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Reconsidering the Drivers of Macular Atrophy Under Chronic Anti-VEGF Therapy. 慢性抗vegf治疗下黄斑萎缩驱动因素的再思考。
IF 5.6 2区 医学 Q1 OPHTHALMOLOGY Pub Date : 2026-01-04 DOI: 10.1111/ceo.70023
Wenjie Li, Ziyu Du, Huixin Tao, Yang Liu
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引用次数: 0
Hard Truth About Surveillance for Uveal Melanoma 关于葡萄膜黑色素瘤监测的真相。
IF 5.6 2区 医学 Q1 OPHTHALMOLOGY Pub Date : 2025-12-26 DOI: 10.1111/ceo.70041
Jasmine H. Francis
<p>There is a hard truth about cancer surveillance that does not appear to dissuade the vibrancy of cancer screening recommendations. The truth is that surveillance does not improve patient survival, except in very specific instances. For most common solid malignancies, routine surveillance in asymptomatic cases does not offer a survival advantage: In breast cancer, randomised trials do not advocate routine metastatic surveillance in asymptomatic survivors [<span>1</span>]. Even in the most common cancer type, lung cancer, routine imaging successfully detects more asymptomatic recurrences but fails to improve survival [<span>2</span>]. The exceptions occur in two specific scenarios: (1) Surveillance of CDKN2A/p16 carriers for pancreatic cancer fosters earlier detection, increased resectability and translates to a survival advantage [<span>3</span>]; and (2) Both randomised controlled trials and meta-analysis show rigorous surveillance after curative resection of Stage II/III colorectal cancer enhances detection and resection of recurrences and confers improved survival. However, interestingly, more frequent scans do not offer added benefit over less intense strategies [<span>4</span>]. This year, Van Ryan et al. reassert the hard truth also applies to uveal melanoma: patients complying with the National Comprehensive Cancer Network (NCCN) guidelines on uveal melanoma surveillance [<span>5</span>] derive no survival benefit [<span>6</span>].</p><p>Given the lack of high-quality evidence, recommendations for cancer surveillance are predominantly based on expert consensus. The systematic review on the ‘Systemic Surveillance Guidelines for Uveal Melanoma’ conducted by Zaman et al. [<span>7</span>] is an example of compiled expert consensus in an effort to homogenise guidelines in Australia. The published literature regarding surveillance for uveal melanoma could be summarised as follows: Surveillance does not impact overall survival; due to increased sensitivity and lack of radiation, Magnetic Resonance Imaging (MRI) is superior to Computed Tomography (CT) and ultrasound (US); risk stratification influences scan intervals: for high risk, q3-6 months for the first 5 years then q6-12 months; q6-12mos for intermediate risk, annual for low risk imaging through 10 years is reasonable [<span>7, 8</span>].</p><p>A word of caution when interpreting published surveillance literature is the notion of lead time bias which is a systematic error in research, particularly in medical screening, that can result in misleading conclusions [<span>9</span>]. To summarise, this bias occurs because survival time is measured from the time of diagnosis, and medical screening shifts this to an earlier time point in the disease's natural history, but without necessarily altering the time of death. Screened patients appear to live longer due to an earlier date of diagnosis afforded by their surveillance, but without necessarily a survival benefit. Lead time bias does not mean
