Purpose: This study investigated the effect of different surface treatments and the effect of silane heat treatment with laser on the shear bond strength (SBS) of a nanoceramic composite to repaired hybrid CAD/CAM blocks.
Materials and methods: 60 hybrid CAD/CAM specimens (Cerasmart, GC) were prepared and randomly divided into six groups according to the different surface treatments (n = 10): group ER: Er:YAG laser+silane (Monobond Plus, Ivoclar Vivadent); group ER+SHT: Er:YAG laser+silane heat treatment; group B: bur+silane; group B+SHT: bur+silane heat treatment; group HF: hydrofluoric acid+silane; group HF+SHT: hydrofluoric acid+silane heat treatment. Afterwards, a universal adhesive (Universal Bond Quick, Kuraray) was applied, and nanoceramic resin composite (Zenit, President) cylinders were bonded to the Cerasmart specimens. They were thermocycled for 10,000 cycles (5-55°C) and subjected to SBS testing using a universal testing machine. Failure modes were examined with a stereomicroscope (15X). Scanning electron microscopy (SEM) was used to evaluate the surface topography (n = 2). The data were statistically analyzed using the Mann-Whitney U-test and the Kruskal-Wallis test (p < 0.05).
Results: Regarding the surface treatments, group ER showed significantly lower SBS than groups B and HF (p < 0.05). Regarding the presence of silane heat treatment by laser, groups ER+SHT and B+SHT showed significantly lower SBS than group HF+SHT(p < 0.05). In addition, group B+SHT showed significantly lower SBS than did group B (p < 0.05).
Conclusion: Er:YAG laser treatment for repairing hybrid CAD/CAM blocks was not as effective as bur roughening or hydrofluoric acid etching. Silane heated by Er:YAG laser was incapable of significantly increasing the bond strength to repaired hybrid CAD/CAM blocks.
目的:本研究探讨了不同表面处理方法和激光硅烷热处理对纳米陶瓷复合材料与修复的混合 CAD/CAM 块体的剪切结合强度(SBS)的影响。Er:YAG 激光+硅烷热处理;B 组:毛刺+硅烷;B+SHT 组:毛刺+硅烷热处理;HF 组:氢氟酸+硅烷;HF+SHT 组:氢氟酸+硅烷热处理。然后,涂上通用粘合剂(Universal Bond Quick,可乐丽),并将纳米陶瓷树脂复合材料(Zenit,总统)圆柱体粘合到 Cerasmart 试样上。这些试样经过 10,000 次热循环(5-55°C),并使用万能试验机进行 SBS 试验。使用体视显微镜(15 倍)检查失效模式。扫描电子显微镜(SEM)用于评估表面形貌(n = 2)。采用 Mann-Whitney U 检验和 Kruskal-Wallis 检验对数据进行统计分析(P < 0.05):结果:在表面处理方面,ER 组的 SBS 明显低于 B 组和 HF 组(p < 0.05)。在使用激光进行硅烷热处理的情况下,ER 组+SHT 和 B 组+SHT 的 SBS 明显低于 HF 组+SHT(p < 0.05)。此外,B+SHT 组的 SBS 明显低于 B 组(P < 0.05):结论:Er:YAG 激光治疗修复混合 CAD/CAM 块的效果不如毛刺粗化或氢氟酸蚀刻。用 Er:YAG 激光加热硅烷无法显著提高修复后的混合 CAD/CAM 块的粘接强度。
{"title":"Repair Bond Strength to Hybrid CAD/CAM Materials after Silane Heat Treatment with Laser.","authors":"Ceren Deger, Burcu Oglakci, Zumrut Ceren Ozduman, Evrim Eliguzeloglu Dalkilic","doi":"10.3290/j.jad.b3956401","DOIUrl":"10.3290/j.jad.b3956401","url":null,"abstract":"<p><strong>Purpose: </strong>This study investigated the effect of different surface treatments and the effect of silane heat treatment with laser on the shear bond strength (SBS) of a nanoceramic composite to repaired hybrid CAD/CAM blocks.