Pub Date : 2025-12-12DOI: 10.1021/acs.orglett.5c04234
Sheng-Jie Shi, Xu-Liang Liu, Lin Yang, De-Sheng Zhan, Lin-Hai Chen, Jian-Peng Yin, Fa-Jun Nan
The first total synthesis of the anti-inflammatory Ganoderma meroterpenoid dimers dispirocochlearoids A–C, along with five of their diastereomers─potential unreported natural products─has been accomplished using a convergent strategy that leveraged common intermediates derived from dayaolingzhiol M. The synthesis features several key steps: a hetero-Diels–Alder reaction, a hydrolysis/double-bond migration cascade to assemble the D/E–bicyclic core, and a condensation/intramolecular aldol/lactonization cascade that constructs the final B/C–bicyclic system of dispirocochlearoids A–C.
抗炎灵芝二萜类二聚体双耳蜗类a - c及其五种非对映体（可能未报道的天然产物）的首次全合成已经完成，该合成利用了从大药灵脂醇m中衍生的常见中间体。合成有几个关键步骤：一个异源diols - alder反应，一个水解/双键迁移级联组装D/ e双环核心，以及一个缩合/分子内醛醇/内酯化级联构建最终的双耳蜗a - c B/ c双环体系。
{"title":"Biomimetic Total Synthesis of Dispirocochlearoids A–C and Related Ganoderma Meroterpenoid Dimers","authors":"Sheng-Jie Shi, Xu-Liang Liu, Lin Yang, De-Sheng Zhan, Lin-Hai Chen, Jian-Peng Yin, Fa-Jun Nan","doi":"10.1021/acs.orglett.5c04234","DOIUrl":"https://doi.org/10.1021/acs.orglett.5c04234","url":null,"abstract":"The first total synthesis of the anti-inflammatory <i>Ganoderma</i> meroterpenoid dimers dispirocochlearoids A–C, along with five of their diastereomers─potential unreported natural products─has been accomplished using a convergent strategy that leveraged common intermediates derived from dayaolingzhiol M. The synthesis features several key steps: a hetero-Diels–Alder reaction, a hydrolysis/double-bond migration cascade to assemble the D/E–bicyclic core, and a condensation/intramolecular aldol/lactonization cascade that constructs the final B/C–bicyclic system of dispirocochlearoids A–C.","PeriodicalId":54,"journal":{"name":"Organic Letters","volume":"251 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145729145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-12DOI: 10.1021/acs.orglett.5c04244
Jing-Wen Jia, Juan Fan, Xiao-Zuan Chen, Zhong-Wen Liu, Xian-Ying Shi
A rhodium-catalyzed C–H amidation of ortho/para-substituted benzaldehydes with dioxazolones has been developed to afford meta-substituted aromatic amides in moderate to good yields. This transformation proceeds via weakly coordinating aldehyde-directed ortho-C–H functionalization and concomitant decarbonylation processes. The aldehyde group notably serves as a unique traceless directing group that effectively controls the regioselectivity of the reaction. This protocol features operational simplicity and avoids the need for a transient directing group.
{"title":"Rhodium-Catalyzed Regioselective C–H Amidation of Benzaldehydes with Dioxazolones: Weakly Coordinating Aldehyde as a Traceless Directing Group","authors":"Jing-Wen Jia, Juan Fan, Xiao-Zuan Chen, Zhong-Wen Liu, Xian-Ying Shi","doi":"10.1021/acs.orglett.5c04244","DOIUrl":"https://doi.org/10.1021/acs.orglett.5c04244","url":null,"abstract":"A rhodium-catalyzed C–H amidation of <i>ortho</i>/<i>para</i>-substituted benzaldehydes with dioxazolones has been developed to afford <i>meta</i>-substituted aromatic amides in moderate to good yields. This transformation proceeds via weakly coordinating aldehyde-directed <i>ortho</i>-C–H functionalization and concomitant decarbonylation processes. The aldehyde group notably serves as a unique traceless directing group that effectively controls the regioselectivity of the reaction. This protocol features operational simplicity and avoids the need for a transient directing group.","PeriodicalId":54,"journal":{"name":"Organic Letters","volume":"10 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145729144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-11DOI: 10.1021/acs.orglett.5c04093
Tanmay Barman, Om Prakash Dash, Jatin Patra, Chandra M. R. Volla
Herein, we report a Rh(III)-catalyzed aldehydic C–H activation followed by strain release C–C cleavage of bicyclobutanes (BCBs) to access α-methylene-1,5-dicarbonyl motifs under mild conditions with excellent yields employing equimolar amounts of both reactants. This protocol is highly chemoselective and accommodates a wide variety of substrates. Synthetic utility of the developed protocol was demonstrated by carrying out gram scale synthesis and further functionalization of the final products. Additionally, α-methylene-1,5-dicarbonyl motifs obtained from amide BCBs undergo alkenyl C–H annulation with alkynes to afford substituted α-pyrones.