有一个关于癌症监测的残酷事实,似乎并没有阻止癌症筛查建议的活力。事实是,除非在非常特殊的情况下,监控并不能提高病人的存活率。对于大多数常见的实体恶性肿瘤,无症状病例的常规监测并不能提供生存优势:在乳腺癌中,随机试验并不提倡对无症状幸存者进行常规转移性监测[10]。即使在最常见的癌症类型肺癌中,常规影像学检查也能成功地发现更多的无症状复发,但不能提高生存率。例外情况发生在两种特定情况下:(1)监测CDKN2A/p16携带者胰腺癌可促进早期发现,增加可切除性,并转化为生存优势[3];(2)随机对照试验和荟萃分析均表明,II/III期结直肠癌根治性切除术后严格的监测可以提高复发的发现和切除,并提高生存率。然而,有趣的是,更频繁的扫描并不比低强度的策略提供额外的好处。今年,Van Ryan等人重申了同样适用于葡萄膜黑色素瘤的残酷事实:遵守国家综合癌症网络(NCCN)关于葡萄膜黑色素瘤监测指南的患者没有获得生存益处。由于缺乏高质量的证据,癌症监测的建议主要基于专家共识。Zaman等人对“葡萄膜黑色素瘤系统监测指南”进行的系统评价是汇编专家共识的一个例子,旨在使澳大利亚的指南统一。已发表的关于葡萄膜黑色素瘤监测的文献可以总结如下:监测不影响总生存率;由于增加的灵敏度和缺乏辐射,磁共振成像(MRI)优于计算机断层扫描(CT)和超声(US);风险分层影响扫描间隔:对于高危人群,前5年每隔3-6个月扫描一次,然后每隔6-12个月扫描一次;Q6-12mos为中度风险,10年内每年进行一次低风险成像是合理的[7,8]。在解释已发表的监测文献时,需要注意的是前置时间偏差的概念,这是研究中的系统性错误,特别是在医学筛查中,可能导致误导性结论。总而言之,这种偏差的发生是因为生存时间是从诊断时开始测量的,而医学筛查将其转移到疾病自然史中的较早时间点,但不一定改变死亡时间。接受筛查的患者似乎活得更长,因为他们的监测提供了更早的诊断日期,但不一定有生存益处。提前期偏倚并不意味着患者的寿命更长,而仅仅意味着他们的转移性疾病被发现得更早。同样,筛查并不能预防转移性疾病和死亡;它只是检测它。为了强调这一点,“监视”一词源于法语,意思是观察:仔细观察孩子的成长并不会影响他们成长的速度或数量。话虽如此,但监测并不影响总体生存率[6,9]这一事实值得仔细考虑。这一论断是有时间条件和反思的,不仅是筛查技术,而且严重依赖于成功治疗葡萄膜黑色素瘤的策略。“监测并不能提高生存率”的观点在2021年可能是正确的;但是几年后,一些有希望的转移性管理策略,这种说法可能会过时。Zaman等人敏锐地讨论了tebentafusp[10]和孤立的肝melphalan输注[11]这两种治疗方式,这两种治疗方式被证明对低负担疾病患者有更好的结果。将这些点联系起来:通过适当的监测及早发现低负担疾病的有利治疗,可以提高生存率。其他潜在的转移性治疗方案包括靶向PRAME[12]的t细胞受体(TCR)-T治疗,扩大melphalan肝脏系统递送至多中心位点[13],以及选择性复制能力的基于1型单纯疱疹病毒的溶瘤免疫治疗RP2,该治疗采用抗ctla -4抗体工程设计,靶向UM和fusogenic protein,以及GM-CSF的细胞毒性作用[14]。在未来,随着这些转移性治疗的增强,实际上,监测可能会提高生存率。Zaman等人注意到,由于已发表数据的严峻质量,不可能进行元分析,从而使他们的重点转向系统评价bb0。这强调了对高质量数据的依赖,以便获得高质量的输出建议。 到目前为止,至少有两个领域在现有可靠的已发表数据方面仍然不发达;但随着技术的进步,它们有可能影响对葡萄膜黑色素瘤监测的建议。首先,除了放射成像之外的其他技术可能提供增强的监测。放射成像图像的分辨率仅限于屏幕上像素的分辨率,而生物标记物的分辨率可能达到150个脱氧核糖核酸(DNA)碱基对的水平。一个例子是血浆游离DNA (cfDNA),或者更具体地说,循环肿瘤DNA,通常在肿瘤被放射学识别之前就能识别血液中的肿瘤DNA片段。这项技术能够提前数月发现转移性疾病,而且相比之下,它是非侵入性的,缺乏辐射暴露,容易重复,相对容易获得。它的效用已在小型葡萄膜黑色素瘤队列中得到证实[15,16],值得进一步推广。一些肿瘤学领域,如肺癌,已经放弃了系列放射成像,转而采用cfDNA监测治疗反应。此外,在临床情况下,当x射线扫描显示新的不确定病变可能太小而无法可靠地活检时,cfDNA可以表征遗传谱并有助于诊断。为了通过治疗负担最低的疾病来获得改善的结果,现在正在努力在放射学证据[15]之前治疗生化转移性葡萄膜黑色素瘤(即只能通过cfDNA检测到):并且由于cfDNA是可量化的,因此可以通过连续血液检测来监测治疗反应。我们正在进入这样一个时代,转移性疾病的存在可以通过血液标记物而不是放射图像来定义,我们的监测策略将希望反映这一点。其次,由于监测方式、间隔和持续时间是风险分层的,因此有必要对“高风险”有更清晰的理解。高风险葡萄膜黑色素瘤的定义可以由许多变量定义,不同机构之间存在差异,并且在很大程度上取决于现有的肿瘤信息。鉴于该领域的科学进步,确保这一定义与当前知识保持同步是很重要的。国家综合癌症网络(NCCN)通过RNA基因组学(基因表达谱2类)、染色体状态、DNA基因组学(BAP1突变)和/或大小[5]来定义高风险。然而,生物标志物技术的出现,如序列cfDNA检测的动态,可能被用来识别高风险肿瘤。根据NCCN, EIF1AX和SF3B1可授予低、中风险bb0。然而,在原发性UM诊断时,通过基于血液的cfDNA检测这些突变可能提示存在转移性疾病(因为DNA来自原发性或转移性肿瘤)。如果cfDNA的变异等位基因频率在原发性葡萄膜黑色素瘤治疗后保持不变或增加,这可能进一步支持cfDNA来自转移性疾病,并支持该临床情况为“高风险”[15,17]。此外,SF3B1突变会导致更高的肺转移风险,采用胸部CT检查可以针对这种情况进行监测。因此,风险定义将受益于反映可能从生物标志物监测中收集的肿瘤信息;随着生物标志物检测的使用越来越多,这是目前一个未满足的需求。如果没有明确的证据表明筛查有利于生存,或者目前的放射技术能够以完美的灵敏度和特异性检测到每一个转移性病例,那么在严格的监测指南中很难坚定不移。然而,随着有希望的转移性葡萄膜黑色素瘤治疗和增强的生物标志物监测,未来可能会改变这种情况。本研究由眼科知识基金会(J.H.F.)和国家癌症研究所(P30 CA008748)支持。作者声明无利益冲突。数据共享不适用于本文,因为在当前研究中没有生成或分析数据集。
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引用次数: 0
Industry-Reported Financial Relationships Among American Ophthalmology Society Board Members. 美国眼科学会董事会成员之间的行业报告财务关系。
IF 5.6 2区 医学 Q1 OPHTHALMOLOGY Pub Date : 2025-12-14 DOI: 10.1111/ceo.70039
Mostafa Bondok, Leonardo Lando, Anne Xuan-Lan Nguyen, Michael Knafo, Albert Y Wu

