American Journal of Geriatric Psychiatry最新文献

{"title":"Is Mental Health More Difficult to Improve Than Physical Function?","authors":"Steven M. Albert Ph.D.","doi":"10.1016/j.jagp.2025.11.004","DOIUrl":"10.1016/j.jagp.2025.11.004","url":null,"abstract":"","PeriodicalId":55534,"journal":{"name":"American Journal of Geriatric Psychiatry","volume":"34 2","pages":"Pages 162-163"},"PeriodicalIF":3.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145644834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined Psychoeducational and Exercise Training Intervention to Improve Mental Health and Physical Functioning in Late-Life: A Randomized Controlled Trial","authors":"Margarita Alegria Ph.D. ,&nbsp;Walter Frontera M.D., Ph.D ,&nbsp;Mario Cruz-Gonzalez Ph.D. ,&nbsp;Sheri Markle M.I.A. ,&nbsp;Aida Jimenez Ph.D. ,&nbsp;Zorangeli Ramos Ph.D. ,&nbsp;Taysha Bruno-Ortiz Ph.D. ,&nbsp;Larimar Fuentes Ph.D. ,&nbsp;Megan Cheung M.S.W. ,&nbsp;Yankau Josephine Wong Ph.D. ,&nbsp;Irene Falgas-Bague M.D., Ph.D. ,&nbsp;Patrick E Shrout Ph.D.","doi":"10.1016/j.jagp.2025.10.006","DOIUrl":"10.1016/j.jagp.2025.10.006","url":null,"abstract":"<div><h3>Objective</h3><div>To assess the effectiveness of an enhanced psychoeducational and exercise training intervention (Positive Minds Strong Bodies-Enhanced [PMSB-E]) on depression and anxiety symptoms and physical functioning.</div></div><div><h3>Design</h3><div>Randomized trial of 427 participants, assigned to intervention or usual care.</div></div><div><h3>Setting</h3><div>51 community-based organizations and 17 clinics in Massachusetts, New York, Puerto Rico, and Maryland, US. Data collected from November 2020 to October 2024, at baseline and months 3, 6, and 12.</div></div><div><h3>Participants</h3><div>Adults aged 60+ or older with mild to severe depression or anxiety symptoms, minor to moderate mobility limitations, and fluency in English, Spanish, Mandarin, or Cantonese.</div></div><div><h3>Interventions</h3><div>Ten psychoeducational and 36 exercise sessions over 6 months compared to usual care (one-on-one phase; 1:1 ratio). Half of the intervention participants were offered an additional 6-month group maintenance phase (1:1 ratio). Control participants received up to 4 usual care calls.</div></div><div><h3>Measurements</h3><div>Primary outcome was change from baseline to month 12 in depression and anxiety symptoms (Hopkins Symptom Checklist-25 [HSCL-25]) and physical functioning (Short Physical Performance Battery [SPPB] and Late-Life Functioning and Disability Instrument [LLFDI]). Secondary outcome was change in month 6.</div></div><div><h3>Results</h3><div>Intervention participants showed improved SPPB scores in month 12 (standardized difference, 0.28; 95% CI, 0.07–0.49) and month 6 (0.34; 95% CI, 0.14–0.55). There were no effects on LLFDI or HSCL-25 scores, nor interaction effects by race and ethnicity. Completing the recommended number of sessions had a larger effect on SPPB scores.</div></div><div><h3>Conclusions</h3><div>PMSB-E replicated previous findings of improving objective physical functioning but not self-reported physical functioning or mental health symptoms. We believe this is due to virtual administration during the pandemic.</div></div>","PeriodicalId":55534,"journal":{"name":"American Journal of Geriatric Psychiatry","volume":"34 2","pages":"Pages 147-161"},"PeriodicalIF":3.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145558873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Authorial Integrity in the Age of Artificial Intelligence: A Scientific Autobiography","authors":"Christopher C. Colenda M.D., M.P.H.","doi":"10.1016/j.jagp.2025.10.004","DOIUrl":"10.1016/j.jagp.2025.10.004","url":null,"abstract":"<div><div>Writing a scientific autobiography is challenging due to the many factors influencing an academic career, including personal experiences, the era of one’s career, research interests, available research tools, institutional environment, societal priorities, and mentorship. Despite changing contexts, certain obligations remain constant: scholars have an obligation to prioritize scientific and personal integrity above the pursuit of individual success, and they must ethically use research tools, including information technology search processes and writing technologies, as part of their scientific processes. The first obligation is built on