A synthetic protocol for the construction of chiral 2,2-disubstituted dihydroquinolines via rhodium-catalyzed asymmetric dearomative arylation and alkenylation of 2-substituted quinolinium salts has been disclosed. 2-Substituted quinolinium triflates and bromide preferred to undergo asymmetric arylation with arylboronic acids, and 2-substituted quinolinium tetrafluoroborate favored to carry out asymmetric alkenylation with alkenylboronic acids, providing a series of chiral 2,2-disubstituted dihydroquinolines with high yields and enantioselectivities. The key for this dearomative reaction stands in the counteranions of 2-substituted quinolinium salts, which guarantee the reactivities and stereoselectivities at the same time.
{"title":"Asymmetric Synthesis of 2,2-Disubstituted Dihydroquinolines via Rhodium-Catalyzed Dearomative Arylation and Alkenylation of 2-Substituted Quinolinium Salts","authors":"Wen-Jun Huang, Jian Chen, Yu-Qing Bai, Yong-Gui Zhou, Guo-Fang Jiang, Bo Wu","doi":"10.1021/acs.orglett.5c05303","DOIUrl":"https://doi.org/10.1021/acs.orglett.5c05303","url":null,"abstract":"A synthetic protocol for the construction of chiral 2,2-disubstituted dihydroquinolines via rhodium-catalyzed asymmetric dearomative arylation and alkenylation of 2-substituted quinolinium salts has been disclosed. 2-Substituted quinolinium triflates and bromide preferred to undergo asymmetric arylation with arylboronic acids, and 2-substituted quinolinium tetrafluoroborate favored to carry out asymmetric alkenylation with alkenylboronic acids, providing a series of chiral 2,2-disubstituted dihydroquinolines with high yields and enantioselectivities. The key for this dearomative reaction stands in the counteranions of 2-substituted quinolinium salts, which guarantee the reactivities and stereoselectivities at the same time.","PeriodicalId":54,"journal":{"name":"Organic Letters","volume":"9 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146122454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-06DOI: 10.1021/acs.orglett.5c05125
Junyu Ma, Yan-En Wang, Yunfei Gao, Yuanyun Gu, Xingtao Chen, Yaqi Yuan, Dan Xiong, Jianyou Mao
Organophosphorus compounds hold significant importance in materials science, medicinal chemistry, and agrochemicals. However, their syntheses have mainly relied on transition metals and prefunctionalized substrates. To overcome these limitations, we herein report a transition-metal-free, chemoselective benzylic phosphination of toluenes mediated by a heterobimetallic LiN(SiMe3)2/Cs2SO4 system. This protocol directly activates inert benzylic C–H bonds with good functional group tolerance, circumventing the need for substrate prefunctionalizations. The practicality of this method is demonstrated by gram-scale synthesis and further derivatization of the phosphine products.
{"title":"Direct Benzylic Phosphination of Toluenes Enabled by a Heterobimetallic LiN(SiMe3)2/Cs2SO4 System","authors":"Junyu Ma, Yan-En Wang, Yunfei Gao, Yuanyun Gu, Xingtao Chen, Yaqi Yuan, Dan Xiong, Jianyou Mao","doi":"10.1021/acs.orglett.5c05125","DOIUrl":"https://doi.org/10.1021/acs.orglett.5c05125","url":null,"abstract":"Organophosphorus compounds hold significant importance in materials science, medicinal chemistry, and agrochemicals. However, their syntheses have mainly relied on transition metals and prefunctionalized substrates. To overcome these limitations, we herein report a transition-metal-free, chemoselective benzylic phosphination of toluenes mediated by a heterobimetallic LiN(SiMe<sub>3</sub>)<sub>2</sub>/Cs<sub>2</sub>SO<sub>4</sub> system. This protocol directly activates inert benzylic C–H bonds with good functional group tolerance, circumventing the need for substrate prefunctionalizations. The practicality of this method is demonstrated by gram-scale synthesis and further derivatization of the phosphine products.","PeriodicalId":54,"journal":{"name":"Organic Letters","volume":"58 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146122453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-06DOI: 10.1021/acs.orglett.6c00281
Abhishek Kundu, Seoyeon Kim, Nilay Hazari, Mycah R. Uehling, Raju Yalla
Alkyl-substituted N-hydroxyphthalimide (NHP) esters are valuable alternatives to alkyl halides in Ni-catalyzed cross-electrophile coupling reactions because they are typically more stable, can generate alkyl radicals under reductive conditions, and are readily prepared from carboxylic acids. However, the range of aryl halides that can be coupled with NHP esters in XEC has so far been largely limited to aryl iodides. Here, we describe a general method for coupling NHP esters bearing 1°, 2°, and strained ring 3° alkyl groups with aryl bromides. This method is compatible with a broad range of substrates, including drug-like aryl bromides, and operates effectively in various non-amide based solvents. The use of a homogeneous organic reductant is crucial for achieving high yields, as it enables precise control over alkyl radical generation from the NHP ester.
