Archives of Cardiovascular Diseases最新文献

{"title":"Optimizing oral low-density lipoprotein cholesterol-lowering therapy in statin-intolerant patients: A simulation study in France","authors":"Francois Schiele ,&nbsp;Michel Farnier ,&nbsp;Bénédicte Borsik","doi":"10.1016/j.acvd.2025.08.008","DOIUrl":"10.1016/j.acvd.2025.08.008","url":null,"abstract":"<div><h3>Background</h3><div>Lipid-lowering therapies effectively reduce low-density lipoprotein cholesterol concentrations and the risk of cardiovascular events, but barriers such as statin intolerance, non-adherence and discontinuation can leave patients at risk.</div></div><div><h3>Aim</h3><div>This study characterized statin-intolerant patients in France, and modelled the low-density lipoprotein cholesterol-lowering effects of ezetimibe and bempedoic acid for those at elevated cardiovascular risk.</div></div><div><h3>Methods</h3><div>Patients were identified based on IQVIA electronic medical records from 1200 general practitioners (September 2022 to August 2023), and this sample was extrapolated to represent the French population. Patients were identified as at high or very high probability of statin intolerance based on statin-associated muscle symptoms, statin downtitration or intermittent dosing/statin switch. The low-density lipoprotein cholesterol-lowering effect of stepwise addition of ezetimibe and bempedoic acid was modelled using a Monte Carlo simulation.</div></div><div><h3>Results</h3><div>Among patients at high or very high cardiovascular risk, 478,370 had statin intolerance: 54.5% at high and 45.5% at very high probability. Overall, 3.6% of patients were not receiving lipid-lowering therapy; most were receiving monotherapy with statins (46.8%) or ezetimibe (24.6%), and 24.4% were receiving a statin<!--> <!-->+<!--> <!-->ezetimibe. Of 179,458 patients with a low-density lipoprotein cholesterol result within 12 months and who received lipid-lowering therapy within 3.5 months of the index date, 90% (<em>n</em> <!-->=<!--> <!-->160,633) were not at low-density lipoprotein cholesterol goal at simulation baseline. In this population, adding ezetimibe reduced the mean low-density lipoprotein cholesterol concentration from 127 to 112<!--> <!-->mg/dL, with a 10.7% increase in goal attainment. Adding bempedoic acid in patients not at goal after ezetimibe further decreased the low-density lipoprotein cholesterol concentration to 86<!--> <!-->mg/dL, increasing goal attainment to 39.1%.</div></div><div><h3>Conclusions</h3><div>Most (90%) statin-intolerant patients in France do not meet low-density lipoprotein cholesterol goals, emphasizing the need for therapeutic strategies and evidence-based guidelines to improve outcomes. This simulation suggests that treatment escalation could increase low-density lipoprotein cholesterol goal attainment to ∼11% with ezetimibe, and to ∼40% with ezetimibe<!--> <!-->+<!--> <!-->bempedoic acid.</div></div>","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":"119 3","pages":"Pages 192-200"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145182367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nut consumption and risk of cardiovascular disease events and all-cause mortality: A systematic review and dose–response meta-analysis of prospective cohort studies","authors":"Mengna Liu ,&nbsp;Mengmeng Wang ,&nbsp;Xueru Fu ,&nbsp;Xinxin He ,&nbsp;Mengdi Wang ,&nbsp;Yijia Su ,&nbsp;Ge Liu ,&nbsp;Fulan Hu ,&nbsp;Ming Zhang ,&nbsp;Yang Zhao ,&nbsp;Dongsheng Hu","doi":"10.1016/j.acvd.2025.08.010","DOIUrl":"10.1016/j.acvd.2025.08.010","url":null,"abstract":"<div><h3>Background</h3><div>Evidence for the effects of nut consumption on cardiovascular disease (CVD) events and all-cause mortality has been reported inconsistently.</div></div><div><h3>Aims</h3><div>To assess the associations between nut consumption and CVD events and all-cause mortality.</div></div><div><h3>Methods</h3><div>We searched the Web of Science, Embase and PubMed up until 24 October 2023. In order to compute relative risks (RRs) and 95% confidence intervals (CIs), random-effects models were employed. Restricted cubic splines were performed to explore potential linear or non-linear associations. Heterogeneity was assessed (Cochran Q statistic) and quantified (<em>I</em>²-statistic). NutriGrade assessed the certainty of the evidence.