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Journal of Pediatrics最新文献

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Severe and Enduring Anorexia Nervosa and Quality of Life: If, When, and How Palliative Care Should be Involved in Patient Care 严重和持久的神经性厌食症和生活质量：是否，何时，以及如何姑息治疗应该参与患者护理。
IF 3.5 2区 医学 Q1 PEDIATRICS
Journal of Pediatrics
Pub Date : 2025-12-09 DOI: 10.1016/j.jpeds.2025.114940
Rory Bade MD , Michaela Blakeslee BA , Paula Cody MD, MPH
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引用次数: 0
Comparing the Burden of Social Needs Across Pediatric Care Settings 比较不同儿科护理机构的社会需求负担
IF 3.5 2区 医学 Q1 PEDIATRICS
Journal of Pediatrics
Pub Date : 2025-12-08 DOI: 10.1016/j.jpeds.2025.114922
Robert A. Dudas MD
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引用次数: 0
Antibiotic Prophylaxis for Gastrointestinal Surgery in Very Young Infants: The Value of National Data and Interpretation by Experts 幼儿胃肠手术的抗生素预防：国家数据的价值和专家的解释
IF 3.5 2区 医学 Q1 PEDIATRICS
Journal of Pediatrics
Pub Date : 2025-12-08 DOI: 10.1016/j.jpeds.2025.114921
Sarah S. Long MD
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引用次数: 0
Pediatric Palliative Care: Are We There Yet? 儿童姑息治疗：我们还在那里吗？
IF 3.5 2区 医学 Q1 PEDIATRICS
Journal of Pediatrics
Pub Date : 2025-12-08 DOI: 10.1016/j.jpeds.2025.114918
Paul G. Fisher MD
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引用次数: 0
Information for Readers 读者资讯
IF 3.5 2区 医学 Q1 PEDIATRICS
Journal of Pediatrics
Pub Date : 2025-12-08 DOI: 10.1016/S0022-3476(25)00451-2
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引用次数: 0
A Better Way to Assess Central Obesity? 评估中心性肥胖的更好方法？
IF 3.5 2区 医学 Q1 PEDIATRICS
Journal of Pediatrics
Pub Date : 2025-12-08 DOI: 10.1016/j.jpeds.2025.114920
Joseph T. Flynn MD, MS
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引用次数: 0
Listening to the Adolescent Voice on Medication Adherence 倾听青少年关于药物依从性的声音
IF 3.5 2区 医学 Q1 PEDIATRICS
Journal of Pediatrics
Pub Date : 2025-12-08 DOI: 10.1016/j.jpeds.2025.114917
Robert A. Dudas MD
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引用次数: 0
How Would Universal Newborn Screening for Congenital Cytomegalovirus Infection Play out? 新生儿先天性巨细胞病毒感染的普遍筛查如何发挥作用？
IF 3.5 2区 医学 Q1 PEDIATRICS
Journal of Pediatrics
Pub Date : 2025-12-08 DOI: 10.1016/j.jpeds.2025.114919
Sarah S. Long MD
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引用次数: 0
Body Composition and Fat Deposition in Children with Cushing Disease and Associations with Cardiometabolic Risk Factors 库欣病儿童的体成分和脂肪沉积及其与心脏代谢危险因素的关系
IF 3.5 2区 医学 Q1 PEDIATRICS
Journal of Pediatrics
Pub Date : 2025-12-03 DOI: 10.1016/j.jpeds.2025.114933
Yetunde B. Omotosho MD, MHSc , James C. Reynolds MD , Jack A. Yanovski MD, PhD , Christina Tatsi MD, MHSc, PhD

Objective

To compare body composition and fat distribution in children with Cushing disease (CD) with body mass index (BMI)-matched peers with obesity and evaluate associations with cardiometabolic risk factors (CRFs).

Study design

In a retrospective cohort study, we compared 23 pediatric patients with active CD and 46 age-, sex-, and BMI z-score–similar controls. Anthropometric measurements, fasting biochemistry, and whole-body dual-energy X-ray absorptiometry had already been performed.

Results

Patients with CD had a greater percentage of total body fat than their BMI-similar controls (47.8% [SD 7.8] in female patients with CD vs 40.0% [SD 10.1] in control patients, P = .016; 46.6% [SD 8.5] in male patients with CD vs 38.3% [SD 9.9] in control patients, P = .019). However, fat distribution, assessed by proportions of fat between the trunk and the limbs, did not differ significantly between the 2 groups, suggesting that a more central obesity phenotype is not clearly identified in this pediatric CD group. In control patients, CRFs showed strong correlations with BMI and markers of fat deposition and distribution, yet in patients with CD, CRFs showed variable correlations with certain factors associating only with markers of fat deposition and distribution rather than BMI.

Conclusions

Pediatric patients with CD have greater adiposity and reduced lean and bone mass compared with BMI-similar peers, despite similar fat distribution. BMI underestimates fat burden in patients with CD and measures derived from dual-energy X-ray absorptiometry may better reflect metabolic risk. Comprehensive body composition assessment should be considered in pediatric patients with CD for risk stratification and management.

Trial registration

ClinicalTrials.gov ID: NCT00001595; NCT00001723; NCT00001522.
目的：比较库欣病（CD）儿童与体重指数（BMI）匹配的肥胖同龄人的身体组成和脂肪分布，并评估其与心脏代谢危险因素（CRFs）的关系。研究设计：在一项回顾性队列研究中，我们比较了23名患有活动性CD的儿科患者和46名年龄、性别和BMI z-score相似的对照组。已经进行了人体测量、空腹生化和全身双能x射线吸收测定（DXA）。结果：CD患者的总脂肪百分比高于bmi相似的对照组（女性CD患者为47.8% [SD 7.8]，对照组为40.0% [SD 10.1]， P=0.016；男性CD患者为46.6% [SD 8.5]，对照组为38.3% [SD 9.9]， P=0.019）。然而，通过躯干和四肢之间的脂肪比例来评估的脂肪分布在两组之间没有显着差异，这表明在儿童CD组中没有明确确定更中心的肥胖表型。在对照组中，CRFs与BMI及脂肪沉积和分布标志物有很强的相关性，而在CD组中，CRFs与某些仅与脂肪沉积和分布标志物相关的因素呈可变相关性，而与BMI无关。结论：尽管脂肪分布相似，但与bmi相似的同龄人相比，儿科CD与更大的肥胖、瘦骨量和骨量减少有关。BMI低估了CD患者的脂肪负担，dxa衍生的测量方法可能更好地反映代谢风险。儿童乳糜泻应考虑综合身体成分评估，以进行风险分层和管理。
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引用次数: 0
Monitoring Head Circumference is Fundamental to Clinical Diagnosis 监测头围是临床诊断的基础
IF 3.5 2区 医学 Q1 PEDIATRICS
Journal of Pediatrics
Pub Date : 2025-12-01 DOI: 10.1016/j.jpeds.2025.114863
Paul G. Fisher MD
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引用次数: 0
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