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Global Burden of Spinal Cord Injuries Attributable to Falls and Road Traffic Injuries in Working-Age Individuals, 1990 to 2021, with Projections through 2040: An Age-Period-Cohort Analysis. 1990年至2021年全球工作年龄人群因跌倒和道路交通伤害造成的脊髓损伤负担,以及到2040年的预测:一项年龄期队列分析
IF 4 3区 医学 Q2 CLINICAL NEUROLOGY Pub Date : 2025-12-31 DOI: 10.1159/000550145
Jianlong Wu, Boxuan Zhong, Xinyu Pei, Boda Chen, Renpeng Fang, Ziguan Zhu

Background: Spinal cord injury (SCI) attributable to falls and road injuries imposes a significant burden on working-age individuals; however, its temporal and geographic patterns in this demographic remain underexplored. This study aimed to evaluate the global, regional, and national burden of SCI attributable to falls (SCIFs) and road injuries (SCIR) among working-age individuals (aged 15-64 years) from 1990 to 2021 and project trends through 2040.

Methods: Using Global Burden of Disease (GBD) 2021 data, global, regional, and national age-standardized incidence rates (ASIR), prevalence rates (ASPR), and years lived with disability rates (ASYR) were assessed according to global parameters and sociodemographic stratification. Trends were quantified by the average annual percentage change (AAPC) and future burdens projected using Bayesian age-period-cohort (BAPC) models.

Results: From 1990 to 2021, global ASIR, ASPR, and ASYR for SCIR declined markedly (AAPC -1.54 [95% confidence interval -1.54 to -1.53], -1.88 [-1.89 to -1.87], and -2.03 [-2.05 to -2.01]), whereas SCIF showed modest or stagnant reductions with regional increases (AAPC -0.24 [-0.27 to -0.22], -0.39 [-0.41 to -0.36], and -0.67 [-0.69 to -0.65]). Males exhibited higher burdens than females, with SCIF increasing with age and peaking at 60-64 years, whereas SCIR shifted toward older groups. High-sociodemographic index (SDI) regions experienced declines in both, whereas middle-SDI areas saw SCIF increases, despite SCIR decreases; low-SDI regions showed slight SCIF rises. Regionally, Western Europe displayed steady reductions, whereas Central Asia experienced an increase in SCIF and Sub-Saharan Africa showed stable or slightly increasing SCIF indicators. National variations were pronounced, with burdens often exceeding SDI expectations in rapidly developing countries. Projections to 2040 indicate a modest rise in SCIF burden (predicted ASIR 3.72 [95% uncertainty interval 1.82-5.63] per 100,000) but a decrease in SCIR (predicted ASIR 1.22 [0.73-1.72] per 100,000).

Conclusions: Although the burden of SCIR has declined substantially from 1990 to 2021 and is projected to continue decreasing, persistent or rising SCIF trends - expected to modestly increase by 2040 - alongside male predominance, age shifts, and socioeconomic disparities emphasize the urgency for tailored prevention: enhanced road-safety measures and occupational reforms targeting falls in high-risk groups to reduce inequities and socioeconomic costs.

背景:由于跌倒和道路伤害导致的脊髓损伤(SCI)对工作年龄个体造成了重大负担;然而,其在这一人口统计中的时间和地理模式仍未得到充分探索。本研究旨在评估1990年至2021年全球、地区和国家工作年龄人群(15-64岁)因跌倒(SCIF)和道路伤害(SCIR)造成的脊髓损伤负担,以及到2040年的项目趋势。方法:使用全球疾病负担(GBD) 2021数据,根据全球参数和社会人口分层评估全球、地区和国家年龄标准化发病率(ASIR)、患病率(ASPR)和残疾生存年数(ASYR)。趋势通过平均年变化百分比(AAPC)和使用贝叶斯年龄-时期-队列(BAPC)模型预测的未来负担来量化。结果:从1990年到2021年,全球ASIR、ASPR和SCIR显著下降(AAPC -1.54[95%置信区间(CI) -1.54至-1.53]、-1.88[-1.89至-1.87]和-2.03[-2.05至-2.01]),而SCIF随区域增加呈现适度或停滞下降(AAPC -0.24[-0.27至-0.22]、-0.39[-0.41至-0.36]和-0.67[-0.69至-0.65])。男性比女性表现出更高的负担,SCIF随着年龄的增长而增加,在60-64岁达到峰值,而SCIR向老年群体转移。高sdi地区的SCIF和SCIR均下降,而中等sdi地区的SCIF增加,尽管SCIR下降;低sdi区域SCIF略有上升。从区域来看,西欧呈稳定下降趋势,中亚呈上升趋势,撒哈拉以南非洲呈稳定或小幅上升趋势。各国差异明显,在快速发展的发展中国家,负担往往超过SDI的预期。到2040年的预测表明,SCIF负担适度上升(预测ASIR为3.72[95%不确定区间(UI) 1.82-5.63] / 10万),但SCIR下降(预测ASIR为1.22[0.73-1.72]/ 10万)。结论:尽管从1990年到2021年,SCIR负担大幅下降,预计将继续下降,但持续或上升的SCIR趋势(预计到2040年将适度增加)以及男性优势、年龄变化和社会经济差异强调了针对性预防的紧迫性:加强道路安全措施和针对高危人群的职业改革,以减少不平等和社会经济成本。
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引用次数: 0
Short-Term Exposure to Ambient Air Pollution and Epilepsy Mortality: A Population-Based Case-Crossover Study. 短期暴露于环境空气污染与癫痫死亡率:一项基于人群的病例交叉研究
IF 4 3区 医学 Q2 CLINICAL NEUROLOGY Pub Date : 2025-12-31 DOI: 10.1159/000550009
Lu Luo, Hong Sun, Yuling Chen, Ruijun Xu, Yi Zheng, Jing Wei, Chunxiang Shi, Sirong Wang, Yuxin Bi, Xiaohong Jia, Xinyi Deng, Sihan Liang, Biao Song, Wenjie Li, Yaoxin Wang, Jinying Huang, Kaiwen Zuo, Yulong Fan, Hongjun Huang, Changkui Ou, Yi Lin, Yuewei Liu, Min Yu

Introduction: As one of the most prevalent neurological disorders, epilepsy imposes a major health burden. Emerging evidence suggests a possible association between air pollution and epilepsy incidence, but its effect on epilepsy-related deaths remains unknown.

