Archives De Pediatrie最新文献

{"title":"Tacrolimus in pediatric patients with Henoch-Schönlein purpura nephritis: Target concentration range.","authors":"Fashuang Li, Huiying Li, Linbo Li, Lilin Zhang","doi":"10.1016/j.arcped.2025.09.002","DOIUrl":"https://doi.org/10.1016/j.arcped.2025.09.002","url":null,"abstract":"<p><strong>Objective: </strong>This study seeks to establish the therapeutic reference range for tacrolimus blood concentrations in pediatric patients diagnosed with Henoch-Schönlein purpura nephritis (HSPN) and to evaluate the factors influencing tacrolimus pharmacokinetics in this population.</p><p><strong>Methods: </strong>Receiver operating characteristic (ROC) curve analysis was utilized to determine the optimal therapeutic threshold for tacrolimus concentration. Comparative analyses were conducted to assess clinical efficacy and adverse event profiles across four groups of tacrolimus concentrations [Group A(<3 ng·mL^-1), Group B (3-<5 ng·mL^-1), Group C (5-<10 ng·mL^-1), and Group D (≥10 ng·mL^-1)], thereby establishing a reference therapeutic range. Kaplan-Meier survival analysis was employed to evaluate differences in continuous remission survival rate and remission duration among four distinct concentration groups, validating the precision of the target trough concentration range. Additionally, multivariate linear regression analysis was performed to identify significant factors influencing tacrolimus concentrations.</p><p><strong>Results: </strong>A cohort of 105 pediatric patients diagnosed with HSPN were enrolled in this study. After six months of tacrolimus therapy, the ROC curve analysis revealed that the tacrolimus trough concentration had significant diagnostic value for clinical efficacy, with an area under the curve (AUC) of 0.816 (P < 0.01), and an optimal cutoff value of 3.02 ng·mL^-1. Comparative analysis of clinical efficacy across four groups demonstrated that Group A exhibited significantly lower efficacy compared to the other groups. After 12 months of tacrolimus treatment, the diagnostic utility of the ROC curve was further confirmed, with an AUC of 0.798 (P > 0.05), indicating limited predictive performance. Although no significant differences in adverse event rates were observed among the four groups, Group D displayed a notably higher incidence of nephrotoxicity relative to the other groups. Multivariate linear regression analysis identified serum creatinine level as a significant determinant of tacrolimus concentration (P < 0.05).</p><p><strong>Conclusion: </strong>In pediatric patients with HSPN in China, maintaining tacrolimus trough concentrations within the therapeutic range of 3-5 ng·mL^-1 has been demonstrated to achieve optimal therapeutic efficacy.</p>","PeriodicalId":55477,"journal":{"name":"Archives De Pediatrie","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145514800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The potential hidden dangers in household products for infant's immune system: Consequences for childcare.","authors":"Christophe Dupont, Sandra Brancato, Rosan Meyer, Martin Chalumeau, Dominique Darmaun, Marie Laure Frelut, Dominique Guimbert, Alexandre Lapillonne, Arnaud de Luca, Sophie Nicklaus, Noel Peretti, Jean-Pierre Chouraqui","doi":"10.1016/j.arcped.2025.09.006","DOIUrl":"https://doi.org/10.1016/j.arcped.2025.09.006","url":null,"abstract":"<p><strong>Background: </strong>The increase in allergic, autoimmune, and metabolic diseases observed in recent decades correlates with increased exposure to new chemicals that can damage the epithelial barrier, regardless of its location, the skin, respiratory, and digestive tract. Infants are often exposed to detergents and disinfectants from birth.</p><p><strong>Objectives, methods, and setting: </strong>Published data indicate a potentially harmful impact of these chemicals on the epithelial barrier, which could promote allergies. The aim of this article is to review the available data on how these chemicals affect the epithelial barrier.</p><p><strong>Results: </strong>We depict the likely harmful role of common household products in the development of allergies in children.</p><p><strong>Conclusion: </strong>We suggest simple changes in everyday life aimed at reducing contact with these products in infants and young children.</p>","PeriodicalId":55477,"journal":{"name":"Archives De Pediatrie","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145460659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical management of 117 patients with halo-gravity traction: corrections, complications, and neurological risks","authors":"Lou Richard,&nbsp;Elie Saghbini,&nbsp;Gauthier Eloy,&nbsp;Reda Kabbaj,&nbsp;Clélia Thouement,&nbsp;Raphael Vialle,&nbsp;Mathilde Gaume","doi":"10.1016/j.arcped.2025.07.006","DOIUrl":"10.1016/j.arcped.2025.07.006","url":null,"abstract":"<div><h3>Background</h3><div>Severe scoliosis, defined by a major curve exceeding 80°, requires surgical correction and is particularly prone to post-operative mechanical and neurological complications.