{"title":"Homogeneous Reductant Facilitated Cross-Electrophile Coupling of Aryl Bromides with NHP Esters","authors":"Abhishek Kundu, Seoyeon Kim, Nilay Hazari, Mycah R. Uehling, Raju Yalla","doi":"10.1021/acs.orglett.6c00281","DOIUrl":"https://doi.org/10.1021/acs.orglett.6c00281","url":null,"abstract":"Alkyl-substituted <i>N</i>-hydroxyphthalimide (NHP) esters are valuable alternatives to alkyl halides in Ni-catalyzed cross-electrophile coupling reactions because they are typically more stable, can generate alkyl radicals under reductive conditions, and are readily prepared from carboxylic acids. However, the range of aryl halides that can be coupled with NHP esters in XEC has so far been largely limited to aryl iodides. Here, we describe a general method for coupling NHP esters bearing 1°, 2°, and strained ring 3° alkyl groups with aryl bromides. This method is compatible with a broad range of substrates, including drug-like aryl bromides, and operates effectively in various non-amide based solvents. The use of a homogeneous organic reductant is crucial for achieving high yields, as it enables precise control over alkyl radical generation from the NHP ester.","PeriodicalId":54,"journal":{"name":"Organic Letters","volume":"1 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146122457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-06DOI: 10.1021/acs.orglett.6c00120
Lin Chen, Yu Wang, Yang Chen, Shifa Zhu
A ruthenium-catalyzed addition of sulfonic acids to acetylene is reported. This method employs bulk industrial feedstock acetylene as C2 synthon under atmospheric pressure to access vinyl sulfonates in good to excellent yields without using toxic mercury catalysts, offering high atom economy and practical scalability. The resulting vinyl sulfonates serve as versatile vinylating reagents and can be readily transformed into diverse functionalized molecules.
{"title":"Ru(II)-Catalyzed Synthesis of Vinyl Sulfonates Using Acetylene as C2-Synthon","authors":"Lin Chen, Yu Wang, Yang Chen, Shifa Zhu","doi":"10.1021/acs.orglett.6c00120","DOIUrl":"https://doi.org/10.1021/acs.orglett.6c00120","url":null,"abstract":"A ruthenium-catalyzed addition of sulfonic acids to acetylene is reported. This method employs bulk industrial feedstock acetylene as C2 synthon under atmospheric pressure to access vinyl sulfonates in good to excellent yields without using toxic mercury catalysts, offering high atom economy and practical scalability. The resulting vinyl sulfonates serve as versatile vinylating reagents and can be readily transformed into diverse functionalized molecules.","PeriodicalId":54,"journal":{"name":"Organic Letters","volume":"241 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146122456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-06DOI: 10.1021/acs.orglett.6c00023
Zhuohan Hu, Lei Huang, Lang Wang, Qianjun Wang, Feng Zhang, Jun Jin, Yanan Li, Xiaojiang Hao, Chunmao Yuan
Hyperacmoses A–C, three seco-norpolyprenylated acylphloroglucinols (PPAPs) (1–3), along with two processors (4 and 5), were purified from Hypericum acmosepalum. Structurally, compounds 1 and 2 represent the first seco-norPPAP with an unprecedented 5/6/5/6/5 pentacyclic framework, while compound 3 is the first seco-norPPAP with a 5/5/6/6 tetracyclic core. Three rare PPAPs had the same biosynthetic precursor, and Baeyer–Villiger oxidation of this precursor at different positions could finally give different types of PPAPs (1–3). Four compounds (1, 2, 4, and 5) exhibited a better triglyceride (TG) inhibitory effect than atorvastatin in oleic acid-induced HepG2 cells. The compound with the highest potential, compound 1, could prohibit the expression of lipid synthesis proteins, FASN and ACACA, by targeting ACSS2.