Methods: We conducted an individual-level time-stratified case-crossover study in Jiangsu province, China (2015-2022) to explore the associations between short-term exposure to air pollution and epilepsy deaths, focusing on fine particulate matter (PM2.5), inhalable particulate matter (PM10), sulfur dioxide (SO2), nitrogen dioxide (NO2), carbon monoxide (CO), and ozone (O3). Exposure at each subject's residential address was assessed by extracting concentrations from ChinaHighAirPollutants, a series of validated gridded datasets with a high spatial resolution (1 km × 1 km). Conditional logistic regression models were fitted to quantify exposure-response associations. The attributable fraction and attributable number from air pollution were calculated to estimate their disease burden.

Results: Each interquartile range (IQR) increase in exposure to PM2.5 (IQR: 32.6 μg/m3), PM10 (IQR: 51.3 μg/m3), SO2 (IQR: 8.5 μg/m3), NO2 (IQR: 20.8 μg/m3), and CO (IQR: 0.3 mg/m3) was significantly associated with a 10.6% (95% CI: 2.9%, 18.9%), 10.5% (2.8%, 18.8%), 9.9% (0.5%, 20.1%), 9.8% (1.2%, 19.2%), and 8.5% (0.5%, 17.1%) higher odds of epilepsy death (all p < 0.05). The association between PM2.5 exposure and epilepsy deaths was significantly stronger among individuals <50 years. Up to 12.3% of epilepsy deaths were attributable to air pollution.

Conclusion: Exposure to ambient air pollution was significantly associated with increased odds of epilepsy death, especially for younger individuals.

引言:作为最普遍的神经系统疾病之一,癫痫造成了重大的健康负担。新出现的证据表明,空气污染与癫痫发病率之间可能存在关联,但其对癫痫相关死亡的影响尚不清楚。方法:我们在中国江苏省(2015-2022)开展了一项个体水平的时间分层病例交叉研究,探讨短期暴露于空气污染与癫痫死亡之间的关系,重点研究细颗粒物(PM2.5)、可吸入颗粒物(PM10)、二氧化硫(SO2)、二氧化氮(NO2)、一氧化碳(CO)和臭氧(O3)。通过从中国大气污染物(CHAP)中提取浓度来评估每个受试者居住地址的暴露,该数据集是一系列高空间分辨率(1公里× 1公里)的经过验证的网格数据集。拟合条件逻辑回归模型来量化暴露-反应关联。计算空气污染的归因分数(AF)和归因数(AN),以估计其疾病负担。结果:PM2.5 (IQR: 32.6 μg/m3)、PM10 (IQR: 51.3 μg/m3)、SO2 (IQR: 8.5 μg/m3)、NO2 (IQR: 20.8 μg/m3)和CO (IQR: 0.3 mg/m3)暴露量每四分位数范围(IQR)增加与癫痫死亡风险升高10.6% (95%CI: 2.9%、18.9%)、10.5%(2.8%、18.8%)、9.9%(0.5%、20.1%)、9.8%(1.2%、19.2%)和8.5%(0.5%、17.1%)显著相关(P均< 0.05)。在< 50岁的人群中,PM2.5暴露与癫痫死亡之间的关联明显更强。高达12.3%的癫痫死亡可归因于空气污染。结论:暴露于环境空气污染与癫痫死亡几率增加显著相关,尤其是对年轻人。
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引用次数: 0
Diverging Global Burden, Risk Factors, and Temporal Trends of Early-Onset and Late-Onset Dementia: A Comprehensive Analysis of the Global Burden of Disease Study 2021. 早发性和晚发性痴呆的不同全球负担、风险因素和时间趋势:2021年全球疾病负担研究的综合分析
IF 4 3区 医学 Q2 CLINICAL NEUROLOGY Pub Date : 2025-12-23 DOI: 10.1159/000549802
Lifang Li, Tara S R Chen, Dongfeng Huang

Introduction: Early-onset dementia (EOD) and late-onset dementia (LOD) differ in etiology, clinical presentation, and societal impact. Characterizing their global burden and associated risk factors is essential for guiding targeted interventions and resource allocation.

Methods: We analyzed data from the Global Burden of Disease (GBD) 2021 study (1990-2021) to estimate incidence, mortality, and disability-adjusted life years (DALYs) for EOD (ages 40-64) and LOD (≥65 years) across 204 countries and territories. Age-standardized rates (ASRs) and estimated annual percentage changes (EAPCs) were calculated. Risk factors examined included smoking, high fasting plasma glucose (FPG), and high body mass index. Associations with the sociodemographic index (SDI) were assessed, and Bayesian age-period-cohort model was used to project trends to 2050.

Results: In 2021, global age-standardized incidence rates (ASIRs) were 63.58 per 100,000 for EOD and 1,173.19 per 100,000 for LOD. Corresponding age-standardized mortality rates (ASMRs) and age-standardized DALY (AS-DALY) rates were substantially higher for LOD. Point estimates for ASRs were consistently higher for females than for males across all metrics. From 1990 to 2021, the burden of EOD increased (ASIR EAPC = 0.13; ASMR EAPC = 0.08; AS-DALY EAPC = 0.08), while LOD trends remained largely stable. Regional variation was observed, with EOD burden highest in China, Canada, Brazil, and the USA and LOD in China, Germany, Italy, and Lebanon. Metabolic risks, particularly high FPG, were major contributors to LOD. SDI was positively correlated with LOD burden (r = 0.176; p < 0.001), indicating a weak but statistically significant association. Projections indicate that EOD cases will increase by 160% and LOD cases by 479% by 2050.

Conclusions: The global dementia burden is rising, with distinct epidemiological patterns for EOD and LOD. Age- and region-specific risk factor profiles highlight the need for tailored prevention strategies, informed healthcare planning, and differentiated clinical management.