</p><p><strong>Materials and methods: </strong>60 hybrid CAD/CAM specimens (Cerasmart, GC) were prepared and randomly divided into six groups according to the different surface treatments (n = 10): group ER: Er:YAG laser+silane (Monobond Plus, Ivoclar Vivadent); group ER+SHT: Er:YAG laser+silane heat treatment; group B: bur+silane; group B+SHT: bur+silane heat treatment; group HF: hydrofluoric acid+silane; group HF+SHT: hydrofluoric acid+silane heat treatment. Afterwards, a universal adhesive (Universal Bond Quick, Kuraray) was applied, and nanoceramic resin composite (Zenit, President) cylinders were bonded to the Cerasmart specimens. They were thermocycled for 10,000 cycles (5-55°C) and subjected to SBS testing using a universal testing machine. Failure modes were examined with a stereomicroscope (15X). Scanning electron microscopy (SEM) was used to evaluate the surface topography (n = 2). The data were statistically analyzed using the Mann-Whitney U-test and the Kruskal-Wallis test (p < 0.05).</p><p><strong>Results: </strong>Regarding the surface treatments, group ER showed significantly lower SBS than groups B and HF (p < 0.05). Regarding the presence of silane heat treatment by laser, groups ER+SHT and B+SHT showed significantly lower SBS than group HF+SHT(p < 0.05). In addition, group B+SHT showed significantly lower SBS than did group B (p < 0.05).</p><p><strong>Conclusion: </strong>Er:YAG laser treatment for repairing hybrid CAD/CAM blocks was not as effective as bur roughening or hydrofluoric acid etching. Silane heated by Er:YAG laser was incapable of significantly increasing the bond strength to repaired hybrid CAD/CAM blocks.</p>","PeriodicalId":55604,"journal":{"name":"Journal of Adhesive Dentistry","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9239194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Renally Bezerra Wanderley Lima, Aline Fedoce Silva, Wellington Luiz de Oliveira da Rosa, Evandro Piva, Rosângela Marques Duarte, Grace Mendonça De Souza
Purpose: To provide an overview of the in-vitro bond strength of universal adhesives to zirconia and analyze whether these adhesives are a reliable alternative to conventional zirconia primers.
Materials and methods: A systematic search was conducted in PubMed/Medline, Scopus, and ISI Web of Science databases up to August 2021. Investigations published in English, assessing resin-mediated bond to zirconia using universal adhesives compared to phosphate/silane-based primer or phosphate-based primer were included. After study selection and data extraction, risk of bias analysis was performed. Statistical analyses were performed using RevMan 5.4, with a random effects model, at a significance level of 0.05.
Results: In total, 23 studies were included for qualitative and quantitative analysis. Universal adhesives showed higher bond strengths than did phosphate-based primers (p < 0.00001) to aged zirconia without airborne alumina-particle abrasion. Similar results were observed when the zirconia surface was airborne-particle abraded at baseline and after dynamic aging (p < 0.0001). When universal adhesives and phosphate-silane based primers were compared, similar bond strengths (p ≥ 0.001) were observed after surface abrasion, regardless of storage condition.
Conclusion: The results showed that universal adhesives generate higher bond strengths when compared to conventional zirconia primers.