{"title":"Hyperacmoses A–C, Three Seco-Norpolyprenylated Acylphloroglucinols from Hypericum acmosepalum with Lipid-Lowering Activity","authors":"Zhuohan Hu, Lei Huang, Lang Wang, Qianjun Wang, Feng Zhang, Jun Jin, Yanan Li, Xiaojiang Hao, Chunmao Yuan","doi":"10.1021/acs.orglett.6c00023","DOIUrl":"https://doi.org/10.1021/acs.orglett.6c00023","url":null,"abstract":"Hyperacmoses A–C, three seco-norpolyprenylated acylphloroglucinols (PPAPs) (<b>1</b>–<b>3</b>), along with two processors (<b>4</b> and <b>5</b>), were purified from <i>Hypericum acmosepalum</i>. Structurally, compounds <b>1</b> and <b>2</b> represent the first seco-norPPAP with an unprecedented 5/6/5/6/5 pentacyclic framework, while compound <b>3</b> is the first seco-norPPAP with a 5/5/6/6 tetracyclic core. Three rare PPAPs had the same biosynthetic precursor, and Baeyer–Villiger oxidation of this precursor at different positions could finally give different types of PPAPs (<b>1</b>–<b>3</b>). Four compounds (<b>1</b>, <b>2</b>, <b>4</b>, and <b>5</b>) exhibited a better triglyceride (TG) inhibitory effect than atorvastatin in oleic acid-induced HepG2 cells. The compound with the highest potential, compound <b>1</b>, could prohibit the expression of lipid synthesis proteins, FASN and ACACA, by targeting ACSS2.","PeriodicalId":54,"journal":{"name":"Organic Letters","volume":"69 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146122455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-05DOI: 10.1021/acs.orglett.6c00380
Yan-Xun Li, Wei-Ting Zhao, Yen-Ku Wu
Controlling regioselectivity in deprotonative arylation of conjugated carbonyl systems remains a longstanding challenge. We report a Pd-catalyzed γ′-arylation of cyclic vinylogous esters (CVEs), enabled by Pd(dba)2/cataCXium A and hexamethylphosphoramide (HMPA) as a regioselectivity-governing additive. The method accommodates a broad range of (hetero)aryl bromides and CVE substrates. The resulting γ′-aryl CVEs were further converted to α-arylcycloalkenones via Stork–Danheiser transposition.
{"title":"HMPA-Enabled Direct γ′-Arylation of Cyclic Vinylogous Esters","authors":"Yan-Xun Li, Wei-Ting Zhao, Yen-Ku Wu","doi":"10.1021/acs.orglett.6c00380","DOIUrl":"https://doi.org/10.1021/acs.orglett.6c00380","url":null,"abstract":"Controlling regioselectivity in deprotonative arylation of conjugated carbonyl systems remains a longstanding challenge. We report a Pd-catalyzed γ′-arylation of cyclic vinylogous esters (CVEs), enabled by Pd(dba)<sub>2</sub>/cataCXium A and hexamethylphosphoramide (HMPA) as a regioselectivity-governing additive. The method accommodates a broad range of (hetero)aryl bromides and CVE substrates. The resulting γ′-aryl CVEs were further converted to α-arylcycloalkenones via Stork–Danheiser transposition.","PeriodicalId":54,"journal":{"name":"Organic Letters","volume":"11 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146122464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
As an important class of compounds, silazanes serve as functional molecules in a variety of fields. Herein, we report a visible-light-induced radical–radical coupling of polysubstituted silanes with NHPI esters to achieve Si–N bond formation. This reaction produces a wide range of silazanes in good yields. Mechanistic studies suggest the involvement of silyl and nitrogen-centered radicals. This strategy provides a practical and general approach for constructing structurally diverse silazanes, which is potentially valuable for the development of functional materials.
