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IF 3.8 2区 医学 Q1 GERIATRICS & GERONTOLOGY
American Journal of Geriatric Psychiatry
Pub Date : 2026-01-01 Epub Date: 2025-11-26 DOI: 10.1016/S1064-7481(25)00514-7
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引用次数: 0
Response to “The Evidence Base for Electroconvulsive Therapy (ECT) in Geriatric Depression” 对“电痉挛疗法（ECT）治疗老年抑郁症的证据基础”的回应。
IF 3.8 2区 医学 Q1 GERIATRICS & GERONTOLOGY
American Journal of Geriatric Psychiatry
Pub Date : 2026-01-01 Epub Date: 2025-08-05 DOI: 10.1016/j.jagp.2025.07.015
Tor Arnison Ph.D. , Axel Nordenskjöld M.D., Ph.D.
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引用次数: 0
Ketamine for Late-Life Depression: Where Do We Stand? 氯胺酮治疗老年抑郁症：我们的研究进展如何？
IF 3.8 2区 医学 Q1 GERIATRICS & GERONTOLOGY
American Journal of Geriatric Psychiatry
Pub Date : 2026-01-01 Epub Date: 2025-09-19 DOI: 10.1016/j.jagp.2025.09.008
Hanadi Ajam Oughli M.D. , Marie Anne Gebara M.D. , Alastair J. Flint M.B.
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引用次数: 0
The Evidence Base for Electroconvulsive Therapy (ECT) in Geriatric Depression 电休克治疗（ECT）治疗老年抑郁症的证据基础。
IF 3.8 2区 医学 Q1 GERIATRICS & GERONTOLOGY
American Journal of Geriatric Psychiatry
Pub Date : 2026-01-01 Epub Date: 2025-07-05 DOI: 10.1016/j.jagp.2025.06.021
Charles H. Kellner M.D. , Alexander Sartorius M.D., Ph.D. , Randall T. Espinoza M.D., M.P.H.
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引用次数: 0
Association Between Ratio of Triglycerides to HDL-C and Cognitive Impairment: A Longitudinal Population-Based Analysis and Mendelian Randomization Study 甘油三酯与HDL-C比值与认知障碍之间的关系：一项纵向人群分析和孟德尔随机化研究。
IF 3.8 2区 医学 Q1 GERIATRICS & GERONTOLOGY
American Journal of Geriatric Psychiatry
Pub Date : 2026-01-01 Epub Date: 2025-09-02 DOI: 10.1016/j.jagp.2025.08.007
Yucheng Huang M.B.B.S. , Lijia Zheng M.P.H. , Meng-Meng Lyu Ph.D.

Objectives

This study aimed to explore the longitudinal association between the triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio and cognitive impairment in older adults and further assess potential causality using Mendelian randomization (MR).

Design

Longitudinal population-based analysis combined with two-sample MR. Data from Waves 6–8 (2015–2019) of the Survey of Health, Ageing, and Retirement in Europe (SHARE) were analyzed using hierarchical regression models and mixed linear effects models. MR utilized genome-wide association studies (GWAS) summary data.

Participants

11,444 adults aged ≥60 years from SHARE Wave 6, with longitudinal follow-up in Waves 7 (N = 2,775) and 8 (N = 5,469).

Measurements

TG/HDL-C ratio, cognitive function (orientation, immediate/delayed recall, verbal fluency, numeracy), and cognitive impairment (defined as scores >1.5 SD below age-group mean). Covariates included socio-demographics, health behaviors, comorbidities, and national-level factors. MR employed genetic variants associated with TG/HDL-C as instrumental variables.

Results

Higher TG/HDL-C ratios were negatively associated with total cognitive scores (β = −0.115, χ² = 15.44, df = 1, p < 0.001), immediate recall (β = −0.029, χ² = 12.34, df = 1, p < 0.001), delayed recall (β = −0.028, χ² = 7.33, df = 1, p < 0.001), verbal fluency (β = −0.038, χ² = 11.53, df = 1, p < 0.001), and numeracy (β = −0.019, χ² = 4.55, df = 1, p < 0.05) in fully adjusted models. Longitudinal analysis revealed increased cognitive impairment risk in the highest TG/HDL-C quartile (OR=1.43, 95% CI:1.01–2.03, χ² = 9.24, df = 1) over 4 years. MR supported a causal link between elevated TG/HDL-C and cognitive decline.

