Archives of Cardiovascular Diseases最新文献

{"title":"Fragmented QRS complexes as an independent predictor of all-cause mortality in patients with systolic heart failure: A retrospective cohort study","authors":"F. Yahia ,&nbsp;S. Ben Farhat ,&nbsp;H. Ghardallou ,&nbsp;N. Elyes ,&nbsp;E. Allouche ,&nbsp;S. Ouali","doi":"10.1016/j.acvd.2025.10.079","DOIUrl":"10.1016/j.acvd.2025.10.079","url":null,"abstract":"<div><h3>Introduction</h3><div>Fragmented QRS complexes (fQRS), electrocardiographic markers of myocardial scarring/conduction abnormalities, are under investigation for prognostic value in heart failure (HF) with reduced left ventricular ejection fraction (LVEF).</div></div><div><h3>Objective</h3><div>To assess the association of fQRS with clinical outcomes in systolic HF (LVEF<!--> <!-->&lt;<!--> <!-->50%).</div></div><div><h3>Method</h3><div>Retrospective analysis of HF patients (LVEF<!--> <!-->&lt;<!--> <!-->50%). fQRS was defined by notching in R/S waves (≥<!--> <!-->2 contiguous leads; narrow/wide QRS criteria). Outcomes were analyzed using Cox models adjusted for clinical covariates.</div></div><div><h3>Results</h3><div>A total of 187 patients were enrolled, those with fQRS (34.8%) exhibited higher all-cause mortality vs. non-fQRS (unadjusted HR: 2.855, 95% CI 1.641–4.966, <em>P</em> <!-->=<!--> <!-->0.0001; adjusted HR: 4.130, 95% CI 2.109–8.088, <em>P</em> <!-->=<!--> <!-->0.0001) (<span><span>Table 1</span></span>). No significant associations with heart failure-related readmissions (HR: 1.084, <em>P</em> <!-->=<!--> <!-->0.755), all-cause rehospitalizations (HR: 1.237, <em>P</em> <!-->=<!--> <!-->0.357), or arrhythmic events (HR: 1.527, <em>P</em> <!-->=<!--> <!-->0.717) were observed.</div></div><div><h3>Conclusion</h3><div>fQRS independently predicts mortality but not readmissions or arrhythmias in systolic HF, supporting its role in risk stratification.</div></div>","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":"119 1","pages":"Pages S45-S46"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145904089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of right ventricular strain analysis in predicting right ventricular involvement in inferior myocardial infarction","authors":"E. Allouche ,&nbsp;R. Mars ,&nbsp;A. Chetoui ,&nbsp;S. Neji ,&nbsp;F. Boudiche El Ayech ,&nbsp;M.S. Aissa ,&nbsp;M. Elarbi ,&nbsp;H. Ben Ahmed ,&nbsp;W. Ouechtati Ben Attia ,&nbsp;L. Bezdah","doi":"10.1016/j.acvd.2025.10.010","DOIUrl":"10.1016/j.acvd.2025.10.010","url":null,"abstract":"<div><h3>Introduction</h3><div>Inferior myocardial infarction (IMI), typically resulting from right coronary artery occlusion, may extend to the right ventricle (RV), increasing morbidity due to impaired cardiac output. Detecting RV involvement remains challenging, as clinical signs and standard ECG changes often lack diagnostic precision.</div></div><div><h3>Objective</h3><div>The aim of this study was to evaluate the utility of RV strain analysis in detecting RV involvement in patients with IMI and to assess its correlation with conventional echocardiographic parameters.</div></div><div><h3>Method</h3><div>This cross-sectional observational study was conducted in the Cardiology Department of Charles Nicolle Hospital. It included patients admitted to the intensive care unit for acute inferior myocardial infarction between January 2022 and December 2024.</div></div><div><h3>Results</h3><div>During the 24-month study period, 50 patients were enrolled. The mean age was 61.86 years (range: 31–83 years). The population included 42 men (84%) and 8 women (16%), with a sex ratio of 5.25.</div><div>Patients with RV infarction showed significantly reduced conventional echocardiographic parameters of RV systolic function, along with impaired strain values, compared to those without RV involvement (<span><span>Table 1</span></span>).