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Matched case–control comparison of surgical success after XEN45 Gel Stent and PRESERFLO MicroShunt implantation in a Caucasian population 白种人植入 XEN45 凝胶支架和 PRESERFLO MicroShunt 后手术成功率的匹配病例对照比较。
IF 4.9 2区 医学 Q1 OPHTHALMOLOGY Pub Date : 2024-06-06 DOI: 10.1111/ceo.14407
Jan Niklas Lüke MD, Thomas S. Dietlein PhD, Randolf A. Widder PhD, Gernot F. Roessler PhD, Vincent Lüke, Philip Enders PhD, Alexandra Lappa PhD, David Kiessling MD

Background

The aim of this study was to compare the outcome of implantation of a XEN45 Gel Stent with the outcome of implantation of a Preserflo MicroShunt in a matched-pair analysis in eyes being naïve to filtering surgery.

Methods

In this comparative, retrospective study, 50 eyes that had undergone XEN45 Gel Stent implantation were compared with 50 eyes after Preserflo implantation. Follow-up was at least 6 months, and surgical success was measured by criteria A (IOP < 21 mmHg, IOP reduction >20%, no repeat surgery); criteria B (IOP < 18 mmHg, IOP reduction >20%, no repeat surgery); and criteria C (IOP ≤15 mmHg, IOP reduction ≥40%, no repeat surgery).

Results

After a follow-up period of 12 months, mean IOP had decreased from preoperative 25.2 ± 4.8 mmHg in the XEN group to 14.5 ± 4.0 (n = 35) and from 25.3 ± 6.8 mmHg to 11.9 ± 2.9 (n = 41) in the Preserflo group, respectively. The IOP at the last follow-up of the two groups differed significantly (p < 0.01). The probability of surgical success did not differ concerning Criteria A and B, but surgical success was significantly higher in the Preserflo group for Criteria C (60%, p < 0.01).

Conclusion

Both the Preserflo and XEN45 Gel Stent provide an effective and safe treatment option for advanced glaucoma and have a high potential to reduce intraocular pressure. Absolute IOP levels of <16 mmHg after 12 months were significantly more frequent in the Preserflo group.