personal integrity, which in turn characterizes how the second is implemented. My career spanned the last quarter of the 20th century through the first quarter of the 21st century. During this period, there were significant advancements in research methodologies, including the capability of internet search technologies to access scientific databases and desktop writing and referencing software. These advances pale in comparison to the meteoric rise of artificial intelligence large language models (AI LLMs) over the last 5 years, where information retrieval and writing tools have transformed how we access and use information – potentially placing our personal and authorial integrity at risk. Given this rapid transformation, my autobiography’s objectives are: 1) to share my developmental perspectives on personal and authorial integrity and examine the impact of early experiences where perceived plagiarism helped me define those principles; 2) to review professional guidelines concerning research integrity and policy recommendations for AI LLMs; 3) to discuss changes in my scholarly content resulting from evolving search strategies, writing tools, and journal growth; and 4) by using examples of AI-generated and AI-assisted writing samples, to address the influence of AI LLMs on authorial integrity, including practical risks, opportunities, and current recommended strategies for managing AI LLMs in scholarly writing. By sharing my perspectives, I hope to provide guidance for those pursuing scholarly careers that ensures their authorial integrity.</div></div>","PeriodicalId":55534,"journal":{"name":"American Journal of Geriatric Psychiatry","volume":"34 2","pages":"Pages 235-244"},"PeriodicalIF":3.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145524988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preliminary Investigation of the Association Between Epigenetic Aging Acceleration and Amyloid Biomarkers in Bipolar Disorder","authors":"Gabriel R. Fries Ph.D. ,&nbsp;Steven De La Garza M.S. ,&nbsp;Ning O. Zhao M.D. ,&nbsp;Andres W. Bass ,&nbsp;Camila N.C. Lima Ph.D. ,&nbsp;Nobuhide Kobori M.D., Ph.D. ,&nbsp;Tatiana Barichello Ph.D. ,&nbsp;Gustavo Turecki M.D., Ph.D. ,&nbsp;Paul E. Schulz M.D. ,&nbsp;Breno S. Diniz M.D., Ph.D. ,&nbsp;Jair C. Soares M.D., Ph.D.","doi":"10.1016/j.jagp.2025.06.008","DOIUrl":"10.1016/j.jagp.2025.06.008","url":null,"abstract":"<div><h3>Objectives</h3><div>Bipolar disorder (BD) has been associated with an elevated risk of Alzheimer’s Disease (AD). We assessed AD biomarkers in BD and tested whether epigenetic aging (EA) acceleration is associated with changes in these markers.</div></div><div><h3>Design, Setting, Participants</h3><div>Cross-sectional study of <em>n</em> = 58 living individuals with BD and <em>n</em> = 20 age- and sex-matched control participants, as well as analyses of postmortem brain samples (Brodmann area 9/46) from <em>n</em> = 46 individuals with BD.</div></div><div><h3>Measurements</h3><div>Amyloid beta (Aβ)₄₀, Aβ₄₂, and total Tau levels were measured in plasma from individuals with BD and controls, and Aβ₄₂ levels were measured in brains. EA and its acceleration (blood: GrimAge and DunedinPACE; brains: DNAmClock_Cortical) were estimated for all samples. Individuals with BD were split into quartiles with slower or accelerated EA if they were in the first or fourth quartiles for GrimAge acceleration (AgeAccelGrim), DunedinPACE, or DNAmClock_Cortical acceleration (DNAmClock_CorticalAccel).</div></div><div><h3>Results</h3><div>Individuals with BD showed a decrease in the Aβ_42/40 ratio (p = 0.048) compared to controls, and a significant decrease in the Aβ_42/40 ratio was also found in individuals with BD with high versus low AgeAccelGrim (p = 0.048). Brain Aβ₄₂ levels significantly correlated with DNAmClock_CorticalAccel (r² = 0.270, p = 0.007), with those with high EA acceleration showing higher brain Aβ₄₂ after controlling for confounders (p = 0.008).</div></div><div><h3>Conclusions</h3><div>Our results provide preliminary evidence that accelerated EA is associated with markers of AD in individuals with BD, suggesting it as a potential target in efforts to prevent dementia and AD in BD.</div></div>","PeriodicalId":55534,"journal":{"name":"American Journal of Geriatric Psychiatry","volume":"34 2","pages":"Pages 210-221"},"PeriodicalIF":3.