Advancements in artificial intelligence are rapidly transforming healthcare, including the diagnosis of aortic aneurysms, which relies on precise measurement of aortic parameters from CT scans. Current manual methods are time-consuming and require expert surgeons, making automation essential. Accurate automation depends on robust aortic semantic segmentation, cross-section reconstruction, and parameter extraction. Existing 2D segmentation models achieve Dice similarity coefficients (DSC) of 0.842–0.890, while 3D models reach 0.750–0.950. Despite the generally high segmentation accuracy, 3D models require substantial computational resources for both training and inference. This presents a substantial challenge for clinical deployment, especially in developing countries. Our research bridges this gap by advancing state-of-the-art 2D deep learning techniques for aortic semantic segmentation on CT scans. In this regard, we developed a pipeline leveraging novel neural network (NN) architectures and computer vision (CV) techniques. Various high-performing semantic segmentation NNs were rigorously compared. The best NNs (such as VAN-S-UNet, rViT-UNet (TransUNet), MiT-B2-UNet) achieved a DSC of 0.938–0.976 for open datasets, and 0.912 for our dataset of 50 aortic CT scans. The proposed pipeline automates the main stages of CT image processing, from raw CT scan data to quantitative aortic assessment, extracting clinically relevant parameters such as cross-sectional area, border length, and major and minor diameters for subsequent pathology diagnosis and informed clinical decision-making. Case study experiments show minor deviations between the results of the proposed method and expert assessments: approximately 5% for perimeter, 6% for major diameter, 10% for minor diameter, and 15% for cross-sectional area measurement.
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