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Künstliche Intelligenz im Management der Anti-VEGF-Therapie: der „Vienna Fluid Monitor“ in der klinischen Praxis 抗维病治疗管理中的人工智慧:临床使用的维也纳流体监视器
4区 医学 Q3 Medicine Pub Date : 2022-04-14 DOI: 10.1007/s00347-022-01618-2
P. Fuchs, L. Coulibaly, G. Reiter, U. Schmidt-Erfurth
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引用次数: 1
Chirurgische Therapieoptionen bei kongenitalen/kindlichen Hornhauttrübungen und Vorderabschnittsdysgenesien 你在表演代号堕胎
4区 医学 Q3 Medicine Pub Date : 2022-04-04 DOI: 10.1007/s00347-022-01612-8
S. Schlereth, Caroline Gietzelt, S. Zwingelberg, M. Matthaei, B. Bachmann, Claus Cursiefen
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引用次数: 2
[Gorlin-Goltz syndrome-not just a syndrome of malignant eyelid tumors]. [Gorlin-Goltz综合症-不仅仅是眼睑恶性肿瘤综合症]。
4区 医学 Q3 Medicine Pub Date : 2022-04-01 Epub Date: 2021-03-26 DOI: 10.1007/s00347-021-01371-y
C Kortuem, A Abaza, C Schramm, F Kortuem
{"title":"[Gorlin-Goltz syndrome-not just a syndrome of malignant eyelid tumors].","authors":"C Kortuem, A Abaza, C Schramm, F Kortuem","doi":"10.1007/s00347-021-01371-y","DOIUrl":"https://doi.org/10.1007/s00347-021-01371-y","url":null,"abstract":"","PeriodicalId":54676,"journal":{"name":"Ophthalmologe","volume":"119 4","pages":"403-406"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s00347-021-01371-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25520060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Silicone oil droplets in the vitreous body after intravitreal injection]. 【玻璃体内注射后硅油滴入玻璃体】。
4区 医学 Q3 Medicine Pub Date : 2022-04-01 Epub Date: 2021-03-09 DOI: 10.1007/s00347-021-01358-9
Lukas Bisorca-Gassendorf, Kai Januschowski, Núria Pérez Guerra, Peter Szurman, Annekatrin Rickmann
{"title":"[Silicone oil droplets in the vitreous body after intravitreal injection].","authors":"Lukas Bisorca-Gassendorf, Kai Januschowski, Núria Pérez Guerra, Peter Szurman, Annekatrin Rickmann","doi":"10.1007/s00347-021-01358-9","DOIUrl":"https://doi.org/10.1007/s00347-021-01358-9","url":null,"abstract":"","PeriodicalId":54676,"journal":{"name":"Ophthalmologe","volume":"119 4","pages":"392-394"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s00347-021-01358-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25452297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Subretinal air injection for treatment of retinal folds after retinal detachment surgery]. 【视网膜下空气注射治疗视网膜脱离手术后视网膜褶皱】。
4区 医学 Q3 Medicine Pub Date : 2022-04-01 Epub Date: 2021-08-30 DOI: 10.1007/s00347-021-01485-3
Viola Radeck, Horst Helbig, Philipp Prahs

Background: Full-thickness retinal folds are an unpleasant complication after vitrectomy or buckle surgery with gas tamponade for the treatment of retinal detachment. If the retinal folds involve the macula, the visual function of the patients will be severely impaired. This article describes a surgical technique for the management of such full-thickness macular folds.

Method: Between January 2017 and June 2020 a total of 6 patients were treated with the following technique. A redetachment was induced with balanced salt solution (BSS), followed by a subretinal air injection with filtered air. The retinal fold was mechanically smoothed out with the aid of perfluorocarbon (PFC). A postoperative drainage of air and BSS was not necessary due to spontaneous resorption.

Results: None of the patients experienced visual loss after redetachment of the retina. The visual acuity improved in 4 of the 6 patients, perception of metamorphopsia improved in 5 out of 6 patients, 2 reported complete disappearance of metamorphopsia and in 1 patient distorted vision was unchanged despite an anatomically smoothed central retina after surgery.

