American Journal of Geriatric Psychiatry最新文献

{"title":"Response to Letter to the Editor","authors":"Yue Li M.M., Yue Zhang M.M., Yuqi Ren M.M., Huanqiu Liu M.D.","doi":"10.1016/j.jagp.2025.09.027","DOIUrl":"10.1016/j.jagp.2025.09.027","url":null,"abstract":"","PeriodicalId":55534,"journal":{"name":"American Journal of Geriatric Psychiatry","volume":"34 2","pages":"Page 264"},"PeriodicalIF":3.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145433467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Randomized Controlled Trial of the Safety and Efficacy of Dronabinol for Agitation in Alzheimer’s Disease","authors":"Paul B. Rosenberg M.D. ,&nbsp;Halima Amjad M.D., M.P.H., Ph.D. ,&nbsp;Haroon Burhanullah M.D. ,&nbsp;Milap Nowrangi M.D. ,&nbsp;Ryan Vandrey Ph.D. ,&nbsp;Mersania Jn Pierre B.A. ,&nbsp;John D. Outen M.S. ,&nbsp;Meghan Schultz R.N., M.S.N ,&nbsp;Christopher Marano M.D. ,&nbsp;Marc Agronin M.D. ,&nbsp;James M. Wilkins M.D., D.Phil. ,&nbsp;David Harper Ph.D. ,&nbsp;Todd Laffaye B.A. ,&nbsp;Eilis Reardon B.A. ,&nbsp;Kathryn Turner B.A. ,&nbsp;Rosain Ozonsi B.S. ,&nbsp;Mia Drury B.A. ,&nbsp;Andre Nguyen B.S. ,&nbsp;Tuna Hasoğlu M.D. ,&nbsp;Julia Cromwell M.D. ,&nbsp;Brent P. Forester M.D., M.Sc.","doi":"10.1016/j.jagp.2025.10.011","DOIUrl":"10.1016/j.jagp.2025.10.011","url":null,"abstract":"<div><h3>Importance</h3><div>Agitation in Alzheimer’s disease (AD) is a great source of distress for patients and caregivers and a major public health burden. Current treatments are only modestly effective and many have safety issues including mortality risk. Novel therapeutic options are needed. There is preliminary evidence for the safety and efficacy of dronabinol (tetrahydrocannabinol, THC) for agitation in AD.</div></div><div><h3>Objective</h3><div>Assess the safety and efficacy of dronabinol (THC) to decrease agitation in AD.</div></div><div><h3>Design</h3><div>THC-AD was a 3-week randomized parallel double-blind placebo-controlled clinical trial, conducted between 2017 and 2024.</div></div><div><h3>Setting</h3><div>5 inpatient and outpatient academic clinical research centers in the Eastern U.S.</div></div><div><h3>Participants</h3><div>Volunteer sample of 75 participants meeting inclusion criteria for agitation of AD (International Psychogeriatric Association Provision Criteria) with Neuropsychiatric Inventory Clinician Version Agitation or Aggression (NPI-C A/A) domains total score of 4 or greater. Major exclusion criteria included seizure disorder, delirium, and non-AD dementia.</div></div><div><h3>Interventions</h3><div>3 weeks dronabinol vs. placebo titrated up to target dose of 10 mg daily in divided twice-daily.</div></div><div><h3>Main Outcomes and Measures</h3><div>Prespecified co-primary agitation outcomes were the Pittsburgh Agitation Scale (PAS) and NPI-C A/A total score.</div></div><div><h3>Results</h3><div>The majority of participants were female and were taking concomitant psychotropic medications (antidepressants and antipsychotics) at baseline. Study participants were moderately agitated at baseline, were diverse in ethnic background (9% Black, 11% Hispanic/Latina/Latino), and had severe cognitive impairment evidenced by MMSE or SIB-8. 84% completed the 3-week trial. Dronabinol decreased agitation on both primary outcomes greater than placebo to a clinically relevant extent. The fitted between-arm difference in PAS decline/week was −0.74 (SE 0.3, p = 0.015, effect size = 0.53) and for NPI-C A/A the decline was not significant at −1.26 (SE 0.67, p = 0.094, effect size = 0.36). No secondary outcomes differed between treatment arms including sleep, activities of daily living, Cohen-Mansfield Agitation Inventory (CMAI), cognition, intoxication, or use of ‘as-needed’ lorazepam or trazodone. Dronabinol treatment was not associated with greater intoxication nor with other adverse events (AEs) except for somnolence.</div></div><div><h3>Conclusions and Relevance</h3><div>Adjunctive dronabinol treatment was safe and effective for treating agitation in AD.