早发性痴呆(EOD)和晚发性痴呆(LOD)在病因、临床表现和社会影响方面有所不同。确定其全球负担和相关风险因素的特征对于指导有针对性的干预措施和资源分配至关重要。方法:我们分析了全球疾病负担(GBD) 2021研究(1990-2021)的数据,以估计204个国家和地区的EOD(40-64岁)和LOD(≥65岁)的发病率、死亡率和残疾调整生命年(DALYs)。计算年龄标准化率(ASRs)和估计年百分比变化(EAPCs)。检查的危险因素包括吸烟、空腹血糖(FPG)高和身体质量指数(BMI)高。评估了与社会人口指数(SDI)的关联,并使用贝叶斯年龄-时期-队列(BAPC)模型预测到2050年的趋势。结果:2021年,EOD的全球年龄标准化发病率(asir)为63.58 / 10万,LOD为1173.19 / 10万。LOD相应的年龄标准化死亡率(ASMRs)和年龄标准化DALY (AS-DALY)率要高得多。在所有指标中,女性的asr点估计值始终高于男性。1990 - 2021年,EOD负担增加(ASIR EAPC = 0.13; ASMR EAPC = 0.08; AS-DALY EAPC = 0.08), LOD趋势基本保持稳定。地区差异明显,中国、加拿大、巴西和美国的EOD负担最高,而中国、德国、意大利和黎巴嫩的LOD负担最高。代谢风险,特别是高FPG,是LOD的主要原因。SDI与LOD负担呈正相关(r = 0.176; P < 0.001),相关性较弱,但有统计学意义。预测显示,到2050年,EOD病例将增加160%,LOD病例将增加479%。结论:全球痴呆负担正在上升,EOD和LOD具有明显的流行病学模式。年龄和地区特定的风险因素概况强调需要量身定制的预防策略,知情的医疗保健计划和差异化的临床管理。
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引用次数: 0
Global, Regional, and National Disparities in the Burden of Alzheimer's Disease and Other Dementias, 1990-2021. 阿尔茨海默病负担的全球、地区和国家差异疾病和其他痴呆症,1990-2021。
IF 4 3区 医学 Q2 CLINICAL NEUROLOGY Pub Date : 2025-12-19 DOI: 10.1159/000549854
Meiling Hu, Tongyun Wang, Jing Song, Ningrui Liu, Yuhong Zeng, Danqing Hu, Yang Guo, Jie Chang, Zhennan Lin

Background: Driven by population ageing, the burden of Alzheimer's disease and other dementias (ADOD) continues to rise. A comprehensive assessment of the ADOD burden at global, regional, and national levels is critical for public health.

Methods: Based on the Global Burden of Disease Study 2021, we assessed the ADOD burden. Temporal trends were analysed using Joinpoint regression; inequalities among countries were evaluated via Lorenz curves; and future trends were projected employing an age-period-cohort model.

Results: In 2021, the age-standardised rates for ADOD were 694.01 (95% uncertainty intervals [UIs]: 602.88 to 794.08) for prevalence, 119.76 (95% UI: 104.96 to 135.89) for incidence, and 481.70 (95% UI: 228.79 to 1,023.96) for disability-adjusted life years (DALYs). Females exhibited a higher ADOD burden than males across all age groups, with an age-standardised prevalence rate of 769.94 (95% UI: 670.71 to 877.57) in females compared to 589.47 (95% UI: 507.48 to 678.79) in males. The slope inequality index of crude DALY rate increased from 315.23 (95% confidence intervals [CIs]: 310.43 to 437.87) in 1990 to 758.29 (95% CI: 692.48 to 908.29) in 2021 at the country level. The Lorenz curves for the crude DALY rate of ADOD in 1990 and 2021 lay below the equality line, indicating a higher burden among countries and territories with a higher socio-demographic index (SDI) ranking. By 2046, global prevalence is projected to reach 124.89 million, a 119.67% increase from 2021.

Conclusion: The ADOD burden has increased globally, with significant regional disparities. Urgent action is required to prevent ADOD, especially among females and in high-SDI regions.

背景:在人口老龄化的推动下,阿尔茨海默病和其他痴呆症(ADOD)的负担持续上升。在全球、区域和国家各级全面评估adhd负担对公共卫生至关重要。方法:基于2021年全球疾病负担研究,我们评估了adhd负担。采用关节点回归分析时间趋势;通过洛伦兹曲线评估国家间的不平等;未来的趋势是采用年龄时期队列模型来预测的。结果:2021年,adhd的年龄标准化患病率为694.01(95%不确定区间[UI]: 602.88 ~ 794.08),发病率为119.76 (95% UI: 104.96 ~ 135.89),残疾调整生命年(DALYs)为481.70 (95% UI: 228.79 ~ 1023.96)。在所有年龄组中,女性的adhd负担均高于男性,年龄标准化患病率为769.94 (95% UI: 670.71-877.57),男性为589.47 (95% UI: 507.48-678.79)。在国家层面,粗DALY率的斜率不平等指数从1990年的315.23 (95% CI: 310.43 ~ 437.87)上升到2021年的758.29 (95% CI: 692.48 ~ 908.29)。1990年和2021年adhd的粗DALY率的Lorenz曲线位于平等线以下,表明社会人口指数(SDI)排名较高的国家和地区负担较高。到2046年,预计全球流行率将达到1.2489亿,比2021年增加119.67%。结论:adhd负担在全球范围内呈上升趋势,区域差异明显。需要采取紧急行动预防多动症,特别是在女性和高sdi地区。
{"title":"Global, Regional, and National Disparities in the Burden of Alzheimer's Disease and Other Dementias, 1990-2021.","authors":"Meiling Hu, Tongyun Wang, Jing Song, Ningrui Liu, Yuhong Zeng, Danqing Hu, Yang Guo, Jie Chang, Zhennan Lin","doi":"10.1159/000549854","DOIUrl":"10.1159/000549854","url":null,"abstract":"<p><strong>Background: </strong>Driven by population ageing, the burden of Alzheimer's disease and other dementias (ADOD) continues to rise. A comprehensive assessment of the ADOD burden at global, regional, and national levels is critical for public health.</p><p><strong>Methods: </strong>Based on the Global Burden of Disease Study 2021, we assessed the ADOD burden. Temporal trends were analysed using Joinpoint regression; inequalities among countries were evaluated via Lorenz curves; and future trends were projected employing an age-period-cohort model.</p><p><strong>Results: </strong>In 2021, the age-standardised rates for ADOD were 694.01 (95% uncertainty intervals [UIs]: 602.88 to 794.08) for prevalence, 119.76 (95% UI: 104.96 to 135.89) for incidence, and 481.70 (95% UI: 228.79 to 1,023.96) for disability-adjusted life years (DALYs). Females exhibited a higher ADOD burden than males across all age groups, with an age-standardised prevalence rate of 769.94 (95% UI: 670.71 to 877.57) in females compared to 589.47 (95% UI: 507.48 to 678.79) in males. The slope inequality index of crude DALY rate increased from 315.23 (95% confidence intervals [CIs]: 310.43 to 437.87) in 1990 to 758.29 (95% CI: 692.48 to 908.29) in 2021 at the country level. The Lorenz curves for the crude DALY rate of ADOD in 1990 and 2021 lay below the equality line, indicating a higher burden among countries and territories with a higher socio-demographic index (SDI) ranking. By 2046, global prevalence is projected to reach 124.89 million, a 119.67% increase from 2021.</p><p><strong>Conclusion: </strong>The ADOD burden has increased globally, with significant regional disparities. Urgent action is required to prevent ADOD, especially among females and in high-SDI regions.</p>","PeriodicalId":54730,"journal":{"name":"Neuroepidemiology","volume":" ","pages":"1-12"},"PeriodicalIF":4.0,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145795359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Botulinum Toxin Underuse in Older Stroke Survivors with Spasticity: A Nationwide Population-Based Cohort Study. 老年中风幸存者痉挛时肉毒杆菌毒素使用不足:一项基于全国人群的队列研究
IF 4 3区 医学 Q2 CLINICAL NEUROLOGY Pub Date : 2025-12-11 DOI: 10.1159/000548679
Etienne Ojardias, Jonathan Levy, Lorène Zerah, Pierre Karam, Anne Forestier, Jean-Yves Loze, Djamel Bensmail, Rebecca Haddad

