Clinical and Experimental Ophthalmology最新文献

英文中文

Axial length adjustment in eyes with silicone oil endotamponade reduces overestimation by a swept-source optical coherence tomography-based biometer 硅油内腔填塞眼的轴向长度调整可减少基于扫源光学相干断层扫描的生物测量仪的过高估计。

IF 4.9 2区医学 Q1 OPHTHALMOLOGY

Clinical and Experimental Ophthalmology

Pub Date : 2024-07-21 DOI: 10.1111/ceo.14418

Klemens Paul Kaiser MD, Tyll Jandewerth MD, Julian Bucur MD, Thomas Kohnen MD, PhD, Christoph Lwowski MD

Background

To assess changes in ocular biometry of the phakic eye after pars-plana-vitrectomy (PPV) and silicone oil (SO) endotamponade in eyes with a retinal detachment.

Methods

This retrospective, consecutive case series included 72 eyes of 72 patients who underwent PPV with 5000-centistokes SO endotamponade between July 2018 and June 2023. Pseudophakic eyes and eyes with a combined phacovitrectomy were excluded. Primary endpoints were keratometry values, anterior chamber depth (ACD), lens thickness (LT), horizontal corneal diameter (HCD), and axial length (AL) measured by swept-source optical coherence tomography-based biometry (IOLMaster 700) preoperatively and six weeks postoperatively. A recently described formula was used to adjust the AL (aAL) in eyes with SO endotamponade and a theoretical intraocular lens (IOL) calculation was performed.

Results

The mean age was 62.1 ± 8.3 years (range: 37–85). After PPV with SO fill, there was an increase in K_mean (0.19 ± 0.51D), while ACD (0.05 ± 0.13 mm), LT (0.03 ± 0.14 mm), and HCD (0.02 ± 0.24 mm) decreased. Preoperatively, the mean AL was 25.22 ± 1.78 mm, while postoperatively the AL was overestimated by 0.12 ± 0.42 mm on average (p = 0.04). By adjusting the AL, the mean difference could be reduced to −0.002 ± 0.41 mm. The aAL resulted in a difference in the refractive outcome in eyes with an AL > 25 mm of 0.34 ± 0.10D in the IOL calculation.

Conclusions

While changes in biometry after PPV with SO endotamponade in the anterior segment are clinically less relevant, a considerable overestimation of AL with IOLMaster 700 was found. We recommend the use of a recently introduced formula for adjusting AL in eyes with SO, allowing overestimation to be minimised considerably.

背景：目的：评估视网膜脱离患者在接受视网膜旁切除术（PPV）和硅油（SO）眼内填塞术后，法眼眼部生物测量的变化：该回顾性连续病例系列包括2018年7月至2023年6月期间接受PPV和5000厘斯托克斯SO内填塞术的72名患者的72只眼睛。假性角膜病变眼和合并虹膜切除术的眼被排除在外。主要终点是角膜测量值、前房深度（ACD）、晶状体厚度（LT）、角膜水平直径（HCD）和轴向长度（AL），测量方法是基于扫源光学相干断层扫描的生物测量法（IOLMaster 700），测量时间为术前和术后六周。使用最近描述的公式调整了有 SO 内陷的眼睛的 AL（aAL），并进行了理论眼内晶状体（IOL）计算：平均年龄为 62.1 ± 8.3 岁（37-85 岁）。SO填充PPV后，Kmean增加（0.19 ± 0.51D），ACD（0.05 ± 0.13 mm）、LT（0.03 ± 0.14 mm）和HCD（0.02 ± 0.24 mm）下降。术前，平均 AL 为 25.22 ± 1.78 毫米，而术后 AL 平均被高估了 0.12 ± 0.42 毫米（p = 0.04）。通过调整 AL，平均差异可降至 -0.002 ± 0.41 毫米。在计算人工晶体时，AL>25毫米的眼睛的屈光结果与AL>25毫米的眼睛的屈光结果相差0.34±0.10D：虽然前段SO内膜填塞PPV后生物测量的变化与临床关系不大，但使用IOLMaster 700发现AL被高估了很多。我们建议使用最近推出的公式来调整有 SO 的眼睛的 AL 值，这样可以大大降低高估的程度。

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引用次数: 0

Repeatability and agreement of total corneal astigmatism measured in keratoconic eyes using four current devices 使用四种当前设备测量角膜病变眼全角膜散光的重复性和一致性。

IF 4.9 2区医学 Q1 OPHTHALMOLOGY

Clinical and Experimental Ophthalmology

Pub Date : 2024-07-21 DOI: 10.1111/ceo.14423

Yue Feng MD, MSc, Tore Nitter MD, PhD, Geir Bertelsen MD, PhD, Aleksandar Stojanovic MD, PhD

Background

To evaluate repeatability and agreement in measurements of total corneal astigmatism (TCA) in keratoconic eyes, using four optical coherence tomography (OCT)-based devices: Anterion, Casia SS-1000, IOLMaster 700, and MS-39.