Background: To assess financial disclosures of American ophthalmology society board members by comparing self-reported disclosures with industry-reported payments and examining characteristics linked to larger financial relationships.

Methods: In this retrospective, cross-sectional study, we assessed all governance board members from American ophthalmology societies in December 2022. Board composition was identified from society websites, payment data from the Open Payments database, and conflict of interest (COI) policies from IRS Form 990 filings. Outcomes included concordance between self- and industry-reported disclosures, payment values, gender and subspecialty differences and academic characteristics.

Results: Among 871 board members from 66 societies, 566 (65.0%) had industry-reported relationships, yet only 22 (2.5%) disclosed COIs on society websites. In 2022, 13 187 payments totaling $57.8 million were reported, with 79.5% related to research. Most societies reported internal COI policies (77.8%) and annual disclosure requirements (75.6%) via IRS filings. Men received significantly higher median payments than women ($217.5 vs. $43.3; p < 0.001). Retina specialists accounted for the largest share of payment value (55.3%), while paediatric ophthalmologists received the least (0.4%). Board members with research payments had higher academic productivity (median h-index: 19 vs. 8; p < 0.001).

Conclusions: Public reporting of board members' financial relationships on ophthalmology society websites was uncommon, likely reflecting differences in society-level disclosure practices rather than individual nondisclosure. These findings underscore an opportunity for societies to enhance transparency by adopting more consistent, transparent COI reporting practices in ophthalmology governance.

