Knowledge the initial extension in the Indian continent during the Jurassic is important for understanding the dynamics of its breakup from Eastern Gondwana. The absence of Jurassic magmatic activity in the eastern Tethyan Himalaya hinders the understanding of this process. We report a provenance and tectonic setting study on the Middle Jurassic Zhela and Late Jurassic Weimei Formations sandstone in Gyangze, eastern Tethyan Himalaya. Detrital zircons of Jurassic sediments indicate four major age peaks: ∼500 Ma, ∼820 Ma, ∼950 Ma, and ∼2450 Ma, which reflect the affinity between the Tethyan Himalaya and India. The differences between the crystallization age and depositional age of isolated detrital zircons from the Middle Jurassic Zhela and Late Jurassic Weimei Formations, indicate that they were formed in an extensional continental margin and deposited on the passive continental margin of India. Combined with regional geological information, our results show that extensional tectonics was dominant on the northern margin of the Indian continent during the Jurassic. The source-sink sedimentary system and the topography remained stable at this time. After the extension event in the Middle and Late Jurassic, the Kerguelen mantle plume commenced activity, indicating the transition from the lithospheric thinning process to active rifting. The mantle plume activity in the Early Cretaceous led to large-scale uplift in the southeast part of the Tethyan Himalaya, that ultimately led to the breakup of India from Eastern Gondwana.