{"title":"Comment on “An update on stroke and transient ischemic attack in Takayasu arteritis: A systematic review and meta-analysis” by Jin et al. Joint Bone Spine 2026;93:105951","authors":"Arun Kumar , Rashmi Mishra , Hariharan Srinivasan , Pradanya Phalak","doi":"10.1016/j.jbspin.2025.106007","DOIUrl":"10.1016/j.jbspin.2025.106007","url":null,"abstract":"","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"93 1","pages":"Article 106007"},"PeriodicalIF":4.3,"publicationDate":"2025-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145531014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-13DOI: 10.1016/j.jbspin.2025.106006
Juan-Manuel Anaya , Ivan David Lozada-Martinez
{"title":"One Health and rheumatology: Research gaps and opportunities for action","authors":"Juan-Manuel Anaya , Ivan David Lozada-Martinez","doi":"10.1016/j.jbspin.2025.106006","DOIUrl":"10.1016/j.jbspin.2025.106006","url":null,"abstract":"","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"93 3","pages":"Article 106006"},"PeriodicalIF":4.3,"publicationDate":"2025-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145531043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-13DOI: 10.1016/j.jbspin.2025.106008
Adamah Amouzougan , Myriam Normand , Hervé Locrelle , Laure Mathevon , Elisa Dalix , Pierre Garnier , Paul Calmels , Hubert Marotte , Thierry Thomas
Objectives
Stroke is the leading cause of acquired physical disability. In recent years, there has been a decline in early mortality due to acute medical care as well as better and earlier prevention of adverse events after stroke, therefore exposing more these patients to fragility fractures. We report very early assessment of bone microarchitecture changes in the first months following stroke-induced hemiplegia in a monocentric prospective study.
Methods
Patients had to be included within 15 days of stroke and 2 follow-up visits were planned at 3 and 6 months. At each time points, microarchitecture parameters were assessed by high-resolution peripheral quantitative computed tomography (HR-pQCT) at the tibia and the radius sites on both paretic and non-paretic sides. P-values were adjusted for multiple comparisons.
Results
Ten patients were included. All were all right-handed, hemiplegia occurring on dominant side in 6 of them. Cortical thickness decreased from baseline on paretic side (PS) as early as 3 months and 6 months both at radius (P = 0.031) and tibia (P = 0.005), while it remained stable on non-paretic side (NPS). The radius cortical area also significantly decreased only on PS (P = 0.049). There was an increase in Ct.Po on both sides over time, only at the tibia. No early changes in trabecular parameters were observed. As a result, failure load rapidly changed at both radial and tibial locations regardless of side, with numerically greater changes at the tibia PS.
Conclusion
Stroke-induced hemiplegia was associated with microarchitectural damages in both tibial and radial cortical envelopes regardless of body side, as early as 3 months post-event. These results suggest the need for early bone loss prevention including pharmacologic treatments.
{"title":"Early upper and lower limbs bone microarchitecture alterations evaluated by HR-PQCT after stroke with hemiplegia","authors":"Adamah Amouzougan , Myriam Normand , Hervé Locrelle , Laure Mathevon , Elisa Dalix , Pierre Garnier , Paul Calmels , Hubert Marotte , Thierry Thomas","doi":"10.1016/j.jbspin.2025.106008","DOIUrl":"10.1016/j.jbspin.2025.106008","url":null,"abstract":"<div><h3>Objectives</h3><div>Stroke is the leading cause of acquired physical disability. In recent years, there has been a decline in early mortality due to acute medical care as well as better and earlier prevention of adverse events after stroke, therefore exposing more these patients to fragility fractures. We report very early assessment of bone microarchitecture changes in the first months following stroke-induced hemiplegia in a monocentric prospective study.</div></div><div><h3>Methods</h3><div>Patients had to be included within 15<!--> <!-->days of stroke and 2 follow-up visits were planned at 3 and 6<!--> <!-->months. At each time points, microarchitecture parameters were assessed by high-resolution peripheral quantitative computed tomography (HR-pQCT) at the tibia and the radius sites on both paretic and non-paretic sides. <em>P</em>-values were adjusted for multiple comparisons.</div></div><div><h3>Results</h3><div>Ten patients were included. All were all right-handed, hemiplegia occurring on dominant side in 6 of them. Cortical thickness decreased from baseline on paretic side (PS) as early as 3<!--> <!-->months and 6<!--> <!-->months both at radius (<em>P</em> <!-->=<!--> <!-->0.031) and tibia (<em>P</em> <!-->=<!--> <!-->0.005), while it remained stable on non-paretic side (NPS). The radius cortical area also significantly decreased only on PS (<em>P</em> <!-->=<!--> <!-->0.049). There was an increase in Ct.Po on both sides over time, only at the tibia. No early changes in trabecular parameters were observed. As a result, failure load rapidly changed at both radial and tibial locations regardless of side, with numerically greater changes at the tibia PS.</div></div><div><h3>Conclusion</h3><div>Stroke-induced hemiplegia was associated with microarchitectural damages in both tibial and radial cortical envelopes regardless of body side, as early as 3<!--> <!-->months post-event. These results suggest the need for early bone loss prevention including pharmacologic treatments.</div></div>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"93 3","pages":"Article 106008"},"PeriodicalIF":4.3,"publicationDate":"2025-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145531038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-13DOI: 10.1016/j.jbspin.2025.106005