背景:通过比较自我报告的披露与行业报告的支付,并检查与更大的财务关系相关的特征,评估美国眼科学会董事会成员的财务披露。方法:在这项回顾性横断面研究中,我们评估了2022年12月来自美国眼科学会的所有治理委员会成员。董事会组成来自社会网站、Open Payments数据库中的支付数据和IRS Form 990文件中的利益冲突(COI)政策。结果包括自我和行业报告的信息披露、支付价值、性别和亚专业差异以及学术特征之间的一致性。结果:在66个协会的871名董事会成员中,566名(65.0%)有行业关系,但只有22名(2.5%)在协会网站上披露了coi。2022年,共有13187笔支付,总计5780万美元,其中79.5%与研究有关。大多数社团通过IRS文件报告了内部COI政策(77.8%)和年度披露要求(75.6%)。男性获得的薪酬中位数明显高于女性(217.5美元对43.3美元);p结论:在眼科学会网站上公开报告董事会成员的财务关系并不常见,这可能反映了社会层面披露实践的差异,而不是个人不披露。这些发现强调了社会通过在眼科治理中采用更一致、更透明的COI报告实践来提高透明度的机会。
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引用次数: 0
Visual Function Assessment in Geographic Atrophy: A Review. 地理萎缩的视觉功能评估综述。
IF 5.6 2区 医学 Q1 OPHTHALMOLOGY Pub Date : 2025-12-12 DOI: 10.1111/ceo.70037
Ye Li, Lauren N Ayton, Adrian T Fung

Geographic atrophy (GA) causes significant vision impairment and reduction in vision-related quality of life. Fundus autofluorescence (FAF) is the gold standard of structural assessment of GA but is a surrogate marker for vision loss, which can be assessed by tests of visual function and functional vision. Best corrected visual acuity (BCVA), the most commonly used visual function test in ophthalmology, is a poor metric for assessing GA progression. This is because GA usually only affects the fovea in its late stage, grows slowly, and spared areas of retina may not 'fit' larger reading chart letters, confounding measurements. For this reason, tests of visual function have been developed, including low luminance visual acuity (LLVA), reading speed, contrast sensitivity, microperimetry, flicker perimetry, and dark adaptation. Functional vision measures are approximated through patient-reported outcomes using various questionnaires. This review explores the strength of association between FAF and tests of visual function in patients with GA. A range of targeted, prespecified endpoints of visual function testing should be included in future clinical trials for treatments of GA, focusing on GA lesion phenotypes that are known to progress rapidly in order to maximise the likelihood of identifying positive results. This is critical in jurisdictions where proof of functional benefit is required for regulatory approval of treatments for GA.

地理萎缩(GA)导致严重的视力损害和视力相关生活质量的降低。眼底自体荧光(FAF)是GA结构评估的金标准,但也是视力丧失的替代标志物,可通过视觉功能和功能视力测试进行评估。最佳矫正视力(BCVA)是眼科中最常用的视觉功能测试,是评估GA进展的较差指标。这是因为GA通常只影响晚期的中央凹,生长缓慢,视网膜的剩余区域可能不适合更大的阅读图表字母,混淆了测量结果。为此,开发了视觉功能测试,包括低亮度视敏度(LLVA)、阅读速度、对比灵敏度、显微视距、闪烁视距和黑暗适应。功能性视力测量通过使用各种问卷的患者报告结果来近似。本综述探讨了GA患者FAF与视觉功能测试之间的相关性。在未来的GA治疗临床试验中,应包括一系列针对性的、预先指定的视觉功能检测终点,重点关注已知进展迅速的GA病变表型,以最大限度地提高识别阳性结果的可能性。这在需要功能性益处证明以获得GA治疗监管批准的司法管辖区至关重要。
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引用次数: 0
Outcomes of Four-Point Sutured Scleral-Fixated Intraocular Lens Implantation Using Gore-Tex Suture in Paediatric Eyes. Gore-Tex缝线在小儿眼内四点巩膜固定人工晶状体植入术的效果。
IF 5.6 2区 医学 Q1 OPHTHALMOLOGY Pub Date : 2025-12-08 DOI: 10.1111/ceo.70038
Li Yen Chan, Ye Li, Shuan Dai

Background: Intraocular lens implantation in children with insufficient zonular support can be challenging. Scleral-fixated intraocular lens (SFIOL) implantation can be useful in these cases. We aim to report the visual and refractive outcomes of four-point sutured SFIOL in children.