</div></div><div><h3>Clinical Trials Registration</h3><div>NCT02792257</div></div>","PeriodicalId":55534,"journal":{"name":"American Journal of Geriatric Psychiatry","volume":"34 2","pages":"Pages 167-179"},"PeriodicalIF":3.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145688911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measuring Apathy Through Computational Lenses: Behavioral and Physiological Signatures of Engagement in Virtual Reality","authors":"Daniel Harlev M.D. ,&nbsp;Ramit Ravona Springer M.D. ,&nbsp;Meir Plotnik Ph.D.,&nbsp;Noham Wolpe M.D., Ph.D.","doi":"10.1016/j.jagp.2025.10.012","DOIUrl":"10.1016/j.jagp.2025.10.012","url":null,"abstract":"","PeriodicalId":55534,"journal":{"name":"American Journal of Geriatric Psychiatry","volume":"34 2","pages":"Pages 256-257"},"PeriodicalIF":3.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145598324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Information for Subscribers","authors":"","doi":"10.1016/S1064-7481(25)00547-0","DOIUrl":"10.1016/S1064-7481(25)00547-0","url":null,"abstract":"","PeriodicalId":55534,"journal":{"name":"American Journal of Geriatric Psychiatry","volume":"34 2","pages":"Page A1"},"PeriodicalIF":3.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145799836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Substance use disorders in later life: a review and synthesis of the literature of an emerging public health concern” Am J Geriatr Psychiatry, 2020, 28(2): 226–236","authors":"Stephanie Yarnell M.D., Ph.D ,&nbsp;Luming Li M.D., M.H.S. ,&nbsp;Brian MacGrory MB BCh BAO, M.H.S., MRCP ,&nbsp;Louis Trevisan M.D. ,&nbsp;Paul Kirwin M.D.","doi":"10.1016/j.jagp.2025.11.012","DOIUrl":"10.1016/j.jagp.2025.11.012","url":null,"abstract":"","PeriodicalId":55534,"journal":{"name":"American Journal of Geriatric Psychiatry","volume":"34 2","pages":"Page 267"},"PeriodicalIF":3.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145752457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Comorbid Anxiety on Treatment Outcomes After Accelerated Theta Burst Stimulation for Late-Life Depression","authors":"Jeanette Hui M.Sc., M.D. ,&nbsp;Alisson P. Trevizol M.D., Ph.D. ,&nbsp;Hyewon H. Lee M.D. ,&nbsp;Reza Zomorrodi Ph.D. ,&nbsp;Christoph Zrenner M.D. ,&nbsp;Benoit H. Mulsant M.D., M.S. ,&nbsp;Daniel M. Blumberger M.D., M.Sc.","doi":"10.1016/j.jagp.2025.09.017","DOIUrl":"10.1016/j.jagp.2025.09.017","url":null,"abstract":"<div><h3>Objectives</h3><div>Accelerated theta burst stimulation (TBS) offers a time-efficient alternative to conventional repetitive transcranial magnetic stimulation and has recently been explored in late-life depression (LLD). Anxiety symptoms frequently occur in depressed older adults and are known to reduce the effectiveness of first-line therapeutic options. The impact of anxiety symptoms on treatment outcomes from accelerated TBS is unknown.</div></div><div><h3>Methods</h3><div>Secondary analyses were performed on data from an open-label pilot trial where 78 outpatients with LLD received a 5-day course of accelerated sequential bilateral TBS (NCT05119699).</div></div><div><h3>Results</h3><div>Participants with a comorbid anxiety disorder had more severe depressive symptoms before and after treatment and lower remission rates at the 4-week follow-up, but not immediately at treatment end. Baseline anxiety symptoms did not significantly affect rates of remission from suicidal ideation at either follow-up time points.</div></div><div><h3>Conclusions</h3><div>Comorbid anxiety symptoms may reduce the effectiveness of accelerated TBS for treating depressive symptoms in older adults.</div></div>","PeriodicalId":55534,"journal":{"name":"American Journal of Geriatric Psychiatry","volume":"34 2","pages":"Pages 229-234"},"PeriodicalIF":3.