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Effects of Anti-Predator Behavior on a Stochastic Predator-Prey System 反捕食者行为对随机捕食者-猎物系统的影响
IF 1.6 4区 数学 Q2 Agricultural and Biological Sciences Pub Date : 2024-02-23 DOI: 10.1142/s0218339024500219
Yanan Sun, Youming Lei, Xinzhi Liu
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引用次数: 0
The Impact of Stochastic Environment on Psychological Health Dynamics 随机环境对心理健康动态的影响
IF 1.6 4区 数学 Q2 Agricultural and Biological Sciences Pub Date : 2024-02-23 DOI: 10.1142/s0218339024500207
Feng Rao, Anqi Wang, Zhanyu Wang
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引用次数: 0
ENDEAVORING THE ROLE OF OBESITY IN EXTRACELLULAR MATRIX DEGRADATION LEADING TO METASTASIS 研究肥胖在细胞外基质降解导致转移中的作用
IF 1.6 4区 数学 Q2 Agricultural and Biological Sciences Pub Date : 2024-02-06 DOI: 10.1142/s0218339024500153
Ani Jain, Parimita Roy
One of the significant causes of death globally is cancer ( http://www.who.org/ ). Another critical problem is obesity, which is associated with an increased cancer threat. This work provides insight into how obesity contributes to cancer progression and metastasis. We developed a diffusive obesity-cancer model consisting of cancer cells, normal cells, fat cells, macrophages, and an extracellular matrix (ECM) for this aim. We have directed the formed model’s global existence and non-negativity. Equilibrium points for the related ODE are calculated, and its existence and stability study is also done. We present a traveling wave analysis of the obesity-cancer model and have calculated the minimum wave speed. Using a combination of analytic and numerical results of traveling waves, we conjecture that the minimal wave speed depends on fat cells’ diffusive rate and haptotaxis coefficient. We followed the theory of the Partial Rank Correlation Coefficient (PRCC) to carry out a global sensitivity analysis to evaluate the most sensitive parameters reliable for cancer progression. We delivered a comprehensive numerical analysis of our deterministic and diffusive models (in 1D and 2D) and analogized the result. Numerical simulation of corresponding spatially explicit systems conveys complex spatio-temporal dynamics, resulting in the appearance of patterns. It also discloses that cancer spread increases with increased haptotaxis coefficient and growth rate of obese cells. Our simulation confirms that the degradation of the ECM increases cancer spread and density.
癌症是全球死亡的重要原因之一 ( http://www.who.org/ )。另一个关键问题是肥胖,肥胖与癌症威胁的增加有关。这项研究深入探讨了肥胖是如何导致癌症进展和转移的。为此,我们建立了一个由癌细胞、正常细胞、脂肪细胞、巨噬细胞和细胞外基质(ECM)组成的扩散性肥胖-癌症模型。我们对该模型的全局存在性和非负性进行了研究。我们计算了相关 ODE 的平衡点,并对其存在性和稳定性进行了研究。我们对肥胖-癌症模型进行了行波分析,并计算了最小波速。结合行波的解析和数值结果,我们推测最小波速取决于脂肪细胞的扩散速率和游走系数。我们根据部分秩相关系数(PRCC)理论进行了全局敏感性分析,以评估对癌症进展最可靠的敏感参数。我们对确定性模型和扩散性模型(一维和二维)进行了全面的数值分析,并对结果进行了类比。对相应的空间显式系统进行的数值模拟传达了复杂的时空动态,从而产生了一些模式。它还揭示了癌症扩散会随着肥胖细胞游走系数和生长速度的增加而增加。我们的模拟证实,ECM 的退化会增加癌症的扩散和密度。
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引用次数: 0
OPTIMAL CONTROL ON FRACTIONAL ENZYME KINETICS WITH INHIBITORS 带抑制剂的部分酶动力学优化控制
IF 1.6 4区 数学 Q2 Agricultural and Biological Sciences Pub Date : 2024-02-01 DOI: 10.1142/s0218339024500189
M. Vellappandi, J. Kokila, V. Govindaraj
In enzyme kinetic chemical reaction, inhibitors are working as a regulators of the metabolism of the systems and the biochemical activities as well. The main focus of this study is to explore the fractional dynamics of enzyme kinetic biochemical reactions with competitive and uncompetitive inhibitors. Further, the analysis continuous with the optimal controls on the system which accelerate biochemical reactions and maximize product generation. Eventually, the numerical analysis have been done by the Adams predictor–corrector method and the forward–backward sweep method for the dynamics and optimal control study, respectively.