{"title":"Merging Aldehydic C–H Activation with Strain Release C–C Bond Cleavage of Bicyclo[1.1.0]butanes under Rh(III) Catalysis","authors":"Tanmay Barman, Om Prakash Dash, Jatin Patra, Chandra M. R. Volla","doi":"10.1021/acs.orglett.5c04093","DOIUrl":"https://doi.org/10.1021/acs.orglett.5c04093","url":null,"abstract":"Herein, we report a Rh(III)-catalyzed aldehydic C–H activation followed by strain release C–C cleavage of bicyclobutanes (BCBs) to access α-methylene-1,5-dicarbonyl motifs under mild conditions with excellent yields employing equimolar amounts of both reactants. This protocol is highly chemoselective and accommodates a wide variety of substrates. Synthetic utility of the developed protocol was demonstrated by carrying out gram scale synthesis and further functionalization of the final products. Additionally, α-methylene-1,5-dicarbonyl motifs obtained from amide BCBs undergo alkenyl C–H annulation with alkynes to afford substituted α-pyrones.","PeriodicalId":54,"journal":{"name":"Organic Letters","volume":"8 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145718398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-11DOI: 10.1021/acs.orglett.5c04417
Hong-Chen Wang,Hong Fu,Peng-Fei Zhao,Yi-Fan Li,Bing Han
Ketones, as simple and readily available bulk chemicals, have long been the focus of synthetic chemistry. Herein, we report a new protocol for the radical deconstruction of unstrained ketones by in situ conversion of them into dihydroquinoline (DHQ) prearomatics and subsequent oxidative aromatization. By combination with subsequent radical cascade reactions of DABSO and aryl acetylene, this protocol can convert acyclic and cyclic ketones and even ketone-containing complex natural products into a series of valuable vinyl sulfones in a one-pot, two-step method.
{"title":"Aromatization-Driven C-C Bond Cleavage of Unstrained Ketone Access to Vinyl Sulfones.","authors":"Hong-Chen Wang,Hong Fu,Peng-Fei Zhao,Yi-Fan Li,Bing Han","doi":"10.1021/acs.orglett.5c04417","DOIUrl":"https://doi.org/10.1021/acs.orglett.5c04417","url":null,"abstract":"Ketones, as simple and readily available bulk chemicals, have long been the focus of synthetic chemistry. Herein, we report a new protocol for the radical deconstruction of unstrained ketones by in situ conversion of them into dihydroquinoline (DHQ) prearomatics and subsequent oxidative aromatization. By combination with subsequent radical cascade reactions of DABSO and aryl acetylene, this protocol can convert acyclic and cyclic ketones and even ketone-containing complex natural products into a series of valuable vinyl sulfones in a one-pot, two-step method.","PeriodicalId":54,"journal":{"name":"Organic Letters","volume":"40 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145728551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-11DOI: 10.1021/acs.orglett.5c04545
Wen-Juan Yuan, Jia-Yi Shou, Feng-Ling Qing
The synthesis of chloro- and bromodifluoromethyl alkyl ethers remained a fundamental challenge in synthetic chemistry. Herein we report the efficient and direct synthesis of chloro- and bromodifluoromethyl alkyl ethers through copper-mediated oxidative chrolo- and bromodifluoromethylation of aliphatic alcohols with difluorocarbene-reagents. This difluorocarbene-involved oxidative coupling protocol exhibited broad functional group compatibility and was applicable to a wide range of primary and secondary alcohols.