研究背景本研究的目的是通过配对分析,比较滤过手术新手植入 XEN45 凝胶支架与植入 Preserflo MicroShunt 的疗效:在这项比较性回顾研究中,50 只接受 XEN45 凝胶支架植入术的眼睛与 50 只接受 Preserflo 植入术的眼睛进行了比较。随访时间至少为 6 个月,手术成功率按照标准 A(眼压降低 20%,无重复手术)、标准 B(眼压降低 20%,无重复手术)和标准 C(眼压≤15 mmHg,眼压降低≥40%,无重复手术)进行衡量:随访12个月后,XEN组的平均眼压从术前的25.2 ± 4.8 mmHg降至14.5 ± 4.0(n = 35),Preserflo组的平均眼压从25.3 ± 6.8 mmHg降至11.9 ± 2.9(n = 41)。两组患者在最后一次随访时的眼压差异显著(P 结论:两组患者在最后一次随访时的眼压差异显著:Preserflo 和 XEN45 凝胶支架都为晚期青光眼提供了有效、安全的治疗方案,并具有降低眼压的巨大潜力。两组患者的绝对眼压水平
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引用次数: 0
Journal-level publication metrics: Traditional and contemporary approaches to improving journal selection for ophthalmic researchers 期刊级别的出版指标:改进眼科研究人员期刊选择的传统和现代方法。
IF 4.9 2区 医学 Q1 OPHTHALMOLOGY Pub Date : 2024-06-05 DOI: 10.1111/ceo.14409
Thomas Muecke, Carmelo Macri MBBS, Stephen Bacchi MBBS, PhD, Weng Onn Chan MBBS
<p>Journal-level publication metrics (JPM) are used to assess the research impact and influence of an academic journal.<span><sup>1</sup></span> The most widely adopted and established JPMs are the Impact factor (IF), Eigenfactor score (EF) and SCImago journal rank (SJR). Researchers often use IF to guide choices of ophthalmic journals for reading and publication. However, as the characteristics of JPMs vary, (Table 1), they should not be used in isolation to evaluate a journal's research activity and influence.<span><sup>2</sup></span></p><p>JPMs do not entirely reflect real-world impact and thus may not fully depict the attention and interest in a journal and its contents. Furthermore, JPMs are not directly comparable and measure different qualities, which leads to differences in rankings. For example, Ali et al. reported that otolaryngology journals ranked below the top quartile for IF were found to be within the top five journals when ranked by EF.<span><sup>3</sup></span> Similarly, we performed a cross-sectional analysis comparing the ranking of IF, SJR and EF, using the most recent citation data published by the sources <i>Clarivate Journal Citation Reports, Scimago Journal Rank</i>, and <i>Eigenfactor Journal Ranking</i>, respectively. We found that the top five ophthalmic journals ranked by IF were also the top five by SJR. Interestingly, however, we found that the top three ophthalmic journals ranked by IF were ranked 15th, 2nd, 16th in terms of EF. Similarly, the top three ophthalmic journals ranked by EF were ranked 10th, 2nd, and 8th, respectively in terms of IF, and 12th, 2nd, and 6th, respectively in terms of SJR.</p><p>The holistic use of JPMs may provide a more transparent view of real-world impact when selecting a journal for reading or manuscript submission. Future research may consider development of metrics that reflect a new angle of user interest and attention. Such metrics could identify user engagement on the journal's website, capturing number of page and article views, time spent on articles, and number of clicks. Additionally, a contemporary metric could capture real-time journal influence through the dissemination of a journal's content through the social media platform X (formerly Twitter), using metadata including the number of tweets, likes and retweets.<span><sup>5</sup></span> These contemporary metrics would reflect how much users are actually reading and sharing the journal's content. While these contemporary metrics may overcome some challenges of traditional JPMs, they may introduce limitations of their own and be subject to manipulation.</p><p>For example, <i>Clinical & Experimental Ophthalmology</i> (CEO) may utilise metadata from their X account (@ClinExpOphthal) to reflect user engagement as a real-time metric on the journal's webpage. While CEO lists metrics including full-text views, other usage metrics that may be incorporated include the duration of full-text views per day and per year. Additional
期刊级出版指标(JPM)用于评估学术期刊的研究影响和影响力。1 最广泛采用和最成熟的JPM是影响因子(IF)、特征因子得分(EF)和SCImago期刊排名(SJR)。研究人员通常使用影响因子来指导阅读和发表眼科期刊。2JPMs 并不完全反映真实世界的影响力,因此可能无法全面反映人们对期刊及其内容的关注和兴趣。2JPM 并不能完全反映真实世界的影响力,因此可能无法全面反映期刊及其内容的受关注程度。3 同样,我们使用 Clarivate 期刊引文报告、Scimago 期刊排名和 Eigenfactor 期刊排名发布的最新引文数据,分别对 IF、SJR 和 EF 的排名进行了横向分析比较。我们发现,IF 排名前五的眼科期刊也是 SJR 排名前五的期刊。但有趣的是,我们发现 IF 排名前三位的眼科期刊在 EF 方面分别排名第 15、第 2 和第 16 位。同样,EF排名前三的眼科期刊在IF方面分别排名第10、第2和第8位,在SJR方面分别排名第12、第2和第6位。未来的研究可能会考虑从新的角度开发反映用户兴趣和关注度的指标。这些指标可以确定用户在期刊网站上的参与度,包括页面和文章浏览量、在文章上花费的时间以及点击次数。5 这些当代指标将反映用户实际阅读和分享期刊内容的程度。例如,《临床与实验眼科学》(Clinical & Experimental Ophthalmology,CEO)可利用其 X 帐户(@ClinExpOphthal)的元数据反映用户参与情况,作为期刊网页上的实时指标。CEO 列出的指标包括全文浏览量,其他可纳入的使用指标还包括每天和每年全文浏览量的持续时间。此外,还可以利用《首席执行官》中发布的每个眼科类别的相关元数据指标来反映《首席执行官》读者群的兴趣所在。此外,显示《首席执行官》在 JPM 排名中持续上升趋势的图表将标志着该期刊在眼科研究方面的影响力与日俱增。了解JPM在眼科领域的实用性和未来应用,对于持续改进眼科循证医学实践非常必要。对JPM进行全面分析,可以改进眼科稿件投稿的期刊定位,更准确地定位文章的预期结果和受众。这可能会扩大作品的影响力,并随之改善作者层面的指标。本文因其观察性质而受到限制。本研究的主要作者获得了阿德莱德大学 2023 年夏季研究奖学金的资助。斯蒂芬-巴奇(Stephen Bacchi)获得了富布赖特奖学金(由金霍恩基金会资助)。
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引用次数: 0
Clinical performance of predicting late age-related macular degeneration development using multimodal imaging 利用多模态成像预测晚期老年性黄斑变性发展的临床表现。
IF 4.9 2区 医学 Q1 OPHTHALMOLOGY Pub Date : 2024-05-30 DOI: 10.1111/ceo.14405
Kai Lyn Goh BOptom, PhD, Carla J. Abbott BOptom, PhD, Thomas G. Campbell DPhil, FRANZCO, Amy C. Cohn MMed, FRANZCO, Dai Ni Ong BMedSc(Hons), FRANZCO, Sanjeewa S. Wickremasinghe DMSc, FRANZCO, Lauren A. B. Hodgson MPH, Robyn H. Guymer PhD, FRANZCO, Zhichao Wu BAppSc(Optom), PhD

Background

To examine whether the clinical performance of predicting late age-related macular degeneration (AMD) development is improved through using multimodal imaging (MMI) compared to using colour fundus photography (CFP) alone, and how this compares with a basic prediction model using well-established AMD risk factors.

Methods

Individuals with AMD in this study underwent MMI, including optical coherence tomography (OCT), fundus autofluorescence, near-infrared reflectance and CFP at baseline, and then at 6-monthly intervals for 3-years to determine MMI-defined late AMD development. Four retinal specialists independently assessed the likelihood that each eye at baseline would progress to MMI-defined late AMD over 3-years with CFP, and then with MMI. Predictive performance with CFP and MMI were compared to each other, and to a basic prediction model using age, presence of pigmentary abnormalities, and OCT-based drusen volume.

Results

The predictive performance of the clinicians using CFP [AUC = 0.75; 95% confidence interval (CI) = 0.68–0.82] improved when using MMI (AUC = 0.79; 95% CI = 0.72–0.85; p = 0.034). However, a basic prediction model outperformed clinicians using either CFP or MMI (AUC = 0.85; 95% CI = 0.78–91; p ≤ 0.002).

Conclusions

Clinical performance for predicting late AMD development was improved by using MMI compared to CFP. However, a basic prediction model using well-established AMD risk factors outperformed retinal specialists, suggesting that such a model could further improve personalised counselling and monitoring of individuals with the early stages of AMD in clinical practice.