</div><div>A very strong, statistically significant positive correlation was observed between right ventricular free lateral wall strain (FWLS-RV) and RV infarction (<em>r</em> <!-->=<!--> <!-->0.921, <em>P</em> <!-->=<!--> <!-->0.001), suggesting its potential as a reliable marker of RV myocardial damage.</div><div>FWLS-RV also demonstrated significant correlations with traditional RV systolic function. A moderate correlation was found with RV fractional shortening (<em>r</em> <!-->=<!--> <!-->0.471, <em>P</em> <!-->&lt;<!--> <!-->0.001), and a strong correlation with tricuspid annular plane systolic excursion (TAPSE) (<em>r</em> <!-->=<!--> <!-->0.72, <em>P</em> <!-->&lt;<!--> <!-->0.001), supporting FWLS-RV as a sensitive marker of RV function.</div></div><div><h3>Conclusion</h3><div>RV strain analysis is a valuable echocardiographic parameter for detecting RV involvement in IMI. It correlates well with conventional measures of RV systolic function, thereby enhancing diagnostic accuracy and guiding targeted clinical care.</div></div>","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":"119 1","pages":"Page S10"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145904112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence, risk factors, and impact of coronary artery disease events after kidney transplantation","authors":"T. Beaudrey ,&nbsp;D. Bedo ,&nbsp;S. Caillard ,&nbsp;N. Florens","doi":"10.1016/j.acvd.2025.10.012","DOIUrl":"10.1016/j.acvd.2025.10.012","url":null,"abstract":"<div><h3>Introduction</h3><div>Coronary artery disease (CAD) is a significant cause of morbidity and mortality among kidney transplant recipients. The epidemiology and impact of coronary events after transplantation remain poorly understood in France. We investigated these aspects using data from 17 French centers, sourced from the Astre and Divat cohorts.</div></div><div><h3>Objective</h3><div>We aimed to describe the epidemiology of coronary artery disease, and its risk factors and impact on graft and patient outcomes.</div></div><div><h3>Method</h3><div>We included adult kidney allograft recipients transplanted between 2008 and 2022, with follow-up until 03/31/2023. The primary outcome was the incidence of coronary events post-transplantation, defined as the need for coronary angiography with percutaneous transluminal angioplasty. We also studied risk factors and the impact of early events on patient and graft survival (&lt;1 month post-transplantation) using univariate and then multivariate Cox models.</div></div><div><h3>Results</h3><div>Among the 19,837 kidney transplant recipients included, 764 experienced a coronary event (3.9%) with a mortality rate of 7.1%. The cumulative incidence was 1.03% at 1 month, 1.86% at 1 year, 3.77% at 5 years, and 6.60% at 10 years (<span><span>Fig. 1</span></span>A and B). Previously known coronary artery disease was the most prominent risk factor, but the majority of events (<em>n</em> <!-->=<!--> <!-->505, 66.1%) occurred in patients without history of CAD. In multivariate analysis, the other risk factors for post-transplant CAD included age, male sex, cardiovascular history, diabetes, smoking, depleting induction therapy, dialysis duration, and delayed graft function. Early coronary events were associated with all-cause mortality (Hazard ratio 1.77, 95% Confidence Interval 1.34–2.33) and a graft failure (Hazard ratio 1.51, 95% CI 1.01–2.25).</div></div><div><h3>Conclusion</h3><div>Post-transplant coronary events are frequent, particularly in the first month, and can occur in patients without history of coronary artery disease, despite pretransplant screening. They are a significant cause of morbidity and mortality and are associated with decline in graft function.