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145318982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Walk With Grief: A Personal Narrative of Coping With the Death of a Same Sex Partner in Late Life","authors":"Sarah T. Stahl Ph.D.,&nbsp;Joelle Kincman Ph.D.,&nbsp;Katalin Szanto M.D.","doi":"10.1016/j.jagp.2025.09.012","DOIUrl":"10.1016/j.jagp.2025.09.012","url":null,"abstract":"<div><div>Grief is a complex and multifaceted process. While there is no reason to think that the grieving process would be dissimilar if an LGBTQ+ individual loses a partner than the grief of a heterosexual individual, they often receive and perceive less practical and emotional support, empathy and are treated unequally legally post loss. To date no studies have investigated whether this experience (disenfranchised loss) more likely leads to prolonged grief disorder or other mental health sequelae. This article describes aspects of disenfranchised grief, loneliness, and artificial intelligence for emotional support based on the personal experience of an older gay widower who was moderately depressed and lonely at the time of enrollment in a clinical trial for late-life bereavement and suicide risk.</div></div>","PeriodicalId":55534,"journal":{"name":"American Journal of Geriatric Psychiatry","volume":"34 2","pages":"Pages 245-251"},"PeriodicalIF":3.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145295043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond Alzheimer’s Pathology: Contributions to Cognitive Decline in Late Life Depression","authors":"Lisanne M. Jenkins Ph.D. ,&nbsp;Ashley A. Heywood Ph.D. ,&nbsp;Caroline Gurvich Ph.D.","doi":"10.1016/j.jagp.2025.09.021","DOIUrl":"10.1016/j.jagp.2025.09.021","url":null,"abstract":"","PeriodicalId":55534,"journal":{"name":"American Journal of Geriatric Psychiatry","volume":"34 2","pages":"Pages 195-198"},"PeriodicalIF":3.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145369380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic Alliance is Linked With Suicidality Trajectories in Psychotherapy for Late-Life Depression","authors":"Miriam I. Hehlmann Ph.D. ,&nbsp;Delaney Callaghan B.A. ,&nbsp;Julia Chafkin Ph.D. ,&nbsp;Joohyun Kang B.A. ,&nbsp;Lindsey Sankin Ph.D. ,&nbsp;Oded Bein Ph.D. ,&nbsp;Nili Solomonov Ph.D.","doi":"10.1016/j.jagp.2025.09.024","DOIUrl":"10.1016/j.jagp.2025.09.024","url":null,"abstract":"<div><h3>Objectives</h3><div>Late-life suicidality is rapidly increasing; psychotherapy may reduce suicidality, but trajectories of change in suicidality remain unclear. A strong therapeutic alliance may protect against persistent suicidality. We examined the association of alliance with suicidality trajectories during brief, remote interventions for depression.</div></div><div><h3>Methods</h3><div>Sixty middle-aged and older adults with major depression were randomized to brief remote psychosocial interventions. Suicidality and alliance were assessed during treatment. Patients’ suicidality trajectories were classified as: 1) absent; 2) improved; 3) persistent, based on pre- to post-treatment changes. All three groups were included in mixed-effects models to examine the association between suicidality and alliance.</div></div><div><h3>Results</h3><div>At baseline, 53% of patients endorsed suicidality, with 45% in the absent group, 45% improved, and 10% persistent. Patients in the absent and improved groups showed stable, strong alliance while the persistent group showed worsening alliance.</div></div><div><h3>Conclusion</h3><div>Simple, remote psychosocial interventions are promising first-line treatments for late-life suicidality. A strong alliance may reduce suicidality and enhance outcomes, guiding timely, personalized interventions.</div></div>","PeriodicalId":55534,"journal":{"name":"American Journal of Geriatric Psychiatry","volume":"34 2","pages":"Pages 222-228"},"PeriodicalIF":3.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145799838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain, Body, and Equity: A Pathway to Healthy Aging","authors":"Hanadi Ajam Oughli M.D.,&nbsp;Helen Lavretsky M.D., M.S.","doi":"10.1016/j.jagp.2025.11.008","DOIUrl":"10.1016/j.jagp.2025.11.008","url":null,"abstract":"","PeriodicalId":55534,"journal":{"name":"American Journal of Geriatric Psychiatry","volume":"34 2","pages":"Pages 164-166"},"PeriodicalIF":3.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145717195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}