背景:目的:研究使用多模态成像(MMI)预测晚期老年性黄斑变性(AMD)发展的临床表现与仅使用彩色眼底照相(CFP)相比是否有所改善,以及这与使用已确立的AMD风险因素的基本预测模型相比有何不同:本研究中的 AMD 患者在基线时接受了包括光学相干断层扫描 (OCT)、眼底自动荧光、近红外反射和 CFP 在内的 MMI 检查,然后在 3 年内每 6 个月接受一次检查,以确定 MMI 定义的晚期 AMD 发展情况。四位视网膜专家分别用 CFP 和 MMI 评估了每只基线眼在 3 年内发展为 MMI 定义的晚期 AMD 的可能性。CFP和MMI的预测性能相互比较,并与使用年龄、是否存在色素异常和基于OCT的色素沉着量的基本预测模型进行比较:临床医生使用 CFP 的预测性能[AUC = 0.75;95% 置信区间 (CI) = 0.68-0.82]在使用 MMI 时有所提高(AUC = 0.79;95% CI = 0.72-0.85;p = 0.034)。然而,基本预测模型的表现优于使用 CFP 或 MMI 的临床医生(AUC = 0.85;95% CI = 0.78-91;p ≤ 0.002):结论:与CFP相比,使用MMI预测晚期AMD发展的临床效果更好。结论:与CFP相比,使用MMI预测AMD晚期发展的临床表现更好。然而,使用成熟的AMD风险因素的基本预测模型的表现优于视网膜专家,这表明这种模型可以进一步改善临床实践中对AMD早期患者的个性化咨询和监测。
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引用次数: 0
Body mass index and astigmatism: A nationwide study 体重指数与散光:一项全国性研究。
IF 4.9 2区 医学 Q1 OPHTHALMOLOGY Pub Date : 2024-05-27 DOI: 10.1111/ceo.14406
Itay Nitzan MD, MPH, Inbal Akavian MD, Or Shmueli MD, Nir Erdinest BOptom, PhD, Yair Hanina BSc, Gilad Twig MD, PhD, Margarita Safir MD

Background

Existing research on the relationship between body mass index (BMI) and astigmatism yields inconsistent results. This study analyses this association in a nationally representative sample of adolescents.

Methods

This retrospective, cross-sectional study included Israeli adolescents who underwent medical assessments before mandatory military service between 2011 and 2022. BMI was categorised based on the US age- and sex-matched percentiles. Astigmatism was categorised by magnitude [low-moderate: 0.75 to <3.00 diopters (D), high: ≥3.00 D], and axis orientation [with-the-rule (WTR), against-the-rule (ATR), or oblique (OBL)]. Sex-stratified regression models adjusted for sociodemographic variables were used.

Results

Of 935 989 adolescents evaluated, 887 325 were included [511 465 (57.6%) males, mean age 17.2 years]. Astigmatism was diagnosed in 123 675 (13.9%) adolescents, of whom 117 081 (13.2%) had low-moderate and 6594 (0.7%) had high astigmatism. WTR astigmatism was the most prevalent (8.2%), followed by ATR (4.1%) and OBL (1.6%) types. Compared with low-normal BMI (5th to 50th percentile), the adjusted ORs for total astigmatism increased with increasing BMI, peaking at 1.65 (1.57–1.74) in males and 1.74 (1.64–1.86) in females with severe obesity. ORs were accentuated for high astigmatism, reaching 3.51 (3.01–4.09) in males, and 3.45 (2.83–4.22) in females with severe obesity. WTR astigmatism demonstrated the strongest association with BMI, with ORs reaching 2.26 (2.13–2.40) in males and 2.04 (1.90–2.20) in females with severe obesity. The results persisted in a series of subgroup analyses.

Conclusions

Obesity is associated with higher odds of astigmatism in adolescence. Further investigation into the role of weight management in astigmatism development is warranted.

