Journal of Pediatrics最新文献

{"title":"Association of Catecholamines with Blood Glucose and Severity of Illness in Infants Born Preterm","authors":"Henrike Hoermann MD ,&nbsp;Marcia Roeper MD ,&nbsp;Martijn van Faassen PhD ,&nbsp;Carsten Hagenbeck MD ,&nbsp;Diran Herebian PhD ,&nbsp;Anneke C. Muller Kobold PhD ,&nbsp;Juergen Dukart PhD ,&nbsp;Ido P. Kema PhD ,&nbsp;Ertan Mayatepek MD ,&nbsp;Thomas Meissner MD ,&nbsp;Sebastian Kummer MD","doi":"10.1016/j.jpeds.2025.114897","DOIUrl":"10.1016/j.jpeds.2025.114897","url":null,"abstract":"<div><h3>Objective</h3><div>To assess whether urinary catecholamine/metanephrine concentrations correlate with illness severity and blood glucose (BG) levels during the first weeks of life among infants born preterm.</div></div><div><h3>Study design</h3><div>This was a prospective cohort study of 33 neonates born at &lt;32 + 0 weeks or with a birth weight &lt;1500 g. Urine was collected 2-3x/week up to 10 weeks of age. Catecholamines/metanephrines were analyzed by an isotope dilution liquid chromatography in combination with tandem mass spectrometry. Severity of illness was estimated using the Neonatal Therapeutic Intervention Scoring System and the number of apneas/bradycardias. BG levels were measured as clinically indicated.</div></div><div><h3>Results</h3><div>Six hundred fifteen urine samples and 3491 BG levels were analyzed. Median age at lowest BG was 686 (IQR 27, 2420) hours for infants &lt;1000 g, 20 (IQR 1, 165) hours for infants between 1000-1499 g and 4 (IQR 1, 104) hours for infants &gt;1500 g. Three neonates were diagnosed with transient hyperinsulinism. Urinary norepinephrine and metanephrine correlated positively with the Neonatal Therapeutic Intervention Scoring System (F(1, 58.73) = 33.24, <em>P</em> &lt; .001; F(1, 310.01) = 19.78, <em>P</em> &lt; .001). Norepinephrine, normetanephrine, and metanephrine correlated positively with the number of apneas/bradycardias during the last 6 hours before urine collection (F(1, 442.69) = 22.12, <em>P</em> &lt; .001; F(1, 598) = 7.40, <em>P</em> = .007; F(1, 591.50) = 29.05, <em>P</em> &lt; .001). Norepinephrine and normetanephrine concentrations correlated positively with BG levels (F(1, 314.6) = 8.58, <em>P</em> = .004; F(1, 312.5) = 10.40, <em>P</em> = .001).</div></div><div><h3>Conclusion</h3><div>Urinary catecholamines in infants born preterm correlate with severity of illness and BG levels. Whether postnatal catecholamines directly influence beta-cell physiology in infants born preterm remains to be elucidated and should be addressed in future studies. A better understanding of the biologic mechanism might help improve glucose management in this vulnerable population.</div></div><div><h3>Trial Registration</h3><div>German Clinical Trials Register: DRKS00026230; <span><span>https://drks.de/search/de/trial/DRKS00026230/details</span><svg><path></path></svg></span>.</div></div>","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":"289 ","pages":"Article 114897"},"PeriodicalIF":3.5,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145524926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hearing Trajectories in Congenital Cytomegalovirus Infection: A 4-Year Follow-Up Study","authors":"Hugo Delille MD ,&nbsp;Marine Parodi MD ,&nbsp;Jean-François Magny MD, PhD ,&nbsp;Marianne Leruez-Ville MD, PhD ,&nbsp;Jacques Fourgeaud PharmD ,&nbsp;Nicolas Bourgon MD, PhD ,&nbsp;Yves Ville MD, PhD ,&nbsp;Sophie Achard MD ,&nbsp;Isabelle Rouillon MD ,&nbsp;Françoise Denoyelle MD, PhD ,&nbsp;Natalie Loundon MD ,&nbsp;François Simon MD, PhD","doi":"10.1016/j.jpeds.2025.114865","DOIUrl":"10.1016/j.jpeds.2025.114865","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate long-term hearing evolution in children with congenital cytomegalovirus (cCMV) and to identify predictive factors for hearing impairment.