{"title":"Copper-Mediated Oxidative Chloro- and Bromodifluoromethylation of Aliphatic Alcohols","authors":"Wen-Juan Yuan, Jia-Yi Shou, Feng-Ling Qing","doi":"10.1021/acs.orglett.5c04545","DOIUrl":"https://doi.org/10.1021/acs.orglett.5c04545","url":null,"abstract":"The synthesis of chloro- and bromodifluoromethyl alkyl ethers remained a fundamental challenge in synthetic chemistry. Herein we report the efficient and direct synthesis of chloro- and bromodifluoromethyl alkyl ethers through copper-mediated oxidative chrolo- and bromodifluoromethylation of aliphatic alcohols with difluorocarbene-reagents. This difluorocarbene-involved oxidative coupling protocol exhibited broad functional group compatibility and was applicable to a wide range of primary and secondary alcohols.","PeriodicalId":54,"journal":{"name":"Organic Letters","volume":"150 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145718388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Molecular editing of N-heterocycles represents a powerful strategy for enhancing compound complexity and structural diversity at a late stage. However, combining both peripheral and skeletal editing of pyrrolidines for the diversity-oriented synthesis of azepinoindoles remains underexplored yet challenging. Herein, we report the ethanol-mediated redox sp3 C-H functionalization of pyrrolidines via the tert-amino effect and trifluoroacetic acid-promoted skeletal remodeling involving pyrrolidine ring expansion, which enables the divergent synthesis of azepino[4,3,2-cd]indoles and azepino[2,3-e]indoles. This method expands the scope of molecular editing of pyrrolidines, featuring metal-free reaction conditions, excellent functional group compatibility, late-stage modification of drug molecules, scalability, operational simplicity, and product derivatization. The mechanistic studies corroborate the proposed reaction pathway.
n -杂环的分子编辑是后期提高化合物复杂性和结构多样性的有力策略。然而，结合吡咯烷的外周和骨架编辑来合成azepinindoles的多样性仍未得到充分的探索和挑战。在本文中，我们报道了乙醇介导的吡咯烷的氧化还原sp3 C-H功能化通过叔氨基效应和三氟乙酸促进的涉及吡咯烷环扩张的骨骼重塑，这使得氮平[4,3,2-cd]吲哚和氮平[2,3-e]吲哚的分化合成成为可能。该方法扩大了吡咯烷类分子编辑的范围，具有无金属反应条件、良好的官能团相容性、药物分子的后期修饰、可扩展性、操作简单、产品衍生化等特点。机理研究证实了所提出的反应途径。
{"title":"Diversity-Oriented Synthesis of Azepinoindoles through sp3 C-H Functionalization and Skeletal Remodeling.","authors":"Yao-Bin Shen,Fen Ma,Hao-Qi Song,Bin Qiu,Xiao-De An,Houchen Wang,Tiesheng Shi,Zhihui Hao,Jian Xiao","doi":"10.1021/acs.orglett.5c04730","DOIUrl":"https://doi.org/10.1021/acs.orglett.5c04730","url":null,"abstract":"Molecular editing of N-heterocycles represents a powerful strategy for enhancing compound complexity and structural diversity at a late stage. However, combining both peripheral and skeletal editing of pyrrolidines for the diversity-oriented synthesis of azepinoindoles remains underexplored yet challenging. Herein, we report the ethanol-mediated redox sp3 C-H functionalization of pyrrolidines via the tert-amino effect and trifluoroacetic acid-promoted skeletal remodeling involving pyrrolidine ring expansion, which enables the divergent synthesis of azepino[4,3,2-cd]indoles and azepino[2,3-e]indoles. This method expands the scope of molecular editing of pyrrolidines, featuring metal-free reaction conditions, excellent functional group compatibility, late-stage modification of drug molecules, scalability, operational simplicity, and product derivatization. The mechanistic studies corroborate the proposed reaction pathway.","PeriodicalId":54,"journal":{"name":"Organic Letters","volume":"26 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145728550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A thiophene-scaffolded alkyne-activating glycosyl donor has been developed, enabling fine reactivity control through ring-size modulation. The expanded spatial arrangement between the carbonyl and alkyne units confers distinct reactivity compared to the classical Yu's donor, facilitating efficient one-pot oligosaccharide assembly under single activation conditions. This reactivity differentiation also supports orthogonal, reactivity-based glycosylation strategies. The thiophene-based ATC donor is readily prepared, bench-stable, and broadly applicable, providing a practical and tunable platform for programmable glycosylation.