</div></div><div><h3>Objective</h3><div>This study aimed to evaluate the corrections and complications obtained by halo-gravity traction (HGT) followed by single posterior approach surgery for severe scoliosis. The secondary objective was to identify any risk factors associated with neurological complications.</div></div><div><h3>Methods</h3><div>A single-center retrospective review of all patients operated on with severe scoliosis or kyphosis of any cause, by a single posterior approach after a period of HGT. Demographic data including age at surgery, sex, and body mass index were collected. Pre-traction, post-traction, postoperative major curve, and kyphosis angles were reported. Perioperative complications both during the traction period and postoperatively were recorded.</div></div><div><h3>Results</h3><div>117 patients with a mean age at surgery of 14.0 ± 2.0 years were included. The mean preoperative major curve was 90.7°±22.1° (from 80.1 to 147.2°) and the mean kyphosis was 60.8°± 31.70 (from 3.3 to 150.2°). The mean major curve after traction was 66.1°±15.2° (from 30.2 to 101.5°) and 33.7°±17.0° (from 0.2° to 104.4°) postoperatively, with a total correction of 69 %. During the HGT period, 8 (6.8 %) complications occurred: 3 superficial infections, 4 pin displacement, and 1 case of encopresis. Postoperatively, eight deficits were observed, with two being permanent. No risk factors for postoperative neurological complications were identified.</div></div><div><h3>Conclusions</h3><div>A 6-week period of HGT is associated with a low complication rate, and is effective to prepare severe scoliosis surgery, even for curvatures exceeding 120°</div></div>","PeriodicalId":55477,"journal":{"name":"Archives De Pediatrie","volume":"32 8","pages":"Pages 552-557"},"PeriodicalIF":1.3,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145245469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spectrum of DMD gene mutations in 507 patients: a retrospective genotype-phenotype study using next-generation sequencing","authors":"Siyi Gan,&nbsp;Li Xu,&nbsp;Hongmei Liao,&nbsp;Liwen Wu","doi":"10.1016/j.arcped.2025.07.002","DOIUrl":"10.1016/j.arcped.2025.07.002","url":null,"abstract":"<div><h3>Background</h3><div>Duchenne muscular dystrophy (DMD) is caused by mutations in the DMD gene, but comprehensive analyses of mutational patterns and clinical correlations remain limited.</div></div><div><h3>Objective</h3><div>To characterize the DMD mutational spectrum and its clinical implications in a large Asian cohort.</div></div><div><h3>Methods &amp; Settings</h3><div>A retrospective genetic analysis of 507 unrelated male DMD/Becker muscular dystrophy patients was conducted at Hunan Children’s Hospital (2018–2021). Multiplex ligation-dependent probe amplification (MLPA) and next-generation sequencing (NGS) were employed for comprehensive variant detection. Variants were classified per ACMG/AMP guidelines.</div></div><div><h3>Results</h3><div>Exon deletions predominated (64.9%), followed by small mutations (26.0%) and duplications (9.1%). Nonsense mutations were the most frequent small variant (16.0%). Domain analysis revealed mutations clustered in the Central Rod Domain (CRD; exons 45–55). The Carboxy-Terminal Domain (CTD) was associated with the most severe phenotype (earliest loss of ambulation, <em>P</em> &lt; 0.05 vs. Actin-Binding Domain [ABD] or CRD). Exon 53 skipping was applicable in 39.39% of eligible patients. De novo mutations accounted for 7.9% (40/507) of cases. Epilepsy comorbidity occurred in 1.34% (6/448) of DMD patients.</div></div><div><h3>Conclusion</h3><div>This study delineates the DMD mutational landscape in a Chinese cohort, highlighting domain-specific phenotypic severity (CTD &gt; ABD &gt; CRD) and identifying exon 53 as the primary therapeutic target for exon skipping. These findings enhance prognostic precision and guide targeted therapeutic strategies.</div></div>","PeriodicalId":55477,"journal":{"name":"Archives De Pediatrie","volume":"32 8","pages":"Pages 547-551"},"PeriodicalIF":1.3,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145245283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatitis in the time of pandemics: A comparative bibliometric analysis of early publications on MIS-C, acute hepatitis of unknown aetiology and Mpox","authors":"Alexandre Fabre MD, PhD ,&nbsp;Paul Guerry PhD ,&nbsp;Aurélie Morand MD, PhD","doi":"10.1016/j.arcped.2025.09.003","DOIUrl":"10.1016/j.arcped.2025.09.003","url":null,"abstract":"<div><h3>Background</h3><div>The emergence of acute hepatitis of unknown etiology in the spring of 2022 was strikingly reminiscent of how multisystem inflammatory syndrome in children (MIS-C) had appeared two years earlier.