</div></div>","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":"119 1","pages":"Page S11"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145904113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Coronary Contrast to Renal Injury: The Emerging Role of Endothelial Dysfunction","authors":"M. Fakhfakh ,&nbsp;F. Nouri ,&nbsp;T. Lassoued ,&nbsp;S. Ferjani ,&nbsp;S. Milouchi","doi":"10.1016/j.acvd.2025.10.009","DOIUrl":"10.1016/j.acvd.2025.10.009","url":null,"abstract":"<div><h3>Introduction</h3><div>Contrast-induced acute kidney injury (CIAKI) is a common and serious complication of coronary angiography, caused by iodinated contrast agents. It significantly worsens cardiovascular prognosis and increases in-hospital morbidity and mortality.</div></div><div><h3>Objective</h3><div>This study aimed to uncover predictive factors of CIAKI and to investigate the contribution of pre-existing endothelial dysfunction to its onset following percutaneous coronary interventions (PCI). Preventive strategies with potential clinical relevance were concurrently evaluated.</div></div><div><h3>Method</h3><div>This was a prospective observational longitudinal study in which we enrolled 187 patients with an indication for coronary angiography. Patients underwent an assessment of renal function: (basal creatinine, 24<!--> <!-->h, 48–72<!--> <!-->h and 1month after administration of contrast medium), we focused then on the evaluation of endothelial quality index (EQI) by finger thermal monitoring with E4 diagnosis Polymath (<span><span>Fig. 1</span></span>).</div></div><div><h3>Results</h3><div>187 patients (134 males), mean age 61.1<!--> <!-->±<!--> <!-->11.8 years, were enrolled; 56.7% were type 2 diabetics. CIAKI occurred in 60 patients (33.7%). Mean EQI was 0.86<!--> <!-->±<!--> <!-->0.61. A vast majority (95.2%) had endothelial dysfunction (EQI<!--> <!-->&lt;<!--> <!-->2), and 75.9% had severe dysfunction (EQI<!--> <!-->&lt;<!--> <!-->1). CIAKI was significantly associated with severe endothelial dysfunction (<em>P</em> <!-->=<!--> <!-->0.007), rescue PCI (<em>P</em> <!-->=<!--> <!-->0.002), contrast volume<!--> <!-->&gt;<!--> <!-->100<!--> <!-->ml (<em>P</em> <!-->=<!--> <!-->0.015), and two-vessel coronary artery disease (<em>P</em> <!-->=<!--> <!-->0.008). Multivariate analysis confirmed severe endothelial dysfunction, rescue PCI, and contrast volume<!--> <!-->≥<!--> <!-->140<!--> <!-->ml as independent risk factors. CIAKI was significantly less frequent in patients receiving pre-/post-hydration with isotonic saline or those under baseline statin therapy (<em>P</em> <!-->=<!--> <!-->0.007 and <em>P</em> <!-->=<!--> <!-->0.008, respectively).</div></div><div><h3>Conclusion</h3><div>This study demonstrates a significant association between severe endothelial dysfunction assessed non-invasively by FTM and the risk of CIAKI. These findings highlight the potential of EQI as a novel, low-cost, reproducible predictor of CIAKI, with promising implications for cardiovascular risk stratification and prevention in interventional cardiology.</div></div>","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":"119 1","pages":"Pages S9-S10"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145904135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular magnetic resonance late gadolinium enhancement risk score for mortality in hypertrophic cardiomyopathy: The HCM-LGE risk score","authors":"J. Florence ,&nbsp;J. Garot ,&nbsp;P. Garot ,&nbsp;F. Sanguineti ,&nbsp;S. Duhamel ,&nbsp;T. Goncalves ,&nbsp;A. Unger ,&nbsp;E. Ballout ,&nbsp;J. Hudelo ,&nbsp;J.-G. Dillinger ,&nbsp;P. Henry ,&nbsp;V. Bousson ,&nbsp;Y. Bohbot ,&nbsp;S. Toupin ,&nbsp;T. Pezel","doi":"10.1016/j.acvd.2025.10.099","DOIUrl":"10.1016/j.acvd.2025.10.099","url":null,"abstract":"<div><h3>Introduction</h3><div>Prognostic stratification is the cornerstone of the management of patients with hypertrophic cardiomyopathy (HCM). Our working group has developed the concept of “late gadolinium enhancement (LGE) granularity” using cardiovascular magnetic resonance (CMR) with an incremental prognostic value in HCM patients.