{"title":"Reactivity Tuning by Ring Size: A Glycosylation Protocol Using Thiophene-Scaffolded Glycosyl Donors.","authors":"Jingyu Tian,Yan Tan,Liya Yang,Mengyu Li,Yanli Qiu,Zijie Zhou,Xin Zhou,Shusheng Lai,Ming Chen,Xiangwei Zheng,Meifang Yang,Houchao Tao","doi":"10.1021/acs.orglett.5c04703","DOIUrl":"https://doi.org/10.1021/acs.orglett.5c04703","url":null,"abstract":"A thiophene-scaffolded alkyne-activating glycosyl donor has been developed, enabling fine reactivity control through ring-size modulation. The expanded spatial arrangement between the carbonyl and alkyne units confers distinct reactivity compared to the classical Yu's donor, facilitating efficient one-pot oligosaccharide assembly under single activation conditions. This reactivity differentiation also supports orthogonal, reactivity-based glycosylation strategies. The thiophene-based ATC donor is readily prepared, bench-stable, and broadly applicable, providing a practical and tunable platform for programmable glycosylation.","PeriodicalId":54,"journal":{"name":"Organic Letters","volume":"5 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145728600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
We report a practical and scalable boron-to-carbon atom swapping methodology that facilitates the efficient synthesis of benzimidazole-based drugs. This exogenous photocatalyst-free, visible-light-driven transformation is selective and controllable, proceeding under mild conditions. It provides a unique strategy to address a series of challenges associated with de novo synthesis and photocatalytic skeleton editing for constructing medicinal benzimidazole derivatives, including high-energy barrier obstacles, metal residue, limited UV light, scalability, and poor functional group tolerance. Specifically, it enables a 100 mmol scale synthesis with broad functional group tolerance, avoiding metal contamination that plagues catalytic systems. Our density functional theory (DFT) calculations support our proposed B-to-C atom swap mechanism and indicate that the solvent alcohol plays an auxiliary role in promoting the reaction initiation by inserting the C–O bond of the aldehyde into the N–B bond.
{"title":"Visible-Light-Driven B-to-C Atom Swap: Scalable Skeletal Editing Access to Benzimidazoles from Diazaborines","authors":"Yonghong Yin, Jianjing Yang, Kelu Yan, Hanwen Zheng, Xiaoxia Zhang, Shihan Liu, Jiangwei Wen","doi":"10.1021/acs.orglett.5c03878","DOIUrl":"https://doi.org/10.1021/acs.orglett.5c03878","url":null,"abstract":"We report a practical and scalable boron-to-carbon atom swapping methodology that facilitates the efficient synthesis of benzimidazole-based drugs. This exogenous photocatalyst-free, visible-light-driven transformation is selective and controllable, proceeding under mild conditions. It provides a unique strategy to address a series of challenges associated with de novo synthesis and photocatalytic skeleton editing for constructing medicinal benzimidazole derivatives, including high-energy barrier obstacles, metal residue, limited UV light, scalability, and poor functional group tolerance. Specifically, it enables a 100 mmol scale synthesis with broad functional group tolerance, avoiding metal contamination that plagues catalytic systems. Our density functional theory (DFT) calculations support our proposed B-to-C atom swap mechanism and indicate that the solvent alcohol plays an auxiliary role in promoting the reaction initiation by inserting the C–O bond of the aldehyde into the N–B bond.","PeriodicalId":54,"journal":{"name":"Organic Letters","volume":"28 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145718383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A library of 29 structurally diverse tripodal ligands sharing a tris(biphenyl)methane scaffold was constructed by Suzuki reactions of the common intermediate 1 and commercial halogenated phenols. Rapid screening was conducted for the ligands using the homometathesis of 4-nitrophenylpropylene as a model reaction, and pyridine ligand CP227 emerged as the optimal ligand. The in situ generated catalyst of CP227 and precatalyst cat-III was highly effective in CHCl3, eliminating the need for toxic CCl4 for 2-component alkyne metathesis catalysts. The catalyst was compatible with substrates bearing aniline, phenol, aldehyde, nitro, pyridine, quinoline, azide, and amide moieties. Various macrocycles were also successfully prepared via ring-closing alkyne metathesis. This study demonstrates the potential of tridentate ligands for alkyne metathesis catalysts with a tailored catalytic performance.