Introduction: While botulinum toxin type A (BoNT-A) is effective for poststroke spasticity, its accessibility in older adults remains unclear. We aimed to examine the association between BoNT-A use and age among stroke survivors.

Methods: This nationwide, population-based, retrospective cohort study analyzed data from the French National Hospital Discharge Database. Stroke survivors admitted between 2014 and 2016 were followed until 2020. BoNT-A use was assessed across different age groups (18-64, 65-74, 75-84, ≥85 years). Multivariable logistic regression was performed to examine the association between BoNT-A use and age, adjusting for potential confounders, including sex, comorbidities, stroke unit hospitalization, and rehabilitation.

Results: BoNT-A use was reported in 1,757 (2.88%), 862 (0.99%), and 183 (0.22%) of 60,928, 86,917, and 82,725 stroke survivors aged 65-74, 75-84, and ≥85 years, respectively. These rates were significantly lower than BoNT-A use in those aged <65 years (5.13%) (p < 0.001). After adjustment, the inverse relationship between age and BoNT-A use was maintained, demonstrating an age-dependent association in the 65-74, 75-84, and ≥85 age groups vs. 18-64 years. Odds ratios (ORs) (95% confidence intervals [CIs]) were 0.49 (0.47-0.53), 0.18 (0.17-0.19), and 0.05 (0.04-0.06), respectively. Stroke unit stays (OR, 1.33; 95% CI, 1.26-1.41) and neurological rehabilitation unit stays (OR, 16.69; 95% CI, 15.59-17.87) were significantly associated with a higher probability of receiving BoNT-A.

Conclusions: BoNT-A use is notably low in older stroke survivors, highlighting the need to enhance equitable access to BoNT-A injections for this population.

虽然A型肉毒毒素(BoNT-A)对中风后痉挛有效,但其在老年人中的可及性尚不清楚。我们的目的是研究中风幸存者中BoNT-A使用与年龄之间的关系。方法:这项全国性、基于人群的回顾性队列研究分析了来自法国国家医院出院数据库的数据。2014年至2016年间承认的中风幸存者被跟踪到2020年。评估不同年龄组(18-64岁、65-74岁、75-84岁、≥85岁)BoNT-A的使用情况。采用多变量logistic回归来检验BoNT-A使用与年龄之间的关系,调整潜在混杂因素,包括性别、合并症、卒中单位住院和康复。结果:在65-74岁、75-84岁和≥85岁的60,928例、86,917例和82,725例脑卒中幸存者中,分别有1,757例(2.88%)、862例(0.99%)和183例(0.22%)使用BoNT-A。结论:老年脑卒中幸存者中BoNT-A的使用率明显较低,这突出了提高这一人群公平获得BoNT-A注射的必要性。
{"title":"Botulinum Toxin Underuse in Older Stroke Survivors with Spasticity: A Nationwide Population-Based Cohort Study.","authors":"Etienne Ojardias, Jonathan Levy, Lorène Zerah, Pierre Karam, Anne Forestier, Jean-Yves Loze, Djamel Bensmail, Rebecca Haddad","doi":"10.1159/000548679","DOIUrl":"10.1159/000548679","url":null,"abstract":"<p><strong>Introduction: </strong>While botulinum toxin type A (BoNT-A) is effective for poststroke spasticity, its accessibility in older adults remains unclear. We aimed to examine the association between BoNT-A use and age among stroke survivors.</p><p><strong>Methods: </strong>This nationwide, population-based, retrospective cohort study analyzed data from the French National Hospital Discharge Database. Stroke survivors admitted between 2014 and 2016 were followed until 2020. BoNT-A use was assessed across different age groups (18-64, 65-74, 75-84, ≥85 years). Multivariable logistic regression was performed to examine the association between BoNT-A use and age, adjusting for potential confounders, including sex, comorbidities, stroke unit hospitalization, and rehabilitation.</p><p><strong>Results: </strong>BoNT-A use was reported in 1,757 (2.88%), 862 (0.99%), and 183 (0.22%) of 60,928, 86,917, and 82,725 stroke survivors aged 65-74, 75-84, and ≥85 years, respectively. These rates were significantly lower than BoNT-A use in those aged <65 years (5.13%) (p < 0.001). After adjustment, the inverse relationship between age and BoNT-A use was maintained, demonstrating an age-dependent association in the 65-74, 75-84, and ≥85 age groups vs. 18-64 years. Odds ratios (ORs) (95% confidence intervals [CIs]) were 0.49 (0.47-0.53), 0.18 (0.17-0.19), and 0.05 (0.04-0.06), respectively. Stroke unit stays (OR, 1.33; 95% CI, 1.26-1.41) and neurological rehabilitation unit stays (OR, 16.69; 95% CI, 15.59-17.87) were significantly associated with a higher probability of receiving BoNT-A.</p><p><strong>Conclusions: </strong>BoNT-A use is notably low in older stroke survivors, highlighting the need to enhance equitable access to BoNT-A injections for this population.</p>","PeriodicalId":54730,"journal":{"name":"Neuroepidemiology","volume":" ","pages":"1-10"},"PeriodicalIF":4.0,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12795544/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145745767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Real-World Data on Switches of the Employment Status in People with Multiple Sclerosis: A Longitudinal Observational Study of the German MS Register. 多发性硬化症患者就业状态转换的真实世界数据:德国多发性硬化症登记的纵向观察研究。
IF 4 3区 医学 Q2 CLINICAL NEUROLOGY Pub Date : 2025-12-11 DOI: 10.1159/000549855
Melanie Peters, Kerstin Eichstädt, Alexander Stahmann, Mathia Kirstein, Ulf Blohm, Peter Flachenecker, Nadine Schumann, Niklas Frahm