Methods: A retrospective review of children who underwent primary or secondary four-point SFIOL using Akreos AO60 or Luxgood intraocular lens with polytetrafluoroethylene monofilament (PTFE, Gore-Tex) at Queensland Children's Hospital, Brisbane, Australia.

Results: Fifty-three eyes of 31 children were included for review. The mean age of SFIOL implantation was 7.86 ± 3.71 years. The median follow-up time was 24 months (IQR 35, range 1-77). The majority of children had subluxed crystalline lenses secondary to Marfan syndrome (44 eyes, 83.02%). Best corrected visual acuity (BCVA) was maintained or improved from the preoperative BCVA in 92.6% of eyes. Median postoperative BCVA improved to logMAR 0.2 (IQR 0.16) at 1-year follow-up (p < 0.01). Compared to target refraction, the postoperative refraction was more myopic, but this was not statistically significant. In 33 eyes that had more than 1 year of follow-up, residual refractive error was within 1.00D for 21 eyes, within 2.00D for 7 eyes, within 3.00D for 3 eyes and greater than 3.00D for 2 eyes. Retinal detachment occurred in three eyes (5.66%). Asymptomatic IOL tilt/decentration was noted in one eye (1.88%).

Conclusions: Four-point SFIOL implantation using Gore-Tex suture offered excellent visual and refractive outcomes. Postoperative complications were rare and there were no new cases of amblyopia during the follow-up period.

背景:儿童晶状体支持不足的人工晶状体植入术具有挑战性。巩膜固定人工晶状体(SFIOL)植入术在这些病例中是有用的。我们的目的是报告儿童四点缝合SFIOL的视力和屈光结果。方法:回顾性分析澳大利亚布里斯班昆士兰儿童医院使用Akreos AO60或Luxgood聚四氟乙烯单丝人工晶状体(PTFE, Gore-Tex)进行原发性或继发性四点SFIOL的儿童。结果:纳入31例患儿53只眼。SFIOL植入术的平均年龄为7.86±3.71岁。中位随访时间为24个月(IQR 35,范围1-77)。继发于马凡氏综合征的晶状体半脱位患儿占多数(44眼,83.02%)。92.6%的眼维持或改善了术前最佳矫正视力(BCVA)。随访1年,术后中位BCVA改善至logmar0.2 (IQR 0.16)。结论:采用Gore-Tex缝线的四点SFIOL植入术具有良好的视力和屈光效果。术后并发症少,随访期间无新增弱视病例。
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引用次数: 0
The Impact of Lions Outback Vision's Kimberley Hub on Cataract Surgery Rate and Wait Time in Rural Western Australia: An Interrupted Time Series Analysis. 狮子内陆视力的金伯利中心对白内障手术率和等待时间在澳大利亚西部农村的影响:中断时间序列分析。
IF 5.6 2区 医学 Q1 OPHTHALMOLOGY Pub Date : 2025-12-08 DOI: 10.1111/ceo.70040
Donald Tran, Jocelyn J Drinkwater, Emma Douglas, Angus W Turner
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引用次数: 0
A Microsurgical Skills Course Improves Cataract Surgery Proficiency in First Year Australia and New Zealand Ophthalmology Trainees. 显微外科技能课程提高第一年澳大利亚和新西兰眼科学员白内障手术的熟练程度。
IF 5.6 2区 医学 Q1 OPHTHALMOLOGY Pub Date : 2025-12-02 DOI: 10.1111/ceo.70035
Vivien Nguyen, Santosh Khanal, Graham Wilson, Constantinos Petsoglou, Yves Kerdraon

Background: The University of Sydney 'Microsurgical Skills Course' (MSC) was made mandatory to the Royal Australian and New Zealand College of Ophthalmologists (RANZCO) Vocational Training Program in 2023. This study evaluates the MSC impact on first-year ophthalmology trainees' cataract surgical performance compared to those who did not complete the MSC.

