Joint Bone Spine最新文献

英文中文

Managing the disease, managing the patient: Towards a comprehensive diagnostic appraoch in psoriatic arthritis and spondyloarthritis

IF 3.8 3区医学 Q1 RHEUMATOLOGY

Joint Bone Spine

Pub Date : 2025-01-29 DOI: 10.1016/j.jbspin.2025.105843

Rik J. Lories

引用次数: 0

Defining a genetic background for bamboo spine and axial spondyloarthritis 确定竹脊柱和轴性脊柱炎的遗传背景。

IF 3.8 3区医学 Q1 RHEUMATOLOGY

Joint Bone Spine

Pub Date : 2025-01-17 DOI: 10.1016/j.jbspin.2025.105842

Şeyma Çolakoğlu Özkaya , Kerem Abacar , Yunus Emre Dilek , Günseli Bayram Akçapınar , Mehmet Pamir Atagündüz , Can Erzik

Objective

Bamboo spine is the most severe complication of axial spondyloarthritis (AxSpA). This study aims to address whether haplotypes of endoplasmic reticulum aminopeptidase (ERAP)1 and ERAP2 single nucleotide polymorphisms (SNPs), previously associated with AxSpA, are associated with the development of bamboo spine in an AxSpA cohort.

Methods

The study included 192 patients with AxSpA followed in MARS (MARmara Spondyloarthritis) clinic and fulfilling the modified New York criteria. ERAP1 and ERAP2 polymorphisms were determined by real-time PCR on genomic DNA using the TaqMan SNP Genotyping Assay for SNPs rs72773968, rs3734016, rs26653, rs26618, rs27895, rs2287987, rs30187, rs10050860, rs17482078, rs27044, rs2549782, rs2248374. The HLA-B genotypes were assessed using the LABTypeTM SSO method.

Results

Male gender (P < 0.001) and HLA-B27 positivity (P < 0.05) were associated with an increased risk of developing a bamboo spine, and peripheral arthritis was significantly less prevalent in AxSpA patients with a bamboo spine (P < 0.05). Of the ten ERAP1 haplotypes, haplotype 3 was significantly more prevalent in AxSpA patients with bamboo spine adjusted for HLA-B27 status (P < 0.05). Haplotype 3 and -6 were significantly more prevalent exclusively in HLA-B27 (+) patients (P < 0.05). Allele frequencies and genotype distributions of single ERAP1 SNPs alone were not significantly different between AxSpA patients with and without bamboo spines. There was no association between bamboo spine development and ERAP2 SNPs.

Conclusions

Our results indicate that HLA-B27 positivity, ERAP1 haplotype 3 and -6, and being male confer a significant risk for developing bamboo spine. Whether the association of haplotype 3 and -6 with bamboo spine is confined only to our Turkish patient cohort may deserve attention in other ethnicities.

目的：竹棘是中轴性脊柱炎（AxSpA）最严重的并发症。本研究旨在研究先前与AXSPA相关的内质网氨基肽酶（ERAP）1和ERAP2单核苷酸多态性（snp）的单倍型是否与AXSPA队列中竹脊柱的发育相关。方法：研究纳入192例在MARS（马尔马拉性脊柱炎）诊所接受AxSpA随访并符合修改后的纽约标准的患者。采用TaqMan SNP基因分型法，实时荧光定量PCR检测ERAP1和ERAP2基因多态性rs72773968、rs3734016、rs26653、rs26618、rs27895、rs2287987、rs30187、rs10050860、rs17482078、rs27044、rs2549782、rs2248374。采用LABTypeTM单点检测法进行HLA-B基因型鉴定。结论：HLA-B27阳性、ERAP1单倍型3和-6、男性与竹棘发生有显著关系。单倍型-3和-6与竹棘的关联是否仅局限于我们的土耳其患者队列，值得在其他种族中关注。

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引用次数: 0

Corrigendum to “Is the microRNA-146a (rs2910164) polymorphism associated with rheumatoid arthritis? Association of microRNA-146a (rs2910164) polymorphism and rheumatoid arthritis could depend on gender” [Joint Bone Spine 2015; 82 :166–71] “microRNA-146a （rs2910164）多态性与类风湿关节炎相关吗？”microRNA-146a （rs2910164）多态性与类风湿关节炎的相关性可能与性别有关。82: 166 - 71)。