</div></div><div><h3>Objective</h3><div>To develop a readily interpretable score based on the CMR-LGE granularity concept to predict all-cause mortality in HCM patients.</div></div><div><h3>Method</h3><div>Between 2008 and 2021, all patients referred for HCM assessment using CMR, without history of cardiovascular disease were prospectively recruited in two French centers. We selected patients with CMR-LGE. The outcome was all-cause death using the French National Registry of Death. Using the variables of the “LGE granularity” model (LGE extent, septal location and subepicardial associated midwall pattern), the HCM-LGE score, was derived from coefficients of the Cox regression (<span><span>Figure 1</span></span>). The first center (N<!--> <!-->=<!--> <!-->723) was split into training set (N<!--> <!-->=<!--> <!-->586) designated for score development, and testing set (N<!--> <!-->=<!--> <!-->137) for performances assessment. The second center (N<!--> <!-->=<!--> <!-->139) was used as the external validation cohort. Score categories were identified using a survival conditional inference tree analysis on the training set, aiming to optimize the log-rank. Performances of the score were assessed using Kaplan-Meier curves analysis and Cox regression on the overall population.</div></div><div><h3>Results</h3><div>Overall, 862 patients (52<!--> <!-->±<!--> <!-->7 years, 54% males) with HCM and CMR-LGE were included. After a median (IQR) follow-up of 9 (7–11) years, 283 (33%) patients died. The proportion of mortality rate for each score points is presented in Figure 1A. In the overall population (N<!--> <!-->=<!--> <!-->862), intermediate and high-risk categories were strongly associated with all-cause mortality (hazard ratio (HR) 8.61, 95% CI: 5.96–12.45, <em>p</em> <!-->&lt;<!--> <!-->0.001; HR 19.31, 95% CI: 13.95–26.73, <em>p</em> <!-->&lt;<!--> <!-->0.001 respectively) (Figure 1B). Based on our HCM-LGE score, we identified a low-risk population (CMR-LGE score below 4) and a high-risk population (CMR-LGE above 5), validated using survival curves in the overall population.</div></div><div><h3>Conclusion</h3><div>Our HCM-LGE score based on the concept of LGE granularity showed an excellent performance to stratify patient risk in HCM patients.</div></div>","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":"119 1","pages":"Page S56"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145904151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenges in the Diagnosis and Management of Non-ST Elevation Acute Coronary Syndromes in Dakar","authors":"A.A. Ngaide ,&nbsp;P.G. Ndiaye ,&nbsp;J.S. Mingou ,&nbsp;S. Abdoulgabar ,&nbsp;M. Dioum ,&nbsp;C.M. Mouhamed ,&nbsp;A. Kane","doi":"10.1016/j.acvd.2025.10.026","DOIUrl":"10.1016/j.acvd.2025.10.026","url":null,"abstract":"<div><h3>Introduction</h3><div>Non-ST elevation acute coronary syndrome (NSTE-ACS) is the most common form of acute coronary syndrome (ACS). Its diagnosis and management remain controversial, particularly in resource-limited settings like Africa, where logistical and financial constraints often complicate optimal care.</div></div><div><h3>Objective</h3><div>This study aimed to assess the overall management of patients hospitalized for NSTE-ACS in Dakar.</div></div><div><h3>Method</h3><div>We conducted a prospective, multicenter, descriptive, and analytical study over a 12-month period across three cardiology departments in Dakar. All patients admitted with a diagnosis of NSTE-ACS were included. Clinical, biological, echocardiographic, and angiographic data were collected and analyzed.