{"title":"Bonding Efficacy of Universal Resin Adhesives to Zirconia Substrates: Systematic Review and Meta-Analysis.","authors":"Renally Bezerra Wanderley Lima, Aline Fedoce Silva, Wellington Luiz de Oliveira da Rosa, Evandro Piva, Rosângela Marques Duarte, Grace Mendonça De Souza","doi":"10.3290/j.jad.b3868649","DOIUrl":"10.3290/j.jad.b3868649","url":null,"abstract":"<p><strong>Purpose: </strong>To provide an overview of the in-vitro bond strength of universal adhesives to zirconia and analyze whether these adhesives are a reliable alternative to conventional zirconia primers.</p><p><strong>Materials and methods: </strong>A systematic search was conducted in PubMed/Medline, Scopus, and ISI Web of Science databases up to August 2021. Investigations published in English, assessing resin-mediated bond to zirconia using universal adhesives compared to phosphate/silane-based primer or phosphate-based primer were included. After study selection and data extraction, risk of bias analysis was performed. Statistical analyses were performed using RevMan 5.4, with a random effects model, at a significance level of 0.05.</p><p><strong>Results: </strong>In total, 23 studies were included for qualitative and quantitative analysis. Universal adhesives showed higher bond strengths than did phosphate-based primers (p < 0.00001) to aged zirconia without airborne alumina-particle abrasion. Similar results were observed when the zirconia surface was airborne-particle abraded at baseline and after dynamic aging (p < 0.0001). When universal adhesives and phosphate-silane based primers were compared, similar bond strengths (p ≥ 0.001) were observed after surface abrasion, regardless of storage condition.</p><p><strong>Conclusion: </strong>The results showed that universal adhesives generate higher bond strengths when compared to conventional zirconia primers.</p>","PeriodicalId":55604,"journal":{"name":"Journal of Adhesive Dentistry","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10718774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Helena C Assis, Glauce C do Nascimento, Renato Roperto, Manoel D Sousa-Neto, Fabiane C Lopes-Olhê
Purpose: To evaluate the effect of carbodiimide (EDC) and chitosan (CHI) on the enzymatic activity (EA) and bond strength (BS) of different composite cements to root dentin.
Materials and methods: Ninety (90) maxillary canines were sectioned, standardizing the length of the roots. The roots were endodontically treated, prepared, divided into 3 groups according to dentin treatment (distilled water [DW], CHI 0.2 wt%, or EDC 0.5M), and further subdivided into 3 subgroups according to composite cement (RelyX ARC [3M Oral Care], Panavia F 2.0 [Kuraray Noritaki], or RelyX U200 [3M Oral Care]). Of the slices obtained by sectioning, the most cervical of each third were subjected to a push-out test and the most apical were subjected to in-situ zymography. Half of the slices were analyzed immediately, and the other half after 6 months. The results were analyzed with ANOVA or the chi-squared test.
Results: RelyX ARC showed higher BS associated with CHI, while RelyX U200 showed higher BS associated with EDC (p = 0.044). For Panavia F 2.0, the treatment did not influence BS (p > 0.05). For the cervical and middle thirds, no differences were observed between the cements, while the apical third revealed higher BS for RelyX U200 (p < 0.001). The highest percentage of adhesive-to-dentin failures was observed for Panavia F 2.0. EDC showed the lowest percentage of adhesive-to-dentin failures. According to zymographic analysis, DW and CHI showed greater fluorescence for RelyX ARC, while EDC exhibited the lowest fluorescence of all cements (p > 0.05).
Conclusion: The different mechanisms of action of solutions for pre-treatment of intraradicular dentin yielded different results depending on the adhesive used. EDC resulted in higher bond strength and higher enzyme inhibition for RelyX U200, while the treatment with chitosan resulted in higher bond strength and lower enzymatic activity for RelyX ARC. Although EDC and chitosan treatments did not influence the bond strength for Panavia F 2.0, both resulted in higher enzyme inhibition for this composite cement.