</div></div><div><h3>Results</h3><div>Thirty-three publications (63 studies) were included. Comparisons between individuals with the highest versus lowest intake of nuts resulted in RRs (95% CIs) for coronary heart disease (CHD), stroke, CVD, CVD mortality and all-cause mortality of 0.81 (0.75–0.87), 0.91 (0.84–0.99), 0.86 (0.82–0.91), 0.74 (0.70–0.78) and 0.77 (0.73–0.81), respectively. With per 28-g increases in weekly nut intake, the RRs (95% CIs) for CHD, stroke, CVD, CVD mortality and all-cause mortality were 0.96 (0.95–0.97), 0.99 (0.97–1.01), 0.98 (0.97–0.99), 0.90 (0.86–0.94) and 0.92 (0.90–0.94), respectively. Nut intake was linearly associated with incidence of stroke (<em>P</em>_{non-linearity} <!-->=<!--> <!-->0.691), CVD (<em>P</em>_{non-linearity} <!-->=<!--> <!-->0.101) and CVD mortality (<em>P</em>_{non-linearity} <!-->=<!--> <!-->0.069) and non-linearly associated with CHD (<em>P</em>_{non-linearity} <!-->&lt;<!--> <!-->0.05) and all-cause mortality (<em>P</em>_{non-linearity} <!-->&lt;<!--> <!-->0.001).</div></div><div><h3>Conclusions</h3><div>This systematic review and meta-analysis revealed an association between nut consumption and reduced risk of CVD and all-cause mortality. It highlighted the importance of nuts as a dietary supplement in the primary prevention of CVD and all-cause mortality.</div></div>","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":"119 3","pages":"Pages 216-232"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145688678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter in response to the article entitled “Antithrombotic approach in percutaneous pulmonary valve implantation (PPVI): What is our standard of care? A study endorsed by the Association for European Paediatric and Congenital Cardiology” by Callegari et al.","authors":"Meng Sun ,&nbsp;Zhiqiang Zhao","doi":"10.1016/j.acvd.2025.11.008","DOIUrl":"10.1016/j.acvd.2025.11.008","url":null,"abstract":"","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":"119 3","pages":"Page 247"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146260344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical impact of congestion in patients admitted for cardiogenic shock","authors":"Miloud Cherbi ,&nbsp;François Roubille ,&nbsp;Eric Bonnefoy ,&nbsp;Paul Gautier ,&nbsp;Etienne Puymirat ,&nbsp;Guillaume Baudry ,&nbsp;Bruno Levy ,&nbsp;Pascal Lim ,&nbsp;Laurent Bonello ,&nbsp;Hamid Merdji ,&nbsp;Meyer Elbaz ,&nbsp;Clément Delmas","doi":"10.1016/j.acvd.2025.08.006","DOIUrl":"10.1016/j.acvd.2025.08.006","url":null,"abstract":"<div><h3>Background</h3><div>Recent guidelines have proposed dichotomizing acute heart failure and cardiogenic shock phenotypes based on signs/symptoms of hypoperfusion/congestion.</div></div><div><h3>Aim</h3><div>We aimed to assess the prognostic significance of congestion and its early evolution during the first 24<!--> <!-->hours in a nationwide cardiogenic shock cohort.</div></div><div><h3>Methods</h3><div>FRENSHOCK was a prospective registry including 772 patients with cardiogenic shock from 49 centres. Patients were classified as cold and wet or cold and dry according to congestive signs. Death at 30<!--> <!-->days was analysed according to baseline phenotype.</div></div><div><h3>Results</h3><div>Among 593 patients with cardiogenic shock included, 70.7% were male; the median age was 67.0 (58.0–77.0) years, and 521 patients (87.9%) presented with congestion. Congestive patients had higher rates of previous cardiac disease (60.5% vs. 43.1%; <em>P</em> <!-->&lt;<!--> <!-->0.01) and chronic kidney disease (24.2% vs. 12.5%; <em>P</em> <!-->=<!--> <!-->0.04). No differences were found regarding Society for Cardiovascular Angiography and Interventions class distribution and lactate concentrations. Congestion was associated with an increased 30-day all-cause death rate (hazard ratio: 1.99, 95% confidence interval: 1.05–3.78; <em>P</em> <!-->=<!--> <!-->0.04), particularly among patients with persistent congestion beyond 24<!--> <!-->hours (hazard ratio: 2.29, 95% confidence interval: 1.20–4.36; <em>P</em> <!-->=<!--> <!-->0.01). Conversely, patients with resolved congestion at 24<!--> <!-->hours had similar outcomes to non-congestive patients (hazard ratio: 0.76, confidence interval: 0.31–1.88; <em>P</em> <!-->=<!--> <!-->0.56). The negative impact of congestion was confirmed in multivariable Cox regression analysis.</div></div><div><h3>Conclusions</h3><div>Congestion and its persistence beyond 24<!--> <!