</div></div><div><h3>Results</h3><div>Out of 2329 patients admitted during the study period, 131 were diagnosed with NSTE-ACS, representing a hospital prevalence of 5.63% and accounting for 26.3% of all hospitalized ACS cases. Based on troponin levels, 86.7% had positive troponin (NSTEMI), while 13.3% had negative troponin (unstable angina). The cohort had a female predominance (56.0%), with a mean age of 61.1 years (range 40–91). The most frequent cardiovascular risk factors were physical inactivity (75.6%), hypertension (64.9%), and diabetes mellitus (36.7%). Chest pain was the leading symptom (81.7%), and physical examination was normal in 75% of cases. Echocardiography revealed segmental wall motion abnormalities in 45% and left ventricular dysfunction in 38.6% of patients. Nearly half of the patients (46.6%) were classified as high ischemic risk.</div><div>Coronary angiography was performed in 64.8% of patients, and coronary artery disease was identified in 82.4% of them, predominantly triple-vessel disease (46.7%). Among those with confirmed coronary disease, only 35.7% underwent percutaneous coronary intervention (PCI). The clinical outcome was generally favorable.</div></div><div><h3>Conclusion</h3><div>The diagnosis and management of NSTE-ACS remain major challenges in sub-Saharan Africa, particularly due to limited access to coronary angiography and revascularization procedures. Strengthening diagnostic infrastructure and improving access to interventional cardiology are essential for optimizing care and outcomes in this high-risk population.</div></div>","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":"119 1","pages":"Pages S17-S18"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145904171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of return to work at one year after stenting or coronary artery bypass surgery","authors":"L. Boulares ,&nbsp;J. Hsinet ,&nbsp;S. Saidane ,&nbsp;A. Chakroun ,&nbsp;K. Mzoughi","doi":"10.1016/j.acvd.2025.10.035","DOIUrl":"10.1016/j.acvd.2025.10.035","url":null,"abstract":"<div><h3>Introduction</h3><div>Coronary heart disease can cause premature disability, resulting in socioeconomic issues. A better understanding of return to work (RTW) and quality of life after percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG) may help inform patients better, and could provide metrics for patients and physicians to understand longer term social outcomes.</div></div><div><h3>Objective</h3><div>The aim of this study was to determine return to work (RTW) rates, long-term employment (&gt;12 months postprocedure), time taken to RTW, and to evaluate the predictive factors of return to work, for the subgroup of professionally active patients aged less than 60 years, treated either with (PCI) or coronary bypass graft surgery (CABG).</div></div><div><h3>Method</h3><div>A descriptive cross-sectional study of active patients aged less than 60 years, followed for acute coronary syndrome in a cardiology department between 2021 and 2024 and who underwent PCI or CABG. The medical data were collected from the hospitalization records. In addition, socio-demographic and occupational characteristics were collected using a questionnaire addressed to patients either during a consultation or by a telephone contact.</div></div><div><h3>Results</h3><div>78 patients were employed preprocedure: 64 patients (82%) underwent PCI and 14 patients (18%) underwent CABG. The median age was 52.39<!--> <!-->±<!--> <!-->54.04 years. The return to work rate was 69.4% with an average delay of 53.5<!--> <!-->±<!--> <!-->40 days. Of these 44 (56.4%) PCI and 10 (12.8%) CABG, there was no significant difference between PCI and CABG patients in RTW nor in long term employment. The median time taken to RTW was 4 weeks after PCI and 12 weeks after CABG (<em>P</em> <!-->=<!--> <!-->0.001).</div><div>Return to work was associated with age under 50 years (<em>P</em> <!-->=<!--> <!-->0.013) and work in the public sector (<em>P</em> <!-->=<!--> <!-->0.017). In addition, physical workload (<em>P</em> <!-->=<!--> <!-->0.003), shift work (<em>P</em> <!-->=<!--> <!