背景:关于体重指数(BMI)与散光之间关系的现有研究得出的结果并不一致。本研究对具有全国代表性的青少年样本进行了分析:这项回顾性横断面研究包括在 2011 年至 2022 年期间服义务兵役前接受医学评估的以色列青少年。体重指数根据美国年龄和性别匹配百分位数进行分类。散光的程度分为[低度-中度:结果:在接受评估的 935 989 名青少年中,有 887 325 名青少年接受了评估[511 465 名(57.6%)男性,平均年龄 17.2 岁]。123 675 名(13.9%)青少年被诊断出散光,其中 117 081 名(13.2%)为中低度散光,6594 名(0.7%)为高度散光。WTR散光最普遍(8.2%),其次是ATR(4.1%)和OBL(1.6%)。与低正常体重指数(第 5 至第 50 百分位数)相比,总散光的调整 ORs 随体重指数的增加而增加,男性达到 1.65(1.57-1.74),重度肥胖女性达到 1.74(1.64-1.86)。高度散光的OR值更高,男性为3.51(3.01-4.09),女性重度肥胖者为3.45(2.83-4.22)。WTR散光与体重指数的关系最为密切,男性的OR值为2.26(2.13-2.40),女性重度肥胖者的OR值为2.04(1.90-2.20)。这些结果在一系列亚组分析中依然存在:结论:肥胖与青春期散光几率较高有关。结论:肥胖与青少年散光发生几率较高有关,因此有必要进一步研究体重管理在散光发生中的作用。
{"title":"Body mass index and astigmatism: A nationwide study","authors":"Itay Nitzan MD, MPH,&nbsp;Inbal Akavian MD,&nbsp;Or Shmueli MD,&nbsp;Nir Erdinest BOptom, PhD,&nbsp;Yair Hanina BSc,&nbsp;Gilad Twig MD, PhD,&nbsp;Margarita Safir MD","doi":"10.1111/ceo.14406","DOIUrl":"10.1111/ceo.14406","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Existing research on the relationship between body mass index (BMI) and astigmatism yields inconsistent results. This study analyses this association in a nationally representative sample of adolescents.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective, cross-sectional study included Israeli adolescents who underwent medical assessments before mandatory military service between 2011 and 2022. BMI was categorised based on the US age- and sex-matched percentiles. Astigmatism was categorised by magnitude [low-moderate: 0.75 to &lt;3.00 diopters (D), high: ≥3.00 D], and axis orientation [with-the-rule (WTR), against-the-rule (ATR), or oblique (OBL)]. Sex-stratified regression models adjusted for sociodemographic variables were used.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of 935 989 adolescents evaluated, 887 325 were included [511 465 (57.6%) males, mean age 17.2 years]. Astigmatism was diagnosed in 123 675 (13.9%) adolescents, of whom 117 081 (13.2%) had low-moderate and 6594 (0.7%) had high astigmatism. WTR astigmatism was the most prevalent (8.2%), followed by ATR (4.1%) and OBL (1.6%) types. Compared with low-normal BMI (5th to 50th percentile), the adjusted ORs for total astigmatism increased with increasing BMI, peaking at 1.65 (1.57–1.74) in males and 1.74 (1.64–1.86) in females with severe obesity. ORs were accentuated for high astigmatism, reaching 3.51 (3.01–4.09) in males, and 3.45 (2.83–4.22) in females with severe obesity. WTR astigmatism demonstrated the strongest association with BMI, with ORs reaching 2.26 (2.13–2.40) in males and 2.04 (1.90–2.20) in females with severe obesity. The results persisted in a series of subgroup analyses.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Obesity is associated with higher odds of astigmatism in adolescence. Further investigation into the role of weight management in astigmatism development is warranted.</p>\u0000 </section>\u0000 </div>","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":"52 6","pages":"616-626"},"PeriodicalIF":4.9,"publicationDate":"2024-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ceo.14406","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141158128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of intraocular pressure and anterior segment parameters in subjects with asymmetrical primary angle closure disease 不对称原发性闭角病患者眼压和眼前节参数的比较。
IF 4.9 2区 医学 Q1 OPHTHALMOLOGY Pub Date : 2024-05-27 DOI: 10.1111/ceo.14402
Shayne S. Tan FRCOphth, Tin A. Tun MBBS, PhD, Tin Aung FRCS(Ed), PhD, Monisha E. Nongpiur MD, PhD

Background

To compare intraocular pressure (IOP) and anterior segment parameters between eyes with unilateral primary angle closure glaucoma (PACG) and their fellow eyes with primary angle closure (PAC) or primary angle closure suspect (PACS).

Methods

Subjects underwent anterior segment imaging using 360-degree swept-source optical coherence tomography (SS-OCT, CASIA Tomey, Nagoya, Japan) and ocular investigations including gonioscopy and IOP measurement. Each SS-OCT scan (divided into 8 frames, 22.5 degrees apart) was analysed and an average was obtained for the following anterior segment parameters: iridotrabecular contact (ITC), angle opening distance (AOD750), iris thickness and curvature, anterior chamber width, depth and area (ACW, ACD and ACA) and lens vault (LV).

Results

Among 132 unilateral PACG subjects (mean age: 62.91 ± 7.2 years; 59.1% male), eyes with PACG had significantly higher presenting IOP (24.81 ± 0.94 vs. 18.43 ± 0.57 mmHg, p < 0.001), smaller gonioscopic Shaffer grade (2.07 ± 0.07 vs. 2.31 ± 0.07, p < 0.001) and a greater extent of peripheral anterior synechiae (PAS, 1.21 ± 0.21 vs. 0.54 ± 0.16 clock hours, p = 0.001). PACG eyes also exhibited increased ITC, ITC area, greater LV and smaller AOD750, ACD and ACA (all p < 0.05). Using the forward stepwise regression model, an increase in 1 mmHg in presenting IOP before laser peripheral iridotomy (LPI) increases the odds of having PACG by 9% (95% confidence interval 5%–14%).

Conclusions

PACG eyes have higher presenting IOP, smaller anterior segment parameters, greater extent of PAS, and larger LV compared to their fellow eyes with angle closure. Narrower anterior chamber dimensions and higher presenting IOP before LPI may increase risk of chronic elevated IOP and glaucomatous optic neuropathy after LPI.