Xinzhe Jing, Ding Ye
{"title":"Comment on: “Global, regional, and national burden of gout in people aged 15–39 years from 1990 to 2021: Trends, cross-country inequalities and forecast to 2035” by Yinglun Zhang et al., Joint Bone Spine 2025;92:105929","authors":"Xinzhe Jing, Ding Ye","doi":"10.1016/j.jbspin.2025.106005","DOIUrl":"10.1016/j.jbspin.2025.106005","url":null,"abstract":"","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"93 1","pages":"Article 106005"},"PeriodicalIF":4.3,"publicationDate":"2025-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145530969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-13DOI: 10.1016/j.jbspin.2025.106004
Daniel Wendling , Philippe Goupille , Renaud Felten , Thao Pham , Anna Molto , Frank Verhoeven , Clément Prati , French spondyloArthritiS Taskforce (FAST)
Axial spondyloarthritis has undergone major changes since the turn of the century, concerning terminology (from ankylosing spondylitis to radiographic axial spondyloarthritis), classification criteria, introduction of targeted therapies (anti-TNF, anti-IL17, JAK inhibitors), and management strategies. Epidemiological data indicate an increasing incidence and a shorter diagnostic delay. Over the past 25 years, additional modifications have been observed: recognition of non-radiographic forms (up to 50% in recent studies), lower male predominance with a sex ratio tending to parity, reduced frequency of HLA-B27 and uveitis, wider use of targeted treatments, and changes in treatment response profiles. Overall disease severity appears to be reduced according to several indicators, including mortality, hip involvement, structural progression, and amyloidosis. The determinants of these changes remain debated and discussed in this narrative review, in the absence of long-term longitudinal studies and because of limited comparability across different time periods. The impact of environmental factors still needs to be assessed.
{"title":"The changing face of axial spondyloarthritis over the last 25 years","authors":"Daniel Wendling , Philippe Goupille , Renaud Felten , Thao Pham , Anna Molto , Frank Verhoeven , Clément Prati , French spondyloArthritiS Taskforce (FAST)","doi":"10.1016/j.jbspin.2025.106004","DOIUrl":"10.1016/j.jbspin.2025.106004","url":null,"abstract":"<div><div>Axial spondyloarthritis has undergone major changes since the turn of the century, concerning terminology (from ankylosing spondylitis to radiographic axial spondyloarthritis), classification criteria, introduction of targeted therapies (anti-TNF, anti-IL17, JAK inhibitors), and management strategies. Epidemiological data indicate an increasing incidence and a shorter diagnostic delay. Over the past 25 years, additional modifications have been observed: recognition of non-radiographic forms (up to 50% in recent studies), lower male predominance with a sex ratio tending to parity, reduced frequency of HLA-B27 and uveitis, wider use of targeted treatments, and changes in treatment response profiles. Overall disease severity appears to be reduced according to several indicators, including mortality, hip involvement, structural progression, and amyloidosis. The determinants of these changes remain debated and discussed in this narrative review, in the absence of long-term longitudinal studies and because of limited comparability across different time periods. The impact of environmental factors still needs to be assessed.</div></div>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"93 3","pages":"Article 106004"},"PeriodicalIF":4.3,"publicationDate":"2025-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145531024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-04DOI: 10.1016/j.jbspin.2025.105997
Songhe Chen , Ye Chen , Ying Zhang , Kai Chen
{"title":"Comment on “Correlation of Naples prognostic score with the risk of all-cause and cardiovascular mortality in individuals with rheumatoid arthritis: A cross-sectional analysis of the NHANES 2001-2018” by Zhou et al. Joint Bone Spine. 2025;92:105928","authors":"Songhe Chen , Ye Chen , Ying Zhang , Kai Chen","doi":"10.1016/j.jbspin.2025.105997","DOIUrl":"10.1016/j.jbspin.2025.105997","url":null,"abstract":"","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"93 1","pages":"Article 105997"},"PeriodicalIF":4.3,"publicationDate":"2025-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145460351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.jbspin.2025.105998
Mustafa Kemal Demir , Onder Ertem , Deniz Konya
{"title":"Hidden nidus on MRI, revealed on CT: Lumbar lamina osteoid osteoma","authors":"Mustafa Kemal Demir , Onder Ertem , Deniz Konya","doi":"10.1016/j.jbspin.2025.105998","DOIUrl":"10.1016/j.jbspin.2025.105998","url":null,"abstract":"","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"93 2","pages":"Article 105998"},"PeriodicalIF":4.3,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145440154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.jbspin.2025.105999
Léa Paolini , Johanna Sigaux , Marie Christophe Boissier , Elodie Rivière
Background
Pain is a neuroimmune condition in which immune cells interact with the somatosensory system, contributing not only in the initiation and sensitization of pain but also in its resolution. This review aims to decipher the immunological pathways implicated in pain, illustrating how immune cells and mediators contribute to pain persistance and examining new therapeutic prospects.
