Understanding the influence of inter-stenosis length (or spacing) on hemodynamics in dually stenosed blood vessels is critical for advancing our knowledge of cardiovascular diseases and their treatment. This study employs a two-phase Eulerian-granular model, incorporating kinetic theory to capture red blood cell (RBC) particle mechanics, to investigate hemodynamics in a dual-stenosed arterial vessel with a 75% degree of stenosis (DOS). To validate our approach, we benchmarked it against in vitro experimental velocity profiles reported by Yeleswarapu et al. (1998). With a maximum deviation of 7.24%, the current model shows improved agreement compared to other tested approaches, including both single-phase (Newtonian) and two-phase (Euler–Euler two-fluid) models. Our findings reveal that shorter inter-stenotic spacings lead to elevated velocity gradients, intensifying local inertial effects. Conversely, a longer spacing allows the flow more distance to recover and re-laminarize, stabilizing the velocity profile. The presence of stenosis significantly disrupts the typical central RBC core surrounded by plasma. Specifically, at short inter-stenotic lengths, the disturbed flow from the first stenosis lacks sufficient distance to re-establish shear gradient-driven RBC migration. This inhibits the formation of a well-defined core hematocrit, resulting in a more dispersed or skewed RBC distribution. Furthermore, short inter-stenotic lengths promote stronger flow interaction and the generation of persistent helical vortices in the downstream region. A greater inter-stenotic length facilitates partial re-laminarization and vortex dissipation, leading to a reduction in downstream helicity and a transition toward more organized flow. Area-averaged wall shear stress (AWSS) increases with decreasing inter-stenotic length, particularly at the stenosis throat. Notably, this study also demonstrates that the single-phase Newtonian model over predicts flow separation and recirculation compared to our two-phase approach. Overall, this study highlights the capabilities of the two-phase Euler–granular model in accurately simulating complex blood flow dynamics within stenosed arteries, offering potential extensions for investigating the hemodynamics of other complex biological systems.
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