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Management of head & neck sarcomas in adults: A retrospective study 成人头颈部肉瘤的治疗:回顾性研究
IF 2.1 2区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-08-01 DOI: 10.1016/j.jcms.2024.01.005

The research purpose is to review the surgical approach and evaluate the results in adult patients with head and neck sarcomas.

The histopathology varied, including two leiomyosarcomas, six malignant fibrous histiocytomas, two malignant peripheral nerve sheath tumors, four dermatofibrosarcomas protuberans, three osteosarcomas, two angiosarcomas, one liposarcoma, one Ewing sarcoma, one synovial sarcoma, two unclassified/non-differentiated sarcomas and one solitary fibrous tumor. Surgical resection included maxillectomy, mandibulectomy, craniectomy, parotidectomy, scalp resection, face skin resection and laminectomy. The reconstruction was performed with one rectus abdominis flap, four radial forearm flaps, two latissimus dorsi flaps, two vascularized fibula flaps, two pectoralis major myocutaneous flaps, two trapezius flaps, two temporalis flaps, seven scalp flaps and two nasolabial flaps.

The total patient number was 24. The hospitalization was uncomplicated, followed by postoperative radiotherapy in the majority of cases. In a mean 15-year follow-up period, 11 patients are still alive and disease-free. There were four recurrences treated with palliative radiotherapy.

The surgical approach for head and neck sarcomas, including the achievement of a functionally acceptable result by organ sparing techniques, remains challenging. Wide resection combined with the appropriate reconstruction, particularly with microsurgical techniques, and followed by adjuvant radiotherapy or chemotherapy offer improved prognosis and quality of life.

研究目的是回顾头颈部肉瘤成年患者的手术方法并评估手术效果。这些患者的组织病理各不相同,包括 2 例雷米肉瘤、6 例恶性纤维组织细胞瘤、2 例恶性周围神经鞘瘤、4 例原发性皮纤维肉瘤、3 例骨肉瘤、2 例血管肉瘤、1 例脂肪肉瘤、1 例尤文肉瘤、1 例滑膜肉瘤、2 例未分类/未分化肉瘤和 1 例单发纤维瘤。手术切除包括上颌骨切除术、下颌骨切除术、颅骨切除术、腮腺切除术、头皮切除术、面部皮肤切除术和椎板切除术。重建手术使用了一个腹直肌皮瓣、四个前臂桡肌皮瓣、两个背阔肌皮瓣、两个血管化腓骨皮瓣、两个胸大肌肌皮瓣、两个斜方肌皮瓣、两个颞肌皮瓣、七个头皮皮瓣和两个鼻唇皮瓣。住院治疗并不复杂,大多数病例术后都接受了放射治疗。在平均长达 15 年的随访中,有 11 名患者仍然存活并且没有患病。头颈部肉瘤的手术治疗方法,包括通过保留器官技术达到功能上可接受的效果,仍然具有挑战性。大范围切除结合适当的重建,特别是采用显微外科技术,再辅以放疗或化疗,可改善预后和生活质量。
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引用次数: 0
The reliability and validity of the juvenile idiopathic arthritis magnetic resonance scoring system for temporomandibular joints 幼年特发性关节炎颞下颌关节磁共振评分系统的可靠性和有效性。
IF 2.1 2区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-08-01 DOI: 10.1016/j.jcms.2024.04.018

In children with juvenile idiopathic arthritis (JIA), the temporomandibular joint (TMJ) can be involved. To prevent TMJ damage due to inflammation, early recognition is important, for which contrast-enhanced magnetic resonance imaging (MRI) is the gold standard. In this study, the interobserver reliability and construct validity of the Juvenile Idiopathic Arthritis Magnetic Resonance Scoring System for Temporomandibular Joints (JAMRIS-TMJ) was assessed. Two radiologists independently examined 38 MRIs using the JAMRIS-TMJ scoring system. Inter-observer reliability was assessed by Cohen's (weighted) kappa (κ), 95% confidence intervals (CIs) and absolute agreement (%). Construct validity was assessed by correlation between the JAMRIS-TMJ items and TMJ involvement, active maximum interincisal mouth opening (AMIO), and anterior maximum voluntary bite force (AMVBF). The interobserver reliability for the JAMRIS-TMJ items varied from poor to good (κ = 0.18–0.61). Joint enhancement had the highest reliability (κ = 0.61). Correlations were found between TMJ involvement, AMIO, and the JAMRIS-TMJ items, although variation between radiologists and TMJ side existed. No correlation was found between AMVBF and the JAMRIS-TMJ items for both radiologists. The strongest correlations were found between most of the JAMRIS-TMJ items and AMIO. Our findings support the utility of AMIO as a clinical measure of TMJ status in children with JIA.