IF 3.8 3区医学 Q1 RHEUMATOLOGY

Joint Bone Spine

Pub Date : 2025-01-01 DOI: 10.1016/j.jbspin.2024.105808

Xindie Zhou , Jinlong Zhu , Hui Zhang , Guoxin Zhou , Yong Huang , Ruiping Liu

引用次数: 0

Detecting new erosions in rheumatoid arthritis over one year – Radiography and high-resolution computed tomography of finger joints 检测类风湿性关节炎患者一年内的新侵蚀--手指关节的 X 射线照相术和高分辨率计算机断层扫描。

IF 3.8 3区医学 Q1 RHEUMATOLOGY

Joint Bone Spine

Pub Date : 2025-01-01 DOI: 10.1016/j.jbspin.2024.105812

Josephine Therkildsen , Rasmus Klose-Jensen , Mathias Hänel , Bente L. Langdahl , Jesper S. Thomsen , Sarah L. Manske , Kresten K. Keller , Ellen-Margrethe Hauge

Objective

To compare the number of new erosions in two metacarpophalangeal (MCP) joints over one year assessed by high-resolution peripheral quantitative computed tomography (HR-pQCT) and conventional radiography (CR). Furthermore, to estimate the diagnostic accuracy of erosive progression by CR with HR-pQCT as the reference standard.

Methods

Paired sets of image data were available from patients with RA (n = 310), who underwent HR-pQCT and CR, including the 2nd and 3rd MCP joints only of the dominant hand at baseline and at the one-year follow-up. Erosion number was determined using HR-pQCT and CR. Erosive volume was estimated from segmented HR-pQCT images, and erosion scores were obtained by the Sharp/van der Heijde method from CR. Erosive progression was defined as an increase in total erosion number or a study-specified increase in total erosive volume or total erosion score.

Results

At baseline, 250 erosions were identified by CR compared to 1864 erosions by HR-pQCT. After one year, 3 new erosions were detected by CR compared to 66 new erosions by HR-pQCT. Erosive progression was identified in 40 patients using HR-pQCT and in 3 patients using CR. With HR-pQCT as reference, CR had a sensitivity of 2.5% (95% CI: 0.1–13.2%) and a specificity of 99.3% (95% CI: 97.3–99.9%) for detecting erosive progression.

Conclusion

HR-pQCT identified more than 20 times the number of new erosions, and more than 10 times as many patients with erosive progression than CR. HR-pQCT is a sensitive tool for monitoring new erosions and erosive progression over one year in RA.

目的比较通过高分辨率外周定量计算机断层扫描（HR-pQCT）和传统放射摄影（CR）评估的两个掌指关节（MCP）一年内新侵蚀的数量。此外，以高分辨率外周定量计算机断层扫描（HR-pQCT）为参考标准，评估CR对侵蚀性进展的诊断准确性：方法：对接受HR-pQCT和CR检查的RA患者（n=310）提供了成对的图像数据集，这些患者在基线和一年随访时仅接受了包括惯用手第2和第3MCP关节在内的检查。通过 HR-pQCT 和 CR 确定侵蚀数量。侵蚀体积根据分段的 HR-pQCT 图像估算，侵蚀评分根据 CR 用 Sharp/van der Heijde 方法获得。侵蚀进展的定义是侵蚀总数的增加或研究指定的侵蚀总体积或侵蚀总分的增加：基线时，CR确定了250处糜烂，而HR-pQCT确定了1864处糜烂。一年后，CR 发现了 3 个新的糜烂，而 HR-pQCT 发现了 66 个新的糜烂。使用 HR-pQCT 的 40 例患者和使用 CR 的 3 例患者均发现了侵蚀进展。以HR-pQCT为参考，CR检测侵蚀进展的敏感性为2.5%（95% CI：0.1-13.2%），特异性为99.3%（95% CI：97.3-99.9%）：结论：HR-pQCT发现的新糜烂数量是CR的20倍以上，糜烂进展患者的数量是CR的10倍以上。HR-pQCT是监测RA一年内新发侵蚀和侵蚀进展的灵敏工具。