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144577625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intranasal Insulin Administration for Reducing Postoperative Delirium After Hip Fracture Surgery in Elderly Patients","authors":"Fu-Shan Xue M.D. ,&nbsp;Yong-Bao Lin M.D. ,&nbsp;Dan-Feng Wang M.D. ,&nbsp;Yan-Hua Guo M.D.","doi":"10.1016/j.jagp.2025.09.025","DOIUrl":"10.1016/j.jagp.2025.09.025","url":null,"abstract":"","PeriodicalId":55534,"journal":{"name":"American Journal of Geriatric Psychiatry","volume":"34 2","pages":"Pages 265-266"},"PeriodicalIF":3.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145423860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to “Brain Amyloid and Cognitive Decline in Late-Life Depression”","authors":"Emma Rhodes Ph.D. ,&nbsp;Philip S. Insel Ph.D. ,&nbsp;Michelle Kassel Ph.D. ,&nbsp;Maria Kryza-Lacombe Ph.D. ,&nbsp;Meryl A. Butters Ph.D. ,&nbsp;David Bickford M.D. ,&nbsp;Duygu Tosun Ph.D. ,&nbsp;Ruth Morin Ph.D. ,&nbsp;Paul Aisen M.D. ,&nbsp;Howie Rosen M.D. ,&nbsp;Rema Raman Ph.D. ,&nbsp;Susan Landau Ph.D. ,&nbsp;Andrew Saykin Psy.D. ,&nbsp;Arthur W. Toga Ph.D. ,&nbsp;Clifford R. Jack M.D. ,&nbsp;Michael W. Weiner M.D. ,&nbsp;Craig Nelson M.D. ,&nbsp;R. Scott Mackin Ph.D.","doi":"10.1016/j.jagp.2025.10.010","DOIUrl":"10.1016/j.jagp.2025.10.010","url":null,"abstract":"","PeriodicalId":55534,"journal":{"name":"American Journal of Geriatric Psychiatry","volume":"34 2","pages":"Pages 258-261"},"PeriodicalIF":3.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145644827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maintenance of Technology-Based Functional Skills Training Gains in Older Participants With and Without Mild Cognitive Impairment: The Role of Booster Training","authors":"Xin Yao Lin Ph.D. ,&nbsp;Philip D. Harvey Ph.D. ,&nbsp;Peter Kallestrup M.S. ,&nbsp;Sara J. Czaja Ph.D.","doi":"10.1016/j.jagp.2025.09.019","DOIUrl":"10.1016/j.jagp.2025.09.019","url":null,"abstract":"<div><h3>Objective</h3><div>Prior research has demonstrated that the technology-based Functional Skills Assessment and Training program (FUNSAT™) improves functional skills among older adults with and without Mild Cognitive Impairment (MCI). The current study examined maintenance of training gains and the role of booster sessions on sustaining training gains.</div></div><div><h3>Design</h3><div>Randomized clinical trial with post-training follow-ups.</div></div><div><h3>Setting</h3><div>14 Community centers in New York City and Miami.</div></div><div><h3>Participants</h3><div>Older adults with normal cognition (n = 74) or MCI (n = 90), ranging in age from 60 to 90 years.</div></div><div><h3>Intervention</h3><div>Computerized cognitive and skills trainings delivered at home 2x weekly for 12 weeks or until mastery.</div></div><div><h3>Measurements</h3><div>The FUNSAT™ program includes financial, medication management, and transportation skills. Completion time and errors were assessed pretraining (T1), post-training (T2), one-month post-training (T3) and 3-months post-training (T4). Participants whose T2 training gains were not sustained at T3 (according to predetermined criteria) received booster training.</div></div><div><h3>Results</h3><div>The percentage of participants needing a booster was low (13% to 34% across tasks); need for booster training was greater for more complex tasks (e.g., internet banking). Participants who did not need a booster improved in performance from T2 to T3. Booster training was efficacious as those receiving booster training subsequently regained training gains and their performance did not differ from the no-booster group at T4.</div></div><div><h3>Conclusions</h3><div>The findings further support the efficacy of the FUNSAT™ training program; most participants maintained or increased their training gains over time. Booster training was beneficial in terms of sustaining gains, indicating that booster sessions play a critical role in skills training.</div></div>","PeriodicalId":55534,"journal":{"name":"American Journal of Geriatric Psychiatry","volume":"34 1","pages":"Pages 31-40"},"PeriodicalIF":3.