-->0.018) and the existence of complications including heart failure (<em>P</em> <!-->=<!--> <!-->0.001) and rhythm disorders (<em>P</em> <!-->=<!--> <!-->0.007) were strongly associated with no return to the professional activity.</div></div><div><h3>Conclusion</h3><div>In this study comparing RTW after PCI or CABG indicates that RTW, is similar for PCI or CABG, albeit the number of matched pairs was small. There are differences, however, in delay in RTW.</div><div>Return to work after percutaneous coronary intervention or coronary bypass graft surgery depends essentially on socio-professional factors and heart complications.</div></div>","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":"119 1","pages":"Page S22"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145904252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New onset atrial fibrillation in acute coronary syndrome: Prevalence, risk factors, and long-term outcomes in a Tunisian population","authors":"M. Ben Halima,&nbsp;Z. Jebbari,&nbsp;K. Ezzaouia,&nbsp;W. Yaakoubi,&nbsp;S. Ouali,&nbsp;F. Meghaieth,&nbsp;A. Farhati,&nbsp;R. Ben Rejeb,&nbsp;N. Larbi,&nbsp;S. Boudiche,&nbsp;M.S. Mourali","doi":"10.1016/j.acvd.2025.10.038","DOIUrl":"10.1016/j.acvd.2025.10.038","url":null,"abstract":"<div><h3>Introduction</h3><div>New-onset AF atrial fibrillation (NOAF) frequently complicates acute coronary syndromes (ACS) leading to adverse outcomes in the short and long term. The reported incidence ranges from 2 to 37% according to recent studies and a number of factors have consistently been shown to be associated with this arrhythmia.</div></div><div><h3>Objective</h3><div>The aim of the study was to determine the prevalence of NOAF in a population of patients admitted for ACS and to identify its predictive factors and study their prognosis.</div></div><div><h3>Method</h3><div>We carried out a prospective, descriptive and comparative observational study during a period of 10 months from January 2023 to November 2023 in the Cardiology department of the Rabta hospital. We included in our study consecutively hospitalized patients with acute coronary syndrome (ACS) who did not have a previous diagnosis of AF.</div></div><div><h3>Results</h3><div>In our study, we included 404 patients hospitalized for ACS. The prevalence of NOAF was 10%. In the multivariate analytical study, we found that age greater than 62 years (<em>P</em> <!-->=<!--> <!-->0.04; adjusted OR<!--> <!-->=<!--> <!-->4.83; CI95%: 1.07–21.77), chronic renal failure (<em>P</em> <!-->=<!--> <!-->0.043; adjusted OR<!--> <!-->=<!--> <!-->6.61; CI95%: 1.06–35.80), history of stroke (<em>P</em> <!-->=<!--> <!-->0.002; adjusted OR<!--> <!-->=<!--> <!-->44.51; CI95%: 3.97–498.10) and uricemia<!--> <!-->≥<!--> <!-->62<!--> <!-->mg/l (<em>P</em> <!-->=<!--> <!-->0.04; adjusted OR<!--> <!-->=<!--> <!-->4.4; CI95%: 1.06–18.15) were independent predictive factors of NOAF. NOAF was associated with a higher in-hospital mortality (5% vs. 0.5% in the group without AF; <em>P</em> <!-->=<!--> <!-->0.04) as well as a higher incidence of in-hospital major cardiovascular events (69% versus 24%; <em>P</em> <!-->=<!--> <!-->0.009). For the 183 patients followed over a mean period of 12 months, the NOAF was associated with a higher extra-hospital mortality (13% vs 6% in the group without AF; <em>P</em> <!-->=<!--> <!-->0.03) but there was not significant difference between patients with and without AF for major cardiovascular events.</div></div><div><h3>Conclusion</h3><div>The prevalence of NOAF in patients with ACS was 10%. Its systematic screening in these patients appears to be a relevant approach because of the strong association between the two pathologies in this population, and the pejorative impact on the prognosis of this arrythmia.