幼年特发性关节炎(JIA)患儿的颞下颌关节(TMJ)可能受累。为防止颞下颌关节因炎症而受损,早期识别非常重要,而对比增强磁共振成像(MRI)是识别颞下颌关节的金标准。本研究评估了青少年特发性关节炎颞下颌关节磁共振评分系统(JAMRIS-TMJ)的观察者间可靠性和结构有效性。两名放射科医生使用 JAMRIS-TMJ 评分系统独立检查了 38 例 MRI。观察者间的可靠性通过科恩(加权)卡帕(κ)、95% 置信区间(CI)和绝对一致率(%)进行评估。结构效度通过 JAMRIS-TMJ 项目与颞下颌关节受累、主动最大颚间张口(AMIO)和前方最大自主咬合力(AMVBF)之间的相关性进行评估。JAMRIS-TMJ 项目的观察者间可靠性从差到好(κ = 0.18-0.61)不等。关节增强的信度最高(κ = 0.61)。颞下颌关节受累、AMIO 和 JAMRIS-TMJ 项目之间存在相关性,但放射医师和颞下颌关节侧之间存在差异。两位放射科医生的 AMVBF 与 JAMRIS-TMJ 项目之间没有相关性。大多数 JAMRIS-TMJ 项目与 AMIO 之间的相关性最强。我们的研究结果支持将 AMIO 作为 JIA 儿童颞下颌关节状况的临床测量方法。
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引用次数: 0
Effect of impacted mandibular third molar extraction on periodontal microbiota and clinical parameters of adjacent teeth: A randomized clinical trial 下颌第三磨牙拔除对邻牙牙周微生物群和临床参数的影响:随机临床试验
IF 2.1 2区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-08-01 DOI: 10.1016/j.jcms.2024.06.001

It is urgently necessary to clarify the effect of extraction of impacted mandibular third molar (IMTM) on the periodontal tissue of adjacent second molars (ASMs). In this study, the ASM periodontal condition and pathogenic microbes were assessed before IMTM extraction and at 1, 4, 8 and 12 weeks postoperatively. Based on the inclusion and exclusion criteria, our study revealed that IMTM extractions adversely affected distal - periodontal probing depth (dPPD), attachment loss (dAL), plaque index (dPLI) and bleeding on probing (dBOP) within 8 weeks, but these indices gradually normalize after 12 weeks. The subgingival pathogens near the ASMs distal surface, Porphyromonas and Pseudomonas, were significantly increased postoperatively. Moreover, relevance of ASMs clinical indices and subgingival microbes after IMTM extractions was found. In contrast to the situation in chronic periodontitis, the effects of IMTM extraction on dPPD, dAL, dPLI and dBOP of ASMs were mainly correlated with Pseudomonas. Additionally, while the IMTM extractions have adverse distal periodontal indices of ASMs within 8 weeks and increase subgingival pathogens, the modified triangular flap (MTF) had fewer distal periodontal indices and less Pseudomonas. Compared to the traditional envelope flap and triangular flap, the MTF benefits the periodontal health, which could be considered as the priority option for IMTM extractions.

迫切需要明确下颌第三磨牙(IMTM)拔除术对邻近第二磨牙(ASM)牙周组织的影响。本研究在下颌第三磨牙拔除术前以及术后 1、4、8 和 12 周评估了相邻第二磨牙的牙周状况和病原微生物。根据纳入和排除标准,我们的研究发现,IMTM拔除术对8周内的远端牙周探诊深度(dPPD)、附着丧失(dAL)、牙菌斑指数(dPLI)和探诊出血量(dBOP)有不利影响,但这些指数在12周后逐渐恢复正常。术后,ASM远端表面附近的龈下病原体--卟啉单胞菌和假单胞菌--明显增加。此外,研究还发现,IMTM 拔牙后 ASM 的临床指数和龈下微生物具有相关性。与慢性牙周炎的情况不同,IMTM 拔牙对 ASM 的 dPPD、dAL、dPLI 和 dBOP 的影响主要与假单胞菌相关。此外,IMTM拔牙在8周内对ASM远端牙周指数不利,并增加龈下病原体,而改良三角瓣(MTF)的远端牙周指数较低,假单胞菌也较少。与传统的包膜瓣和三角瓣相比,MTF有利于牙周健康,可作为IMTM拔牙的优先选择。
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引用次数: 0
Classifications for the temporomandibular joint (TMJ): A systematic review of the literature 颞下颌关节(TMJ)的分类:文献系统回顾。
IF 2.1 2区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-08-01 DOI: 10.1016/j.jcms.2024.04.010
Ross O.C. Elledge
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引用次数: 0
The influence of three different primary treatment protocols on 5-year-old maxillary growth in patients with complete unilateral cleft lip and palate 三种不同的初级治疗方案对完全性单侧唇腭裂患者 5 岁时上颌骨生长的影响。
IF 2.1 2区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-08-01 DOI: 10.1016/j.jcms.2024.04.020

