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Machine Learning for Diagnosis of Diseases with Complete Gene Expression Profile 机器学习用于具有完整基因表达谱的疾病诊断
IF 0.7 4区 计算机科学 Q3 Engineering Pub Date : 2023-10-01 DOI: 10.1134/S0005117923070093
A. M. Mikhailov, M. F. Karavai, V. A. Sivtsov, M. A. Kurnikova

This paper considers the use of machine learning for diagnosis of diseases that is based on the analysis of a complete gene expression profile. This distinguishes our study from other approaches that require a preliminary step of finding a limited number of relevant genes (tens or hundreds of genes). We conducted experiments with complete genetic expression profiles (20 531 genes) that we obtained after processing transcriptomes of 801 patients with known oncologic diagnoses (oncology of the lung, kidneys, breast, prostate, and colon). Using the indextron (instant learning index system) for a new purpose, i.e., for complete expression profile processing, provided diagnostic accuracy that is 99.75% in agreement with the results of histological verification.

本文考虑在分析完整基因表达谱的基础上,将机器学习用于疾病诊断。这将我们的研究与其他需要初步寻找有限数量相关基因(数十或数百个基因)的方法区分开来。我们用完整的基因表达谱进行了实验(20 531个基因),这些基因是我们在处理801名已知肿瘤学诊断(肺、肾、乳腺、前列腺和结肠肿瘤学)患者的转录组后获得的。将indextron(即时学习指数系统)用于一个新的目的,即用于完整的表达谱处理,提供了与组织学验证结果一致的99.75%的诊断准确性。
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引用次数: 0
Suboptimal Robust Stabilization of an Unknown Autoregressive Object with Uncertainty and Offset External Perturbation 具有不确定性和偏移外摄动的未知自回归对象的次优鲁棒镇定
IF 0.7 4区 计算机科学 Q3 Engineering Pub Date : 2023-10-01 DOI: 10.1134/S0005117923060097
V. F. Sokolov

In this paper, the problem of suboptimal stabilization of an object with discrete time, output and control uncertainties, and bounded external perturbation is considered. The autoregressive nominal model coefficients, uncertainty amplification coefficients, norm and external disturbance offset are assumed to be unknown. The quality indicator is the worst-case asymptotic upper bound of the output modulus of the object. The solution of the problem in conditions of non-identifiability of all unknown parameters is based on the method of recurrent target inequalities and optimal online estimation, in which the quality index of the control problem serves as an identification criterion. A non-linear replacement of the unknown parameter perturbations that reduces the optimal online estimation problem to a fractional linear programming problem is proposed. The performance of adaptive suboptimal control is illustrated by numerical simulation results.

本文研究了具有离散时间、输出和控制不确定性以及有界外部扰动的对象的次优镇定问题。假设自回归标称模型系数、不确定性放大系数、范数和外部扰动偏移是未知的。质量指标是对象输出模的最坏情况渐近上界。在所有未知参数都不可识别的情况下,该问题的求解基于递归目标不等式和最优在线估计的方法,其中控制问题的质量指数作为识别准则。提出了一种未知参数扰动的非线性替换方法,将最优在线估计问题简化为分数线性规划问题。数值模拟结果说明了自适应次优控制的性能。
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引用次数: 0
Optimizing the Placement and Number of Measurement Points in Heating Process Control 加热过程控制中测量点的位置和数量的优化
IF 0.7 4区 计算机科学 Q3 Engineering Pub Date : 2023-10-01 DOI: 10.1134/S0005117923060024
V. M. Abdullayev

In this paper, a heating process control law with steam supply is designed for a fluid in a heat exchanger. The process is described by a linear hyperbolic equation of the first order with a nonlocal boundary condition with a time-delayed argument. The temperature of the supplied steam is found as a linear dependence on fluid temperature values at measurement points in the heat exchanger. Explicit formulas are obtained for the gradient of the objective functional of the control problem in the space of the feedback coefficients (parameters) of this dependence. A numerical scheme is developed for determining the feedback parameters based on these formulas. Finally, an algorithm is proposed for determining the rational (optimal) number of measurement points.