背景:目的:比较单侧原发性闭角型青光眼(PACG)患者与原发性闭角型青光眼(PAC)或疑似原发性闭角型青光眼(PACS)患者的眼压(IOP)和眼前节参数:受试者使用 360 度扫源光学相干断层扫描(SS-OCT,CASIA Tomey,日本名古屋)进行眼前节成像,并接受包括眼底镜检查和眼压测量在内的眼部检查。对每次 SS-OCT 扫描(分为 8 帧,相距 22.5 度)进行分析,并得出以下前节参数的平均值:虹膜睫状体接触(ITC)、开角距离(AOD750)、虹膜厚度和弧度、前房宽度、深度和面积(ACW、ACD 和 ACA)以及晶状体穹窿(LV):在 132 名单侧 PACG 受试者(平均年龄:62.91 ± 7.2 岁;59.1% 为男性)中,PACG 患者的眼压明显更高(24.81 ± 0.94 vs. 18.43 ± 0.57 mmHg,p 结论:PACG 患者的眼压明显更高(24.81 ± 0.94 vs. 18.43 ± 0.57 mmHg,p):与角膜闭合症患者相比,PACG 患者的眼压更高、前节参数更小、PAS 范围更大、LV 更大。在 LPI 之前,较窄的前房尺寸和较高的眼压可能会增加 LPI 后眼压长期升高和青光眼性视神经病变的风险。
{"title":"Comparison of intraocular pressure and anterior segment parameters in subjects with asymmetrical primary angle closure disease","authors":"Shayne S. Tan FRCOphth,&nbsp;Tin A. Tun MBBS, PhD,&nbsp;Tin Aung FRCS(Ed), PhD,&nbsp;Monisha E. Nongpiur MD, PhD","doi":"10.1111/ceo.14402","DOIUrl":"10.1111/ceo.14402","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>To compare intraocular pressure (IOP) and anterior segment parameters between eyes with unilateral primary angle closure glaucoma (PACG) and their fellow eyes with primary angle closure (PAC) or primary angle closure suspect (PACS).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Subjects underwent anterior segment imaging using 360-degree swept-source optical coherence tomography (SS-OCT, CASIA Tomey, Nagoya, Japan) and ocular investigations including gonioscopy and IOP measurement. Each SS-OCT scan (divided into 8 frames, 22.5 degrees apart) was analysed and an average was obtained for the following anterior segment parameters: iridotrabecular contact (ITC), angle opening distance (AOD750), iris thickness and curvature, anterior chamber width, depth and area (ACW, ACD and ACA) and lens vault (LV).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among 132 unilateral PACG subjects (mean age: 62.91 ± 7.2 years; 59.1% male), eyes with PACG had significantly higher presenting IOP (24.81 ± 0.94 vs. 18.43 ± 0.57 mmHg, <i>p</i> &lt; 0.001), smaller gonioscopic Shaffer grade (2.07 ± 0.07 vs. 2.31 ± 0.07, <i>p</i> &lt; 0.001) and a greater extent of peripheral anterior synechiae (PAS, 1.21 ± 0.21 vs. 0.54 ± 0.16 clock hours, <i>p</i> = 0.001). PACG eyes also exhibited increased ITC, ITC area, greater LV and smaller AOD750, ACD and ACA (all <i>p</i> &lt; 0.05). Using the forward stepwise regression model, an increase in 1 mmHg in presenting IOP before laser peripheral iridotomy (LPI) increases the odds of having PACG by 9% (95% confidence interval 5%–14%).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>PACG eyes have higher presenting IOP, smaller anterior segment parameters, greater extent of PAS, and larger LV compared to their fellow eyes with angle closure. Narrower anterior chamber dimensions and higher presenting IOP before LPI may increase risk of chronic elevated IOP and glaucomatous optic neuropathy after LPI.</p>\u0000 </section>\u0000 </div>","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":"52 7","pages":"724-731"},"PeriodicalIF":4.9,"publicationDate":"2024-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141158167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retention time of different ophthalmic viscosurgical devices during phacoemulsification in rabbit ocular model: A comparative analysis 在兔眼模型中进行超声乳化时,不同眼科粘弹剂手术器械的滞留时间:比较分析。
IF 4.9 2区 医学 Q1 OPHTHALMOLOGY Pub Date : 2024-05-20 DOI: 10.1111/ceo.14401
Daf Shalev MD, Guy Kleinmann MD

Background

To compare retention times of various ophthalmic viscosurgical devices (OVDs) and soft-shell combinations.

Methods

Experimental study. Eighteen rabbit eyes were divided into six groups of three eyes, based on OVDs tested. A: Endocoat, B: HealonPro, C: Viscoat, D: Provisc, E: Endocoat and HealonPro and F: Viscoat and Provisc. OVDs were stained with 10% fluorescein dye before being injected into the anterior chamber. Phacoemulsification, using fixed parameters, was performed. If OVD persisted after 60 s, a standardised irrigation and aspiration technique replaced phacoemulsification. The time until central and complete clearance of the OVD were video-recorded and measured.

Results

Mean central retention times (CRT) were found to be: HealonPro—5.33 ± 2.56 s, Provisc—3.33 ± 1.11 s, Endocoat—75.0 ± 3.26 s, Viscoat—62.33 ± 5.19 s, combining HealonPro with Endocoat—22.67 ± 4.75 s and Provisc with Viscoat—11.0 ± 0.82 s. The mean total retention time (TRT) was: Endocoat—80.0 ± 8.17 s, Viscoat—81.67 ± 2.09 s, HealonPro with Endocoat—81.33 ± 3.35 s, and Provisc with Viscoat—71.0 ± 2.94 s. For HealonPro and Provisc, CRT and TRT remained identical across all trials.

Conclusions

Retention times varied, with cohesive OVDs exhibiting shorter durations than dispersive OVDs. Among dispersive OVDs, TRTs were comparable; however, Endocoat displayed an extended CRT. In soft shell trials, the combination of HealonPro and Endocoat exhibited prolonged CRT and TRT, suggesting enhanced corneal protection.