</div></div><div><h3>Study design</h3><div>A retrospective, single-center study in a tertiary pediatric otolaryngology referral center in Paris. The study included 244 patients with cCMV born between January 2013 and December 2018, with documented infection and at least 4 years of hearing follow-up. Data collected included prenatal history, diagnosis, birth symptoms, additional investigations, and therapy. Hearing thresholds were measured every 6 months for 2 years and then annually.</div></div><div><h3>Results</h3><div>At birth, cCMV-related sensorineural hearing loss (SNHL) prevalence in this cohort was 10%. At age 4, prevalence increased to 15% overall (35% of symptomatic and 2% of asymptomatic patients). No significant fluctuations were observed except with intercurrent otitis media with effusion. Risk factors for SNHL included cerebral imaging abnormalities (OR = 7.4 [95% CI 3-20.1], <em>P</em> &lt; .001), clinical symptoms at birth (OR = 5.9 [95% CI 1.8-19.6], <em>P</em> &lt; .01), affected contralateral ear at birth (OR = 6.7 [95% CI 2.9-15.4], <em>P</em> &lt; .001), and first-trimester infection (OR = 3.7 [95% CI 1.6-9.6], <em>P</em> &lt; .01).</div></div><div><h3>Conclusions</h3><div>Identifiable risk factors for SNHL may guide management and parental counseling of patients with cCMV.</div></div>","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":"289 ","pages":"Article 114865"},"PeriodicalIF":3.5,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145370562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health-Related Quality of Life in Children with Hypoplastic Left Heart Syndrome: Changes over Time and Associations with Neurodevelopmental and Clinical Factors","authors":"Karen Uzark PhD, CPNP ,&nbsp;Sunkyung Yu MS ,&nbsp;Katherine Afton BS ,&nbsp;Andrew M. Atz MD ,&nbsp;Alejandro Floh MD ,&nbsp;Nadine A. Kasparian PhD ,&nbsp;Linda M. Lambert MSN, FNP ,&nbsp;Tonia Morrison MSM, CCRC ,&nbsp;Amee Shah MD ,&nbsp;Erica Sood PhD ,&nbsp;Divya Suthar MD, MHA ,&nbsp;Felicia Trachtenberg PhD ,&nbsp;Jodie K. Votava-Smith MD ,&nbsp;Jason Williams MD ,&nbsp;Jane W. Newburger MD, MPH ,&nbsp;Caren S. Goldberg MD, MS","doi":"10.1016/j.jpeds.2025.114868","DOIUrl":"10.1016/j.jpeds.2025.114868","url":null,"abstract":"<div><h3>Objectives</h3><div>To evaluate changes in health-related quality of life (HRQOL) over time as perceived by parents and to examine associations between neurodevelopmental and clinical factors and patient-reported HRQOL in a large multicenter cohort of children with hypoplastic left heart syndrome.</div></div><div><h3>Study design</h3><div>Longitudinal/cohort. The Pediatric Quality of Life Inventory (PedsQL) was administered to 163 parents/165 Fontan survivors enrolled in the Single Ventricle Reconstruction (SVR) trial follow-up studies. In addition to examination of changes in parent-reported HRQOL over time, univariate associations between clinical and neurodevelopmental measures and concurrent self-reported PedsQL scores were evaluated.</div></div><div><h3>Results</h3><div>Despite no significant change in reported heart problems/cardiac symptoms, PedsQL scores reported by parents decreased between SVR II (median age: 6.1 years, interquartile range: 6.0-6.2) and SVR III (median age: 10.9 years, interquartile range: 10.4-11.4) across all domains: total <em>P</em> &lt; .001, physical <em>P</em> = .02, psychosocial <em>P</em> &lt; .001, emotional <em>P</em> &lt; .001, social <em>P</em> ≤ .001, and school <em>P</em> &lt; .001. There was a corresponding increase in proportions with “at risk” impaired HRQOL: total 28% to 39%, physical 27% to 39%, psychosocial 25% to 40%, emotional 20% to 34%, social 22% to 31%, and school 21% to 38%. While there were no significant correlations between medical variables and self-reported PedsQL scores, neurodevelopmental dysfunction across multiple measures was significantly correlated with worse self-reported HRQOL.