Conclusion: With careful consideration of the indications, this surgical technique has shown to be a safe and promising therapeutic strategy for the treatment of macular full-thickness retinal folds after retinal detachment surgery.

背景:全层视网膜褶皱是玻璃体切除术或带扣手术加气体填塞治疗视网膜脱离后令人不快的并发症。如果视网膜褶皱累及黄斑,将严重损害患者的视觉功能。这篇文章描述了一种手术技术来处理这种全层黄斑皱褶。方法:于2017年1月至2020年6月对6例患者采用以下技术进行治疗。用平衡盐溶液(BSS)诱导视网膜脱离,然后用过滤空气注入视网膜下空气。在全氟碳(PFC)的帮助下,机械地抚平视网膜褶皱。由于自发吸收,术后不需要引流空气和BSS。结果:无一例患者在视网膜脱离后出现视力丧失。6例患者中4例视力改善,5例患者变形感觉改善,2例患者变形完全消失,1例患者手术后尽管解剖平滑了中央视网膜,但畸变视力仍未改变。结论:在仔细考虑适应证的情况下,该手术技术是治疗视网膜脱离术后黄斑全层视网膜褶皱的一种安全且有前景的治疗策略。
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引用次数: 1
Sektorielle Irisheterochromie: Hinweis auf eine systemische Erkrankung 虹膜异状,表明有系统疾病
4区 医学 Q3 Medicine Pub Date : 2022-04-01 DOI: 10.1007/s00347-022-01615-5
Johannes Birtel, F. Holz, P. Herrmann
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引用次数: 0
[Performance of a new 7 mm intraocular lens with follow-up over 1.5 years]. [新型7 mm人工晶状体的性能,随访超过1.5年]。
4区 医学 Q3 Medicine Pub Date : 2022-04-01 Epub Date: 2021-10-05 DOI: 10.1007/s00347-021-01504-3
Jens Schrecker, Berthold Seitz, Achim Langenbucher

Background: Good visibility over the entire fundus is mandatory for optimal diagnostics and treatment of retinal pathologies. If an IOL implantation is planned in the context of retinal pathologies, a model with an enlarged optic diameter offers various advantages. The two most important benefits are an enhanced view at the fundus periphery and an improvement of the IOL positional stability especially with combined vitrectomy and the use of gas or silicone oil tamponades. The purpose of this study was to evaluate the performance and positional stability of a new 7 mm IOL.

Material and methods: This prospective study included 55 eyes of 39 patients who were scheduled for standardized cataract surgery and received a monofocal 7.0 mm optic IOL (Aspira-aXA, HumanOptics). An incision size of 2.0 mm was chosen. Follow-up visits were performed 1 week (1W), 1 month (1M), 4 months (4M) and 1.5 years (1.5J) postoperatively. Measurements included subjective refraction, uncorrected and corrected distance visual acuity (UDVA and CDVA) as well as IOL stability regarding decentration, tilt and rotation (IOLs had a pseudomarking on the periphery of the optics).

Results: Except for the postoperative occurrence of an Irvine-Gass syndrome in one eye, no intraoperative or postoperative complications were reported. The CDVA did not change significantly (p = 0.40) within the postoperative course from 1 month (median 0.00 logMAR; -0.10 to 0.22 logMAR) to 1.5 years (median 0.00 logMAR; -0.10 to 0.10 logMAR). The IOL was found to be stable over the postoperative course as decentration was < 0.02 mm and tilt < 5.5°. There was a median rotation of 1.8° (0.0-13.4°) within the first postoperative week, which was not significantly different from the rotation between surgery and 1.5 years (median 1.4°; 0.0-10.9°).

Conclusion: With comparable functional performance and the same small incision size as with usual 6.0 mm IOLs, the Aspira-aXA offers the advantages of a 7.0 mm optic in the diagnostics and treatment of peripheral retinal pathologies. In addition, the lens shows good position stability in the capsular bag.