{"title":"Heterocyclic Tridentate Ligands for Effective Alkyne Metathesis","authors":"Ting Zhang, Huateng Zhang, Li-Hong Wang, Ning Xu, Wenju Chang, Haobing Wang, Xing Jiang","doi":"10.1021/acs.orglett.5c04292","DOIUrl":"https://doi.org/10.1021/acs.orglett.5c04292","url":null,"abstract":"A library of 29 structurally diverse tripodal ligands sharing a tris(biphenyl)methane scaffold was constructed by Suzuki reactions of the common intermediate <b>1</b> and commercial halogenated phenols. Rapid screening was conducted for the ligands using the homometathesis of 4-nitrophenylpropylene as a model reaction, and pyridine ligand <b>CP227</b> emerged as the optimal ligand. The <i>in situ</i> generated catalyst of <b>CP227</b> and precatalyst <b>cat-III</b> was highly effective in CHCl<sub>3</sub>, eliminating the need for toxic CCl<sub>4</sub> for 2-component alkyne metathesis catalysts. The catalyst was compatible with substrates bearing aniline, phenol, aldehyde, nitro, pyridine, quinoline, azide, and amide moieties. Various macrocycles were also successfully prepared via ring-closing alkyne metathesis. This study demonstrates the potential of tridentate ligands for alkyne metathesis catalysts with a tailored catalytic performance.","PeriodicalId":54,"journal":{"name":"Organic Letters","volume":"14 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145718384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
An unprecedented strategy for the ring-opening transformation of silacyclobutanes using potassium fluoride and diaryliodonium salts has been developed. In this multicomponent reaction, silacyclobutanes undergo ring opening mediated by potassium fluoride and diaryliodonium salts, followed by reaction with in situ-generated dithioaminoacetic acid to afford 3-(fluorosilyl)propyl dithiocarbamates. This study has expanded the potential applications of the silicon-containing building block silacyclobutanes, successfully achieving their silicon–carbon dual functionalization under metal catalyst-free conditions.
{"title":"KF and Diaryl Iodide Salt-Mediated Ring Opening of Silacyclobutanes with Carbon Disulfide and Amines to Generate 3-(Fluorosilyl)propyl Dithiocarbamates","authors":"Jiaze Qin, Mangang Guan, Shuairan Wang, Peihua Liu, Ziyao Tang, Xueliang Ren, Rulong Yan","doi":"10.1021/acs.orglett.5c04593","DOIUrl":"https://doi.org/10.1021/acs.orglett.5c04593","url":null,"abstract":"An unprecedented strategy for the ring-opening transformation of silacyclobutanes using potassium fluoride and diaryliodonium salts has been developed. In this multicomponent reaction, silacyclobutanes undergo ring opening mediated by potassium fluoride and diaryliodonium salts, followed by reaction with in situ-generated dithioaminoacetic acid to afford 3-(fluorosilyl)propyl dithiocarbamates. This study has expanded the potential applications of the silicon-containing building block silacyclobutanes, successfully achieving their silicon–carbon dual functionalization under metal catalyst-free conditions.","PeriodicalId":54,"journal":{"name":"Organic Letters","volume":"45 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145718400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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