</div></div><div><h3>Conclusions</h3><div>By parent report, HRQOL in children with hypoplastic left heart syndrome decreases over time unrelated to their cardiac symptoms and complications. Neurodevelopmental dysfunction is associated with worse patient-reported HRQOL. Routine assessment of neurodevelopmental function and HRQOL is essential to inform interventions to improve outcomes.</div></div>","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":"289 ","pages":"Article 114868"},"PeriodicalIF":3.5,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145370576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"School-Based Specialty Visits via Telemedicine Improve Chronic Asthma","authors":"Thomas R. Welch MD","doi":"10.1016/j.jpeds.2025.114972","DOIUrl":"10.1016/j.jpeds.2025.114972","url":null,"abstract":"","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":"289 ","pages":"Article 114972"},"PeriodicalIF":3.5,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146187296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality Assessment of Cochrane and Non-Cochrane Systematic Reviews in Neonatal Medicine: A Meta-Analysis","authors":"Prathamesh Khedkar MD ,&nbsp;Haribalakrishna Balasubramanian DM, MSc ,&nbsp;Ashutosh Pai MD ,&nbsp;Anitha Ananthan MD ,&nbsp;Rajendra Prasad Anne DM ,&nbsp;Diwakar Mohan MD, MPH, DrPH ,&nbsp;Nandkishor Kabra DM, MSc, FAAP ,&nbsp;Shripada C. Rao DM, FRACP, PhD ,&nbsp;Sanjay Patole MD, MPH","doi":"10.1016/j.jpeds.2025.114871","DOIUrl":"10.1016/j.jpeds.2025.114871","url":null,"abstract":"<div><h3>Objective</h3><div>To compare the methodological and reporting performance of Cochrane reviews (CR) and non-Cochrane reviews (NCR) of clinical trials evaluating neonatal interventions.</div></div><div><h3>Study design</h3><div>PubMed, Embase, the Cochrane database, and Web of Science were searched from January 2015 to December 2023 for pairwise meta-analyses and systematic reviews. Review quality was assessed using A Measurement Tool to Assess Systematic Reviews-2 and compared across covariate-matched cohorts of CR and NCR. Trends in quality over time and across journal quartiles were examined using the Jonckheere Terpstra test.</div></div><div><h3>Results</h3><div>A total of 453 systematic reviews were included (202 CR and 251 NCR). A significantly greater number of NCR were rated as critically low quality compared with CR (71% vs 8%; <em>P</em> &lt; .001); significantly fewer NCR were rated high or moderate quality (5.5% vs 13%; <em>P</em> = .007). The performance of CR was significantly higher than NCR for review protocol establishment (100% vs 49%), comprehensiveness of literature search (100% vs 57%), justification of exclusions (99% vs 38%), and reporting of trial funding (23% vs 5%). Reporting of review protocol, literature search, study exclusions, and sensitivity analyses improved across NCR categories ordered by increasing impact factor (<em>P</em> &lt; .01 for trend). Over the 9-year period, a positive trend was observed in protocol reporting of NCR (from 23% to 71%) and reporting of trial funding in CR (from 9% to 72%).</div></div><div><h3>Conclusions</h3><div>The mmethodological quality of neonatal CR was significantly better than NCR. NCR published in high-impact journals were superior to those in low-impact journals. Methodology and reporting of both review categories improved consistently over a 9-year time frame.