The dynamics of thin-shell encapsulated microbubbles (EMBs) in viscoelastic fluids forced by ultrasound are investigated in this paper. EMBs, which are gas-filled microbubbles encased in a stiff albumin or flexible lipid shell, have been shown to improve the performance of biomedical procedures such as ultrasound contrast imaging and sonoporation. To gain computationally efficient initial insights, the flow is assumed irrotational and axisymmetric, and is solved via the boundary element method. The viscoelastic fluid is modelled using the Oldroyd B model with both the fluid and the properties of the shell accounted for through the dynamic boundary condition at the bubble surface. A large bubble shell thickness is found to have a significant stabilising effect on the bubble, markedly reducing bubble deformation and response to the ultrasound pulse. For realistic ultrasound and biological fluid parameters, shell properties appear to dominate over fluid rheology. Although at lower shell thicknesses the dynamics are governed by a competition between viscous, elastic and inertial forces. A larger response is observed for lower frequency ultrasound and for pressure amplitudes typical to sonoporation, large translational movement in the direction of the pulse is predicted as well as deformation and the potential for bubble fragmentation. The model and quantitative insights herein have the potential to form the basis of a low-cost computational tool useful for EMB design, fabrication and characterisation in the near future.
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