眠时间短的失眠症的整体和局部形态学相似性。

IF 3.9 2区医学 Q1 CLINICAL NEUROLOGY

Progress in Neuro-Psychopharmacology & Biological Psychiatry

Pub Date : 2025-11-03 DOI: 10.1016/j.pnpbp.2025.111551

Zhangwei Lv , Haobo Zhang , Yuhan Fan , Yuanyuan Chen , Yuxian Wei , Xu Lei

Insomnia disorder is a heterogeneous psychiatric condition characterized by differences in psychological traits and neurobiological mechanisms, necessitating precise phenotyping for targeted interventions. This clinical control study, part of a two-year multicenter research project, examined differences in sleep parameters, psychological characteristics, and morphometric similarity (MS) patterns between insomnia phenotypes classified by objective total sleep time (oTST). The study enrolled 997 adult patients with insomnia disorder, of whom 270 underwent MRI scanning. Participants were categorized into insomnia with objective normal sleep duration (INSD) and insomnia with objective short sleep duration (ISSD) based on oTST measured using a wearable forehead sleep recorder. Primary outcomes included sleep parameters (e.g., wake after sleep onset and rapid eye movement percentage), psychological characteristics (e.g., rumination), and MS patterns assessed through MS mapping. Results showed that the ISSD phenotype showed shorter wake after sleep onset, lower eye movement sleep (REM) percentage, and higher non-REM stage 2 percentage, whereas the INSD phenotype exhibited greater sleep perception bias and more fragmented sleep. Additionally, ISSD showed higher global MS and distinct regional MS patterns, including lower MS in the right middle temporal gyrus and higher MS in the right postcentral gyrus. It also exhibited decoupling with the visual network and de-differentiation with the ventral attention and default mode networks. These findings reveal distinct neurobiological mechanisms underlying insomnia phenotypes and highlight the need for phenotype-based interventions.

失眠是一种异质性精神疾病，其特点是心理特征和神经生物学机制的差异，需要精确的表型来进行有针对性的干预。这项临床对照研究是一项为期两年的多中心研究项目的一部分，研究了按客观总睡眠时间（oTST）分类的失眠表型之间睡眠参数、心理特征和形态相似性（MS）模式的差异。该研究招募了997名患有失眠症的成年患者，其中270人接受了核磁共振扫描。参与者被分为客观正常睡眠时间失眠（INSD）和客观短睡眠时间失眠（ISSD），基于使用可穿戴式前额睡眠记录仪测量的oTST。主要结局包括睡眠参数（如入睡后醒来和快速眼动百分比）、心理特征（如反刍）和通过质谱图评估的质谱模式。结果表明，ISSD表型表现为睡眠后觉醒时间较短，眼动睡眠（REM）比例较低，非REM第二阶段（N2）比例较高，而INSD表型表现为更大的睡眠感知偏差和更多的碎片化睡眠。此外，ISSD表现出更高的整体质谱和明显的区域质谱模式，包括右侧颞中回低质谱和右侧中央后回高质谱。它还表现出与视觉网络的解耦和与腹侧注意网络和默认模式网络的去分化。这些发现揭示了失眠表型背后的独特神经生物学机制，并强调了基于表型干预的必要性。

{"title":"Global and regional morphometric similarity in insomnia with objective short sleep duration","authors":"Zhangwei Lv , Haobo Zhang , Yuhan Fan , Yuanyuan Chen , Yuxian Wei , Xu Lei","doi":"10.1016/j.pnpbp.2025.111551","DOIUrl":"10.1016/j.pnpbp.2025.111551","url":null,"abstract":"<div><div>Insomnia disorder is a heterogeneous psychiatric condition characterized by differences in psychological traits and neurobiological mechanisms, necessitating precise phenotyping for targeted interventions. This clinical control study, part of a two-year multicenter research project, examined differences in sleep parameters, psychological characteristics, and morphometric similarity (MS) patterns between insomnia phenotypes classified by objective total sleep time (oTST). The study enrolled 997 adult patients with insomnia disorder, of whom 270 underwent MRI scanning. Participants were categorized into insomnia with objective normal sleep duration (INSD) and insomnia with objective short sleep duration (ISSD) based on oTST measured using a wearable forehead sleep recorder. Primary outcomes included sleep parameters (e.g., wake after sleep onset and rapid eye movement percentage), psychological characteristics (e.g., rumination), and MS patterns assessed through MS mapping. Results showed that the ISSD phenotype showed shorter wake after sleep onset, lower eye movement sleep (REM) percentage, and higher non-REM stage 2 percentage, whereas the INSD phenotype exhibited greater sleep perception bias and more fragmented sleep. Additionally, ISSD showed higher global MS and distinct regional MS patterns, including lower MS in the right middle temporal gyrus and higher MS in the right postcentral gyrus. It also exhibited decoupling with the visual network and de-differentiation with the ventral attention and default mode networks. These findings reveal distinct neurobiological mechanisms underlying insomnia phenotypes and highlight the need for phenotype-based interventions.</div></div>","PeriodicalId":54549,"journal":{"name":"Progress in Neuro-Psychopharmacology & Biological Psychiatry","volume":"143 ","pages":"Article 111551"},"PeriodicalIF":3.9,"publicationDate":"2025-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145454008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Distinct functional profiles of partial agonist antipsychotics in cAMP and β-arrestin signaling mechanisms of dopamine D2 and D3 receptors in vitro 部分激动剂抗精神病药物在体外多巴胺D2和D3受体cAMP和β-抑制素信号传导机制中的独特功能特征。