Findings
Innate and adaptive immune cells such as macrophages, T and B cells, neutrophils, mast cells, and NK cells contribute to pain modulation through both pro-inflammatory and anti-inflammatory pathways. Peripheral and central sensitization as well as the recent concept of immunoception highlight the major role of neuroimmune interactions in pain perception. Therapeutic strategies targeting the immune system including cytokine inhibitors, low-dose IL-2, Janus kinase inhibitors, or emerging strategies such as vagus nerve stimulation, gut microbiota modulation, and specialized pro-resolving mediators might be of interest in pain resolution.
Conclusions
Pain modulation involves complex neuroimmune interactions, with immune cells playing dual roles as both triggers and regulators of pain. A deeper understanding of these mechanisms opens new therapeutic avenues, emphasizing the potential of targeting immune pathways to prevent and manage chronic pain, particularly in rheumatic disorders.
{"title":"Immune control of pain","authors":"Léa Paolini , Johanna Sigaux , Marie Christophe Boissier , Elodie Rivière","doi":"10.1016/j.jbspin.2025.105999","DOIUrl":"10.1016/j.jbspin.2025.105999","url":null,"abstract":"<div><h3>Background</h3><div>Pain is a neuroimmune condition in which immune cells interact with the somatosensory system, contributing not only in the initiation and sensitization of pain but also in its resolution. This review aims to decipher the immunological pathways implicated in pain, illustrating how immune cells and mediators contribute to pain persistance and examining new therapeutic prospects.</div></div><div><h3>Findings</h3><div>Innate and adaptive immune cells such as macrophages, T and B cells, neutrophils, mast cells, and NK cells contribute to pain modulation through both pro-inflammatory and anti-inflammatory pathways. Peripheral and central sensitization as well as the recent concept of immunoception highlight the major role of neuroimmune interactions in pain perception. Therapeutic strategies targeting the immune system including cytokine inhibitors, low-dose IL-2, Janus kinase inhibitors, or emerging strategies such as vagus nerve stimulation, gut microbiota modulation, and specialized pro-resolving mediators might be of interest in pain resolution.</div></div><div><h3>Conclusions</h3><div>Pain modulation involves complex neuroimmune interactions, with immune cells playing dual roles as both triggers and regulators of pain. A deeper understanding of these mechanisms opens new therapeutic avenues, emphasizing the potential of targeting immune pathways to prevent and manage chronic pain, particularly in rheumatic disorders.</div></div>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"93 3","pages":"Article 105999"},"PeriodicalIF":4.3,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145440211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.jbspin.2025.106002
Giulia La Barbera , Francesco Ciodaro , Giovanni Luppino , Federica Li Pomi , Sabrina Loteta , Giovanni Miceli , Clelia Cusmano , Valeria Chirico , Angela Alibrandi , Roberto Chimenz , Carmela Visalli , Francesco Borgia , Giovanni Conti
Objective
The incudomalleal and incudostapedial articulations are synovial joints that may be involved in the inflammatory process in patients with juvenile idiophathic arthritis (JIA). The aim of the study was to assess the frequency of hearing impairment and associated risk factors in JIA patients.
Methods
We performed a cohort study on 45 patients with three JIA subtype (oligoarticular, polyarticular and psoriatic) aged between 3 and 18 years. The control group consisted of 30 healthy sex and age-matched children. Subjects underwent audiological exams and clinical-rheumatologic evaluations, including joint count (Juvenile Arthritis Disease Activity Score = cJADAS10) and inflammatory markers.