</div></div>","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":"289 ","pages":"Article 114871"},"PeriodicalIF":3.5,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145370597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Longitudinal Cohort Study of Children with Peripheral Facial Nerve Palsy in Lyme Disease Endemic Areas","authors":"Sophi R. Lederer MD ,&nbsp;Desiree N. Neville MD ,&nbsp;Fran Balamuth MD, PhD, MSCE ,&nbsp;Laura L. Chapman MD ,&nbsp;Amy D. Thompson MD, MSCR ,&nbsp;Meagan M. Ladell MD ,&nbsp;Anupam B. Kharbanda MD, MSc ,&nbsp;Michael C. Monuteaux ScD ,&nbsp;Lise E. Nigrovic MD, MPH ,&nbsp;for Pedi Lyme Net","doi":"10.1016/j.jpeds.2025.114879","DOIUrl":"10.1016/j.jpeds.2025.114879","url":null,"abstract":"<div><div>In our longitudinal cohort of 385 children with peripheral facial nerve palsy, 7 of 145 (4.8%; 95% CI 2.4-9.6%) with Lyme disease did not initially receive appropriate antibiotics and 98 of 240 (40.8%; 95% CI 34.8-47.2%) with idiopathic facial palsy received antibiotics unnecessarily. A rapid and accurate Lyme diagnostic could improve initial treatment.</div></div>","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":"289 ","pages":"Article 114879"},"PeriodicalIF":3.5,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145433022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Limitations of Comprehensive Respiratory Viral Testing in Managing Young Infants with Fever","authors":"Vincent Julien Chessex ,&nbsp;Florence Anne Barbey MD ,&nbsp;Patrick Haberstich ,&nbsp;Henrik Köhler MD, MHBA ,&nbsp;Dimitri Christian Michel Vetterli MD","doi":"10.1016/j.jpeds.2025.114882","DOIUrl":"10.1016/j.jpeds.2025.114882","url":null,"abstract":"<div><h3>Objective</h3><div>To assess whether and when comprehensive respiratory viral testing contributes to risk stratification and management of febrile young infants (FYI).</div></div><div><h3>Study design</h3><div>Single-center, retrospective cohort study of hospitalized FYI, aged ≤90 days (born at term) or ≤52 6/7 postmenstrual weeks (born preterm), over a 5-year period. A total of 456 infants with either a positive respiratory viral test result, regardless of diagnostic assay, or a negative respiratory viral test result obtained by comprehensive panel were included in the final analysis. Main outcomes were serious bacterial infection (SBI) rates overall and in specific subsamples, stratified by viral test results. Rates were estimated assuming a binomial distribution, with confidence intervals derived from a normal approximation. Risk ratios with 95% confidence intervals were calculated using uncertainty propagation.</div></div><div><h3>Results</h3><div>Among 456 FYI (mean age 41 days), 70 (15.4%) had SBI, including 6 cases of bacteremia and 1 of meningitis. Infants with a positive viral test result had an SBI rate of 11.9% (42/354), including 2 cases of bacteremia, with significantly lower rates observed only in those testing positive for influenza (6%) and respiratory syncytial virus (4%). Regardless of viral test results, 93% (65/70) of SBI cases had abnormal inflammatory markers or urinalysis. Invasive bacterial infections occurred in both virus-positive (2/354) and virus-negative infants (5/102).</div></div><div><h3>Conclusions</h3><div>Comprehensive respiratory viral testing appears to have limited value for SBI risk stratification in FYI. It does not seem to support clinical decision-making or replace established risk stratification by inflammatory markers and urinalysis. Targeted testing may represent a more appropriate use of resources.