Methods

Three consecutive measurements were taken with each device in 136 eyes. TCA values were converted into components J₀ and J₄₅. The Anterion and the IOLMaster 700 also provided axial length (AL) measurements. The repeatability was calculated using pooled within-subject standard deviation (S_w). The agreement among the four devices was assessed by pairwise comparisons and Bland–Altman plots.

Results

For all devices, the repeatability of TCA measurements showed S_w ≤0.23 D for TCA magnitude, ≤0.14 D for J₀, and ≤0.12 D for J₄₅. There were statistically significant differences in TCA magnitude for each pair, except for IOLMaster 700 with MS-39, and Anterion with MS-39. The repeatability (S_w) of axis measurements had a statistically significant negative correlation with the TCA magnitude (p < 0.001 for all devices). Both Anterion and IOLMaster 700 had high repeatability in AL measurements (S_w: 0.007 mm for Anterion and 0.009 mm for IOLMaster 700). The difference in AL between the two was 0.015 ± 0.033 mm (p < 0.001).

Conclusions

All four devices showed good repeatability in TCA measurements in keratoconic eyes, the agreement for TCA measurements between the tested devices was generally low. Anterion and IOLMaster 700 showed good repeatability and agreement in AL measurements.

背景：目的：评估使用四种光学相干断层扫描（OCT）设备测量角膜病变眼全角膜散光（TCA）的重复性和一致性：Anterion、Casia SS-1000、IOLMaster 700 和 MS-39：方法：使用每种设备对 136 只眼睛进行了三次连续测量。将 TCA 值转换成 J0 和 J45 组份。Anterion 和 IOLMaster 700 还提供了轴向长度 (AL) 测量值。重复性是通过汇总的受试者内标准偏差 (Sw) 计算得出的。通过配对比较和布兰德-阿尔特曼图评估了四种设备之间的一致性：所有设备的 TCA 测量重复性显示，TCA 幅值的 Sw ≤ 0.23 D，J0 ≤ 0.14 D，J45 ≤ 0.12 D。除 IOLMaster 700 与 MS-39 和 Anterion 与 MS-39 外，每对晶体的 TCA 量级在统计学上都有显著差异。轴测量的重复性（Sw）与 TCA 幅值呈统计学意义上的显著负相关（P w：Anterion 为 0.007 mm，IOLMaster 700 为 0.009 mm）。两者之间的 AL 差异为 0.015 ± 0.033 毫米（p 结论）：所有四种设备在角膜病变眼的 TCA 测量中都表现出良好的重复性，但测试设备之间的 TCA 测量一致性普遍较低。Anterion 和 IOLMaster 700 在 AL 测量中表现出良好的重复性和一致性。

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引用次数: 0

Real world impact: Towards holistic analysis of author-level publication metrics 真实世界的影响：对作者层面的出版指标进行整体分析。

IF 4.9 2区医学 Q1 OPHTHALMOLOGY

Clinical and Experimental Ophthalmology

Pub Date : 2024-07-15 DOI: 10.1111/ceo.14420

Thomas Muecke, Stephen Bacchi MBBS, PhD, Robert Casson DPhil, FRANZCO, Weng Onn Chan FRANZCO

引用次数: 0

Seventeen years of bird-related eye injuries at the Royal Victorian Eye and Ear Hospital, Melbourne, 2006–2022 2006-2022 年墨尔本维多利亚皇家眼耳医院十七年来与鸟类有关的眼部伤害。

IF 4.9 2区医学 Q1 OPHTHALMOLOGY

Clinical and Experimental Ophthalmology

Pub Date : 2024-07-09 DOI: 10.1111/ceo.14416

Jeremy P. M. Flanagan MD, Melissa Moyes MBChB, Todd Goodwin MBBS, Carmel Crock MBBS, Thomas G. Campbell PhD