背景:整个眼底的良好可视性对于视网膜病变的最佳诊断和治疗是必需的。如果在视网膜病变的情况下计划人工晶状体植入术,具有扩大视径的模型提供了各种优势。两个最重要的好处是增强眼底周围的视野和改善人工晶状体位置的稳定性,特别是联合玻璃体切除术和使用气体或硅油填塞。本研究的目的是评估新型7 mm人工晶状体的性能和位置稳定性。材料和方法:本前瞻性研究纳入39例55只眼的患者,这些患者计划进行标准化白内障手术,并接受单焦点7.0 mm光学IOL (Aspira-aXA, HumanOptics)。切口大小选择2.0 mm。术后1周(1W)、1个月(1M)、4个月(4M)、1.5年(1.5 j)进行随访。测量包括主观屈光、未矫正和矫正的距离视力(UDVA和CDVA)以及IOL的稳定性,包括离体、倾斜和旋转(IOL在光学系统外围有假标记)。结果:除术后单眼出现Irvine-Gass综合征外,无术中、术后并发症发生。术后1个月内CDVA无显著变化(p = 0.40)(中位数0.00 logMAR;-0.10至0.22 logMAR)至1.5年(中位数0.00 logMAR;-0.10到0.10 logMAR)。结论:与通常的6.0 mm IOL相比,Aspira-aXA具有相当的功能性能和相同的小切口尺寸,在诊断和治疗周围视网膜病变方面具有7.0 mm光学的优势。此外,晶状体在囊袋内具有良好的位置稳定性。
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引用次数: 3
[Histological changes in keratoconus and wound healing after corneal cross-linking]. [角膜交联术后角膜炎和伤口愈合的组织学变化]。
4区 医学 Q3 Medicine Pub Date : 2022-04-01 Epub Date: 2021-12-07 DOI: 10.1007/s00347-021-01537-8
Louisa M Bulirsch, Constance Weber, Marlene Saßmannshausen, Markus Kohlhaas, Frank G Holz, Karin U Loeffler, Martina C Herwig-Carl

Background: Keratoconus is classified as a corneal ectasia and is a multifactorial disease. In those affected, mostly adolescent patients visual deterioration occurs due to the development of irregular astigmatism. Treatment by corneal cross-linking (CXL) has been indicated in progressive disease for several years.

Objective: To present the pathophysiology and histological changes in keratoconus as well as wound healing processes after CXL and their potential complications.

Material and methods: Histological changes in keratoconus as well as wound healing processes after CXL and their potential complications are presented based on histological examination of corneal specimens with keratoconus with and without a condition after CXL. Relevant literature and own data are analyzed and discussed.

Results: Besides inflammatory processes, atopic and genetic dispositions play a role in the development of keratoconus. The histological characteristics of keratoconus include changes in the epithelium, Bowman's layer and stroma. Wound healing processes after CXL include healing of the surface epithelium and transient loss of keratocytes and nerve fibers.

Conclusion: Keratoconus shows characteristic histopathological changes, such as epithelial irregularities, stromal thinning and breaks of Bowman's layer, whereas the endothelium and Descemet's membrane remain unchanged (apart from cases of corneal hydrops). After CXL wound healing processes can be followed primarily in vivo by confocal microscopy. Complications after CXL are rare. Persistent loss of keratocytes can be clinically manifested as a visually relevant scar.

背景:角膜炎属于角膜异位症,是一种多因素疾病。患者多为青少年,由于出现不规则散光,视力会下降。数年来,角膜交联术(CXL)已被用于治疗进展性角膜病:材料和方法:根据对角膜交联术(CXL)后有条件和无条件的角膜标本进行的组织学检查,介绍角膜病的病理生理学和组织学变化,以及 CXL 术后的伤口愈合过程及其潜在并发症。对相关文献和自身数据进行了分析和讨论:结果:除炎症过程外,特应性和遗传倾向在角膜炎的发展中也起到了一定的作用。角膜炎的组织学特征包括上皮、鲍曼层和基质的变化。CXL 后的伤口愈合过程包括表面上皮的愈合以及角膜细胞和神经纤维的短暂脱落:结论:角膜塑形镜显示出特征性的组织病理学变化,如上皮不规则、基质变薄和鲍曼层断裂,而内皮和德斯梅特膜保持不变(角膜水肿病例除外)。CXL 后的伤口愈合过程主要可通过共聚焦显微镜在体内跟踪观察。CXL 术后并发症很少见。角膜细胞的持续丧失在临床上可表现为视觉上的疤痕。
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引用次数: 0
[Attitude of patients to possible telemedicine in ophthalmology : Survey by questionnaire in patients with glaucoma]. 眼科患者对远程医疗的态度:青光眼患者的问卷调查
4区 医学 Q3 Medicine Pub Date : 2022-04-01 Epub Date: 2021-09-20 DOI: 10.1007/s00347-021-01501-6
Sarah B Zwingelberg, Karl Mercieca, Eva Elksne, Stephanie Scheffler, Verena Prokosch