在酶促化学反应中,抑制剂是系统代谢和生化活动的调节剂。本研究的重点是探索有竞争性和无竞争性抑制剂的酶促生化反应的分数动态。此外,分析还包括对系统的最佳控制,以加速生化反应并最大限度地生成产物。最后,在动力学和最优控制研究中,分别采用亚当斯预测-校正方法和前向-后向扫频方法进行了数值分析。
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引用次数: 0
OPTIMAL CONTROL ON FRACTIONAL ENZYME KINETICS WITH INHIBITORS 带抑制剂的部分酶动力学优化控制
IF 1.6 4区 数学 Q2 Agricultural and Biological Sciences Pub Date : 2024-02-01 DOI: 10.1142/s0218339024500189
M. Vellappandi, J. Kokila, V. Govindaraj
In enzyme kinetic chemical reaction, inhibitors are working as a regulators of the metabolism of the systems and the biochemical activities as well. The main focus of this study is to explore the fractional dynamics of enzyme kinetic biochemical reactions with competitive and uncompetitive inhibitors. Further, the analysis continuous with the optimal controls on the system which accelerate biochemical reactions and maximize product generation. Eventually, the numerical analysis have been done by the Adams predictor–corrector method and the forward–backward sweep method for the dynamics and optimal control study, respectively.
在酶促化学反应中,抑制剂是系统代谢和生化活动的调节剂。本研究的重点是探索有竞争性和无竞争性抑制剂的酶促生化反应的分数动态。此外,分析还包括对系统的最佳控制,以加速生化反应并最大限度地生成产物。最后,在动力学和最优控制研究中,分别采用亚当斯预测-校正方法和前向-后向扫频方法进行了数值分析。
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引用次数: 0
MATHEMATICAL MODEL FOR SYSTEM DYNAMICS OF (Ca2+) AND DOPAMINE IN A FIBROBLAST CELL 纤维泡沫细胞中(Ca2+)和多巴胺的系统动力学数学模型
IF 1.6 4区 数学 Q2 Agricultural and Biological Sciences Pub Date : 2024-02-01 DOI: 10.1142/s0218339024500177
Ankit Kothiya, N. Adlakha
Fibroblasts significantly affect wound healing, cancer progression and development. Disturbances in the calcium [Formula: see text] and dopamine [Formula: see text] dynamics leads to fibrotic disorders like cancer and fibrosis. Calcium signaling is required for [Formula: see text] concentrations in fibroblasts. Alteration in the many processes of [Formula: see text] kinetics can disturb [Formula: see text] regulation in fibroblast cells. No model has been reported till date for the study of spatiotemporal relationships of [Formula: see text] with calcium signaling in fibroblasts. A model is provided here to study the dynamic relationship of [Formula: see text] regulation with calcium signaling in a fibroblast cell. Finite element and Crank–Nicholson techniques are employed for numerical simulation. The numerical results provide insights into the buffer, source influx, and diffusion effects on the spatiotemporal dynamics of [Formula: see text] and [Formula: see text] in a fibroblast. Disturbances in the constitutive processes in the system dynamics of [Formula: see text] and [Formula: see text] can cause fibrotic diseases such as fibrosis and cancer in various organs.