背景:比较各种眼科粘切装置(OVD)和软壳组合的保留时间:比较各种眼科粘切装置(OVD)和软壳组合的保留时间:实验研究。根据测试的 OVD,将 18 只兔眼分为六组,每组三只眼。A:Endocoat;B:HealonPro;C:Viscoat;D:Provisc;E:Endocoat 和 HealonPro;F:Viscoat 和 Provisc。在将 OVDs 注入前房之前,先用 10% 荧光素染料进行染色。使用固定参数进行超声乳化。如果 OVD 在 60 秒后仍然存在,则采用标准化灌洗和抽吸技术取代超声乳化。视频记录并测量了中心和完全清除 OVD 的时间:结果:平均中央滞留时间(CRT)为HealonPro-5.33±2.56秒,Provisc-3.33±1.11秒,Endocoat-75.0±3.26秒,Viscoat-62.33±5.19秒,HealonPro与Endocoat结合-22.67±4.75秒,Provisc与Viscoat结合-11.0±0.82秒。总滞留时间(TRT)的平均值为Endocoat-80.0 ± 8.17 秒,Viscoat-81.67 ± 2.09 秒,带 Endocoat 的 HealonPro-81.33 ± 3.35 秒,带 Viscoat 的 Provisc-71.0 ± 2.94 秒。对于 HealonPro 和 Provisc,所有试验的 CRT 和 TRT 保持一致:滞留时间各不相同,内聚型 OVD 的滞留时间短于分散型 OVD。在分散型 OVD 中,TRT 具有可比性;但 Endocoat 的 CRT 较长。在软壳试验中,HealonPro和Endocoat的组合显示出更长的CRT和TRT,表明角膜保护能力得到了增强。
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引用次数: 0
Genetics in neovascular age-related macular degeneration susceptibility and treatment response to anti-VEGF intravitreal injection: A case series study. 新生血管性老年性黄斑变性易感性和抗血管内皮生长因子玻璃体内注射治疗反应的遗传学:病例系列研究。
IF 4 2区 医学 Q1 OPHTHALMOLOGY Pub Date : 2024-05-16 DOI: 10.1111/ceo.14388
Fang-Yu Chang, Chu-Hsuan Huang, Chang-Hao Yang, Jung-Tzu Chang, Chung-May Yang, Tzzy-Chang Ho, Yi-Ting Hsieh, Tso-Ting Lai, Chao-Wen Lin, Chang-Pin Lin, Yi-Chieh Chen, Ying-Ju Lai, Pei-Lung Chen, Jacob Shujui Hsu, Ta-Ching Chen

Background: To identify genotypes associated with neovascular age-related macular degeneration (nAMD) and investigate the associations between genotype variations and anti-vascular endothelial growth factor (VEGF) treatment response.

Methods: This observational, retrospective, case series study enrolled patients diagnosed with nAMD who received anti-VEGF treatment in National Taiwan University Hospital with at least one-year follow-up between 2012 and 2020. A genome-wide association study (GWAS) was conducted on enrolled patients and controls. Correlations between the genotypes identified from GWAS and the treatment response of functional/anatomical biomarkers, including visual acuity (VA), presence of intraretinal or subretinal fluid (SRF), serous or fibrovascular pigmented epithelium detachment (PED), and disruption of the ellipsoid zone (EZ), were analysed.

Results: In total, 182 patients with nAMD and 1748 controls were enrolled. GWAS revealed 16 single nucleotide polymorphisms (SNPs) as risk loci for nAMD, including seven loci in CFH and ARMS2/HTRA1 and nine novel loci, including rs117517872 and rs79835234(COPB2-DT), rs7525578(RAP1A), rs2123738(LOC105376755), rs1374879(CNTN3), rs3812692(SAR1A), rs117501587(PRKCA), rs9965945(CNDP1), and rs189769231(MATK). Our study revealed rs800292(CFH), rs11200638(HTRA1), and rs2123738(LOC105376755) correlated with poor treatment response in VA (P = 0.005), SRF (P = 0.044), and fibrovascular PED (P = 0.007), respectively. Rs9965945(CNDP1) was correlated with poor response in disruption of EZ (P = 0.046) and serous PED (P = 0.049).

Conclusions: Among the 16 SNPs found in the GWAS, four loci-CFH, ARMS2/HTRA1, and two novel loci-were correlated with the susceptibility of nAMD and anatomical/functional responses after anti-VEGF treatment.