目的:评估碳二亚胺(EDC)和壳聚糖(CHI)对不同复合材料水门汀与牙根的酶活性(EA)和粘接强度(BS)的影响:对九十(90)颗上颌犬齿进行切片,统一牙根长度。牙根经过根管治疗、制备,根据牙本质处理(蒸馏水 [DW]、CHI 0.2 wt% 或 EDC 0.5M)分为 3 组,再根据复合树脂(RelyX ARC [3M 口腔护理公司]、Panavia F 2.0 [Kuraray Noritaki] 或 RelyX U200 [3M 口腔护理公司])分为 3 个亚组。在切片中,每三分之一的最颈部进行推挤试验,最顶端进行原位酶谱分析。一半切片立即进行分析,另一半在 6 个月后进行分析。结果采用方差分析或卡方检验进行分析:结果:RelyX ARC 的 BS 值较高,与 CHI 有关,而 RelyX U200 的 BS 值较高,与 EDC 有关(p = 0.044)。对于 Panavia F 2.0,处理方法对 BS 没有影响(p > 0.05)。在牙颈部和中三分之一处,没有观察到不同水门汀之间的差异,而在根尖三分之一处,RelyX U200 的 BS 较高(p < 0.001)。Panavia F 2.0 的粘接失败率最高。EDC 显示的粘合剂对牙本质失败的比例最低。根据酶谱分析,DW 和 CHI 对 RelyX ARC 显示出更高的荧光,而 EDC 在所有水门汀中显示出最低的荧光(p > 0.05):牙本质内预处理溶液的不同作用机制产生了不同的结果,这取决于所使用的粘合剂。对 RelyX U200 而言,EDC 可产生较高的粘接强度和较高的酶抑制作用,而对 RelyX ARC 而言,壳聚糖处理可产生较高的粘接强度和较低的酶活性。虽然 EDC 和壳聚糖处理对 Panavia F 2.0 的粘接强度没有影响,但这两种处理对这种复合水泥都有较高的酶抑制作用。
{"title":"Can Carbodiimide (EDC) and Chitosan Cross-linking Agents Effect the Longevity of Fiberglass Posts Luted with Different Types of Composite Cements to Root Dentin?","authors":"Helena C Assis, Glauce C do Nascimento, Renato Roperto, Manoel D Sousa-Neto, Fabiane C Lopes-Olhê","doi":"10.3290/j.jad.b3868623","DOIUrl":"10.3290/j.jad.b3868623","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the effect of carbodiimide (EDC) and chitosan (CHI) on the enzymatic activity (EA) and bond strength (BS) of different composite cements to root dentin.</p><p><strong>Materials and methods: </strong>Ninety (90) maxillary canines were sectioned, standardizing the length of the roots. The roots were endodontically treated, prepared, divided into 3 groups according to dentin treatment (distilled water [DW], CHI 0.2 wt%, or EDC 0.5M), and further subdivided into 3 subgroups according to composite cement (RelyX ARC [3M Oral Care], Panavia F 2.0 [Kuraray Noritaki], or RelyX U200 [3M Oral Care]). Of the slices obtained by sectioning, the most cervical of each third were subjected to a push-out test and the most apical were subjected to in-situ zymography. Half of the slices were analyzed immediately, and the other half after 6 months. The results were analyzed with ANOVA or the chi-squared test.</p><p><strong>Results: </strong>RelyX ARC showed higher BS associated with CHI, while RelyX U200 showed higher BS associated with EDC (p = 0.044). For Panavia F 2.0, the treatment did not influence BS (p > 0.05). For the cervical and middle thirds, no differences were observed between the cements, while the apical third revealed higher BS for RelyX U200 (p < 0.001). The highest percentage of adhesive-to-dentin failures was observed for Panavia F 2.0. EDC showed the lowest percentage of adhesive-to-dentin failures. According to zymographic analysis, DW and CHI showed greater fluorescence for RelyX ARC, while EDC exhibited the lowest fluorescence of all cements (p > 0.05).</p><p><strong>Conclusion: </strong>The different mechanisms of action of solutions for pre-treatment of intraradicular dentin yielded different results depending on the adhesive used. EDC resulted in higher bond strength and higher enzyme inhibition for RelyX U200, while the treatment with chitosan resulted in higher bond strength and lower enzymatic activity for RelyX ARC. Although EDC and chitosan treatments did not influence the bond strength for Panavia F 2.0, both resulted in higher enzyme inhibition for this composite cement.</p>","PeriodicalId":55604,"journal":{"name":"Journal of Adhesive Dentistry","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9215727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pauline M J Hoekstra-van Hout, Jan G J H Schols, Shamir B Mehta, Niek J M Opdam, Tatiana Pereira Cenci, Bas A C Loomans
Purpose: This retrospective case series of 9 patients aimed to describe clinical outcomes and patient satisfaction following the implementation of the posterior Dahl concept to manage localized posterior tooth wear.