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引用次数: 0

Association between ankylosing spondylitis and neurodegenerative diseases: Systematic review and meta-analysis 强直性脊柱炎与神经退行性疾病之间的关系：系统回顾与荟萃分析。

IF 3.8 3区医学 Q1 RHEUMATOLOGY

Joint Bone Spine

Pub Date : 2025-01-01 DOI: 10.1016/j.jbspin.2024.105793

Anling Luo , Qin Yang , Zhao Zhang, Yujia Yang, Xuzi Li, Yiting Deng, Li He, Muke Zhou

Background

Increasing evidence indicates the mechanism of overlapping immune dysfunction and inflammation disorder shared by ankylosing spondylitis (AS) and neurodegenerative diseases (NDs). However, the exact correlation between the two is still unclear. Different studies have reported inconsistent results about how AS and NDs are related.

Objective

This study aimed to investigate the association between AS and risk of NDs.

Methods

We searched electronic databases including PubMed, EMBASE, Web of Science, and Cochrane Central Register of Controlled Trials to identify studies reporting relationship between NDs risk and AS published before April 10th, 2024. Pooled odds ratios (ORs) and corresponding 95% confidence intervals (95% CIs) were estimated. All analyses were conducted using Stata V.12.0 software.

Results

A total of 15 comparisons out of 10 studies involving 851,936 participants were included. The results showed that the risk of NDs was higher among AS patients than those who were not (OR: 1.36, 95% CI: 1.15–1.60, P < 0.001). In addition, subgroup analysis showed that AS was associated with an increased risk of Parkinson's disease (PD) development (OR: 1.55, 95% CI: 1.31–1.83, P < 0.001), whereas there is no observed association with Alzheimer's disease (AD) and dementia (OR: 1.22, 95% CI: 0.96–1.55, P = 0.098; OR: 1.34, 95% CI: 0.96–1.87, P = 0.089, respectively).

Conclusion

The current meta-analysis identified AS as a risk factor for the development of NDs. Clinicians should be aware of the potential association between these diseases. Further research is necessary to confirm the causal relationship and underlying mechanisms between AS and NDs.

背景：越来越多的证据表明，强直性脊柱炎（AS）和神经退行性疾病（NDs）存在免疫功能障碍和炎症紊乱的重叠机制。然而，两者之间的确切相关性仍不清楚。关于强直性脊柱炎和神经退行性疾病之间的关系，不同研究的结果并不一致：本研究旨在探讨强直性脊柱炎与 NDs 风险之间的关系：我们检索了电子数据库，包括 PubMed、EMBASE、Web of Science 和 Cochrane Central Register of Controlled Trials，以确定 2024 年 4 月 10 日之前发表的报告 NDs 风险与 AS 之间关系的研究。估计了汇总的几率比（OR）和相应的 95% 置信区间（CI）。所有分析均使用Stata V.12.0软件进行：共纳入了 10 项研究中的 15 项比较，涉及 851 936 名参与者。结果显示，强直性脊柱炎患者的玖玖彩票网正规吗风险高于非强直性脊柱炎患者（OR 1.36，95% CI 1.15-1.60，P < 0.001）。此外，亚组分析表明，强直性脊柱炎与帕金森病（PD）发病风险增加有关（OR 1.55，95% CI 1.31-1.83，P <0.001），而与阿尔茨海默病（AD）和痴呆症（分别为OR 1.22，95% CI 0.96-1.55，P = 0.098；OR 1.34，95% CI 0.96-1.87，P = 0.089）没有相关性：目前的荟萃分析确定强直性脊柱炎是玖玖彩票android客户端发病的一个风险因素。临床医生应该意识到这些疾病之间的潜在关联。有必要开展进一步研究，以确认强直性脊柱炎与 NDs 之间的因果关系和潜在机制。

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引用次数: 0

A large-scale multi-omics polygenic risk score analysis identified candidate risk locus associated with rheumatoid arthritis 一项大规模的多组学多基因风险评分分析确定了与类风湿关节炎相关的候选风险位点。

IF 3.8 3区医学 Q1 RHEUMATOLOGY

Joint Bone Spine

Pub Date : 2024-12-26 DOI: 10.1016/j.jbspin.2024.105841

Jingni Hui , Dan He , Chen Liu, Panxing Shi, Ruixue Zhou, Meijuan Kang, Ye Liu, Yifan Gou, Bingyi Wang, Shiqiang Cheng, Xuena Yang, Chuyu Pan, Wenming Wei, Feng Zhang

Objective

This study aimed to investigate the associations of multi-omics polygenic risk score (PRS) and rheumatoid arthritis (RA) to identify potential genes/proteins and biological pathways.