本文针对换热器中的流体,设计了一种带蒸汽供应的加热过程控制律。该过程由一阶线性双曲方程描述,该方程具有带时滞变元的非局部边界条件。所供应的蒸汽的温度与热交换器中测量点处的流体温度值成线性关系。得到了控制问题的目标函数在这种依赖性的反馈系数(参数)空间中的梯度的显式公式。基于这些公式,提出了一种确定反馈参数的数值方案。最后,提出了一种确定合理(最佳)测量点数量的算法。
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引用次数: 0
On Asymptotically Optimal Approach for Finding of the Minimum Total Weight of Edge-Disjoint Spanning Trees with a Given Diameter 求给定直径边不相交生成树最小总重的渐近最优方法
IF 0.7 4区 计算机科学 Q3 Engineering Pub Date : 2023-10-01 DOI: 10.1134/S0005117923070068
E. Kh. Gimadi, A. A. Shtepa

We consider the intractable problem of finding several edge-disjoint spanning trees of the minimum total weight with a given diameter in complete undirected graph in current paper. The weights of edges of a graph are random variables from several continuous distributions: uniform, biased truncated exponential, biased truncated normal. The approximation algorithm with time complexity (mathcal{O})(n2), where n is number of vertices in graph, is proposed for solving this problem. The asymptotic optimality conditions for constructed algorithm is presented for each considered probabilistic distribution.

本文讨论了在完全无向图中求几个给定直径的最小总权边不相交生成树的棘手问题。图的边的权重是来自几个连续分布的随机变量:均匀、有偏截尾指数、有偏截断正态。针对这一问题,提出了具有时间复杂性的近似算法(mathcal{O})(n2),其中n是图中的顶点数。对于每个考虑的概率分布,给出了构造算法的渐近最优性条件。
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引用次数: 0
Determination of the Relative Positioning Based on Magnetic Gradiometry Measurements 根据磁梯度测量确定相对位置
IF 0.7 4区 计算机科学 Q3 Engineering Pub Date : 2023-10-01 DOI: 10.1134/s0005117923100119

Abstract

The paper is devoted to solving the problem of determining the relative spatial arrangement and orientation of objects. The task was set: to show the fundamental possibility of spatial and angular relative positioning when using the parameters of the magnetic field gradient in tensor form and in the form of gradient of an absolute value vector as measurement information for the magnetic field of a local dipole source. The solution of the problem is presented along with the features and limitations for both forms of representation are considered. The principles of construction of magnetic gradiometry measurement systems are briefly described, the limitations of technical implementation are considered, and the benefits of using an alternating magnetic field source is outlined. The results of modelling are presented, proving the possibility of using the proposed positioning method for various engineering problems.

摘要 本文致力于解决确定物体相对空间排列和方向的问题。本文的任务是:以张量形式和绝对值矢量梯度形式的磁场梯度参数作为局部偶极源磁场的测量信息,说明空间和角度相对定位的基本可能性。本文介绍了问题的解决方法,并考虑了两种表示形式的特点和局限性。简要介绍了磁梯度测量系统的构造原理,考虑了技术实施的局限性,并概述了使用交变磁场源的好处。介绍了建模结果,证明了在各种工程问题中使用所建议的定位方法的可能性。
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引用次数: 0
On Continuous Random Processes with Fuzzy States 关于具有模糊状态的连续随机过程
IF 0.7 4区 计算机科学 Q3 Engineering Pub Date : 2023-10-01 DOI: 10.1134/S0005117923070081
V. L. Khatskevich

Continuous random processes with fuzzy states are studied. The properties of their numerical characteristics (expectations and correlation functions) corresponding to those of numerical random processes are established. The results obtained are based on the properties of fuzzy random variables. Applications to the problem of transforming a random signal with fuzzy states by a linear dynamic system are considered.