-->hours of management are frequent in patients with cardiogenic shock, and are significantly associated with an increased 30-day all-cause death rate, which may reflect either a direct harmful effect of congestion or difficulties in achieving decongestion in sicker patients. Further studies are warranted to clarify optimal decongestion strategies in patients with cardiogenic shock.</div></div>","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":"119 3","pages":"Pages 201-209"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145088258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combination of a proximity catheterization laboratory and high-volume operators is associated with improved outcome after primary percutaneous coronary intervention","authors":"Farzin Beygui ,&nbsp;Boudjema Ouazar ,&nbsp;Lin Schwob ,&nbsp;Adrien Lemaitre ,&nbsp;Katrien Blanchart ,&nbsp;Mathieu Bignon ,&nbsp;Rémi Sbatier ,&nbsp;Chloé Péron ,&nbsp;Guillaume Malcor ,&nbsp;Vincent Roule","doi":"10.1016/j.acvd.2025.08.011","DOIUrl":"10.1016/j.acvd.2025.08.011","url":null,"abstract":"","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":"119 3","pages":"Pages 244-246"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145152014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neoaortic outcomes after the arterial switch operation: A systematic review and meta-analysis","authors":"Sherif Negm ,&nbsp;Alaa B. Mahmoud ,&nbsp;Beatrice Desnous ,&nbsp;Elatafy E. Elatafy ,&nbsp;Virginie Fouilloux ,&nbsp;Celia Gran ,&nbsp;Loïc Macé ,&nbsp;Marien Lenoir","doi":"10.1016/j.acvd.2025.08.013","DOIUrl":"10.1016/j.acvd.2025.08.013","url":null,"abstract":"<div><h3>Background</h3><div>The arterial switch operation has become the treatment of choice for neonates with transposition of great arteries.</div></div><div><h3>Aim</h3><div>This systematic review and meta-analysis aimed to summarize the current evidence regarding neoaortic root dilatation and aortic valve insufficiency as long-term outcomes after the arterial switch operation, and to identify associated risk factors.</div></div><div><h3>Methods</h3><div>A systematic search of PubMed, EMBASE and Cochrane databases was conducted for human studies published in English or French until May 2024.</div></div><div><h3>Results</h3><div>Out of 1480 identified records, 80 studies were included in the final analysis. The total incidence of moderate-to-severe aortic insufficiency was 588 out of 20,338 patients (2.89%). The total number of neoaortic reinterventions was 306 in 11,291 patients (2.71%). The total number of neoaortic reinterventions for aortic insufficiency was 78 in 4757 patients (1.63%). Distensibility of both the aortic root and the ascending aorta in patients after the arterial switch operation was significantly lower than in the normal population. Several factors were significantly associated with an increased risk of moderate-to-severe aortic insufficiency: ventricular septal defect (<em>P</em> <!-->&lt;<!--> <!-->0.001); pulmonary artery banding (<em>P</em> <!-->=<!--> <!-->0.007); aortopulmonary mismatch (<em>P</em> <!-->&lt;<!--> <!-->0.001); and neoaortic root dilatation (<em>P</em> <!-->&lt;<!--> <!-->0.001). Coronary anomalies showed a borderline association (<em>P</em> <!-->=<!--> <!-->0.055), and the trapdoor technique was significant in one study (<em>P</em> <!-->=<!--> <!-->0.0005). Distensibility of both the aortic root and the ascending aorta was found to be significantly reduced in patients after the arterial switch operation compared with healthy controls, reflecting increased vascular stiffness.</div></div><div><h3>Conclusions</h3><div>Significant neoaortic valve insufficiency and reintervention remain relatively rare after the arterial switch operation. However, measurable risk factors–including ventricular septal defect, pulmonary artery banding, aortopulmonary mismatch and coronary anomalies–are associated with an increased long-term risk of valve dysfunction or surgical reintervention.