</div></div><div><h3>Objective</h3><div>To carry out a bibliometric analysis of the early literature on acute hepatitis of unknown aetiology, and another coincident but non-pediatric disease, Mpox, in comparison with our previous findings on the early coverage of MIS-C.</div></div><div><h3>Methods and Settings</h3><div>A review of the literature was conducted in the MEDLINE database, on preprint servers, and among Reuters news articles. Articles were included if they had been published in 2022 and were specifically about acute hepatitis of unknown aetiology or Mpox.</div></div><div><h3>Results</h3><div>The first newspaper/non-academic journal article on acute hepatitis of unknown aetiology was published in week 14 and the weekly number rapidly peaked in week 16 before decreasing gradually down to zero in week 22. The first peer-reviewed article was published in week 15 and remained between 3 and 7 from weeks 17 to 23. Just under a quarter (23.5 %) of references in these articles were to health agency publications on acute hepatitis of unknown aetiology. Over 7-week periods beginning just before the corresponding health agency alerts, 25 articles were published on MIS-C (21 peer-reviewed and 4 preprints), 20 articles were published on acute hepatitis of unknown aetiology (18 peer-reviewed and 4 preprints), and 74 on Mpox (48 peer-reviewed and 26 preprints). The proportion of preprints was significantly associated with disease type (<em>p</em> = 0.03), as was the proportion of clinical studies, with values of 52 %, 10 %, and 18 %, respectively (<em>p</em> = 0.002). Many more non-academic articles were published on Mpox (<em>N</em> = 180) than on acute hepatitis of unknown aetiology (17) or MIS-C (24).</div></div><div><h3>Conclusion</h3><div>Although Mpox attracted more overall attention, the medical community responded similarly rapidly to acute hepatitis of unknown aetiology and to MIS-C. The fact that a major source of early information on these diseases was health agency reports suggests that these should be included in bibliographic databases for ease of access.</div></div>","PeriodicalId":55477,"journal":{"name":"Archives De Pediatrie","volume":"32 8","pages":"Pages 527-531"},"PeriodicalIF":1.3,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145454221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing maternal and infant health: A systematic review of breastfeeding interventions among refugee, migrant, and asylum seeker populations","authors":"Ana Claudia Lopes ,&nbsp;Tatiana Pereira ,&nbsp;Marisa Lousada","doi":"10.1016/j.arcped.2025.09.001","DOIUrl":"10.1016/j.arcped.2025.09.001","url":null,"abstract":"<div><h3>Background</h3><div>Breastfeeding interventions among refugee, migrant, and asylum seeker populations hold significant promise for improving maternal, infant, and community health.</div></div><div><h3>Objectives</h3><div>This systematic review aims to comprehensively synthesize existing interventions and assess their effectiveness within these vulnerable demographics.</div></div><div><h3>Methods and Setting</h3><div>Following the PRISMA framework, a thorough literature search was conducted across four electronic databases—PubMed, Cochrane Library, Web of Science, and Scopus—from February 2014 to February 2024, focusing on studies involving refugees, migrants, and asylum seekers who received breastfeeding interventions. Methodological quality appraisal was executed utilizing the Effective Public Health Practice Project Quality Assessment Tool for Quantitative Studies.</div></div><div><h3>Results</h3><div>Of the scrutinized studies, nine met the stringent eligibility criteria and were subsequently included in this review. Two independent researchers meticulously performed data extraction and analysis. The synthesized findings revealed a spectrum of breastfeeding interventions tailored to migrant populations, comprising both individualized and group-based approaches. Significant outcomes included elevated breastfeeding initiation rates and positive indicators, such as sustained exclusive breastfeeding for up to six months, increased maternal self-efficacy, enhanced dietary diversity, and the adoption of healthier dietary practices.</div></div><div><h3>Conclusion</h3><div>The collated evidence underscores the potential of breastfeeding interventions to profoundly influence maternal and child health outcomes within migrant communities. Nonetheless, the interpretation of results warrants caution due to the scarcity of high-quality studies and inherent methodological limitations. This review underscores the imperative for further rigorous research to elucidate the nuanced impacts of breastfeeding interventions in migrant populations and to inform evidence-based practices for optimizing maternal and infant health outcomes globally.