IF 3.9 2区医学 Q1 CLINICAL NEUROLOGY

Progress in Neuro-Psychopharmacology & Biological Psychiatry

Pub Date : 2025-11-03 DOI: 10.1016/j.pnpbp.2025.111554

Katalin Domány-Kovács, Sándor Kolok, Dalma Kurkó, Zsófia Bekes, Ferenc Horti, Amrita Bobok, József Nagy, Zoltán Kapui , Balázs Lendvai, András Visegrády, Béla Kiss

Aripiprazole, brexpiprazole and cariprazine represent a new generation of atypical antipsychotics with partial agonist activity at dopamine D₂ and D₃ receptors. So far, the functional activity of these partial agonists has mainly been studied at G-protein-dependent cyclic adenosine monophosphate (cAMP) signaling pathways of D₂ and D₃ receptors. While their effects at D₂ receptor-mediated β-arrestin translocation were relatively well characterized the comparative investigation at D₃-dependent β-arrestin translocation is still largely missing. Moreover, antagonism of these partial agonists either at D₂ or D₃ receptors has not been studied at multiple cellular signaling pathways. In this study, we compared the agonist and antagonist features of aripiprazole, brexpiprazole, cariprazine on dopamine receptor-mediated cAMP and β-arrestin pathways in multiple cell lines expressing recombinant human D₂ or D₃ receptors using homogeneous time-resolved fluorescence and luminescent enzyme fragment complementation technologies. We demonstrated that the three partial agonists display qualitatively similar functional profile at D₂ receptor-mediated cAMP and β-arrestin pathways. While cariprazine showed partial agonism and partial antagonism at D₃ receptor-mediated β-arrestin translocation, aripiprazole and brexpiprazole displayed only weak or no agonist but potent antagonist activity. These data suggest differentiated mechanism of action of cariprazine at the D₃ receptor signaling compared to aripiprazole and brexpiprazole.

阿立哌唑、brexpiprazole和cariprazine是新一代具有多巴胺D2和D3受体部分激动剂活性的非典型抗精神病药物。到目前为止，这些部分激动剂的功能活性主要研究于D2和D3受体的g蛋白依赖性环腺苷单磷酸（cAMP）信号通路。虽然它们在D2受体介导的β-阻滞蛋白易位中的作用已经得到了较好的表征，但对d3依赖性β-阻滞蛋白易位的比较研究仍在很大程度上缺失。此外，这些部分激动剂对D2或D3受体的拮抗作用尚未在多种细胞信号通路中得到研究。在本研究中，我们采用均匀时间分辨荧光和发光酶片段互补技术，比较了阿立哌唑、brexpiprazole和cariprazine在表达重组人D2或D3受体的多种细胞系中对多巴胺受体介导的cAMP和β-阻滞素通路的激动剂和拮抗剂特性。我们证明了这三种部分激动剂在D2受体介导的cAMP和β-阻滞素途径上表现出质量相似的功能特征。在D3受体介导的β-抑制素易位中，卡吡嗪表现出部分激动作用和部分拮抗作用，而阿立哌唑和brexpiprazole表现出微弱或无激动作用，但具有强拮抗作用。这些数据表明，与阿立哌唑和brexpiprazole相比，cariprazine对D3受体信号的作用机制是不同的。

{"title":"Distinct functional profiles of partial agonist antipsychotics in cAMP and β-arrestin signaling mechanisms of dopamine D2 and D3 receptors in vitro","authors":"Katalin Domány-Kovács, Sándor Kolok, Dalma Kurkó, Zsófia Bekes, Ferenc Horti, Amrita Bobok, József Nagy, Zoltán Kapui , Balázs Lendvai, András Visegrády, Béla Kiss","doi":"10.1016/j.pnpbp.2025.111554","DOIUrl":"10.1016/j.pnpbp.2025.111554","url":null,"abstract":"<div><div>Aripiprazole, brexpiprazole and cariprazine represent a new generation of atypical antipsychotics with partial agonist activity at dopamine D<sub>2</sub> and D<sub>3</sub> receptors. So far, the functional activity of these partial agonists has mainly been studied at G-protein-dependent cyclic adenosine monophosphate (cAMP) signaling pathways of D<sub>2</sub> and D<sub>3</sub> receptors. While their effects at D<sub>2</sub> receptor-mediated β-arrestin translocation were relatively well characterized the comparative investigation at D<sub>3</sub>-dependent β-arrestin translocation is still largely missing. Moreover, antagonism of these partial agonists either at D<sub>2</sub> or D<sub>3</sub> receptors has not been studied at multiple cellular signaling pathways. In this study, we compared the agonist and antagonist features of aripiprazole, brexpiprazole, cariprazine on dopamine receptor-mediated cAMP and β-arrestin pathways in multiple cell lines expressing recombinant human D<sub>2</sub> or D<sub>3</sub> receptors using homogeneous time-resolved fluorescence and luminescent enzyme fragment complementation technologies. We demonstrated that the three partial agonists display qualitatively similar functional profile at D<sub>2</sub> receptor-mediated cAMP and β-arrestin pathways. While cariprazine showed partial agonism and partial antagonism at D<sub>3</sub> receptor-mediated β-arrestin translocation, aripiprazole and brexpiprazole displayed only weak or no agonist but potent antagonist activity. These data suggest differentiated mechanism of action of cariprazine at the D<sub>3</sub> receptor signaling compared to aripiprazole and brexpiprazole.</div></div>","PeriodicalId":54549,"journal":{"name":"Progress in Neuro-Psychopharmacology & Biological Psychiatry","volume":"143 ","pages":"Article 111554"},"PeriodicalIF":3.9,"publicationDate":"2025-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145454033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0