</div></div>","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":"119 1","pages":"Page S23"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145904255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of gender and diabetes on the outcome of patients undergoing percutaneous coronary intervention with rotational atherectomy","authors":"P. Chenard,&nbsp;A.M. Boutaleb,&nbsp;V. Coussens,&nbsp;A. Cianci,&nbsp;L. Lebivic,&nbsp;V. Aboyans,&nbsp;M. Boukhris","doi":"10.1016/j.acvd.2025.10.040","DOIUrl":"10.1016/j.acvd.2025.10.040","url":null,"abstract":"<div><h3>Introduction</h3><div>The complexity of coronary lesions treated by percutaneous coronary intervention (PCI) has gradually increased with high prevalence of calcified lesions. The use of rotational atherectomy (RA) has become more common. However, the outcome of such a debulking device in specific patient subsets remains not well understood.</div></div><div><h3>Objective</h3><div>This study aimed to investigate the combined impact of gender and diabetes on the management and outcomes of patients undergoing PCI with RA.</div></div><div><h3>Method</h3><div>We conducted a retrospective single-center study of patients who underwent PCI with RA between January 2019 and December 2022. The primary outcome was the occurrence of major adverse cardiovascular events (MACE), including myocardial infarction (MI), cardiovascular (CV) death, and target vessel failure (TVF). Secondary outcomes included individual occurrences of MI, CV death, and TVF, along with data on technical success and safety outcomes, such as per-procedural and in-hospital complications.</div></div><div><h3>Results</h3><div>A total of 238 patients (mean age 77.2<!--> <!-->±<!--> <!-->9.2 years; 74.8% male; diabetes prevalence 36.1%) were included: men with diabetes (<em>n</em> <!-->=<!--> <!-->66, 27.7%), women with diabetes (<em>n</em> <!-->=<!--> <!-->20, 8.4%), men without diabetes (<em>n</em> <!-->=<!--> <!-->112, 47.1%), and women without diabetes (<em>n</em> <!-->=<!--> <!-->40, 16.8%).</div><div>No in-hospital death was observed in patients without diabetes. In presence of diabetes, in-hospital death was significantly higher in women as compared with men (7.5% vs. 0.9%; <em>P</em> <!-->=<!--> <!-->0.025).</div><div>The mean follow-up was 2.40<!--> <!-->±<!--> <!-->1.41 years. Men with diabetes had a higher incidence of MACE than men without diabetes (<em>P</em> <!-->=<!--> <!-->0.037) (<span><span>Fig. 1</span></span>), mainly due to more MI (<em>P</em> <!-->&lt;<!--> <!-->0.01). No significant difference was found in CV death (<em>P</em> <!-->=<!--> <!-->0.995) or TVF (<em>P</em> <!-->=<!--> <!-->0.285). After adjustment, diabetes was an independent predictor of MACE in men [hazard ratio (HR)<!--> <!-->=<!--> <!-->1.97; 95% CI: 1.04–3.71; <em>P</em> <!-->=<!--> <!-->0.037], but not in women.</div></div><div><h3>Conclusion</h3><div>In patients who underwent PCI with RA, women were more prone to have in-hospital complications, while long-term outcomes were worse in men, especially those with diabetes.</div></div>","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":"119 1","pages":"Page S24"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145904257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular health: Prevent, innovate, share","authors":"Pr Victor Aboyans (Scientific Secretary of JESFC),&nbsp;Pr Anne Bernard (Deputy Scientific Secretary, in charge of the Simulation Village),&nbsp;Pr Stéphane Lafitte (in charge of CME and the Digital Village),&nbsp;Pr Hélène Eltchaninoff (President-Elect of the SFC),&nbsp;Pr Christophe Leclercq (Past President of the SFC),&nbsp;Pr Bernard Iung (President of the SFC)","doi":"10.1016/j.acvd.2025.12.004","DOIUrl":"10.1016/j.acvd.2025.12.004","url":null,"abstract":"","PeriodicalId":55472,"journal":{"name":"Archives of Cardiovascular Diseases","volume":"119 1","pages":"Pages S1-S2"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145904075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}