Materials and methods: Localized occlusal space was created in the posterior dentition. Supra-occluding direct restorations were placed bilaterally for the restoration of molars. Intraoral scans were taken at the pre-treatment stage, immediately post-restoration, and during follow-up appointments. Scans were used to undertake analysis of any occlusal changes and re-establishment of the occlusion. A questionnaire was used to assess patient satisfaction, alleviation of any pre-treatment concerns, and evaluation of post-treatment complaints.
Results: Immediately post-treatment, all patients showed an increase in the vertical dimension. Opening of the bite in the untreated areas following restoration of worn posterior molars resulted either in a tendency towards or the actual reestablishment of the occlusion. One patient completely lacked compensatory vertical tooth movement in the untreated areas, culminating in the persistence of a vertical open bite. One restoration displayed cohesive fracture after 4 months. Pre-treatment problems (eg, sensitivity) were fully resolved amongst all patients after 6 months. Post-treatment complaints were minor and demonstrated resolution within a relatively short period of time. Eight patients reported being "very satisfied" with their treatment outcomes.
Conclusion: Application of the posterior Dahl concept appears to offer a promising, relatively simple, minimally invasive and effective approach for the management of localized posterior tooth wear, which is well accepted by patients.
{"title":"Posterior Dahl: A Minimally Invasive Method for the Treatment of Localized Posterior Tooth Wear.","authors":"Pauline M J Hoekstra-van Hout, Jan G J H Schols, Shamir B Mehta, Niek J M Opdam, Tatiana Pereira Cenci, Bas A C Loomans","doi":"10.3290/j.jad.b3837959","DOIUrl":"10.3290/j.jad.b3837959","url":null,"abstract":"<p><strong>Purpose: </strong>This retrospective case series of 9 patients aimed to describe clinical outcomes and patient satisfaction following the implementation of the posterior Dahl concept to manage localized posterior tooth wear.</p><p><strong>Materials and methods: </strong>Localized occlusal space was created in the posterior dentition. Supra-occluding direct restorations were placed bilaterally for the restoration of molars. Intraoral scans were taken at the pre-treatment stage, immediately post-restoration, and during follow-up appointments. Scans were used to undertake analysis of any occlusal changes and re-establishment of the occlusion. A questionnaire was used to assess patient satisfaction, alleviation of any pre-treatment concerns, and evaluation of post-treatment complaints.</p><p><strong>Results: </strong>Immediately post-treatment, all patients showed an increase in the vertical dimension. Opening of the bite in the untreated areas following restoration of worn posterior molars resulted either in a tendency towards or the actual reestablishment of the occlusion. One patient completely lacked compensatory vertical tooth movement in the untreated areas, culminating in the persistence of a vertical open bite. One restoration displayed cohesive fracture after 4 months. Pre-treatment problems (eg, sensitivity) were fully resolved amongst all patients after 6 months. Post-treatment complaints were minor and demonstrated resolution within a relatively short period of time. Eight patients reported being \"very satisfied\" with their treatment outcomes.</p><p><strong>Conclusion: </strong>Application of the posterior Dahl concept appears to offer a promising, relatively simple, minimally invasive and effective approach for the management of localized posterior tooth wear, which is well accepted by patients.</p>","PeriodicalId":55604,"journal":{"name":"Journal of Adhesive Dentistry","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10624458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Purpose: To investigate the bond durability of composite cement to zirconia after treatment with a 15-methacryloyloxypentadecyl dihydrogen phosphate (15-MPDP)-containing adhesive and 2 commercially available adhesives.
Materials and methods: Ninety zirconia bars were fabricated and bonded to prepolymerized resin composite cylinders with a composite cement after surface treatment for 20 s using the following adhesives: Adper Easy One (AEO, negative control), Single Bond Universal (SBU, positive control), and 10 wt% 15-MPDP powder mixed with Adper Easy One (15- MPDP). After storage in distilled water at 37°C for 24 h, the specimens were divided into 3 subgroups according to the aging treatment applied (n = 10): no aging treatment (0/TC), 10,000 thermocycles (1/TC), and 37,500 thermocycles (3/TC). Shear bond strength (SBS) was analyzed using two-way ANOVA (p < 0.05), and the fracture surfaces were examined under a dental microscope.