Introduction: Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system affecting 2.9 million people worldwide. MS symptom variety can have a significant impact on the economic and occupational participation of people with MS (pwMS). The objective of this study was to investigate the trends in the employment (EMP) status change of pwMS over a 2-year period and to identify the associated sociodemographic, clinical and symptom-specific factors.

Methods: The present longitudinal observational study analysed real-world registry data from pwMS characterised by ≥1 documented data set during 2014-2023, an age of 18-60 years, ≥2 data sets during a 2-year period (±2 months) and a documented EMP status change. The transition from EMP to non-employment (NEMP) or vice versa within a 2-year period was investigated during two visits: baseline (pre-transition) and follow-up (post-transition). Univariable and multivariable logistic regression models were utilised to identify associated variables.

Results: The study population (N = 940) was classified into NEMP-to-EMP patients (n = 269) and EMP-to-NEMP patients (n = 671). EMP-to-NEMP patients were found to be older in median (45.6 vs. 39.3 years) and more likely to have chronic progressive MS at baseline (14.2% vs. 4.8%) than NEMP-to-EMP patients. Moderate/severe disability level emerged as the most robust predictor of EMP-to-NEMP switches (odds ratio [OR] = 1.89, p = 0.005). Pain (baseline: OR = 1.96, p = 0.017; follow-up: OR = 5.57, p = 0.025) and cognitive impairment (baseline: OR = 1.78, p = 0.048; follow-up: OR = 10.47, p = 0.005) were significant symptomatic predictors of EMP-to-NEMP transitions.

Conclusion: The results emphasise the particular importance of pain and cognitive impairment as independent symptomatic predictors, whose impact on work ability may be underestimated.

简介:多发性硬化症(MS)是一种中枢神经系统慢性自身免疫性疾病,影响全球290万人。多发性硬化症症状的多样性对多发性硬化症患者的经济和职业参与有显著影响。本研究的目的是调查两年来pwMS的就业(EMP)状况变化趋势,并确定相关的社会人口学、临床和症状特异性因素。方法:本纵向观察研究分析了来自pwMS的真实世界注册数据,其特征是2014-2023年期间≥1个记录数据集,年龄为18-60岁,两年(±2个月)期间≥2个数据集以及记录的EMP状态变化。在基线(过渡前)和后续(过渡后)两次访问期间,调查了两年内从EMP过渡到失业(NEMP)或反之亦然的情况。使用单变量和多变量逻辑回归模型来识别相关变量。结果:研究人群(N=940)分为nemp - emp患者(N= 269)和empp - nemp患者(N= 671)。研究发现,与nemp - emp患者相比,empp - nemp患者的中位年龄更大(45.6岁vs 39.3岁),基线时更有可能出现慢性进展性MS (14.2% vs 4.8%)。中度/重度残疾水平是empp - nemp转换最可靠的预测因子(优势比[OR]=1.89, p=0.005)。疼痛(基线:OR=1.96, p=0.017;随访:OR=5.57, p=0.025)和认知障碍(基线:OR=1.78, p=0.048;随访:OR=10.47, p=0.005)是empp向nemp过渡的显著症状预测因子。结论:研究结果强调了疼痛和认知障碍作为独立症状预测因子的重要性,它们对工作能力的影响可能被低估了。
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引用次数: 0
Environmental Factors and Risk of Early-Onset Dementia: A Population-Based Case-Control Study. 环境因素与早发性痴呆风险:一项基于人群的病例对照研究
IF 4 3区 医学 Q2 CLINICAL NEUROLOGY Pub Date : 2025-12-11 DOI: 10.1159/000549445
Camilla Soncini, Annalisa Chiari, Kenneth J Rothman, Niccolò Martini, Andrea Cherubini, Francesca Despini, Sofia Costanzini, Gianfranco De Girolamo, Manuela Tondelli, Giulia Vinceti, Giovanna Zamboni, Sergio Teggi, Giuseppe Maffeis, Marco Vinceti, Tommaso Filippini

Introduction: Dementia with symptom onset before the age of 65 is referred to as early-onset dementia (EOD). Many gaps exist regarding EOD etiology, including the role of environmental factors.

Methods: We conducted a population-based case-control study in Modena province, Northern Italy, enrolling and geocoding 326 EOD cases and 1,941 sex- and age-matched controls, to investigate the association of traffic-related benzene, green spaces around the place of residence, and exposure to artificial outdoor light at night (LAN). We used nonlinear modeling to assess the relation between environmental variables and disease risk, overall, and separately for Alzheimer's dementia (AD) and non-AD.

Results: Green spaces generally showed an inverse association with EOD risk that was almost linear for AD and inverted U-shaped for non-AD. We observed a weak positive association between traffic-related benzene exposure and EOD risk that seemed limited to AD, with little change in risk for non-AD. Exposure to LAN showed an inverse linear association with small differences across the two disease subgroups. Analyses stratified by sex and age showed generally stronger (but statistically imprecise) associations in females and older individuals.