Methods

Based on multi-omics data from 48,813 participants in the INTERVAL cohort, we calculated multi-omics PRS for 13,646 mRNAs (RNASeq), 308 proteins (Olink), 2380 proteins (SomaScan), 726 metabolites (Metabolon), and 141 metabolites (Nightingale). Using the generalized linear model, we first evaluated the associations between multi-omics PRS and RA in 58,813 UK Biobank participants. The Gene Ontology (GO) project and Kyoto Encyclopedia of Genes and Genomes (KEGG) were performed to identify the functional pathways in RA. Furthermore, differential gene expression profile datasets were used to validate the identified genes/proteins in our study.

Results

We identified 59 transcriptomics PRS and 29 proteomics PRS significantly associated with RA. Both proteomics and transcriptomic PRS identified HLA-DQA2 (RNASeq: OR = 1.19, P = 1.18 × 10^–24; SomaScan: OR = 1.24, P = 4.43 × 10^–27) and AGER (RNASeq: OR = 0.91, P = 4.18 × 10^–4; SomaScan: OR = 0.93, P = 3.97 × 10^–3) were significantly associated with RA. Proteomic PRS from different profiling platforms (SomaScan and Olink) identified a consistent association between TFF3 (SomaScan: OR = 0.90, P = 4.08 × 10^–6; Olink: OR = 0.93, P = 4.87 × 10^–3) and RA. The identified gene/proteins were mainly enriched in the NF-kappa B signaling pathway (hsa04064, P = 5.06 × 10^–5) and Cytokine-cytokine receptor interaction (hsa04060, P = 2.49 × 10^–4). In addition, a total of 12 candidate genes in our study were verified in two independent GEO datasets, such as FLOT1 and ABCF1.

Conclusion

Our findings provide novel insights into the involvement of identified genes/proteins and pathways in the pathogenesis of RA from multi-omics levels.

目的：本研究旨在探讨多组学多基因风险评分（PRS）与类风湿关节炎（RA）的相关性，以发现潜在的基因/蛋白和生物学途径。方法：基于来自INTERVAL队列中48813名参与者的多组学数据，我们计算了13646种mrna （RNASeq）、308种蛋白质（Olink）、2380种蛋白质（SomaScan）、726种代谢物（Metabolon）和141种代谢物（Nightingale）的多组学PRS。使用广义线性模型，我们首先评估了58,813名英国生物银行参与者的多组学PRS和RA之间的关系。通过基因本体（GO）计划和京都基因与基因组百科全书（KEGG）来确定RA的功能途径。此外，差异基因表达谱数据集用于验证我们研究中鉴定的基因/蛋白。结果：我们鉴定出59个转录组PRS和29个蛋白质组PRS与RA显著相关。蛋白质组学和转录组学均鉴定出HLA-DQA2 (RNASeq: OR=1.19， P=1.18×10-24；SomaScan: OR=1.24， P=4.43×10-27)和AGER (RNASeq: OR=0.91， P=4.18×10-4；SomaScan: OR=0.93， P=3.97×10-3)与RA显著相关。来自不同分析平台（SomaScan和Olink）的蛋白质组学PRS确定了TFF3之间的一致关联(SomaScan: OR=0.90， P=4.08×10-6；相关性：OR=0.93， P=4.87×10-3)和RA。所鉴定的基因/蛋白主要富集于NF-kappa B信号通路（hsa04064， P=5.06×10-5）和细胞因子-细胞因子受体相互作用（hsa04060， P=2.49×10-4）。此外，我们的研究中共有12个候选基因在两个独立的GEO数据集中进行了验证，如FLOT1和ABCF1。结论：我们的研究结果从多组学水平对已鉴定的基因/蛋白和途径参与RA的发病机制提供了新的见解。