</div></div>","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":"119 3","pages":"Pages 233-243"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145454142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to a letter from Meng Sun and Zhiqiang Zhao commenting on the article entitled “Antithrombotic approach in percutaneous pulmonary valve implantation (PPVI): What is our standard of care? A study endorsed by the Association for European Paediatric and Congenital Cardiology”","authors":"Alessia Callegari ,&nbsp;Gianfranco Butera ,&nbsp;Thomas Krasemann ,&nbsp;Ruth Heying ,&nbsp;Ina Michel-Behnke ,&nbsp;Damien Bonnet ,&nbsp;Sophie Malekzadeh-Milani","doi":"10.1016/j.acvd.2025.12.001","DOIUrl":"10.1016/j.acvd.2025.12.001","url":null,"abstract":"","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":"119 3","pages":"Pages 248-249"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145992101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcatheter closure of ostium secundum atrial septal defects in 2253 children and adults: Early outcomes","authors":"Grégoire Albenque ,&nbsp;Estibaliz Valdeolmillos ,&nbsp;Claire Foray ,&nbsp;Marine Cachanado ,&nbsp;Philippe Brenot ,&nbsp;Benoît Gerardin ,&nbsp;Lisa Guirgis ,&nbsp;Emmanuelle Fournier ,&nbsp;Sarah Cohen ,&nbsp;Florence Lecerf ,&nbsp;Mohamed Jaber ,&nbsp;Joy Zoghbi ,&nbsp;Bastien Provost ,&nbsp;Régine Roussin ,&nbsp;Emre Belli ,&nbsp;Clément Batteux ,&nbsp;Jérôme Petit ,&nbsp;Sébastien Hascoët","doi":"10.1016/j.acvd.2025.07.010","DOIUrl":"10.1016/j.acvd.2025.07.010","url":null,"abstract":"<div><h3>Background</h3><div>Transcatheter closure of ostium secundum atrial septal defect (osASD) has been the first-line treatment in most children and adults since the 2000s. Some major adverse events (MAE), such as aortic erosion, have been infrequently reported.</div></div><div><h3>Aims</h3><div>To report early outcomes in different subgroups by age and investigate risk factors associated with MAE.</div></div><div><h3>Methods</h3><div>This prospective, single-centre, cohort study included 2253 consecutive patients referred for transcatheter osASD with Amplatzer Septal Occluder (ASO) (Abbott®) between May 1998 and December 2021. Peri-procedural data associated with MAE at 1 month were investigated.</div></div><div><h3>Results</h3><div>Of 2253 patients, 1388 (61.6%) were adults and 865 (38.4%) were children, including 38 (1.7%) who weighed<!--> <!-->&lt;<!--> <!-->15<!--> <!-->kg. Mean<!--> <!-->±<!--> <!-->standard deviation osASD diameter was 18<!--> <!-->±<!--> <!-->7<!--> <!-->mm, 22.7% of patients had a deficient aortic rim and 0.9% had a deficient inferior vena cava rim. Procedural success was achieved in 98.1% (95% confidence interval [CI] 97.4–98.6%). A total of 32 peri-procedural MAE occurred in 31 patients (1.4%, 95% CI 0.9–−1.9%) including 19 device embolizations (0.8%) and two cardiac erosions (0.1%). No peri-procedural deaths were reported. There were no significant differences in the incidence of MAE between age and weight subgroups. In univariate analysis, MAE were significantly associated with atrial arrhythmia history before the intervention (<em>P<!--> </em>=<!--> <!-->0.013), inferior vena cava rim deficiency (<em>P<!--> </em>&lt;<!--> <!-->0.001), antero-inferior rim deficiency (<em>P<!--> </em>=<!--> <!-->0.004), absence of balloon sizing (<em>P<!--> </em>=<!--> <!-->0.026), larger prosthesis size (<em>P<!--> </em>=<!--> <!-->0.017), maximal atrial septal defect size/body surface area<!--> <!-->≥<!--> <!-->20<!--> <!-->mm/m² (<em>P</em> <!-->=<!--> <!-->0.008).</div></div><div><h3>Conclusion</h3><div>Transcatheter osASD closure using ASO has a high procedural success rate across a broad population of children and adults, reinforcing that transcatheter osASD closure is the intervention of choice for a wide range of patients and osASD morphologies.</div></div>","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":"119 3","pages":"Pages 185-191"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145076736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Homozygous familial hypercholesterolemia: New therapeutic approach and a call for action!","authors":"Antonio Gallo ,&nbsp;Franck Boccara ,&nbsp;Sophie Béliard","doi":"10.1016/j.acvd.2025.09.001","DOIUrl":"10.1016/j.acvd.2025.09.001","url":null,"abstract":"","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":"119 3","pages":"Pages 182-184"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145294460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic acidosis and sodium bicarbonate: Key considerations for cardiovascular health in CKD","authors":"Dalil Sadki,&nbsp;Sami Fawaz","doi":"10.1016/j.acvd.2025.08.005","DOIUrl":"10.1016/j.acvd.2025.08.005","url":null,"abstract":"","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":"119 3","pages":"Pages 179-181"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145967913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}