Methods: This retrospective study analysed de-identified RANZCO surgical logbook data and EyeSi survey responses from first-year trainees across Australia and New Zealand. The intervention cohort (2023-2024 first-year trainees) completed the MSC, while the control cohort (2022 first-year trainees) did not. Data included demographics, prior surgical experience, number of cataract surgeries, surgical role, senior surgeon takeovers and intraoperative complications.

Results: Among 112 trainees (intervention = 77; control = 35), 11 613 cataract surgeries were recorded during the first 12 months of training. By 3 months, trainees in the intervention cohort performed more cataract surgeries (36.2 ± 22.6 vs. 26.0 ± 17.4, p = 0.017), assumed more senior roles in surgery (p < 0.001), required fewer senior surgeon takeovers (p < 0.001) and had a lower rate of posterior capsule tear (PCT) (1.3% vs. 2.9%, p < 0.001) compared to the control cohort. By 12 months, cataract surgery numbers and PCT rates (1.4% vs. 1.8%; p = 0.186) were similar; however, the intervention cohort still held a higher rate of leading surgical roles (p < 0.001) and less senior surgeon takeover (p < 0.001).

Conclusions: The MSC accelerates early surgical proficiency while improving patient safety. This resource will serve as a foundation for assessing surgical outcomes beyond cataract surgery and extending past the first 12 months of training.

背景:悉尼大学显微外科技能课程(MSC)于2023年成为澳大利亚和新西兰皇家眼科学院(RANZCO)职业培训计划的必修课程。本研究评估了MSC对一年级眼科学员白内障手术表现的影响,与未完成MSC的学员进行了比较。方法:本回顾性研究分析了澳大利亚和新西兰一年级实习医生的RANZCO手术日志数据和EyeSi调查反馈。干预组(2023-2024年一年级学员)完成了MSC,而对照组(2022年一年级学员)没有完成MSC。数据包括人口统计、既往手术经验、白内障手术次数、手术角色、高级外科医生接管和术中并发症。结果:在112名学员中(干预组77人,对照组35人),在培训的前12个月共记录了11 613例白内障手术。到3个月时,干预组的受术者进行了更多的白内障手术(36.2±22.6 vs. 26.0±17.4,p = 0.017),在手术中担任了更高级的角色(p结论:MSC加速了早期手术熟练程度,同时提高了患者的安全性。该资源将作为评估白内障手术以外的手术结果的基础,并延伸至培训后的前12个月。
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引用次数: 0
Review of Retinopathy of Prematurity Management in the Anti-VEGF Era: Evolving Global Paradigms, Persistent Challenges and Our AI-Assisted Future. 抗vegf时代早产儿视网膜病变管理综述:不断发展的全球范式,持续的挑战和我们人工智能辅助的未来。
IF 5.6 2区 医学 Q1 OPHTHALMOLOGY Pub Date : 2025-12-01 Epub Date: 2025-09-04 DOI: 10.1111/ceo.14598
Kyle V Marra, Jimmy S Chen, Eric Nudleman, Shira L Robbins

Retinopathy of prematurity (ROP) remains a major cause of preventable blindness in premature infants worldwide, with increasing incidence due to advancements in neonatal care. Management of ROP has been revolutionised by anti-vascular endothelial growth factor (anti-VEGF) treatments. Pivotal clinical trials have demonstrated the efficacy of anti-VEGF in the management of Type 1 ROP, while investigation of safety and long-term effects is ongoing. However, infants with ROP often have persistent avascular retina (PAR) despite treatment and require lifelong monitoring for myopia, glaucoma, amblyopia, strabismus, significant refractive error, retinal tears and detachment and adult reactivation of ROP. Alternative therapeutics, including beta-blockers, polyunsaturated fatty acids and vitamin A, remain under investigation. Alongside therapeutic advancements, artificial intelligence (AI) and telemedicine programmes have the potential to expand screening accessibility, particularly in underserved regions, and improve inter-observer variability, though challenges in implementation remain. Together, advanced therapeutics and AI-enhanced screening hold promise for improving outcomes and reducing ROP-related blindness globally.