The study evaluated the effects of three different primary treatment protocols on maxillary growth in patients aged 5 years with complete unilateral cleft lip and palate (UCLP). The secondary objective was to assess the influence of initial cleft severity, family history of class III, and status of permanent lateral incisor on maxillary growth.

In total, 54 patients with non-syndromic complete UCLP were included and grouped as follows: group An underwent lip adhesion, cheilorhinoplasty associated with tibial periosteal graft for hard palate repair, and finally veloplasty; group B underwent lip adhesion, then cheilorhinoplasty with intravelar veloplasty, and finally a hard-palate repair; group C underwent cheilorhinoplasty with intravelar veloplasty and then a hard-palate repair. Five-year maxillary growth was assessed on dental models, both clinically and digitally.

No difference was found with GOSLON-Yardstick scoring. Five-year measurements showed that group C tended to have the best maxillary arch morphology (p = 0.012). Initial cleft severity did not impact maxillary growth, but status of permanent lateral incisor and family history of class III did (p = 0.019 and p = 0.004, respectively).

In patients aged 5 years, the two-stage approach appeared to be the least detrimental to growth development. Predictive factors for growth retardation included the absence of lateral incisor and a family history of class III.

该研究评估了三种不同的初级治疗方案对 5 岁完全性单侧唇腭裂(UCLP)患者上颌骨生长的影响。研究的次要目标是评估最初的唇腭裂严重程度、III级家族史以及永久侧切牙的状态对上颌骨生长的影响。研究共纳入了54名非综合征完全性唇腭裂患者,并将其分组如下:A组患者接受唇粘连术、颧骨成形术和胫骨骨膜移植术进行硬腭修复,最后进行包茎成形术;B组患者接受唇粘连术,然后进行颧骨成形术和龈内包茎成形术,最后进行硬腭修复;C组患者接受颧骨成形术和龈内包茎成形术,然后进行硬腭修复。在牙科模型上对五年的上颌骨生长情况进行了临床和数字评估。GOSLON-Yardstick评分没有发现差异。五年的测量结果显示,C组的上颌骨牙弓形态最好(p = 0.012)。最初的唇裂严重程度并不影响上颌的生长,但永久侧切牙的状态和家族史中的 III 级却有影响(p = 0.019 和 p = 0.004)。在5岁的患者中,两期法似乎对生长发育的影响最小。生长发育迟缓的预测因素包括无侧切牙和家族有Ⅲ类牙病史。
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引用次数: 0
Clinical and social success in epithetic ear rehabilitation – Retrospectively evaluating the long-term survival of auricular implants 人工耳康复的临床和社会成功--回顾性评估耳廓植入物的长期存活率
IF 2.1 2区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-08-01 DOI: 10.1016/j.jcms.2024.02.003

Purpose

The aim of this study was to evaluate existing staging recommendations for peri-implantitis and its applicability for auricular bone anchoring.

Materials and methods

In this cross-sectional study, 44 patients treated with 47 ear epitheses and 128 implants were analyzed over 191.6 months (mean). Peri-implant sulcus depth, sulcus fluid flow rate, and peri-implant skin reaction, as well as cleaning habits and patients’ quality of life, were analyzed. Mixed effect linear and mixed effect ordered logistic regression models were used.

Results

Two of the 128 implants were lost (1.6 %). A total of 14.5 % of all patients presented light erythemas, 19.4 % showed stage 2, 4.8 % stage 3, and 12.9 % an acute infection according to Holgers. A correlation between skin reaction and sulcus fluid flow rate was observed, when grouping patients with acute signs of inflammation. Concerning patient satisfaction, 58.1 % of the patients were highly satisfied with their epitheses, 39.5 % very satisfied, and one patient was just satisfied. Younger age correlated with lower satisfaction rates.

Conclusion

Implant-retained auricular epitheses are a safe, highly sufficient and satisfying way of extending ear reconstruction. Sulcus depth and skin reaction are quick and valuable assessment tools in auricular implants, but skin reaction alone was clinically insufficient to predict peri-implant pocket inflammation.