Background: The COVID-19 pandemic in 2020 and 2021 severely restricted the care of ophthalmology patients. Teleophthalmological services, such as video consultation or medical telephone advice could, at least partially, compensate for the lack of necessary controls in the case of chronic diseases; however, teleophthalmological options are currently still significantly underrepresented in Germany.

Objective: In order to determine the willingness of patients to use telemedicine and the virtual clinic, we conducted a survey using a questionnaire on the subject of teleophthalmology in university medicine patients with known glaucoma as a chronic disease during the first wave of the COVID-19 pandemic.

Methods: A total of100 patients were interviewed. The questionnaire contained 22 questions with multiple choice possible answers. The inclusion criterion was the presence of glaucoma as a chronic disease, age over 18 years, and sufficient linguistic understanding to answer the questions. The data were collected, analyzed and anonymously evaluated.

Results: In the patient survey it could be shown that the respondents with glaucoma are very willing to do teleophthalmology and that this would be utilized. Of the patients surveyed 74.0% would accept telemedicine and virtual clinics. Of the ophthalmological patients surveyed 54.0% stated that their visit to the doctor/clinic could not take place due to SARS-CoV‑2 and 17.0% of the patients stated that the SARS-CoV‑2 pandemic had changed their opinion of telemedicine.

Discussion: The acceptance of telemedicine in patients with chronic open-angle glaucoma seems surprisingly high. This has been increased even further by the SARS-CoV‑2 pandemic. These results reflect a general willingness of patients with chronic eye disease but do not reflect the applicability and acceptance and applicability from a medical point of view; however, this form of virtual consultation is accepted by the majority of patients with glaucoma and could be considered for certain clinical pictures.

背景:2020年和2021年的COVID-19大流行严重制约了眼科患者的护理。远程眼科服务,如视频咨询或医疗电话咨询,至少可以部分弥补慢性病缺乏必要控制的情况;然而,目前在德国,远距眼科的选择仍然明显不足。目的:为了确定患者使用远程医疗和虚拟诊所的意愿,我们对新冠肺炎第一波大流行期间已知青光眼慢性疾病的大学医学院患者进行了远程眼科调查。方法:对100例患者进行访谈。调查问卷包含22个问题,可能的答案是多项选择。纳入标准是青光眼作为慢性疾病存在,年龄超过18岁,有足够的语言理解能力来回答问题。数据被收集、分析和匿名评估。结果:在对青光眼患者的调查中,青光眼患者对远距眼科的意愿非常高,并愿意接受远距眼科的治疗。在接受调查的患者中,74.0%的人会接受远程医疗和虚拟诊所。在接受调查的眼科患者中,54.0%的患者表示,由于SARS-CoV - 2,他们无法去看医生/诊所,17.0%的患者表示,SARS-CoV - 2大流行改变了他们对远程医疗的看法。讨论:远程医疗在慢性开角型青光眼患者中的接受度似乎高得惊人。SARS-CoV - 2大流行进一步加剧了这种情况。这些结果反映了慢性眼病患者的普遍意愿,但不能从医学角度反映其适用性、接受度和适用性;然而,这种形式的虚拟咨询被大多数青光眼患者所接受,并且可以考虑用于某些临床图像。
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引用次数: 3
[New variant in ADAMTS10 gene in 30‑year-old patient with myopia and narrow-angle glaucoma]. [30岁近视和窄角型青光眼患者ADAMTS10基因新变异]。
4区 医学 Q3 Medicine Pub Date : 2022-04-01 Epub Date: 2021-10-04 DOI: 10.1007/s00347-021-01482-6
Anne-C Zajonz, Max Griebsch, Anton Vurdaft, Olga Riemer, Annechristin Meiner, Hubertus von Below
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引用次数: 0
期刊
Ophthalmologe
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