Results
Audiological impairment was detected in 16/45 (35.5%) patients with JIA. Hypoacusis was found in a significant number of ears in JIA patients (16/90 = 17.8%; P < 0.05) compared with to control group ears. Hypoacusis was frequently observed in patients with psoriasis (6/16 ears). Abnormal findings in tympanometry were observed in five types of As (with a shallow peak), four with type B (flat pattern), and in two with type C (with a negative pressure). The stapedius reflex was absent in only one patient (3%). JIA patients with hypoacusis had a significantly greater cJADAS10 (P < 0.001) and Childhood Health Assessment Questionnaire (CHAQ) (P < 0.001), a functional and quality of life assessment tool, than JIA patients with normal audiometry.
Conclusion
Hearing impairment and/or abnormal tympanograms suggest ear involvement in patients with JIA. This may be considered a complication of the disease and/or a marker of JIA activity, according cJADAS10, and could represent a valuable criterion to select the best therapeutic strategy. Therefore, JIA patients should perform an Ear, Nose and Throat (ENT) evaluation to allow early detection of auditory system involvement to prevent the impact of hearing loss.
{"title":"Ear involvement in patients affected by juvenile idiopathic arthritis","authors":"Giulia La Barbera , Francesco Ciodaro , Giovanni Luppino , Federica Li Pomi , Sabrina Loteta , Giovanni Miceli , Clelia Cusmano , Valeria Chirico , Angela Alibrandi , Roberto Chimenz , Carmela Visalli , Francesco Borgia , Giovanni Conti","doi":"10.1016/j.jbspin.2025.106002","DOIUrl":"10.1016/j.jbspin.2025.106002","url":null,"abstract":"<div><h3>Objective</h3><div>The incudomalleal and incudostapedial articulations are synovial joints that may be involved in the inflammatory process in patients with juvenile idiophathic arthritis (JIA). The aim of the study was to assess the frequency of hearing impairment and associated risk factors in JIA patients.</div></div><div><h3>Methods</h3><div>We performed a cohort study on 45 patients with three JIA subtype (oligoarticular, polyarticular and psoriatic) aged between 3 and 18<!--> <!-->years. The control group consisted of 30 healthy sex and age-matched children. Subjects underwent audiological exams and clinical-rheumatologic evaluations, including joint count (Juvenile Arthritis Disease Activity Score<!--> <!-->=<!--> <!-->cJADAS10) and inflammatory markers.</div></div><div><h3>Results</h3><div>Audiological impairment was detected in 16/45 (35.5%) patients with JIA. Hypoacusis was found in a significant number of ears in JIA patients (16/90<!--> <!-->=<!--> <!-->17.8%; <em>P</em> <!--><<!--> <!-->0.05) compared with to control group ears. Hypoacusis was frequently observed in patients with psoriasis (6/16 ears). Abnormal findings in tympanometry were observed in five types of As (with a shallow peak), four with type B (flat pattern), and in two with type C (with a negative pressure). The stapedius reflex was absent in only one patient (3%). JIA patients with hypoacusis had a significantly greater cJADAS10 (<em>P</em> <!--><<!--> <!-->0.001) and Childhood Health Assessment Questionnaire (CHAQ) (<em>P</em> <!--><<!--> <!-->0.001), a functional and quality of life assessment tool, than JIA patients with normal audiometry.</div></div><div><h3>Conclusion</h3><div>Hearing impairment and/or abnormal tympanograms suggest ear involvement in patients with JIA. This may be considered a complication of the disease and/or a marker of JIA activity, according cJADAS10, and could represent a valuable criterion to select the best therapeutic strategy. Therefore, JIA patients should perform an Ear, Nose and Throat (ENT) evaluation to allow early detection of auditory system involvement to prevent the impact of hearing loss.</div></div>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"93 3","pages":"Article 106002"},"PeriodicalIF":4.3,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145440157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.jbspin.2025.106000
Alice Courties , Camille Daste , Alexis F. Homs , Inès Kouki , Françoise Alliot-Launois , Lisa Bialé , Pierre-Emmanuel Cailleaux , Adeline Cambon , Roland Chapurlat , Michel Chammas , Grégoire Cormier , Marie-Christine Fabre , Véronique Gaud-Listrat , Augustin Latourte , Antonio Lopez , Emmanuel Maheu , Nathalie Nayral , François Rannou , Anne-Christine Rat , Alexandra Rören , Jérémie Sellam
Objectives
To establish French recommendations for the management of people living with hand osteoarthritis (OA) on behalf of the French Society of Rheumatology (SFR) and of the French Society of Physical and Rehabilitation Medicine (SOFMER).