本研究的目的是评估现有的种植体周围炎分期建议及其在耳骨固定中的适用性。材料和方法在这项横断面研究中,分析了 44 名患者在 191.6 个月(平均值)内接受的 47 例耳外翻和 128 例种植体治疗。研究分析了种植体周围沟槽深度、沟槽液流率、种植体周围皮肤反应以及清洁习惯和患者的生活质量。结果128颗种植体中有两颗丢失(1.6%)。根据 Holgers 标准,所有患者中有 14.5% 出现轻度红斑,19.4% 出现二期红斑,4.8% 出现三期红斑,12.9% 出现急性感染。在对有急性炎症症状的患者进行分组时,发现皮肤反应与沟液流速之间存在相关性。在患者满意度方面,58.1% 的患者对他们的外显子治疗非常满意,39.5% 非常满意,还有一名患者仅表示满意。结论种植体固定耳廓外翻是一种安全、充分和令人满意的耳廓重建方法。沟槽深度和皮肤反应是耳廓种植体快速而有价值的评估工具,但临床上仅皮肤反应不足以预测种植体周围的袋炎症。
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引用次数: 0
EACMFS Prizes & Awards EACMFS 奖项
IF 2.1 2区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-08-01 DOI: 10.1016/S1010-5182(24)00223-3
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引用次数: 0
Does the adjunctive use of autologous platelet concentrate during secondary alveolar bone grafting reduce the risk of wound dehiscence? A systematic review and meta-analysis 二次牙槽骨移植过程中辅助使用自体血小板浓缩物是否能降低伤口开裂的风险?系统综述与荟萃分析。
IF 2.1 2区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-08-01 DOI: 10.1016/j.jcms.2024.04.016

Wound dehiscence is a common complication after secondary alveolar bone grafting (SABG), leading to unfavourable surgical outcomes. Studies have shown that autologous platelet concentrates (APC) may enhance wound healing and improve outcomes. Therefore, this review aimed to evaluate in patients with alveolar clefts, whether using APC and iliac crest bone graft can mitigate the likelihood of wound dehiscence formation compared with those who underwent iliac bone grafting only following SABG. A comprehensive literature search was conducted using various electronic databases, including PubMed, Embase, Scopus, Web of Science, EBSCOhost, Ovid MEDLINE, LILACS, Cochrane Library, and grey literature, to include studies until July 31, 2023, without any restriction to language and time of publication. Only randomized (RCT) and controlled (CCT) clinical trials were included. Two independent reviewers screened the studies based on the predefined criteria, after which a qualitative and quantitative analysis was conducted. The search yielded 821 studies, of which seven were deemed eligible for systematic review. The risk of bias assessment done using “The Cochrane collaboration tool for risk of bias assessment” for six RCTs and the “Risk of Bias in Non-randomized Studies - of Interventions” for one CCT revealed a moderate to high risk of bias. The meta-analysis of five studies showed that the overall risk of developing wound dehiscence was lower in the APC group (RR = 0.33; 95% CI: 0.16, 0.71; p = 0.005; χ2 = 0.82; I2 = 0%). Subgroup analyses based on study design further supported these findings. Although the adjuvant use of APC for alveolar cleft reconstruction reduces the risk of wound dehiscence, more studies with increased scientific rigour and fewer confounding variables are warranted.

伤口开裂是继发性牙槽骨移植术(SABG)后常见的并发症,会导致不利的手术效果。研究表明,自体血小板浓缩物(APC)可促进伤口愈合,改善手术效果。因此,本综述旨在评估牙槽骨裂患者在接受 SABG 后,与仅接受髂骨移植的患者相比,使用 APC 和髂嵴植骨是否能减少伤口裂开的可能性。我们使用各种电子数据库(包括 PubMed、Embase、Scopus、Web of Science、EBSCOhost、Ovid MEDLINE、LILACS、Cochrane Library 和灰色文献)进行了全面的文献检索,包括 2023 年 7 月 31 日之前的研究,对语言和发表时间没有任何限制。只纳入了随机(RCT)和对照(CCT)临床试验。两位独立审稿人根据预先确定的标准对研究进行筛选,然后进行定性和定量分析。搜索结果显示有 821 项研究,其中 7 项被认为符合系统性审查的条件。使用 "Cochrane 协作偏倚风险评估工具 "对 6 项研究进行了偏倚风险评估,并使用 "非随机研究-干预措施的偏倚风险 "对 1 项 CCT 进行了偏倚风险评估,结果显示存在中度至高度偏倚风险。五项研究的荟萃分析表明,APC 组发生伤口开裂的总体风险较低(RR = 0.33;95% CI:0.16,0.71;P = 0.005;χ2 = 0.82;I2 = 0%)。基于研究设计的亚组分析进一步支持了这些发现。尽管在牙槽裂重建中辅助使用 APC 可降低伤口开裂的风险,但仍需进行更多科学严谨、混杂变量更少的研究。
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引用次数: 0
Predictors of length of stay following maxillofacial abscess surgery: A 10-year retrospective cohort 颌面部脓肿手术后住院时间的预测因素:10年回顾性队列。
IF 2.1 2区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-08-01 DOI: 10.1016/j.jcms.2024.05.001