研究了具有模糊状态的连续随机过程。建立了它们的数值特征(期望和相关函数)的性质,这些性质与数值随机过程的性质相对应。所获得的结果是基于模糊随机变量的性质。考虑了线性动态系统对具有模糊状态的随机信号进行变换的应用。
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引用次数: 0
Analytical Investigation of a Single-Server Queueing System with an Incoming MAP Event Flow 具有传入MAP事件流的单服务器排队系统的分析研究
IF 0.7 4区 计算机科学 Q3 Engineering Pub Date : 2023-10-01 DOI: 10.1134/S000511792307007X
A. M. Gortsev, L. A. Nezhelskaya

This paper considers a single-server queueing system with an incoming Markovian Arrival Process (MAP) request flow with two states. Explicit expressions are derived for the stationary probability distribution of the states and several numerical characteristics of the system (the probability of idle time of the server, the expected number of requests in the system, and the mean queue length). The resulting numerical characteristics are presented in tables and plotted in graphical form as well. The recurrent MAP flow with two states as a special case of correlated MAP request flows is studied.

本文考虑了一个单服务器排队系统,该系统具有两种状态的传入马尔可夫到达过程(MAP)请求流。导出了状态的平稳概率分布和系统的几个数字特征(服务器空闲时间的概率、系统中的预期请求数和平均队列长度)的显式表达式。由此产生的数值特征以表格形式呈现,并以图形形式绘制。研究了具有两种状态的递归MAP流作为相关MAP请求流的特例。
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引用次数: 0
Statistical Complexity as a Criterion for the Useful Signal Detection Problem 统计复杂度作为有用信号检测问题的判据
IF 0.7 4区 计算机科学 Q3 Engineering Pub Date : 2023-10-01 DOI: 10.1134/S0005117923070056
A. A. Galyaev, P. V. Lysenko, L. M. Berlin

Three variants of the statistical complexity function, which is used as a criterion in the problem of detection of a useful signal in the signal-noise mixture, are considered. The probability distributions maximizing the considered variants of statistical complexity are obtained analytically and conclusions about the efficiency of using one or another variant for detection problem are made. The comparison of considered information characteristics is shown and analytical results are illustrated on an example of synthesized signals. A method is proposed for selecting the threshold of the information criterion, which can be used in decision rule for useful signal detection in the signal-noise mixture. The choice of the threshold depends a priori on the analytically obtained maximum values. As a result, the complexity based on the total variation demonstrates the best ability of useful signal detection.

考虑了统计复杂度函数的三种变体,该函数被用作信噪混合中有用信号的检测问题的标准。分析地获得了最大化所考虑的统计复杂度变体的概率分布,并得出了使用一个或另一个变体解决检测问题的效率的结论。给出了所考虑的信息特性的比较,并以合成信号为例说明了分析结果。提出了一种选择信息准则阈值的方法,该方法可用于信噪混合中有用信号检测的决策规则。阈值的选择先验地取决于分析获得的最大值。结果,基于总变化的复杂性证明了有用信号检测的最佳能力。
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引用次数: 0
Erratum to: Inverse Kinematics of a 5-DOF Hybrid Manipulator 五自由度混合机械手逆运动学勘误表
IF 0.7 4区 计算机科学 Q3 Engineering Pub Date : 2023-10-01 DOI: 10.1134/S0005117923070111
A. V. Antonov, A. S. Fomin
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引用次数: 1
The Guaranteeing Estimation Method to Calibrate a Gyro Unit 陀螺单元标定的保证估计方法
IF 0.7 4区 计算机科学 Q3 Engineering Pub Date : 2023-10-01 DOI: 10.1134/S0005117923070020
P. A. Akimov, A. I. Matasov

This paper is devoted to the guaranteeing estimation method with application to the calibration problem of a gyro unit. Mathematical models are constructed to describe the kinematics of the gyro unit on a test bench. The applicability limits and errors of the models are investigated. A numerical solution procedure is developed for guaranteeing estimation problems based on their reduction to l1-approximation problems.

本文致力于保证估计方法,并将其应用于陀螺单元的校准问题。在试验台上建立了描述陀螺单元运动学的数学模型。研究了模型的适用范围和误差。在将估计问题简化为l1近似问题的基础上,开发了一种数值求解程序来保证估计问题。
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引用次数: 0
期刊
Automation and Remote Control
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