Conclusions

Elevated TG/HDL-C ratios are longitudinally associated with cognitive decline in older adults. Managing lipid metabolism may mitigate cognitive impairment, highlighting the importance of TG/HDL-C as a modifiable risk factor in aging populations.
目的：本研究旨在探讨甘油三酯与高密度脂蛋白胆固醇（TG/HDL-C）比值与老年人认知功能障碍之间的纵向关联，并利用孟德尔随机化（MR）进一步评估潜在的因果关系。设计：采用分层回归模型和混合线性效应模型，结合欧洲健康、老龄化和退休调查（SHARE）第6-8期（2015-2019）的双样本mr数据，进行纵向人群分析。MR利用全基因组关联研究（GWAS）汇总数据。参与者：来自SHARE第6波的11444名年龄≥60岁的成年人，在第7波（N = 2775）和第8波（N = 5469）进行纵向随访。测量：TG/HDL-C比值、认知功能（定向、即时/延迟回忆、语言流畅性、计算能力）和认知障碍（定义为得分>低于年龄组平均1.5 SD）。协变量包括社会人口统计学、健康行为、合并症和国家层面的因素。MR采用与TG/HDL-C相关的遗传变异作为工具变量。结果:高TG / hdl - c比值与总认知得分负相关(β= -0.115,χ²= 15.44,df = 1, p < 0.001),立即召回(β= -0.029,χ²= 12.34,df = 1, p < 0.001),延迟回忆(β= -0.028,χ²= 7.33,df = 1, p < 0.001),语言流利(β= -0.038,χ²= 11.53,df = 1, p < 0.001),计算能力(β= -0.019,χ²= 4.55,df = 1, p < 0.05)在充分调整模型。纵向分析显示，4年内TG/HDL-C最高四分位数的认知障碍风险增加（OR=1.43, 95% CI:1.01-2.03, χ²= 9.24,df =1）。MR支持TG/HDL-C升高与认知能力下降之间的因果关系。结论：TG/HDL-C比值升高与老年人认知能力下降具有纵向相关性。管理脂质代谢可能减轻认知障碍，强调TG/HDL-C作为老龄化人群可改变的危险因素的重要性。
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引用次数: 0
Invited Perspective on “Daily Associations Between Caregiving Time and Spousal Caregivers' Well-Being: The Moderating Roles of Daily Marital Interactions.” (Yang et al. 2025) “照顾时间与配偶照顾者幸福感之间的日常关联：日常婚姻互动的调节作用”之邀请观点。（Yang et al. 2025）。
IF 3.8 2区 医学 Q1 GERIATRICS & GERONTOLOGY
American Journal of Geriatric Psychiatry
Pub Date : 2026-01-01 Epub Date: 2025-09-23 DOI: 10.1016/j.jagp.2025.09.009
Rose Lin Ph.D., Maria M. Quiñones-Cordero Ph.D.
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引用次数: 0
The Silencing of Science is a Call for Communications 科学的沉默是对交流的呼唤。
IF 3.8 2区 医学 Q1 GERIATRICS & GERONTOLOGY
American Journal of Geriatric Psychiatry
Pub Date : 2026-01-01 Epub Date: 2025-10-25 DOI: 10.1016/j.jagp.2025.10.007
Joseph K. Balintfy BA
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引用次数: 0
Acknowledgment of Triage Editors and Reviewers 2025 分类编辑和审稿人致谢2025。
IF 3.8 2区 医学 Q1 GERIATRICS & GERONTOLOGY
American Journal of Geriatric Psychiatry
Pub Date : 2026-01-01 Epub Date: 2025-10-06 DOI: 10.1016/j.jagp.2025.09.022
Charles F. Reynolds III M.D.
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引用次数: 0
Avoiding Stigma and Sensationalism in Therapeutic Psilocybin Communications: Considerations for Reaching Older Patients 在治疗性裸盖菇素交流中避免污名化和耸人听闻：涉及老年患者的考虑。
IF 3.8 2区 医学 Q1 GERIATRICS & GERONTOLOGY
American Journal of Geriatric Psychiatry
Pub Date : 2025-12-01 Epub Date: 2025-07-23 DOI: 10.1016/j.jagp.2025.07.003
Charlotte M. Gillespie MSc, Jesse M. Bering PhD