早产儿视网膜病变(ROP)仍然是全世界早产儿可预防性失明的主要原因,由于新生儿护理的进步,发病率不断上升。抗血管内皮生长因子(anti-VEGF)治疗已经彻底改变了ROP的治疗方法。关键的临床试验已经证明了抗vegf治疗1型ROP的有效性,而安全性和长期效果的研究正在进行中。然而,尽管接受了治疗,患有ROP的婴儿经常有持续的无血管性视网膜(PAR),并且需要终生监测近视、青光眼、弱视、斜视、严重屈光不全、视网膜撕裂和脱离以及成人ROP的再激活。替代疗法,包括-受体阻滞剂、多不饱和脂肪酸和维生素A,仍在研究中。除了治疗方面的进步,人工智能(AI)和远程医疗规划有可能扩大筛查的可及性,特别是在服务不足的地区,并改善观察者之间的差异,尽管在实施方面仍然存在挑战。在全球范围内,先进的治疗方法和人工智能增强筛查有望改善结果并减少rop相关性失明。
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引用次数: 0
Examining the Quality of Care Provided at Singapore's Primary Eye Care Model and Lessons Learned to Maintain Quality Care-Mixed-Methods Study. 检查新加坡初级眼保健模式提供的护理质量和维持高质量护理的经验教训-混合方法研究。
IF 5.6 2区 医学 Q1 OPHTHALMOLOGY Pub Date : 2025-12-01 Epub Date: 2025-08-26 DOI: 10.1111/ceo.14600
Wanfen Yip, Adeline Kon, Michelle Jessica Pereira, Joseph Antonio De Castro Molina, Kiok Liang Teow, Vernon Khet Yau Yong, Hon Tym Wong, Tock Han Lim, Vivien Cherng Hui Yip
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引用次数: 0
Out-Of-The-Bag Intraocular Lens Dislocation in Dead Bag Syndrome and Its Association With Eye Rubbing. 死袋综合征的体外晶状体脱位及其与眼部摩擦的关系。
IF 5.6 2区 医学 Q1 OPHTHALMOLOGY Pub Date : 2025-12-01 Epub Date: 2025-09-08 DOI: 10.1111/ceo.14606
Soon-Phaik Chee, Nicole Shu-Wen Chan, Jia Xu Lim

Background: To describe clinical features, risk factors and outcomes of out-of-the-bag (OTB) intraocular lens (IOL) dislocation in dead bag syndrome (DBS).

Methods: Retrospective review of a single-surgeon series of eyes with IOLs that developed OTB IOL dislocation, managed at Singapore National Eye Centre (January 2014-December 2021), with a minimum of 6 months of follow-up. Eyes with OTB IOL dislocation following secondary IOL implantation and intraoperative capsule complications were excluded. Patient demographics, ocular history, clinical findings, ocular trauma/eye rubbing, surgical procedures and postoperative outcomes were obtained.

Results: Fifty eyes (40 unilateral, 5 bilateral) of 45 patients were included. Patients were predominantly male (82.2%), presenting at 61.9 ± 14.1 years old, 11.2 ± 6.0 years after cataract surgery. Eye rubbing was the only form of ocular trauma (n = 34; 68.0%). Compared to non-eye rubbers, eye rubbers were significantly more likely to have elevated intraocular pressure (IOP) (32.4% vs. 6.2%; OR 10.9, 95% confidence interval [CI] 1.12-107; p = 0.040), larger posterior capsule defects (median 60% vs. 50%; p = 0.029), vitreous in the anterior chamber (38.2% vs. 6.2%; OR 10.3, 95% CI 1.05-101; p = 0.045) and lower endothelial cell counts than the non-affected eye (-145 ± 507 vs. 315 ± 639 cells/mm2; p = 0.026). The most common complications after IOL exchange were elevated IOP (n = 11; 22.0%) including glaucoma (n = 8; 16.0%) and recurrent IOL subluxation (n = 7; 14.0%).

Conclusions: Eye rubbing appears to play an important role in the development of OTB IOL dislocations in DBS and is associated with more severe clinical manifestations. Treating the underlying cause and counselling patients to avoid or minimise eye rubbing may reduce this complication.