Results: Significant differences in the SBSs among the surface treatments and aging treatments were observed (both p < 0.001). The 15-MPDP and SBU groups showed significantly higher SBSs than the AEO group, whereas similar SBSs were found in the 15-MPDP and SBU groups. Significant reductions in the SBSs were found after 37,500 thermocycles (p < 0.001), although no significant difference between specimens aged with 10,000 thermocycles and non-aged specimens was observed.
Conclusions: The 15-MPDP-containing dental adhesive exhibited bond durability comparable to that of a well-established 10-MDP-containing universal adhesive. Aging by 10,000 thermocycles may be insufficient to disrupt the bond of composite cement to zirconia.
{"title":"15-Methacryloyloxypentadecyl Dihydrogen Phosphate Improves Resin-to-Zirconia Bonding Durability.","authors":"Zhi-Cen Lu, Ling-Hui Jia, Zhi-Feng Zheng, Hao Yu","doi":"10.3290/j.jad.b3831385","DOIUrl":"10.3290/j.jad.b3831385","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the bond durability of composite cement to zirconia after treatment with a 15-methacryloyloxypentadecyl dihydrogen phosphate (15-MPDP)-containing adhesive and 2 commercially available adhesives.</p><p><strong>Materials and methods: </strong>Ninety zirconia bars were fabricated and bonded to prepolymerized resin composite cylinders with a composite cement after surface treatment for 20 s using the following adhesives: Adper Easy One (AEO, negative control), Single Bond Universal (SBU, positive control), and 10 wt% 15-MPDP powder mixed with Adper Easy One (15- MPDP). After storage in distilled water at 37°C for 24 h, the specimens were divided into 3 subgroups according to the aging treatment applied (n = 10): no aging treatment (0/TC), 10,000 thermocycles (1/TC), and 37,500 thermocycles (3/TC). Shear bond strength (SBS) was analyzed using two-way ANOVA (p < 0.05), and the fracture surfaces were examined under a dental microscope.</p><p><strong>Results: </strong>Significant differences in the SBSs among the surface treatments and aging treatments were observed (both p < 0.001). The 15-MPDP and SBU groups showed significantly higher SBSs than the AEO group, whereas similar SBSs were found in the 15-MPDP and SBU groups. Significant reductions in the SBSs were found after 37,500 thermocycles (p < 0.001), although no significant difference between specimens aged with 10,000 thermocycles and non-aged specimens was observed.</p><p><strong>Conclusions: </strong>The 15-MPDP-containing dental adhesive exhibited bond durability comparable to that of a well-established 10-MDP-containing universal adhesive. Aging by 10,000 thermocycles may be insufficient to disrupt the bond of composite cement to zirconia.</p>","PeriodicalId":55604,"journal":{"name":"Journal of Adhesive Dentistry","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10667376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jaiane Bandoli Monteiro, Pedro Henrique Condé Oliveira Prado, Gabriela Ribeiro Zucco, Tiago Moreira Bastos Campos, João Paulo Barros Machado, Vladimir Jesus Trava-Airoldi, Renata Marques de Melo
Purpose: To evaluate the effect of plasma-enhanced chemical vapor deposition (PECVD) with silicon hydride (SiH4) at different times on HT-zirconia surface characteristics and bonding of composite cement before and after thermocycling.
Materials and methods: Blocks of HT zirconia were obtained, polished, sintered and divided into five groups, according to PECVD time (n = 31): Zr-30 (30 s), Zr-60 (60 s), Zr-120 (120 s) and Zr-300 (300 s). The control group (Zr-0) did not receive PECVD. X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), energy dispersive spectroscopy (EDS) in conjunction with field-emission scanning electron microscopy (FE-SEM), x-ray photoelectron spectroscopy (XPS), goniometry, and profilometry tests were used for chemical and topographic characterization. Monobond N silane (Ivoclar Vivadent) was applied to the surface, and a cylinder of composite cement (Variolink N) was made (3 x 3 mm). Half of the specimens of each group were stored for 24 h or subjected to thermocycling (6 x 103 cycles). A shear bond strength (SBS) test was performed. Results were subjected to one-way ANOVA and Tukey's tests (α = 0.05).