Conclusion: Overall, these results are consistent with some environmental influences on EOD risk, particularly with a beneficial effect of green spaces and LAN, as well as a possible adverse role of air pollution, particularly for AD.

在65岁之前出现症状的痴呆被称为早发性痴呆(EOD)。关于排爆的病因存在许多空白,包括环境因素的作用。方法:我们在意大利北部摩德纳省进行了一项基于人群的病例对照研究,招募326例EOD病例和1941例性别和年龄匹配的对照组,并对其进行地理编码,以调查交通相关苯、居住地周围绿地和夜间室外人造光暴露的关系。我们使用非线性模型来评估阿尔茨海默氏痴呆症(AD)和非AD的环境变量与疾病风险之间的关系。结果:绿地总体上与EOD风险呈负相关,AD与非AD呈倒u型关系,几乎呈线性关系。我们观察到与交通相关的苯暴露与EOD风险之间存在微弱的正相关,似乎仅限于AD,而非AD的风险变化不大。夜间光照与两种疾病亚组之间的微小差异呈反比线性相关。按性别和年龄分层的分析显示,女性和老年人之间的关联通常更强(但统计上不精确)。结论:总体而言,这些结果与一些环境因素对EOD风险的影响是一致的,特别是绿地和夜间照明的有利作用,以及空气污染可能的不利作用,特别是对AD。
{"title":"Environmental Factors and Risk of Early-Onset Dementia: A Population-Based Case-Control Study.","authors":"Camilla Soncini, Annalisa Chiari, Kenneth J Rothman, Niccolò Martini, Andrea Cherubini, Francesca Despini, Sofia Costanzini, Gianfranco De Girolamo, Manuela Tondelli, Giulia Vinceti, Giovanna Zamboni, Sergio Teggi, Giuseppe Maffeis, Marco Vinceti, Tommaso Filippini","doi":"10.1159/000549445","DOIUrl":"10.1159/000549445","url":null,"abstract":"<p><strong>Introduction: </strong>Dementia with symptom onset before the age of 65 is referred to as early-onset dementia (EOD). Many gaps exist regarding EOD etiology, including the role of environmental factors.</p><p><strong>Methods: </strong>We conducted a population-based case-control study in Modena province, Northern Italy, enrolling and geocoding 326 EOD cases and 1,941 sex- and age-matched controls, to investigate the association of traffic-related benzene, green spaces around the place of residence, and exposure to artificial outdoor light at night (LAN). We used nonlinear modeling to assess the relation between environmental variables and disease risk, overall, and separately for Alzheimer's dementia (AD) and non-AD.</p><p><strong>Results: </strong>Green spaces generally showed an inverse association with EOD risk that was almost linear for AD and inverted U-shaped for non-AD. We observed a weak positive association between traffic-related benzene exposure and EOD risk that seemed limited to AD, with little change in risk for non-AD. Exposure to LAN showed an inverse linear association with small differences across the two disease subgroups. Analyses stratified by sex and age showed generally stronger (but statistically imprecise) associations in females and older individuals.</p><p><strong>Conclusion: </strong>Overall, these results are consistent with some environmental influences on EOD risk, particularly with a beneficial effect of green spaces and LAN, as well as a possible adverse role of air pollution, particularly for AD.</p>","PeriodicalId":54730,"journal":{"name":"Neuroepidemiology","volume":" ","pages":"1-12"},"PeriodicalIF":4.0,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12782616/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145745842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Impact of Parkinson's Disease Psychosis on Caregiver Burden: A Systematic Literature Review. 帕金森病精神病对照顾者负担的影响:一项系统的文献综述。
IF 4 3区 医学 Q2 CLINICAL NEUROLOGY Pub Date : 2025-12-09 DOI: 10.1159/000549830
Joshua N Liberman, Nazia Rashid, Aspen Smith, Chijioke M Okeke, Javeria Khalid, Nancy Rogacki, Ismaeel Yunusa

Introduction: Studies of Parkinson's disease (PD) caregiver stress have examined many contributing factors, but a clear understanding of the impact of Parkinson's disease psychosis (PDP) on caregiver burden has been difficult to ascertain from existing evidence. The evidence has been collected primarily in small, heterogeneous studies that do not lend themselves to meta-analysis.

Objective: The aim of this study was to understand current evidence on the association between PDP and caregiver burden despite the heterogeneity of populations studied and methods used.

Methods: Following PRISMA guidelines, PubMed, Embase, and ClinicalTrials.gov were searched from inception through April 1, 2025, for English-language articles using predefined search terms. Eligible original research included individuals with PD, assessment of psychosis symptoms, defined caregivers, and evaluation of the association between psychosis and caregiver burden. Data were extracted independently, and study quality was assessed using the Newcastle Ottawa Scale. The exposure was PDP, and the outcome was caregiver burden.

Results: Twenty-six articles met inclusion criteria. Most studies enrolled fewer than 100 participants; 9 of these (34.6%) had low risk of bias. Psychosis symptoms were assessed via validated questionnaires in 17 studies, self-report in 7, and unspecified methods in 2. Definitions of caregiver varied, with 4 studies including paid caregivers. Among 10 studies adjusting for confounders, 6 (60%) reported a significant positive association between PDP symptoms and caregiver burden. Of the 4 multivariate studies without a significant association, 3 found positive relationships between other patient psychiatric symptoms and this burden.

Conclusion: While the quality of research is variable and studies include an array of different population definitions and measurement approaches, higher quality studies indicate PDP is associated with greater caregiver burden. To facilitate the well-being of patients with PDP and their caregivers, it is important to identify and address the specific caregiver challenges due to psychosis symptoms in PD.