Psilocybin’s efficacy as a treatment for treatment-resistant depression (TRD) has led to a wave of new legislation permitting its usage in medical settings. Older adults are affected disproportionately by TRD and may be especially good candidates for this promising treatment. However, due to the drug’s past (and present) illicit status and exposure to historic antidrug messaging, older prospective patients may hold more stigmatized attitudes towards this treatment than those who are younger. Stigma and sensationalism pose special challenges for the dissemination of effective, accurate information about therapeutic psilocybin, with recent “hype” around the drug treatment possibly further alienating these individuals. Because current clinical communication strategies may be inadvertently reinforcing negative attitudes about psychedelics rather than reducing them, we offer some general communication guidelines for therapeutic psilocybin geared towards the older patient profile.
裸盖菇素作为治疗难治性抑郁症（TRD）的功效已经引发了一波允许在医疗环境中使用裸盖菇素的新立法。老年人受TRD的影响尤为严重，可能特别适合这种有希望的治疗方法。然而，由于该药过去（和现在）的非法地位，以及暴露于历史上的反药物信息，年龄较大的潜在患者可能比年轻人对这种治疗持更污名化的态度。污名化和耸人听闻主义给传播有效、准确的治疗性裸盖菇素信息带来了特殊的挑战，最近围绕这种药物治疗的“炒作”可能进一步疏远了这些人。由于目前的临床沟通策略可能无意中加强了对迷幻药的负面态度，而不是减少它们，我们提供了一些针对老年患者的治疗性裸盖菇素的一般沟通指南。
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引用次数: 0
The Current State of International Human Rights of Older Persons 《国际老年人人权现状》。
IF 3.8 2区 医学 Q1 GERIATRICS & GERONTOLOGY
American Journal of Geriatric Psychiatry
Pub Date : 2025-12-01 Epub Date: 2025-08-20 DOI: 10.1016/j.jagp.2025.08.004
Robert Kohn M.D.
The UN has produced various declarations addressing the human rights of older persons. The UN does not have a specific treaty or convention regarding human rights of older persons as part of its human rights system. Recently the Open-ended Working Group on Ageing has recommended to the General Assembly to adopt a binding convention on human rights for older persons. There has been progress already at the regional level. The European Convention of Human Rights Article 23 has been ratified by less than half the countries. The African Charter on Human and Peoples’ Rights is the first human rights instrument to include older persons as a distinct group. In November 2024 a protocol on older persons human rights was adopted. The Organization of American States adopted the Inter-American Convention on Protecting the Human Rights of Older Persons, the first human rights document specific to older persons and the only legally binding instrument. Although progress has been made on focusing on human rights on older persons, a binding UN international convention on human rights of older persons would be a tool to improve dignified mental healthcare.
联合国就老年人的人权问题发表了各种宣言。联合国没有将老年人人权作为其人权体系一部分的具体条约或公约。最近，老龄问题不限成员名额工作组建议大会通过一项关于老年人人权的具有约束力的公约。在区域一级已经取得了进展。《欧洲人权公约》第23条只有不到一半的国家批准。《非洲人权和人民权利宪章》是第一个将老年人作为一个独特群体纳入的人权文书。2024年11月，通过了一项关于老年人人权的议定书。美洲国家组织通过了《美洲保护老年人人权公约》，这是第一份专门针对老年人的人权文件，也是唯一具有法律约束力的文书。虽然在注重老年人的人权方面取得了进展，但一项具有约束力的联合国老年人人权国际公约将是改善有尊严的精神保健的工具。
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引用次数: 0
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