</div></div>","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":"289 ","pages":"Article 114882"},"PeriodicalIF":3.5,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145433142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Administration of 100% Oxygen during Deferred Cord Clamping Does Not Cause Systemic Hyperoxia in Infants Born Extremely Preterm","authors":"Anup C. Katheria MD ,&nbsp;Rebecca A. Dorner MD, MHS ,&nbsp;Felix Ines RCP ,&nbsp;Ana Morales MPH ,&nbsp;Shashank Sanjay BS ,&nbsp;Alexis Rae Rosete BS ,&nbsp;Kaitlyn Fitzgerald BS ,&nbsp;Debra Poeltler PhD ,&nbsp;Henry C. Lee MD ,&nbsp;Satyan Lakshminrusimha MD","doi":"10.1016/j.jpeds.2025.114886","DOIUrl":"10.1016/j.jpeds.2025.114886","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate cerebral oxygenation and hemodynamic changes in infants born extremely preterm receiving 100% oxygen compared with 30% during deferred cord clamping (DCC).</div></div><div><h3>Study design</h3><div>Infants born at 22^0/7 to 28^6/7 weeks received DCC for 90 seconds in conjunction with 30% (LO group) or 100% (HI group) oxygen. After cord clamping, infants were resuscitated per current guidelines (30% oxygen and titration based on peripheral atrial oxygen saturation, SpO₂). Heart rate, mean airway pressure (MAP), SpO₂ and inspired fraction of oxygen (FiO₂) were collected for 10 minutes. Blood pressure and cerebral tissue oxygenation were collected for 24 hours. Longitudinal models were used to compare effects of high vs low oxygen.</div></div><div><h3>Results</h3><div>Seventy-four infants had detailed monitoring at birth (72 infants had 24-hour cerebral monitoring). There was no difference between groups across the first 10 minutes in MAP, FiO₂, blood pressure, heart rate, or cerebral tissue oxygenation. Infants in the LO group had lower SpO₂ at 4, 5, and 6 minutes (<em>P</em> &lt; .05). Cord arterial PO2 (PaO₂) was similar in both groups. The duration of hyperoxemia (SpO₂ &gt;95th percentile on Dawson curves, HI 156 ± 145 vs LO 103 ± 122 seconds, <em>P</em> = .18) or hypoxemia (&lt;25^th percentile, HI: 127 ± 89 vs LO: 121 ± 79 seconds, <em>P</em> = .89) were similar between the groups.</div></div><div><h3>Conclusions</h3><div>Providing high oxygen during DCC transiently improves SpO₂ without causing hyperoxia or changes in MAP or FiO₂. A large, randomized controlled trial is needed to determine if 100% oxygen during DCC improves survival and reduces longer-term morbidities in infants born extremely preterm.</div></div>","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":"289 ","pages":"Article 114886"},"PeriodicalIF":3.5,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145433095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety of Direct Amoxicillin Challenges to Evaluate Penicillin Allergy in Infants and Toddlers","authors":"Rasa Tiano DO, MS ,&nbsp;Ellen Ruan BS ,&nbsp;Devangi Shah MD ,&nbsp;Timothy G. Chow MD ,&nbsp;Christine RF. Rukasin MD","doi":"10.1016/j.jpeds.2025.114867","DOIUrl":"10.1016/j.jpeds.2025.114867","url":null,"abstract":"<div><div>In a retrospective cohort from two pediatric referral centers, we demonstrate that direct amoxicillin challenges appear to be safe in infants and toddlers with a nonhigh risk penicillin allergy label. Our data support expanding the benefits of early penicillin allergy delabeling to this population.</div></div>","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":"289 ","pages":"Article 114867"},"PeriodicalIF":3.5,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145370602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is Sensorineural Hearing Loss Predictable among Infants with Congenital Cytomegalovirus Infection?","authors":"Sarah S. Long MD","doi":"10.1016/j.jpeds.2025.114973","DOIUrl":"10.1016/j.jpeds.2025.114973","url":null,"abstract":"","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":"289 ","pages":"Article 114973"},"PeriodicalIF":3.5,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146187297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}