Methods
A systematic review of the literature, including systematic reviews, meta-analyses, and randomized controlled trials on pharmacological and non-pharmacological treatments, was conducted from inception until November 24, 2023. Based on this review and expert consensus, a multidisciplinary group of 25 healthcare professionals—including rheumatologists, physical and rehabilitation medicine physicians, hand surgeons, general practitioner, geriatrician, occupational therapists, physiotherapists, and patients—formulated the recommendations. Each statement was assigned a level of evidence, a grade of recommendation, and a level of agreement based on EULAR standardized procedures for recommendations.
Results
The group established four general principles and 11 specific recommendations. The general principles emphasize treatment objectives, individualized management, patient education, and a multimodal approach combining non-pharmacological and pharmacological therapies. Four specific recommendations address non-pharmacological strategies, including exercise, ergonomic advice, assistive devices, orthoses and heat applications. The group advises against the use of electromagnetic waves, laser therapy, acupuncture, or kinesiotaping. Seven specific recommendations cover pharmacological treatments, advocating for topical and oral NSAIDs, acetaminophen, chondroitin sulfate for symptom relief, low-dose oral corticosteroids for inflammatory flares, and intra-articular steroid injections for inflammatory painful interphalangeal OA. Given the current data, the group advises against the use of conventional synthetic or biological disease-modifying anti-rheumatic drugs (DMARDs).
Conclusions
These recommendations provide a structured approach for the management of people living with hand OA in France, aligning with national healthcare practices and patient needs.
{"title":"French Societies of Rheumatology and of Physical and Rehabilitation Medicine recommendations for the management of people living with hand osteoarthritis","authors":"Alice Courties , Camille Daste , Alexis F. Homs , Inès Kouki , Françoise Alliot-Launois , Lisa Bialé , Pierre-Emmanuel Cailleaux , Adeline Cambon , Roland Chapurlat , Michel Chammas , Grégoire Cormier , Marie-Christine Fabre , Véronique Gaud-Listrat , Augustin Latourte , Antonio Lopez , Emmanuel Maheu , Nathalie Nayral , François Rannou , Anne-Christine Rat , Alexandra Rören , Jérémie Sellam","doi":"10.1016/j.jbspin.2025.106000","DOIUrl":"10.1016/j.jbspin.2025.106000","url":null,"abstract":"<div><h3>Objectives</h3><div>To establish French recommendations for the management of people living with hand osteoarthritis (OA) on behalf of the French Society of Rheumatology (SFR) and of the French Society of Physical and Rehabilitation Medicine (SOFMER).</div></div><div><h3>Methods</h3><div>A systematic review of the literature, including systematic reviews, meta-analyses, and randomized controlled trials on pharmacological and non-pharmacological treatments, was conducted from inception until November 24, 2023. Based on this review and expert consensus, a multidisciplinary group of 25 healthcare professionals—including rheumatologists, physical and rehabilitation medicine physicians, hand surgeons, general practitioner, geriatrician, occupational therapists, physiotherapists, and patients—formulated the recommendations. Each statement was assigned a level of evidence, a grade of recommendation, and a level of agreement based on EULAR standardized procedures for recommendations.</div></div><div><h3>Results</h3><div>The group established four general principles and 11 specific recommendations. The general principles emphasize treatment objectives, individualized management, patient education, and a multimodal approach combining non-pharmacological and pharmacological therapies. Four specific recommendations address non-pharmacological strategies, including exercise, ergonomic advice, assistive devices, orthoses and heat applications. The group advises against the use of electromagnetic waves, laser therapy, acupuncture, or kinesiotaping. Seven specific recommendations cover pharmacological treatments, advocating for topical and oral NSAIDs, acetaminophen, chondroitin sulfate for symptom relief, low-dose oral corticosteroids for inflammatory flares, and intra-articular steroid injections for inflammatory painful interphalangeal OA. Given the current data, the group advises against the use of conventional synthetic or biological disease-modifying anti-rheumatic drugs (DMARDs).</div></div><div><h3>Conclusions</h3><div>These recommendations provide a structured approach for the management of people living with hand OA in France, aligning with national healthcare practices and patient needs.</div></div>","PeriodicalId":54902,"journal":{"name":"Joint Bone Spine","volume":"93 2","pages":"Article 106000"},"PeriodicalIF":4.3,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145440153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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