引用次数: 0

In-vivo high-frequency quantitative ultrasound-derived parameters of the anterior sclera correlated with level of myopia and presence of staphyloma 体内高频定量超声波得出的前巩膜参数与近视程度和葡萄肿的存在相关。

IF 4.9 2区医学 Q1 OPHTHALMOLOGY

Clinical and Experimental Ophthalmology

Pub Date : 2024-07-04 DOI: 10.1111/ceo.14415

Cameron Hoerig PhD, Quan V. Hoang MD, PhD, Jonathan Mamou PhD

Background

A high-frequency point-of-care (POC) ultrasound instrument was used to evaluate the microstructural and biomechanical properties of the anterior sclera in vivo using parameters computed from quantitative ultrasound (QUS) methods.

Methods

In this cross-sectional study, both eyes of 85 enrolled patients were scanned with the POC instrument and ultrasound data were processed to obtain QUS parameters. Pearson correlation and multi-linear regression were used to identify relationships between QUS parameters and refractive error (RE) or axial length. After categorising eyes based on RE, binary support vector machine (SVM) classifiers were trained using the QUS or ophthalmic parameters (anterior chamber depth, central corneal thickness, corneal power, and intraocular pressure) to classify each eye. Classifier performance was evaluated by computing the area under the receiver-operating characteristic curve (AUC).

Results

Individual QUS parameters correlated with RE and axial length (p < 0.05). Multi-linear regression revealed significant correlation between the set of QUS parameters and both RE (R = 0.49, p < 0.001) and axial length (R = 0.46, p = 0.001). Classifiers trained with QUS parameters achieved higher AUC (𝑝 = 0.06) for identifying myopic eyes (AUC = 0.71) compared to classifiers trained with ophthalmic parameters (AUC = 0.63). QUS-based classifiers attained the highest AUC when identifying highly myopic eyes (AUC = 0.77).

Conclusions

QUS parameters correlate with progressing myopia and may be indicative of myopia-induced microstructural and biomechanical changes in the anterior sclera. These methods may provide critical clinical information complementary to standard ophthalmic measurements for predicting myopia progression and risk assessment for posterior staphyloma formation.

背景：方法：使用高频护理点（POC）超声仪器，利用定量超声（QUS）方法计算的参数，评估体内前巩膜的微观结构和生物力学特性：在这项横断面研究中，使用 POC 仪器扫描了 85 名入选患者的双眼，并对超声波数据进行了处理，以获得 QUS 参数。采用皮尔逊相关和多线性回归来确定 QUS 参数与屈光不正（RE）或轴向长度之间的关系。根据 RE 对眼睛进行分类后，使用 QUS 或眼科参数（前房深度、角膜中央厚度、角膜力和眼压）训练二元支持向量机 (SVM) 分类器，对每只眼睛进行分类。通过计算接收者工作特征曲线下面积（AUC）来评估分类器的性能：结果：单个 QUS 参数与 RE 和轴长相关（p 结论：QUS 参数与眼压和眼压的进展相关：QUS 参数与近视度数的进展相关，并可指示近视引起的前巩膜微结构和生物力学变化。这些方法可提供重要的临床信息，补充标准眼科测量方法，用于预测近视进展和评估后葡萄膜瘤形成的风险。

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引用次数: 0

Ageing and retinal thickness: An important association 老化与视网膜厚度：重要关联

IF 4.9 2区医学 Q1 OPHTHALMOLOGY

Clinical and Experimental Ophthalmology

Pub Date : 2024-07-01 DOI: 10.1111/ceo.14389

Robyn H. Guymer FRANZCO, PhD

引用次数: 0

Continuing Professional Development 持续专业发展

IF 4.9 2区医学 Q1 OPHTHALMOLOGY

Clinical and Experimental Ophthalmology

Pub Date : 2024-07-01 DOI: 10.1111/ceo.14403

引用次数: 0

The quest for safe and effective myopia control in children 追求安全有效的儿童近视控制。

IF 4.9 2区医学 Q1 OPHTHALMOLOGY

Clinical and Experimental Ophthalmology

Pub Date : 2024-07-01 DOI: 10.1111/ceo.14391

Loreto V. T. Rose FRANZCO, PhD

引用次数: 0

Clinical outcomes of femtosecond laser-assisted corneal allogenic intrastromal ring segment (CAIRS) in the treatment of keratoconus 飞秒激光辅助角膜同种异体基质内环段（CAIRS）治疗角膜炎的临床效果。

IF 4.9 2区医学 Q1 OPHTHALMOLOGY

Clinical and Experimental Ophthalmology

Pub Date : 2024-06-27 DOI: 10.1111/ceo.14411

Ahmet Kirgiz MD, Burcu Kemer Atik MD, Merve Emul MD, Muhittin Taskapili MD

Background

To evaluate the results of corneal allogenic intrastromal ring segment (CAIRS) implantation in keratoconus.