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引用次数: 0

Translation and cross-cultural adaptation of the Coping with Rheumatic Stressors (CORS) into French language 《应对风湿病应激源》的法语翻译与跨文化改编。

IF 3.8 3区医学 Q1 RHEUMATOLOGY

Joint Bone Spine

Pub Date : 2024-12-26 DOI: 10.1016/j.jbspin.2024.105839

Clementina López-Medina , Sofia Ramiro , Caroline van Durme , Zineb Ez-Zaitouni , Adrien Nzeusseu Toukap , Olivier Fogel , Anna Moltó

引用次数: 0

Predictors of return to work after multidisciplinary rehabilitation program for patients with chronic low back pain 慢性腰痛患者多学科康复计划后重返工作岗位的预测因素。

IF 3.8 3区医学 Q1 RHEUMATOLOGY

Joint Bone Spine

Pub Date : 2024-12-26 DOI: 10.1016/j.jbspin.2024.105840

Stéphane Le Cam , Violaine Foltz , Bruno Fautrel , Florian Bailly

Introduction

Patients with chronic low back pain face functional, psychological, social and professional difficulties. Multidisciplinary rehabilitation programs (MRP) can be an effective treatment to help these patients to improve their condition and return to work.

Objective

To determine baseline predictors for return to work after an MRP for patients with chronic low back pain struggling to maintain their job.

Methods

A monocentric cohort study was conducted. Patients who had followed a MRP between January 2015 and December 2020 were included. The program consisted of physical activities and different workshops inspired by behavioural therapy, at full time during one month. Pain, lifestyle, history of the disease, function, psychosocial characteristics were evaluated at baseline. Return to work at different possible time point after the MRP was collected. A bivariate and a multivariate analysis were performed to evaluate which factors were associated with return to work.

Results

Overall, 251 patients were included. Professional status, duration off work, intensity of low back pain, self-perceived disability, fear-avoidance beliefs at work were associated with return to work after the MRP on bivariate analysis. Having worked in the past 6 months and the absence of high fear-avoidance beliefs at work at baseline were associated with return to work on multivariate analysis.

Discussion

This study suggests that patients with chronic low back pain and professional difficulties need to be included quickly in a MRP, with specific attention to beliefs about pain.

慢性腰痛患者面临着功能、心理、社会和专业方面的困难。多学科康复项目（MRP）是一种有效的治疗方法，可以帮助这些患者改善病情并重返工作岗位。目的：确定慢性腰痛患者努力维持工作的MRP后重返工作的基线预测因素。方法：采用单中心队列研究。纳入了2015年1月至2020年12月期间接受MRP的患者。该项目包括一个月的全天体育活动和受行为疗法启发的不同工作坊。在基线时评估疼痛、生活方式、病史、功能、心理社会特征。在MRP收集后的不同时间点返回工作岗位。进行了双变量和多变量分析，以评估哪些因素与重返工作岗位有关。结果：共纳入251例患者。双变量分析显示，职业状态、休息时间、腰痛强度、自我感知残疾、工作恐惧回避信念与MRP后重返工作岗位相关。多变量分析表明，过去6个月的工作经历和在基线时不存在高度恐惧回避信念与重返工作岗位有关。讨论：本研究表明，慢性腰痛和专业困难的患者需要迅速纳入MRP，特别注意对疼痛的信念。

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引用次数: 0

Transient migratory osteoporosis of epiphyseal lower limbs during FLOT chemotherapy for gastric cancer 胃癌FLOT化疗期间下肢骨骺一过性迁移性骨质疏松。

IF 3.8 3区医学 Q1 RHEUMATOLOGY

Joint Bone Spine

Pub Date : 2024-12-24 DOI: 10.1016/j.jbspin.2024.105829

Arthur Bouchut , Gilles Grimon , Xavier Mariette , Gaetane Nocturne

引用次数: 0

Inflammation and depressive mood 炎症和抑郁情绪。

IF 3.8 3区医学 Q1 RHEUMATOLOGY

Joint Bone Spine

Pub Date : 2024-12-22 DOI: 10.1016/j.jbspin.2024.105832

Cédric Lemogne , Charles Ouazana Vedrines , Lucile Capuron , Nicolas Hoertel

引用次数: 0

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