</div></div>","PeriodicalId":55477,"journal":{"name":"Archives De Pediatrie","volume":"32 8","pages":"Pages 517-526"},"PeriodicalIF":1.3,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145454140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"French-Belgian consensus statement to managing spinal deformities in children with spinal muscular atrophy treated with SMN restoring therapies","authors":"Mathilde Gaume ,&nbsp;Lisa Viallard ,&nbsp;Pascal Rippert ,&nbsp;Martin Bail ,&nbsp;Raphael Vialle ,&nbsp;Isabelle Desguerres ,&nbsp;Capucine de Lattre ,&nbsp;Vincent Cunin ,&nbsp;Carole Vuillerot","doi":"10.1016/j.arcped.2025.09.004","DOIUrl":"10.1016/j.arcped.2025.09.004","url":null,"abstract":"<div><h3>Background</h3><div>Spinal muscular atrophy (SMA) affects the motor neurons of the anterior spinal cord, causing progressive muscle weakness and atrophy. SMN restoring therapies have led to the emergence of new phenotypes in spinal muscular atrophy (SMA), including early-onset scoliosis. Guidelines regarding the optimal treatment for scoliosis and its consequences are lacking.</div></div><div><h3>Objective</h3><div>To provide guidelines to help clinical decision-making and to standardise the management of neuromuscular scoliosis (NMS) in children with SMA.</div></div><div><h3>Methods</h3><div>We conducted a Delphi study with 31 experts between July 2023 and February 2024. Three rounds were conducted using anonymous electronic questionnaires to determine consensus on items grouped into 5 main domains: Respiratory monitoring (7 items), Trunk orthoses (4 items), Surgical approaches (13 items), Preoperative care (17), post-operative care (10 items). Experts were asked to rate their agreement with each item on a scale from 1 (strongly disagree) to 9 (strongly agree). Consensus was considered to have been achieved if the median value of the responses was ≥ 7. Items that did not reach consensus in one round were reformulated in the following round using comments provided by the experts.</div></div><div><h3>Results</h3><div>The experts included 12 orthopaedic surgeons, 9 physical medicine and rehabilitation physicians and 10 paediatricians/child neurologists. Fourty-seven items achieved consensus. In the first round, consensus was achieved for 33 of the 51 items. The second round included 15 items, and a consensus was achieved for 11 items. In the third round, 3 of the 4 items included achieved consensus and the fourth item was dropped due to a lack of agreement.</div></div><div><h3>Conclusions</h3><div>The recommendations generated from the questionnaire provide a relevant consensus-based guidance for the multidisciplinary management of spinal deformities in children with SMA.</div></div>","PeriodicalId":55477,"journal":{"name":"Archives De Pediatrie","volume":"32 8","pages":"Pages 538-546"},"PeriodicalIF":1.3,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145460661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occurrence and prediction of clinical interventions during transfer of near-term and term infants with respiratory distress on CPAP. An observational study","authors":"Alexia Morel ,&nbsp;Julien Baleine ,&nbsp;Christophe Milesi ,&nbsp;Maliha Badr ,&nbsp;Arthur Gaudaire ,&nbsp;Alexandra Deveze ,&nbsp;Sylvain Paulhac ,&nbsp;Charline Andrieu ,&nbsp;Marion Palpacuer ,&nbsp;Gilles Cambonie ,&nbsp;Arthur Gavotto","doi":"10.1016/j.arcped.2025.07.001","DOIUrl":"10.1016/j.arcped.2025.07.001","url":null,"abstract":"<div><h3>Background</h3><div>Neonatal respiratory distress (NRD) requiring continuous positive airway pressure (CPAP) is a common indication for inter-hospital transfer of late preterm and term neonates. The optimal composition of the inter-hospital team transfer - involving an advanced neonatal nurse and an ambulance driver or a complete team, which also includes a paediatrician - remains uncertain. Particularly when clinical interventions are required.</div></div><div><h3>Objectives</h3><div>To assess the occurrence of clinical interventions necessitating a complete transport team during the inter-hospital transfer of neonates with NRD on CPAP. A secondary objective was to evaluate whether data provided to the transfer regulation centre predicted such interventions.