{"title":"Photoinduced Radical Coupling for Si–N Bond Formation","authors":"Bao-Ru Yuan, Xiao-Chu Wang, Zhihan Zhang, Ying Cheng, Wen-Jing Xiao","doi":"10.1021/acs.orglett.6c00058","DOIUrl":"https://doi.org/10.1021/acs.orglett.6c00058","url":null,"abstract":"As an important class of compounds, silazanes serve as functional molecules in a variety of fields. Herein, we report a visible-light-induced radical–radical coupling of polysubstituted silanes with NHPI esters to achieve Si–N bond formation. This reaction produces a wide range of silazanes in good yields. Mechanistic studies suggest the involvement of silyl and nitrogen-centered radicals. This strategy provides a practical and general approach for constructing structurally diverse silazanes, which is potentially valuable for the development of functional materials.","PeriodicalId":54,"journal":{"name":"Organic Letters","volume":"89 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146122461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-05DOI: 10.1021/acs.orglett.5c05370
Bingwei Hu, Xiao Zheng
N-Benzyl amides are important structural motifs in pharmaceuticals and natural products. The nucleophilic substitution reactions between aromatic nucleophiles and N-acyliminium ion precursors (N-acyl hemiaminal derivatives) represent one of the most common and powerful approaches. However, these protocols are typically limited by the scope of aromatic substrates or the requirement for air-sensitive reagents. Herein, we report a nickel-catalyzed reductive arylation reaction between N-acyl hemiaminals and readily available aryl halides, which enables the synthesis of a series of structurally diverse N-benzyl amide derivatives under mild conditions through simple operations. Mechanistic studies support a nickel-catalyzed cross-coupling pathway mediated by an N-acyliminium ion intermediate and exclude the participation of an N-acyl α-aminoalkyl radical.
n -苄基酰胺是药物和天然产物中重要的结构基序。芳香族亲核试剂与n -酰基半胺衍生物之间的亲核取代反应是最常见和最有效的方法之一。然而，这些方案通常受到芳香底物的范围或对空气敏感试剂的要求的限制。本文报道了一种镍催化的n -酰基半胺与芳烃卤化物之间的还原性芳基化反应，该反应可以在温和的条件下通过简单的操作合成一系列结构多样的n -苄基酰胺衍生物。机制研究支持镍催化的交叉偶联途径由n -酰基离子中间体介导，排除了n -酰基α-氨基烷基自由基的参与。
{"title":"Nickel-Catalyzed Reductive Arylation of N-Acyl Hemiaminals","authors":"Bingwei Hu, Xiao Zheng","doi":"10.1021/acs.orglett.5c05370","DOIUrl":"https://doi.org/10.1021/acs.orglett.5c05370","url":null,"abstract":"<i>N</i>-Benzyl amides are important structural motifs in pharmaceuticals and natural products. The nucleophilic substitution reactions between aromatic nucleophiles and <i>N</i>-acyliminium ion precursors (<i>N</i>-acyl hemiaminal derivatives) represent one of the most common and powerful approaches. However, these protocols are typically limited by the scope of aromatic substrates or the requirement for air-sensitive reagents. Herein, we report a nickel-catalyzed reductive arylation reaction between <i>N</i>-acyl hemiaminals and readily available aryl halides, which enables the synthesis of a series of structurally diverse <i>N-</i>benzyl amide derivatives under mild conditions through simple operations. Mechanistic studies support a nickel-catalyzed cross-coupling pathway mediated by an <i>N</i>-acyliminium ion intermediate and exclude the participation of an <i>N</i>-acyl α-aminoalkyl radical.","PeriodicalId":54,"journal":{"name":"Organic Letters","volume":"89 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146122459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
An efficient micellar palladium-catalyzed aqueous Buchwald–Hartwig amination has been developed, enabled by the self-assembly of amphiphilic copolymer polyethylene glycol–polyvinylethylene glycol (PEG–PVEG). Using 0.5 mol % BrettPhos-Pd-G3 as a catalyst, the aqueous amination showed broad a substrate scope, including aryl bromides, aryl chlorides, sterically hindered reaction partners, and amides. The practical utility of this micellar system was demonstrated by the gram-scale synthesis of a key pharmaceutical API intermediate and catalyst recycling.
