CEA is conducting feasibility studies on Test Blanket Modules (TBM) replacement operations in ITER Port Cells, employing an innovative validation concept through simulations using Extended Reality (XR). Collaborating with MATISEC (company specialized in production of security equipment for hostile environments), this study addresses nuclear engineering with motivation to assess in early design phase the use of Personnel Protection Equipment. This study also focusses on the new Immersive Air-Fed Suit (AFS) tailored for XR simulations to prepare hands on operations in hazardous environment. To address the increased operator's workload and fatigue associated with AFS use, the concept uses a modified MATISEC MRV5 prototype. It incorporates internal and external sensors, inertial units, optical and posture sensors, instrumented gloves and depth cameras. Integrated with the XDE physics engine(interactive physics engine) from CEA LIST (Laboratory for Integration of Systems and Technology), these components form an interactive simulation enabling to perform technical tasks in a virtual environment. The virtual simulation replicates human behavior and accurately simulates assembling/disassembling insulation, flanges or cutting/welding pipes operations with scale one tangible tools. The augmented suit and virtual reality resources allow the exploration of intervention scenarios, aligning with French labor regulations limiting AFS use due to operator fatigue. This technology is implemented in the Virtual Integration Platform for Engineering & Remote handling (VIPER) at CEA IRFM (Institute for Magnetic Fusion Research) in Cadarache. This innovative concept allows to check Human Factors requirements early in the design process, integrating advanced monitoring systems for real-time data. Applied to the Pipe Forest accessibility use case for TBM replacement in port cells #16 and #18, it streamlines the design and integration of complex components in constrained working environments minimizing worker exposure in line with the ALARA principle of radiation safety (As Low As Reasonably Achievable). The immersive simulation capabilities position the project as a valuable tool for industries prioritizing worker safety, particularly in nuclear facilities. This innovation extends its applicability to various fields, ranging from engineering analysis to worker training, offering a novel approach to integrate human factors into technical studies.