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145331415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Writing for the Public: A Graduate Seminar in Science Communication","authors":"Caterina Rosano M.D., M.P.H. ,&nbsp;Niles Frantz ,&nbsp;Joseph Balintfy ,&nbsp;Christopher Thomas ,&nbsp;Margaret McDonald Ph.D., M.F.A. ,&nbsp;Mary Ganguli M.D., M.P.H.","doi":"10.1016/j.jagp.2025.09.026","DOIUrl":"10.1016/j.jagp.2025.09.026","url":null,"abstract":"<div><div>Public trust in research and scientific advances appears to be deteriorating. It behooves us, as researchers and educators, to take more responsibility for improving our communication strategies to reach the public and explain the value and relevance of our work to their lives. To address this need, the Training Program in Population Neuroscience of Aging at the University of Pittsburgh piloted a seminar on writing for the media, focusing on the local Western Pennsylvania audience. Six graduate and postdoctoral trainees in public health attended the seminar. Instructors besides public health faculty included local newspaper editors and science communication specialists working at the National Institutes of Health, at an advocacy organization, and at our university’s own communications program. In weekly seminar sessions, instructors discussed audiences, motivations, and formats for science writing. Trainees pitched story ideas, shared proposed outlines, and obtained ongoing feedback from instructors and fellow trainees. Over the course of several weeks, trainees prepared op-ed style articles for potential newspaper publication. Four of the six trainees succeeded in publishing articles in the local newspaper. A course to learn how to write for the public is both feasible and needed in academic settings.</div></div>","PeriodicalId":55534,"journal":{"name":"American Journal of Geriatric Psychiatry","volume":"34 1","pages":"Pages 117-122"},"PeriodicalIF":3.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145461260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Being With a Dying, Nonreligious Person","authors":"George S. Alexopoulos M.D.","doi":"10.1016/j.jagp.2025.09.006","DOIUrl":"10.1016/j.jagp.2025.09.006","url":null,"abstract":"<div><div>Death is a unique and dramatic event. The desire to imagine life as endless may be hard-wired, preserved through evolution because it promotes behaviors that protect the organism. Beliefs in an afterlife may be an extension of our theory-of-mind mental functions, our innate tendency to attribute consciousness to others, projected onto a self that persists after death. Afterlife beliefs also reflect the intuitive teleological thinking of childhood that is automatic and suppressed but not erased in adulthood. Religions respond to this need by offering narratives of survival after death. By contrast, most nonreligious people hold a physicalist worldview in which the person dies with the body, leaving them the task to construct a personal, coherent account of their own mortality. Existentialists view death as a boundary that exposes the fragility of human life. This awareness permeates every aspect of life, sustaining a tension between the longing for transcendence and the reality of finitude. A clinical vignette illustrates the need to listen attentively and try to understand the nonreligious dying patient. The person in the vignette, fully aware of her prognosis, avoided direct discussion of death. Despite her expertise in palliative care, she pursued treatments that prolonged both life and suffering. In her final days, she focused on easing the emotional turmoil her dying caused to loved ones, seeking continuity in her relationships. Facing mortality allows for authentic engagement with existence, a confrontation that deepens life’s meaning precisely because it is finite.</div></div>","PeriodicalId":55534,"journal":{"name":"American Journal of Geriatric Psychiatry","volume":"34 1","pages":"Pages 138-143"},"PeriodicalIF":3.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145260418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling Personality Heterogeneity in Late-Life Suicide Attempters: Methodological Considerations and Clinical Implications","authors":"Jinchao Zhao M.D.,&nbsp;Le Xiong M.D.,&nbsp;Weiliang Cao M.D.","doi":"10.1016/j.jagp.2025.09.007","DOIUrl":"10.1016/j.jagp.2025.09.007","url":null,"abstract":"","PeriodicalId":55534,"journal":{"name":"American Journal of Geriatric Psychiatry","volume":"34 1","pages":"Pages 129-130"},"PeriodicalIF":3.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145295039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}