背景:确定与新生血管性老年黄斑变性(nAMD)相关的基因型,并研究基因型变异与抗血管内皮生长因子(VEGF)治疗反应之间的关联:这项观察性、回顾性、病例系列研究纳入了2012年至2020年期间在台湾大学医院接受抗血管内皮生长因子治疗且随访至少一年的确诊nAMD患者。研究人员对入选患者和对照组进行了全基因组关联研究(GWAS)。研究分析了从 GWAS 中确定的基因型与功能/解剖生物标志物治疗反应之间的相关性,这些生物标志物包括视力(VA)、视网膜内或视网膜下积液(SRF)、浆液性或纤维血管性色素上皮脱落(PED)以及椭圆形区(EZ)的破坏:结果:共招募了 182 名 nAMD 患者和 1748 名对照者。GWAS发现了16个单核苷酸多态性(SNPs)作为nAMD的风险位点,包括CFH和ARMS2/HTRA1中的7个位点以及9个新的位点、包括 rs117517872 和 rs79835234(COPB2-DT)、rs7525578(RAP1A)、rs2123738(LOC105376755)、rs1374879(CNTN3)、rs3812692(SAR1A)、rs117501587(PRKCA)、rs9965945(CNDP1)和 rs189769231(MATK)。我们的研究发现,rs800292(CFH)、rs11200638(HTRA1)和rs2123738(LOC105376755)分别与VA(P = 0.005)、SRF(P = 0.044)和纤维血管性PED(P = 0.007)的不良治疗反应相关。Rs9965945(CNDP1)与EZ中断(P = 0.046)和浆液性PED(P = 0.049)的不良反应相关:结论:在 GWAS 发现的 16 个 SNPs 中,4 个位点-CFH、ARMS2/HTRA1 和 2 个新位点-与 nAMD 易感性和抗 VEGF 治疗后的解剖/功能反应相关。
{"title":"Genetics in neovascular age-related macular degeneration susceptibility and treatment response to anti-VEGF intravitreal injection: A case series study.","authors":"Fang-Yu Chang, Chu-Hsuan Huang, Chang-Hao Yang, Jung-Tzu Chang, Chung-May Yang, Tzzy-Chang Ho, Yi-Ting Hsieh, Tso-Ting Lai, Chao-Wen Lin, Chang-Pin Lin, Yi-Chieh Chen, Ying-Ju Lai, Pei-Lung Chen, Jacob Shujui Hsu, Ta-Ching Chen","doi":"10.1111/ceo.14388","DOIUrl":"https://doi.org/10.1111/ceo.14388","url":null,"abstract":"<p><strong>Background: </strong>To identify genotypes associated with neovascular age-related macular degeneration (nAMD) and investigate the associations between genotype variations and anti-vascular endothelial growth factor (VEGF) treatment response.</p><p><strong>Methods: </strong>This observational, retrospective, case series study enrolled patients diagnosed with nAMD who received anti-VEGF treatment in National Taiwan University Hospital with at least one-year follow-up between 2012 and 2020. A genome-wide association study (GWAS) was conducted on enrolled patients and controls. Correlations between the genotypes identified from GWAS and the treatment response of functional/anatomical biomarkers, including visual acuity (VA), presence of intraretinal or subretinal fluid (SRF), serous or fibrovascular pigmented epithelium detachment (PED), and disruption of the ellipsoid zone (EZ), were analysed.</p><p><strong>Results: </strong>In total, 182 patients with nAMD and 1748 controls were enrolled. GWAS revealed 16 single nucleotide polymorphisms (SNPs) as risk loci for nAMD, including seven loci in CFH and ARMS2/HTRA1 and nine novel loci, including rs117517872 and rs79835234(COPB2-DT), rs7525578(RAP1A), rs2123738(LOC105376755), rs1374879(CNTN3), rs3812692(SAR1A), rs117501587(PRKCA), rs9965945(CNDP1), and rs189769231(MATK). Our study revealed rs800292(CFH), rs11200638(HTRA1), and rs2123738(LOC105376755) correlated with poor treatment response in VA (P = 0.005), SRF (P = 0.044), and fibrovascular PED (P = 0.007), respectively. Rs9965945(CNDP1) was correlated with poor response in disruption of EZ (P = 0.046) and serous PED (P = 0.049).</p><p><strong>Conclusions: </strong>Among the 16 SNPs found in the GWAS, four loci-CFH, ARMS2/HTRA1, and two novel loci-were correlated with the susceptibility of nAMD and anatomical/functional responses after anti-VEGF treatment.</p>","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140961012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genetics in neovascular age-related macular degeneration susceptibility and treatment response to anti-VEGF intravitreal injection: A case series study 新生血管性老年性黄斑变性易感性和抗血管内皮生长因子玻璃体内注射治疗反应的遗传学:病例系列研究。
IF 4.9 2区 医学 Q1 OPHTHALMOLOGY Pub Date : 2024-05-16 DOI: 10.1111/ceo.14388
Fang-Yu Chang MD, Chu-Hsuan Huang MD, Chang-Hao Yang MD, PhD, Jung-Tzu Chang MD, Chung-May Yang MD, PhD, Tzzy-Chang Ho MD, Yi-Ting Hsieh MD, PhD, Tso-Ting Lai MD, Chao-Wen Lin MD, Chang-Pin Lin MD, Yi-Chieh Chen MD, Ying-Ju Lai MS, Pei-Lung Chen MD, PhD, Jacob Shujui Hsu PhD, Ta-Ching Chen MD, PhD

Background

To identify genotypes associated with neovascular age-related macular degeneration (nAMD) and investigate the associations between genotype variations and anti-vascular endothelial growth factor (VEGF) treatment response.

Methods

This observational, retrospective, case series study enrolled patients diagnosed with nAMD who received anti-VEGF treatment in National Taiwan University Hospital with at least one-year follow-up between 2012 and 2020. A genome-wide association study (GWAS) was conducted on enrolled patients and controls. Correlations between the genotypes identified from GWAS and the treatment response of functional/anatomical biomarkers, including visual acuity (VA), presence of intraretinal or subretinal fluid (SRF), serous or fibrovascular pigmented epithelium detachment (PED), and disruption of the ellipsoid zone (EZ), were analysed.

Results

In total, 182 patients with nAMD and 1748 controls were enrolled. GWAS revealed 16 single nucleotide polymorphisms (SNPs) as risk loci for nAMD, including seven loci in CFH and ARMS2/HTRA1 and nine novel loci, including rs117517872 and rs79835234(COPB2-DT), rs7525578(RAP1A), rs2123738(LOC105376755), rs1374879(CNTN3), rs3812692(SAR1A), rs117501587(PRKCA), rs9965945(CNDP1), and rs189769231(MATK). Our study revealed rs800292(CFH), rs11200638(HTRA1), and rs2123738(LOC105376755) correlated with poor treatment response in VA (P = 0.005), SRF (P = 0.044), and fibrovascular PED (P = 0.007), respectively. Rs9965945(CNDP1) was correlated with poor response in disruption of EZ (P = 0.046) and serous PED (P = 0.049).

Conclusions

Among the 16 SNPs found in the GWAS, four loci—CFH, ARMS2/HTRA1, and two novel loci—were correlated with the susceptibility of nAMD and anatomical/functional responses after anti-VEGF treatment.