{"title":"Pd-Catalyzed Aqueous Buchwald–Hartwig Amination with Amphiphilic Polymer PEG–PVEG","authors":"Qiong Chai, Fengming Zhang, Minghang Wang, Meiqi Li, Yong Jian Zhang","doi":"10.1021/acs.orglett.6c00030","DOIUrl":"https://doi.org/10.1021/acs.orglett.6c00030","url":null,"abstract":"An efficient micellar palladium-catalyzed aqueous Buchwald–Hartwig amination has been developed, enabled by the self-assembly of amphiphilic copolymer polyethylene glycol–polyvinylethylene glycol (PEG–PVEG). Using 0.5 mol % BrettPhos-Pd-G3 as a catalyst, the aqueous amination showed broad a substrate scope, including aryl bromides, aryl chlorides, sterically hindered reaction partners, and amides. The practical utility of this micellar system was demonstrated by the gram-scale synthesis of a key pharmaceutical API intermediate and catalyst recycling.","PeriodicalId":54,"journal":{"name":"Organic Letters","volume":"47 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146122460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-05DOI: 10.1021/acs.orglett.6c00198
Sofaya Joshi, Arijit Sahoo, Ponneri C. Ravikumar
The controlled synthesis of both E- and Z-stereoisomers remains a long-standing challenge in organic synthesis, yet it is important for accessing structurally and functionally diverse enamides. This study demonstrates the synthesis of E- and Z-hydrophenoxylated enamides using a nickel(II)-catalyst alongside phenols. The stereochemical outcome is controlled by the ligand environment and temperature. Ligands promote syn-addition via a keteniminium intermediate to afford the E-isomer, and elevated temperatures enable efficient E→Z isomerization to deliver the Z-isomer with excellent selectivity. This efficient and versatile strategy exhibits a broad substrate scope and functional group tolerance, including acids, bioactive estrone derivatives, sesamol, and related compounds.
{"title":"Ligand- and Temperature-Controlled Stereodivergent Nickel-Catalyzed Hydrophenoxylation of Ynamides","authors":"Sofaya Joshi, Arijit Sahoo, Ponneri C. Ravikumar","doi":"10.1021/acs.orglett.6c00198","DOIUrl":"https://doi.org/10.1021/acs.orglett.6c00198","url":null,"abstract":"The controlled synthesis of both <i>E</i>- and <i>Z</i>-stereoisomers remains a long-standing challenge in organic synthesis, yet it is important for accessing structurally and functionally diverse enamides. This study demonstrates the synthesis of <i>E</i>- and <i>Z</i>-hydrophenoxylated enamides using a nickel(II)-catalyst alongside phenols. The stereochemical outcome is controlled by the ligand environment and temperature. Ligands promote <i>syn</i>-addition via a keteniminium intermediate to afford the <i>E</i>-isomer, and elevated temperatures enable efficient <i>E→Z</i> isomerization to deliver the <i>Z</i>-isomer with excellent selectivity. This efficient and versatile strategy exhibits a broad substrate scope and functional group tolerance, including acids, bioactive estrone derivatives, sesamol, and related compounds.","PeriodicalId":54,"journal":{"name":"Organic Letters","volume":"25 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146122463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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