成纤维细胞对伤口愈合、癌症进展和发展有着重要影响。钙[计算公式:见正文]和多巴胺[计算公式:见正文]动态紊乱会导致癌症和纤维化等纤维化疾病。成纤维细胞中的[公式:见正文]浓度需要钙信号传递。改变[公式:见正文]动力学的许多过程会扰乱成纤维细胞中的[公式:见正文]调节。迄今为止,还没有研究成纤维细胞中[公式:见正文]与钙信号转导时空关系的模型。本文提供了一个模型来研究成纤维细胞中[公式:见正文]调控与钙信号传导的动态关系。数值模拟采用了有限元和 Crank-Nicholson 技术。数值结果深入揭示了缓冲、源流入和扩散对成纤维细胞中[公式:见正文]和[公式:见正文]时空动态的影响。公式:见正文]和[公式:见正文]系统动力学组成过程的紊乱可导致纤维化疾病,如各种器官的纤维化和癌症。
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引用次数: 0
MATHEMATICAL MODEL FOR SYSTEM DYNAMICS OF (Ca2+) AND DOPAMINE IN A FIBROBLAST CELL 纤维泡沫细胞中(Ca2+)和多巴胺的系统动力学数学模型
IF 1.6 4区 数学 Q2 Agricultural and Biological Sciences Pub Date : 2024-02-01 DOI: 10.1142/s0218339024500177
Ankit Kothiya, N. Adlakha
Fibroblasts significantly affect wound healing, cancer progression and development. Disturbances in the calcium [Formula: see text] and dopamine [Formula: see text] dynamics leads to fibrotic disorders like cancer and fibrosis. Calcium signaling is required for [Formula: see text] concentrations in fibroblasts. Alteration in the many processes of [Formula: see text] kinetics can disturb [Formula: see text] regulation in fibroblast cells. No model has been reported till date for the study of spatiotemporal relationships of [Formula: see text] with calcium signaling in fibroblasts. A model is provided here to study the dynamic relationship of [Formula: see text] regulation with calcium signaling in a fibroblast cell. Finite element and Crank–Nicholson techniques are employed for numerical simulation. The numerical results provide insights into the buffer, source influx, and diffusion effects on the spatiotemporal dynamics of [Formula: see text] and [Formula: see text] in a fibroblast. Disturbances in the constitutive processes in the system dynamics of [Formula: see text] and [Formula: see text] can cause fibrotic diseases such as fibrosis and cancer in various organs.
成纤维细胞对伤口愈合、癌症进展和发展有着重要影响。钙[计算公式:见正文]和多巴胺[计算公式:见正文]动态紊乱会导致癌症和纤维化等纤维化疾病。成纤维细胞中的[公式:见正文]浓度需要钙信号传递。改变[公式:见正文]动力学的许多过程会扰乱成纤维细胞中的[公式:见正文]调节。迄今为止,还没有研究成纤维细胞中[公式:见正文]与钙信号转导时空关系的模型。本文提供了一个模型来研究成纤维细胞中[公式:见正文]调控与钙信号传导的动态关系。数值模拟采用了有限元和 Crank-Nicholson 技术。数值结果深入揭示了缓冲、源流入和扩散对成纤维细胞中[公式:见正文]和[公式:见正文]时空动态的影响。公式:见正文]和[公式:见正文]系统动力学组成过程的紊乱可导致纤维化疾病,如各种器官的纤维化和癌症。
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引用次数: 0
MODELING THE IMPACT OF RAINFALL AND TEMPERATURE ON STERILE INSECT CONTROL STRATEGIES IN A TROPICAL ENVIRONMENT 模拟降雨和温度对热带环境中昆虫不育控制策略的影响
IF 1.6 4区 数学 Q2 Agricultural and Biological Sciences Pub Date : 2024-01-05 DOI: 10.1142/s0218339024500128
Y. DUMONT, M. DUPREZ

The sterile insect technique (SIT) is a biological control technique that can be used either to eliminate or decay a wild mosquito population under a given threshold to reduce the nuisance or the epidemiological risk. In this work, we propose a model using a differential system that takes into account the variations of rainfall and temperature over time and study their impacts on sterile males’ releases strategies. Our model is as simple as possible to avoid complexity while being able to capture the temporal variations of an Aedes albopictus mosquito population in a domain treated by SIT, located in Réunion island. The main objective is to determine what period of the year is the most suitable to start a SIT control to minimize the duration of massive releases and the number of sterile males to release, either to reduce the mosquito nuisance, or to reduce the epidemiological risk. Since sterilization is not 100% efficient, we also study the impact of different levels of residual fertility within the released sterile males population. Our study shows that rainfall plays a major role in the dynamics of the mosquito and the SIT control, that the best period to start a massive SIT treatment lasts from July to December, that residual fertility has to be as small as possible, at least for nuisance reduction. Indeed, when the main objective is to reduce the epidemiological risk, we show that residual fertility is not necessarily an issue. Increasing the size of the releases is not always interesting. We also highlight the importance of combining SIT with mechanical control, i.e., the removal of breeding sites, in particular when the initial mosquito population is large. Last but not least our study shows the usefulness of the modeling approach to derive various simulations to anticipate issues and demand in terms of sterile insects’ production.