导读:帕金森病(PD)照顾者压力的研究已经检查了许多促成因素,但从现有证据中很难明确了解帕金森病精神病(PDP)对照顾者负担的影响。这些证据主要是在小型的异质研究中收集的,这些研究不适合进行荟萃分析。目的:了解目前关于PDP和照顾者负担之间关系的证据,尽管研究人群和方法存在异质性。方法:按照PRISMA指南,检索PubMed、Embase和ClinicalTrials.gov网站从建立到2025年4月1日的英文文章,使用预定义的搜索词。符合条件的原始研究包括PD患者、精神病症状评估、确定的照顾者以及精神病与照顾者负担之间关系的评估。数据独立提取,使用纽卡斯尔渥太华量表评估研究质量。暴露是PDP,结果是照顾者负担。结果:26篇文章符合纳入标准。大多数研究招募的参与者少于100人;其中9例(34.6%)偏倚风险较低。17项研究通过有效问卷、7项自我报告和2项未指定方法评估精神病症状。护理人员的定义各不相同,有4项研究包括有偿护理人员。在校正混杂因素的10项研究中,6项(60%)报告了PDP症状与照顾者负担之间的显著正相关。在没有显著相关性的4项多变量研究中,3项发现其他患者精神症状与这种负担呈正相关。结论:虽然研究的质量是可变的,研究包括一系列不同的人群定义和测量方法,但高质量的研究表明,PDP与更大的照顾者负担有关。为了促进PDP患者及其护理人员的福祉,识别和解决由于PD精神病症状引起的特定护理人员挑战是很重要的。
{"title":"The Impact of Parkinson's Disease Psychosis on Caregiver Burden: A Systematic Literature Review.","authors":"Joshua N Liberman, Nazia Rashid, Aspen Smith, Chijioke M Okeke, Javeria Khalid, Nancy Rogacki, Ismaeel Yunusa","doi":"10.1159/000549830","DOIUrl":"10.1159/000549830","url":null,"abstract":"<p><strong>Introduction: </strong>Studies of Parkinson's disease (PD) caregiver stress have examined many contributing factors, but a clear understanding of the impact of Parkinson's disease psychosis (PDP) on caregiver burden has been difficult to ascertain from existing evidence. The evidence has been collected primarily in small, heterogeneous studies that do not lend themselves to meta-analysis.</p><p><strong>Objective: </strong>The aim of this study was to understand current evidence on the association between PDP and caregiver burden despite the heterogeneity of populations studied and methods used.</p><p><strong>Methods: </strong>Following PRISMA guidelines, PubMed, Embase, and <ext-link ext-link-type=\"uri\" xlink:href=\"http://ClinicalTrials.gov\" xmlns:xlink=\"http://www.w3.org/1999/xlink\">ClinicalTrials.gov</ext-link> were searched from inception through April 1, 2025, for English-language articles using predefined search terms. Eligible original research included individuals with PD, assessment of psychosis symptoms, defined caregivers, and evaluation of the association between psychosis and caregiver burden. Data were extracted independently, and study quality was assessed using the Newcastle Ottawa Scale. The exposure was PDP, and the outcome was caregiver burden.</p><p><strong>Results: </strong>Twenty-six articles met inclusion criteria. Most studies enrolled fewer than 100 participants; 9 of these (34.6%) had low risk of bias. Psychosis symptoms were assessed via validated questionnaires in 17 studies, self-report in 7, and unspecified methods in 2. Definitions of caregiver varied, with 4 studies including paid caregivers. Among 10 studies adjusting for confounders, 6 (60%) reported a significant positive association between PDP symptoms and caregiver burden. Of the 4 multivariate studies without a significant association, 3 found positive relationships between other patient psychiatric symptoms and this burden.</p><p><strong>Conclusion: </strong>While the quality of research is variable and studies include an array of different population definitions and measurement approaches, higher quality studies indicate PDP is associated with greater caregiver burden. To facilitate the well-being of patients with PDP and their caregivers, it is important to identify and address the specific caregiver challenges due to psychosis symptoms in PD.</p>","PeriodicalId":54730,"journal":{"name":"Neuroepidemiology","volume":" ","pages":"1-17"},"PeriodicalIF":4.0,"publicationDate":"2025-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145710603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trends and Future Projections of Neurological Disorder Burden in Europe, 1990-2021: Latest Insights from the GBD 2021 Study. 1990-2021年欧洲神经系统疾病负担的趋势和未来预测:来自GBD 2021研究的最新见解
IF 4 3区 医学 Q2 CLINICAL NEUROLOGY Pub Date : 2025-12-05 DOI: 10.1159/000549912
Xinquan Wang, Kai Wen, Yanxia Li, Yujiao He, Weijin Shen, Hongxing Wang

Background: The systematic assessment of the burden of common neurological disorders in Europe based on latest epidemiological data remains lacking.

Methods: We extracted data on disability-adjusted life years (DALYs), mortality, prevalence, and incidence of neurological disorders from the Global Burden of Disease 2021 study from 1990 to 2021. Future trends over the next 15 years were projected using autoregressive integrated moving average modeling.

Results: In 2021, the age-standardized DALYs rates (ASDRs) of neurological disorders in Europe (1,502.3/100,000 population) were significantly higher than the global average (1,385.1/100,000 population). Among them, the ASDRs in Western Europe (1,584.23/100,000 population) were notably higher than that in Central Europe (1,354.65/100,000 population) and Eastern Europe (1,375.03/100,000 population). Ischemic stroke (31.98%) and Alzheimer's disease (20.24%) were the major contributors to the disease burden in Europe. Age-stratified analysis revealed that the elderly population (≥65 years old) bore the burden of stroke and Alzheimer's disease and other dementia. The overall disease burden was higher in females. From 1990 to 2021, data indicated a significant decline in the disease burden of ischemic stroke, Alzheimer's disease and other dementias, encephalitis, idiopathic epilepsy, intracerebral hemorrhage, and meningitis. Conversely, Parkinson's disease and other neurological disorders showed an upward trend. ARIMA forecast analysis suggested that from 2021 to 2036, the predicted ASDRs for neurological disorders would be lower compared to previous levels.

Conclusion: Neurological disorders impose a greater burden in Europe than globally, primarily driven by ischemic stroke and Alzheimer's disease, with Western Europe, elderly, and female populations being disproportionately affected.