背景:探讨死袋综合征(DBS)患者的临床特征、危险因素及预后。方法:回顾性分析2014年1月至2021年12月在新加坡国家眼科中心(Singapore National Eye Centre)进行的单外科手术治疗的一系列眼部人工晶状体发生OTB人工晶状体脱位的病例,随访时间至少6个月。排除二次人工晶状体植入术后晶状体脱位及术中囊膜并发症。获得患者人口统计学、眼部病史、临床表现、眼外伤/眼部摩擦、手术方式和术后结果。结果:纳入45例患者50只眼(单侧40只,双侧5只)。患者以男性为主(82.2%),年龄为61.9±14.1岁,术后11.2±6.0岁。揉眼是唯一的眼外伤形式(n = 34; 68.0%)。与非护眼者相比,护眼者明显更容易出现眼压升高(32.4% vs. 6.2%; OR 10.9, 95%可信区间[CI] 1.12-107; p = 0.040)、后囊缺损较大(中位数60% vs. 50%; p = 0.029)、前房玻璃体(38.2% vs. 6.2%; OR 10.3, 95% CI 1.05-101; p = 0.045)和内皮细胞计数较低(-145±507 vs. 315±639细胞/mm2; p = 0.026)。人工晶状体置换术后最常见的并发症是IOP升高(n = 11; 22.0%),包括青光眼(n = 8; 16.0%)和复发性IOL半脱位(n = 7; 14.0%)。结论:眼部摩擦在DBS患者体外晶状体脱位的发生中起重要作用,并伴有更严重的临床表现。治疗根本原因并建议患者避免或尽量减少揉眼可能会减少这种并发症。
{"title":"Out-Of-The-Bag Intraocular Lens Dislocation in Dead Bag Syndrome and Its Association With Eye Rubbing.","authors":"Soon-Phaik Chee, Nicole Shu-Wen Chan, Jia Xu Lim","doi":"10.1111/ceo.14606","DOIUrl":"10.1111/ceo.14606","url":null,"abstract":"<p><strong>Background: </strong>To describe clinical features, risk factors and outcomes of out-of-the-bag (OTB) intraocular lens (IOL) dislocation in dead bag syndrome (DBS).</p><p><strong>Methods: </strong>Retrospective review of a single-surgeon series of eyes with IOLs that developed OTB IOL dislocation, managed at Singapore National Eye Centre (January 2014-December 2021), with a minimum of 6 months of follow-up. Eyes with OTB IOL dislocation following secondary IOL implantation and intraoperative capsule complications were excluded. Patient demographics, ocular history, clinical findings, ocular trauma/eye rubbing, surgical procedures and postoperative outcomes were obtained.</p><p><strong>Results: </strong>Fifty eyes (40 unilateral, 5 bilateral) of 45 patients were included. Patients were predominantly male (82.2%), presenting at 61.9 ± 14.1 years old, 11.2 ± 6.0 years after cataract surgery. Eye rubbing was the only form of ocular trauma (n = 34; 68.0%). Compared to non-eye rubbers, eye rubbers were significantly more likely to have elevated intraocular pressure (IOP) (32.4% vs. 6.2%; OR 10.9, 95% confidence interval [CI] 1.12-107; p = 0.040), larger posterior capsule defects (median 60% vs. 50%; p = 0.029), vitreous in the anterior chamber (38.2% vs. 6.2%; OR 10.3, 95% CI 1.05-101; p = 0.045) and lower endothelial cell counts than the non-affected eye (-145 ± 507 vs. 315 ± 639 cells/mm<sup>2</sup>; p = 0.026). The most common complications after IOL exchange were elevated IOP (n = 11; 22.0%) including glaucoma (n = 8; 16.0%) and recurrent IOL subluxation (n = 7; 14.0%).</p><p><strong>Conclusions: </strong>Eye rubbing appears to play an important role in the development of OTB IOL dislocations in DBS and is associated with more severe clinical manifestations. Treating the underlying cause and counselling patients to avoid or minimise eye rubbing may reduce this complication.</p>","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":" ","pages":"1115-1124"},"PeriodicalIF":5.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145024834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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Clinical and Experimental Ophthalmology
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