Methods

The medical records of patients with keratoconus who underwent CAIRS implantation were reviewed. The CAIRS, prepared by trephination from the donor cornea, was implanted into a tunnel created using the femtosecond laser. The depth of the tunnel was 200 μ; the inner diameter of the tunnel was 4.5 mm; and the outer diameter was 7 mm. Uncorrected visual acuity (UCVA), best corrected visual acuity (BCVA), keratometry, minimum corneal thickness (CT), endothelial cell density (ECD), and high order aberration values were recorded preoperatively and at the 1st, 3rd, and 6th months postoperatively.

Results

A total of 23 eyes of 23 patients were included in the study. Preoperative UCVA (0.08 ± 0.01) and BCVA (0.25 ± 0. 11) values improved postoperatively and reached 0.40 ± 0.05 and 0.68 ± 0.09, respectively, at the end of the 6-month follow-up period (p¹ < 0.001, p² = 0.016; respectively). A statistically significant flattening of all keratometric values was observed in the postoperative period compared to preoperatively (p < 0.001 for all). There were no statistical differences between CT and ECC values at the preoperative and postoperative visits (p¹ = 0.654, p² = 0.769; respectively). In addition, coma aberration values were lower than the preoperative values at all postoperative visits (p < 0.05 for all).

Conclusions

These results suggest that CAIRS implantation is a safe treatment option with good visual and keratometric outcomes for suitable patients with keratoconus.

背景：评估异体角膜基质内环段（CAIRS）植入角膜的效果：评估角膜同种异体基质内环节段（CAIRS）植入术在角膜屈光不正中的效果：方法：回顾了接受 CAIRS 植入术的角膜炎患者的病历。CAIRS由供体角膜切削制备而成，被植入用飞秒激光创建的隧道中。隧道深度为 200 μ，内径为 4.5 mm，外径为 7 mm。记录术前、术后第 1、3 和 6 个月的未矫正视力 (UCVA)、最佳矫正视力 (BCVA)、角膜度数、最小角膜厚度 (CT)、内皮细胞密度 (ECD) 和高阶像差值：研究共纳入了 23 名患者的 23 只眼睛。术前的 UCVA（0.08 ± 0.01）和 BCVA（0.25 ± 0.11）值在术后均有所改善，在 6 个月的随访期结束时分别达到 0.40 ± 0.05 和 0.68 ± 0.09（p1 2 = 0.016；分别为 0.40 ± 0.05 和 0.68 ± 0.09）。与术前相比，术后所有角膜测量值都出现了统计学意义上的明显变平（p1 = 0.654，p2 = 0.769；分别为0.654和0.769）。此外，在所有术后检查中，昏迷像差值均低于术前值（p 结论：术后所有检查均显示昏迷像差值低于术前值：这些结果表明，对于合适的角膜病患者来说，CAIRS 植入术是一种安全的治疗方案，具有良好的视觉和角膜测量效果。