昆虫不育技术(SIT)是一种生物控制技术,既可用于消灭野生蚊子种群,也可用于在给定阈值下使其衰减,以减少滋扰或流行病风险。在这项工作中,我们提出了一个考虑到降雨量和温度随时间变化的差分系统模型,并研究了它们对不育雄蚊释放策略的影响。我们的模型尽可能简单,以避免复杂性,同时能够捕捉到位于留尼汪岛的白纹伊蚊种群在经 SIT 处理的区域内的时间变化。主要目的是确定一年中哪个时期最适合开始 SIT 控制,以尽量缩短大规模释放的持续时间和释放不育雄蚊的数量,从而减少蚊虫滋扰或降低流行病风险。由于绝育并非百分之百有效,我们还研究了释放的不育雄蚊群体中不同水平的剩余生育力的影响。我们的研究表明,降雨量对蚊子的动态和 SIT 控制起着重要作用,从 7 月到 12 月是开始大规模 SIT 处理的最佳时期,残余繁殖力必须尽可能小,至少是为了减少滋扰。事实上,当主要目标是降低流行病学风险时,我们发现剩余生殖力并不一定是个问题。增加释放量并不总是有意义的。我们还强调了将 SIT 与机械控制(即清除繁殖地)相结合的重要性,尤其是在初始蚊虫数量较大时。最后但并非最不重要的一点是,我们的研究显示了建模方法的实用性,可以通过各种模拟来预测不育昆虫生产方面的问题和需求。
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引用次数: 0
Impact of hunting cooperation and fear effect in a generalist predator-prey model 综合捕食者-猎物模型中狩猎合作和恐惧效应的影响
IF 1.6 4区 数学 Q2 Agricultural and Biological Sciences Pub Date : 2023-11-28 DOI: 10.1142/s021833902340003x
Anuj Kumar Umrao, Prashant K. Srivastava
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引用次数: 0
BIFURCATION ANALYSIS AND CHAOS CONTROL OF DISCRETE PREDATOR–PREY MODEL WITH ADDITIVE ALLEE EFFECT 具有加法等位基因效应的离散捕食者-猎物模型的分岔分析与混沌控制
IF 1.6 4区 数学 Q2 Agricultural and Biological Sciences Pub Date : 2023-11-21 DOI: 10.1142/s0218339023500493
Hanghang Li, Xinli Hu
This paper presents a study of a discrete prey–predator model with additive Allee effect. The model is discretized using the forward Euler method, and the system is analyzed using bifurcation theory and chaos control. The equilibrium point of the discrete system is obtained through equilibrium analysis, and the stability of the equilibrium point is determined by analyzing the parameter conditions. The study also establishes the existence and direction of Neimark–Sacker bifurcation at the positive equilibrium point. The paper proposes two control strategies to manage chaotic behavior and Neimark–Sacker bifurcation: exponential control and hybrid feedback control. These control methods are demonstrated to be effective in controlling the chaotic behavior and bifurcation of the system through numerical simulation. Overall, the results of the study provide important insights into the dynamics of the discrete prey–predator model with additive Allee effect, as well as effective methods for controlling chaos and bifurcation in the system.
本文研究了一个具有加性阿利效应的离散猎物-捕食者模型。采用正演欧拉法对模型进行离散化,并利用分岔理论和混沌控制对系统进行分析。通过平衡分析得到离散系统的平衡点,并通过分析参数条件确定平衡点的稳定性。研究还确定了正平衡点处 Neimark-Sacker 分岔的存在和方向。论文提出了两种控制策略来控制混沌行为和 Neimark-Sacker 分叉:指数控制和混合反馈控制。通过数值模拟,证明了这些控制方法能有效地控制系统的混沌行为和分岔。总之,研究结果为研究具有加性阿利效应的离散捕食者-捕食者模型的动力学提供了重要启示,也为控制该系统的混沌和分岔提供了有效方法。
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引用次数: 0
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Journal of Biological Systems
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