背景:基于最新流行病学数据对欧洲常见神经系统疾病负担的系统评估仍然缺乏。方法:我们从1990年至2021年的全球疾病负担2021研究中提取了残疾调整生命年(DALYs)、死亡率、患病率和神经系统疾病发病率的数据。利用自回归综合移动平均模型预测了未来15年的趋势。结果:2021年,欧洲神经系统疾病的年龄标准化DALYs率(ASDRs)为1,502.3/10万人口,显著高于全球平均水平(1,385.1/10万人口)。其中,西欧的asdr(1,584.23/10万人)明显高于中欧(1,354.65/10万人)和东欧(1,375.03/10万人)。缺血性中风(31.98%)和阿尔茨海默病(20.24%)是欧洲疾病负担的主要来源。年龄分层分析显示,老年人群(≥65岁)承受着卒中、阿尔茨海默病和其他痴呆的负担。女性的总体疾病负担更高。从1990年到2021年,数据显示缺血性中风、阿尔茨海默病和其他痴呆症、脑炎、特发性癫痫、脑出血和脑膜炎的疾病负担显著下降。相反,帕金森氏症和其他神经系统疾病呈上升趋势。ARIMA预测分析表明,从2021年到2036年,神经系统疾病的预测asdr将低于以前的水平。结论:神经系统疾病在欧洲造成的负担比全球更大,主要是由缺血性中风和阿尔茨海默病引起的,西欧、老年人和女性人群受到的影响不成比例。
{"title":"Trends and Future Projections of Neurological Disorder Burden in Europe, 1990-2021: Latest Insights from the GBD 2021 Study.","authors":"Xinquan Wang, Kai Wen, Yanxia Li, Yujiao He, Weijin Shen, Hongxing Wang","doi":"10.1159/000549912","DOIUrl":"10.1159/000549912","url":null,"abstract":"<p><strong>Background: </strong>The systematic assessment of the burden of common neurological disorders in Europe based on latest epidemiological data remains lacking.</p><p><strong>Methods: </strong>We extracted data on disability-adjusted life years (DALYs), mortality, prevalence, and incidence of neurological disorders from the Global Burden of Disease 2021 study from 1990 to 2021. Future trends over the next 15 years were projected using autoregressive integrated moving average modeling.</p><p><strong>Results: </strong>In 2021, the age-standardized DALYs rates (ASDRs) of neurological disorders in Europe (1,502.3/100,000 population) were significantly higher than the global average (1,385.1/100,000 population). Among them, the ASDRs in Western Europe (1,584.23/100,000 population) were notably higher than that in Central Europe (1,354.65/100,000 population) and Eastern Europe (1,375.03/100,000 population). Ischemic stroke (31.98%) and Alzheimer's disease (20.24%) were the major contributors to the disease burden in Europe. Age-stratified analysis revealed that the elderly population (≥65 years old) bore the burden of stroke and Alzheimer's disease and other dementia. The overall disease burden was higher in females. From 1990 to 2021, data indicated a significant decline in the disease burden of ischemic stroke, Alzheimer's disease and other dementias, encephalitis, idiopathic epilepsy, intracerebral hemorrhage, and meningitis. Conversely, Parkinson's disease and other neurological disorders showed an upward trend. ARIMA forecast analysis suggested that from 2021 to 2036, the predicted ASDRs for neurological disorders would be lower compared to previous levels.</p><p><strong>Conclusion: </strong>Neurological disorders impose a greater burden in Europe than globally, primarily driven by ischemic stroke and Alzheimer's disease, with Western Europe, elderly, and female populations being disproportionately affected.</p>","PeriodicalId":54730,"journal":{"name":"Neuroepidemiology","volume":" ","pages":"1-16"},"PeriodicalIF":4.0,"publicationDate":"2025-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145687924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Pathology, Alzheimer's and Related Dementias Study (PARDoS): Design and Characteristics of the First 4,700+ Brazilian Participants. 病理学、阿尔茨海默病和相关痴呆研究(PARDoS):前4700+巴西参与者的设计和特征。
IF 4 3区 医学 Q2 CLINICAL NEUROLOGY Pub Date : 2025-12-02 DOI: 10.1159/000547564
Jose M Farfel, Ana W Capuano, Sukriti Nag, Maria Carolina M Sampaio, John Gibbons, Robert S Wilson, David A Bennett

Introduction: The Pathology, Alzheimer's and Related Dementias Study (PARDoS) is a community-based clinical-pathologic study of aging and dementia in a large and diverse sample of Brazilians. Its long-term objective was to identify the environmental, genetic, and molecular drivers of common conditions across the adult life span with an emphasis on Alzheimer's disease and related disorders clinical and neuropathologic traits.

Methods: From July 31, 2021, through February 11, 2025, 4,790 brains were collected at two autopsy centers and a major hospital system in the State of São Paulo, Brazil. Samples of other organs are also being collected. Their mean age was 71.7 years (range 18-106), 40.2% were black/mixed, 52.7% were male, their mean education was 6.3 years (range 0-25). Among those aged 65+, 32.9% had dementia and 18.8% had mild cognitive impairment. Neuropathologic data collection is ongoing.

Conclusion: PARDoS fills several major gaps among clinical-pathologic studies given the large numbers and its unique age and education range and socioeconomic status, race, sex, and other organ collection. Here, we present the study design, demographic characteristics of the first 4,790 autopsied participants, and clinical characteristics of the first 4,283 with informant interviews.

病理学、阿尔茨海默氏症和相关痴呆研究(PARDoS)是一项基于社区的临床病理研究,在巴西大量不同的样本中研究衰老和痴呆。其长期目标是确定成人一生中常见疾病的环境,遗传和分子驱动因素,重点是阿尔茨海默病和相关疾病的临床和神经病理特征。从2021年7月31日到2025年2月11日,在巴西圣保罗州的两个尸检中心和一个主要医院系统收集了4790个大脑。其他器官的样本也正在收集中。平均年龄71.7岁(18 ~ 106岁),黑人/混血儿占40.2%,男性占52.7%,平均受教育年限6.3年(0 ~ 25岁)。在65岁以上的人群中,32.9%患有痴呆,18.8%患有轻度认知障碍。神经病理数据收集正在进行中。PARDoS填补了临床病理研究中的几个主要空白,因为它的数量大,年龄和教育范围独特,社会经济地位,种族,性别和其他器官收集。在这里,我们介绍了研究设计、第一批4790名尸检参与者的人口统计学特征,以及第一批4283人的临床特征。
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引用次数: 0
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Neuroepidemiology
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