{"title":"Clinical outcomes of femtosecond laser-assisted corneal allogenic intrastromal ring segment (CAIRS) in the treatment of keratoconus","authors":"Ahmet Kirgiz MD, Burcu Kemer Atik MD, Merve Emul MD, Muhittin Taskapili MD","doi":"10.1111/ceo.14411","DOIUrl":"10.1111/ceo.14411","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>To evaluate the results of corneal allogenic intrastromal ring segment (CAIRS) implantation in keratoconus.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The medical records of patients with keratoconus who underwent CAIRS implantation were reviewed. The CAIRS, prepared by trephination from the donor cornea, was implanted into a tunnel created using the femtosecond laser. The depth of the tunnel was 200 μ; the inner diameter of the tunnel was 4.5 mm; and the outer diameter was 7 mm. Uncorrected visual acuity (UCVA), best corrected visual acuity (BCVA), keratometry, minimum corneal thickness (CT), endothelial cell density (ECD), and high order aberration values were recorded preoperatively and at the 1st, 3rd, and 6th months postoperatively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 23 eyes of 23 patients were included in the study. Preoperative UCVA (0.08 ± 0.01) and BCVA (0.25 ± 0. 11) values improved postoperatively and reached 0.40 ± 0.05 and 0.68 ± 0.09, respectively, at the end of the 6-month follow-up period (<i>p</i><sup>1</sup> < 0.001, <i>p</i><sup>2</sup> = 0.016; respectively). A statistically significant flattening of all keratometric values was observed in the postoperative period compared to preoperatively (<i>p</i> < 0.001 for all). There were no statistical differences between CT and ECC values at the preoperative and postoperative visits (<i>p</i><sup>1</sup> = 0.654, <i>p</i><sup>2</sup> = 0.769; respectively). In addition, coma aberration values were lower than the preoperative values at all postoperative visits (<i>p</i> < 0.05 for all).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>These results suggest that CAIRS implantation is a safe treatment option with good visual and keratometric outcomes for suitable patients with keratoconus.</p>\u0000 </section>\u0000 </div>","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":"52 7","pages":"713-723"},"PeriodicalIF":4.9,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ceo.14411","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141472832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aetiology and epidemiology of surgical vitreoretinal presentations in an Australian paediatric population: A seven-year retrospective study 澳大利亚儿科玻璃体视网膜手术病因和流行病学：一项为期七年的回顾性研究。

IF 4.9 2区医学 Q1 OPHTHALMOLOGY

Clinical and Experimental Ophthalmology

Pub Date : 2024-06-27 DOI: 10.1111/ceo.14413

Amelia Bai MD, MMedR, Abhishek Sharma FRANZCO, PHD, Mark Chiang FRANZCO, MPhil, Lawrence Lee FRANZCO

Background

Paediatric vitreoretinal pathology is distinct from adult cases in both presentation and surgical planning. Here we aim to report the aetiology and epidemiology in children 0–18 years requiring vitreoretinal surgery at a major tertiary paediatric hospital in Queensland, Australia.

Methods

Retrospective review of cases requiring vitreoretinal surgery between May 2015 and October 2022 was conducted. Demographics, ocular and medical history, surgical pathology, procedures performed, and epidemiology data were retrieved. Patients were grouped into three main aetiologies: traumatic, syndromic, or secondary.

Results

A total of 124 patients, the majority male (87, 70.2%) with a mean age of 10.3 years underwent vitreoretinal surgery. Trauma accounted for 32.3% of cases requiring surgery of which 47% were due to a penetrating eye injury. 35.5% were associated with a syndromic cause with common aetiology including coats, congenital cataract, sticklers, and retinopathy of prematurity. 32.3% developed secondary pathology and retinal detachment was the primary cause for surgery (55%). The average time from symptom onset to presentation was 30 days (SD 56.88) with patients living an average of 306.2 km (SD 558.9) away from the Queensland Children's Hospital. Older age was significantly associated with increased days to presentation in the traumatic group (p < 0.05).

Conclusions

This study provides an insight into the aetiology and epidemiology of paediatric vitreoretinal presentations in Queensland, Australia.

背景：小儿玻璃体视网膜病变在表现形式和手术计划上都与成人病例不同。在此，我们旨在报告澳大利亚昆士兰州一家大型三级儿科医院中需要进行玻璃体视网膜手术的 0-18 岁儿童的病因学和流行病学：方法：对2015年5月至2022年10月期间需要进行玻璃体视网膜手术的病例进行回顾性审查。方法：对2015年5月至2022年10月期间需要进行玻璃体视网膜手术的病例进行了回顾性审查，并检索了人口统计学、眼部病史和病史、手术病理学、已实施的手术以及流行病学数据。患者主要分为三种病因：外伤性、综合征或继发性：共有124名患者接受了玻璃体视网膜手术，其中大部分为男性（87人，70.2%），平均年龄为10.3岁。在需要进行手术的病例中，外伤占 32.3%，其中 47% 是由于穿透性眼外伤。35.5%的病例与综合病因有关，常见病因包括大衣、先天性白内障、粘连、早产儿视网膜病变等。32.3%的患者出现继发性病变，视网膜脱离是手术的主要原因（55%）。从症状出现到就诊的平均时间为 30 天（标准差 56.88），患者居住地距离昆士兰儿童医院平均 306.2 公里（标准差 558.9）。在创伤组中，年龄越大，发病天数越多（P本研究有助于深入了解澳大利亚昆士兰州儿童玻璃体视网膜病例的病因学和流行病学。

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