The aim of this study was to identify predictors of length of stay (LOS) after surgical therapy of maxillofacial abscess. Patients diagnosed with a maxillofacial abscess who underwent extraoral incision and drainage under general anesthesia between January 1st, 2012 and January 1st, 2022 were retrospectively reviewed Univariable and multivariable linear regressions were performed to identify the association between pre- and perioperative variables and the LOS. In total, 228 patients were included. In the forward stepwise multivariable analysis, all factors with a p-value <0.2 in the univariable model were included. Ultimately, six independent predictors of increased LOS were identified: female (coef. 0.14, 95% CI 0.03–0.25), immunosuppression (coef. 0.37, 95%CI 0.13–0.61), penicillin allergy (coef. 0.25, 95% CI 0.04–0.46), C-reactive protein (coef. 0.0008, 95% CI 0.0001–0.0014), multiple spaces involvement (coef. 0.36, 95% CI 0.13–0.59), and time to operation (coef. 0.005, 95% CI 0.002–0.008). In conclusion, our study provides new insights into predicting LOS for patients admitted with maxillofacial abscesses. The identification of these markers not only enhances the ability to forecast LOS, but also lays the groundwork for optimizing resource planning and potentially integrating them into a primary prevention algorithm.

本研究旨在确定颌面部脓肿手术治疗后住院时间(LOS)的预测因素。研究人员对 2012 年 1 月 1 日至 2022 年 1 月 1 日期间在全身麻醉下接受口外切开引流术的颌面部脓肿患者进行了回顾性研究,并进行了单变量和多变量线性回归,以确定术前和围手术期变量与住院时间之间的关系。共纳入了 228 名患者。在前向逐步多变量分析中,所有因素的 p 值为
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引用次数: 0
Transoral endoscopic assisted reduction and internal fixation of mandibular condylar neck fractures with short condylar segment 经口内窥镜辅助下颌髁状突颈部短髁状突骨折的复位和内固定术
IF 2.1 2区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-08-01 DOI: 10.1016/j.jcms.2024.04.019

This study aimed to assess the reliability and safety of transoral endoscopic-assisted reduction internal fixation (TERIF) for treating short-segment condylar neck fractures (CNF), including hardware removal.

Patients with displaced CNF and short condylar segments treated using TERIF were included in the study. Clinical evaluation covered dental occlusion, range of mouth opening, deviation during mouth opening, protrusion, laterotrusion, pain, and chewing. Radiological evaluation was used to assess fracture displacement, angulation, head dislocation, postoperative reduction, fixation stability, and bone healing. The same technique was used to treat 15 patients with 18 CNF and short condylar segments. Hardware removal was performed for nine fractures in eight patients after fracture healing using the same approach.

All patients regained satisfactory, pain-free mouth opening with no deviation and complete bone healing. Computed tomographic images displayed adequate reduction and stable fixation during the follow-up period for all patients. No temporary or permanent facial nerve impairment occurred in any of the patients.

TERIF is a reliable and safe treatment for CNF with short condylar segments, even in the presence of head dislocation, medial override, and malunited fractures; hardware can be safely removed after healing using the same approach.

本研究旨在评估经口内窥镜辅助复位内固定术(TERIF)治疗短节段髁状突颈部骨折(CNF)的可靠性和安全性,包括硬件移除。临床评估包括牙齿咬合、张口范围、张口时的偏差、前突、后突、疼痛和咀嚼。放射学评估用于评估骨折移位、成角、头部脱位、术后复位、固定稳定性和骨愈合。同样的技术用于治疗 15 名患者的 18 个 CNF 和短髁状突。所有患者都恢复了令人满意的无痛张口功能,无偏斜,骨愈合完全。在随访期间,计算机断层扫描图像显示所有患者的骨折都得到了充分的复位和稳定的固定。TERIF 是治疗髁状突短节 CNF 的一种可靠而安全的方法,即使在存在头部脱位、内侧覆盖和错合骨折的情况下也是如此。
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引用次数: 0
期刊
Journal of Cranio-Maxillofacial Surgery
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