背景为了确定与新生血管性年龄相关性黄斑变性(nAMD)相关的基因型,并研究基因型变异与抗血管内皮生长因子(VEGF)治疗反应之间的关联。方法这项观察性、回顾性、病例系列研究招募了2012年至2020年期间在台湾大学医院接受抗血管内皮生长因子治疗且随访至少一年的确诊为nAMD的患者。研究人员对入选患者和对照组进行了全基因组关联研究(GWAS)。结果共招募了 182 名 nAMD 患者和 1748 名对照者。GWAS发现了16个单核苷酸多态性(SNPs)作为nAMD的风险位点,包括CFH和ARMS2/HTRA1中的7个位点以及9个新的位点、包括 rs117517872 和 rs79835234(COPB2-DT)、rs7525578(RAP1A)、rs2123738(LOC105376755)、rs1374879(CNTN3)、rs3812692(SAR1A)、rs117501587(PRKCA)、rs9965945(CNDP1)和 rs189769231(MATK)。我们的研究发现,rs800292(CFH)、rs11200638(HTRA1)和rs2123738(LOC105376755)分别与VA(P = 0.005)、SRF(P = 0.044)和纤维血管性PED(P = 0.007)的不良治疗反应相关。结论在 GWAS 发现的 16 个 SNPs 中,4 个位点-CFH、ARMS2/HTRA1 和 2 个新位点-与 nAMD 易感性和抗 VEGF 治疗后的解剖/功能反应相关。
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引用次数: 0
Evaluating keratometry and corneal astigmatism data from biometers and anterior segment tomographers and mapping to reconstructed corneal astigmatism 评估来自生物测量仪和前段断层成像仪的角膜测量和角膜散光数据,并绘制重建角膜散光图。
IF 4.9 2区 医学 Q1 OPHTHALMOLOGY Pub Date : 2024-05-13 DOI: 10.1111/ceo.14387
Achim Langenbucher PhD, Leonardo Taroni MD, PhD, Catarina P. Coutinho MSc, Alan Cayless PhD, Nóra Szentmáry MD, PhD, Peter Hoffmann MD, Jascha Wendelstein MD, Giacomo Savini MD, PhD

Background

To compare results from different corneal astigmatism measurement instruments; to reconstruct corneal astigmatism from the postimplantation spectacle refraction and toric intraocular lens (IOL) power; and to derive models for mapping measured corneal astigmatism to reconstructed corneal astigmatism.

Methods

Retrospective single centre study involving 150 eyes treated with a toric IOL (Alcon SN6AT, DFT or TFNT). Measurements included IOLMaster 700 keratometry (IOLMK) and total keratometry (IOLMTK), Pentacam keratometry (PK) and total corneal refractive power in 3 and 4 mm zones (PTCRP3 and PTCRP4), and Aladdin keratometry (AK). Regression-based models mapping the measured C0 and C45 components (Alpin's method) to reconstructed corneal astigmatism were derived.

Results

Mean C0 components were 0.50/0.59/0.51 dioptres (D) for IOLMK/PK/AK; 0.2/0.26/0.31 D for IOLMTK/PTCRP3/PTCRP4; and 0.26 D for reconstructed corneal astigmatism. All corresponding C45 components ranged around 0. The prediction models had main diagonal elements lower than 1 with some crosstalk between C0 and C45 (nonzero off-diagonal elements). Root-mean-squared residuals were 0.44/0.45/0.48/0.51/0.50/0.47 D for IOLMK/IOLMTK/PK/PTCRP3/PTCRP4/AK.

Conclusions

Results from the different modalities are not consistent. On average IOLMTK/PTCRP3/PTCRP4 match reconstructed corneal astigmatism, whereas IOLMK/PK/AK show systematic C0 offsets of around 0.25 D. IOLMTK/PTCRP3/PTCRP4. Prediction models can reduce but not fully eliminate residual astigmatism after toric IOL implantation.

背景:比较不同角膜散光测量仪器的测量结果;根据植入后的眼镜屈光度数和散光人工晶体(IOL)的功率重建角膜散光;推导测量角膜散光与重建角膜散光的映射模型:回顾性单中心研究,涉及 150 只接受散光人工晶体(Alcon SN6AT、DFT 或 TFNT)治疗的眼睛。测量项目包括 IOLMaster 700 角膜度数 (IOLMK) 和总角膜度数 (IOLMTK)、Pentacam 角膜度数 (PK) 和 3 毫米和 4 毫米区的总角膜屈光力 (PTCRP3 和 PTCRP4) 以及阿拉丁角膜度数 (AK)。结果发现,测量的 C0 和 C45 分量(Alpin 方法)与重建的角膜散光之间存在回归模型:结果:IOLMK/PK/AK的平均C0分量为0.50/0.59/0.51屈光度(D);IOLMK/PTCRP3/PTCRP4的平均C0分量为0.2/0.26/0.31屈光度;重建角膜散光的平均C0分量为0.26屈光度。所有相应的 C45 分量都在 0 左右。预测模型的主对角线元素低于 1,C0 和 C45 之间存在一些串扰(非零对角线元素)。IOLMK/IOLMTK/PK/PTCRP3/PTCRP4/AK 的均方根残差为 0.44/0.45/0.48/0.51/0.50/0.47 D:不同模式的结果并不一致。平均而言,IOLMTK/PTCRP3/PTCRP4 与重建的角膜散光相匹配,而 IOLMK/PK/AK 则显示出约 0.25 D 的系统性 C0 偏移。预测模型可以减少但不能完全消除散光人工晶体植入术后的残余散光。
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引用次数: 0
Corneal endothelial evaluations in immunoglobulin g4-related ophthalmic disease 免疫球蛋白 g4 相关眼科疾病中的角膜内皮评价
IF 4.9 2区 医学 Q1 OPHTHALMOLOGY Pub Date : 2024-05-01 DOI: 10.1111/ceo.14384
Kenneth Ka Hei Lai AFCOphthHK, Andrew Kin Ting Kuk FCOphthHK, Andy Chi On Cheng FCOphthHK, Chi Ho Kwong FCOphthHK, Kenneth Kai Wang Li FCOphthHK, Wendy Pui Fan Lam FCOphthHK, Hunter Kwok Lai Yuen FCOphthHK, Kelvin Kam Lung Chong FCOphthHK
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引用次数: 0
期刊
Clinical and Experimental Ophthalmology
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