</div></div><div><h3>Methods and Setting</h3><div>This retrospective observational study was conducted at the Paediatric Emergency Transport Service (PETS) of a level 3 maternity hospital between 2021 and 2023. A total of 110 infants ≥34 weeks’ gestational age were included, all transported for NRD with CPAP (mean gestational age 37.6 ± 2.2 weeks, mean birth weight 3042±615 g). Clinical interventions recorded included intubation, surfactant administration, inhaled nitric oxide (iNO) administration, needle aspiration for pneumothorax, and prostaglandin E1 infusion. Complete team transport involved a paediatrician, an advanced neonatal nurse, and an ambulance driver.</div></div><div><h3>Results</h3><div>Clinical interventions occurred in 11 cases (10%). Factors associated with the need for intervention included higher FiO₂ (71.4 ± 18.5% vs 28.3 ± 8.0%, <em>p</em> &lt; 0.01), presence of pneumothorax (<em>p</em> &lt; 0.01), and transfer from higher-level maternity hospitals (<em>p</em> &lt; 0.01). The ROC curve for FiO₂ predicting intervention had an area of 0.99 (95% CI 0.97–1.01, <em>p</em> = 0.001), with a cut-off of &gt;40% yielding 91% sensitivity, 98% specificity, 83% positive predictive value, and 99% negative predictive value.</div></div><div><h3>Conclusions</h3><div>High oxygen dependency and the presence of pneumothorax are key indicators for mobilizing a complete transport team during the transfer of late preterm and term neonates with NRD on CPAP. Early identification of these factors could enhance team allocation and resource utilization.</div></div>","PeriodicalId":55477,"journal":{"name":"Archives De Pediatrie","volume":"32 8","pages":"Pages 575-579"},"PeriodicalIF":1.3,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145245882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing vitamin D supplementation: the role of physician awareness and patient adherence","authors":"Berkay Yalçınkaya,&nbsp;Ahmet Furkan Çolak,&nbsp;Murat Kara","doi":"10.1016/j.arcped.2025.08.003","DOIUrl":"10.1016/j.arcped.2025.08.003","url":null,"abstract":"","PeriodicalId":55477,"journal":{"name":"Archives De Pediatrie","volume":"32 8","pages":"Pages 599-600"},"PeriodicalIF":1.3,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145260032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Franco-African paediatric teledermatology: a store-and-forward network","authors":"Asmaa Lahrougui ,&nbsp;Dalila Benlahcene ,&nbsp;Saïd Afif ,&nbsp;Emmanuel Mahé","doi":"10.1016/j.arcped.2025.09.007","DOIUrl":"10.1016/j.arcped.2025.09.007","url":null,"abstract":"<div><h3>Background</h3><div>Given the frequency of dermatological diseases in children and the difficulties in accessing specialist care in Africa, teledermatology services, such as store-and-forward (SAF), could be used an alternative approach for improving patient care. The dermatology department of the Argenteuil hospital in France developed a SAF network with paediatricians from seven French-speaking African countries. This study assessed the value of this Franco-African SAF collaboration by identifying the advantages and challenges associated with the first 100 uses of the SAF system.</div></div><div><h3>Methods</h3><div>Paediatricians belonging to medical societies in French-speaking African countries were provided with information on how to register for the SAF service. The first 100 SAF requests were evaluated. Information about the paediatricians who used the service, and patient demographic, clinical and management data were systematically collected.</div></div><div><h3>Results</h3><div>Twenty-five (10.2%) paediatricians, out of 244 who registered, submitted cases to the SAF network. In 95 cases, a response was sent within 24 h of submission. In 24 cases, additional information was needed (clinical data, <em>n</em> = 17; photos, <em>n</em> = 6; a histological report, <em>n</em> = 1; identity details, <em>n</em> = 1). The mean age of the children was 5.8 ± 5.0 years, with a predominance of girls (<em>n</em> = 61). Most patients had chronic pathologies (≥ 1 month) (<em>n</em> = 56) belonging to three main groups: chronic inflammatory diseases (<em>n</em> = 42), infectious diseases (<em>n</em> = 23), and genetic diseases (<em>n</em> = 11). As a result of the SAF requests, further examinations were proposed in 39 cases, treatment in 82 cases, and hospitalisation in 11 cases.</div></div><div><h3>Conclusion</h3><div>The SAF approach is an effective solution for improving access to dermatological care in Africa, providing an alternative method for expert consultation when resources are limited, without diminishing the role of local dermatologists. For dermatologists, this solution provides access to expertise on unusual pathologies and allows solutions to be offered that are tailored to the resources available in the field.</div></div>","PeriodicalId":55477,"journal":{"name":"Archives De Pediatrie","volume":"32 8","pages":"Pages 592-598"},"PeriodicalIF":1.3,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145454299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}