Results: For experimental groups, XPS showed that formation of Si-O bonds contributed to increased surface free energy (SFE). FE-SEM and EDS showed that the longer the deposition time, the greater the amount of silicon on the surface. Zr-60 and Zr-300 presented higher and lower surface roughnesses, respectively. The silicon penetrated the microstructure, causing higher stress concentrations. The bond strength to composite cement was improved after all PECVD deposition times.
Conclusion: The PECVD technique with SiH4, associated with chemical treatment with primer based on silane methacrylate, is a solely chemical surface treatment capable of maintaining bonding between composite cement and HT zirconia.
{"title":"High-Translucency Zirconia Following Chemical Vapor Deposition with SiH4: Evidence of Surface Modifications and Improved Bonding.","authors":"Jaiane Bandoli Monteiro, Pedro Henrique Condé Oliveira Prado, Gabriela Ribeiro Zucco, Tiago Moreira Bastos Campos, João Paulo Barros Machado, Vladimir Jesus Trava-Airoldi, Renata Marques de Melo","doi":"10.3290/j.jad.b3801051","DOIUrl":"10.3290/j.jad.b3801051","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the effect of plasma-enhanced chemical vapor deposition (PECVD) with silicon hydride (SiH4) at different times on HT-zirconia surface characteristics and bonding of composite cement before and after thermocycling.</p><p><strong>Materials and methods: </strong>Blocks of HT zirconia were obtained, polished, sintered and divided into five groups, according to PECVD time (n = 31): Zr-30 (30 s), Zr-60 (60 s), Zr-120 (120 s) and Zr-300 (300 s). The control group (Zr-0) did not receive PECVD. X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), energy dispersive spectroscopy (EDS) in conjunction with field-emission scanning electron microscopy (FE-SEM), x-ray photoelectron spectroscopy (XPS), goniometry, and profilometry tests were used for chemical and topographic characterization. Monobond N silane (Ivoclar Vivadent) was applied to the surface, and a cylinder of composite cement (Variolink N) was made (3 x 3 mm). Half of the specimens of each group were stored for 24 h or subjected to thermocycling (6 x 103 cycles). A shear bond strength (SBS) test was performed. Results were subjected to one-way ANOVA and Tukey's tests (α = 0.05).</p><p><strong>Results: </strong>For experimental groups, XPS showed that formation of Si-O bonds contributed to increased surface free energy (SFE). FE-SEM and EDS showed that the longer the deposition time, the greater the amount of silicon on the surface. Zr-60 and Zr-300 presented higher and lower surface roughnesses, respectively. The silicon penetrated the microstructure, causing higher stress concentrations. The bond strength to composite cement was improved after all PECVD deposition times.</p><p><strong>Conclusion: </strong>The PECVD technique with SiH4, associated with chemical treatment with primer based on silane methacrylate, is a solely chemical surface treatment capable of maintaining bonding between composite cement and HT zirconia.</p>","PeriodicalId":55604,"journal":{"name":"Journal of Adhesive Dentistry","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10528910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Christina Boutsiouki, Roland Frankenberger, Susanne Lücker, Norbert Krämer
Purpose: This study compared a 2%-CHX dentin pre-treatment with three CHX adhesives (experimentally admixed 0.1% CHX in primer or bonding agent, or industrially added 0.2% CHX in universal adhesive) by evaluating dentin bond strengths after biological loading in a fully automated artificial mouth model.
Materials and methods: The occlusal dentin of 50 freshly extracted human third molars was exposed, and the teeth were randomly assigned to 5 groups according to the adhesive protocol (n = 10): 1. control, Scotchbond Multipurpose (3M Oral Care; CTRL); 2. 2% CHX dentin pre-treatment (DENT); 3. 0.1% CHX experimentally admixed into the primer (PRIM); 4. 0.1% CHX experimentally admixed into the bonding agent (BOND); 5. Peak Universal Bond containing 0.2% CHX (Ultradent; PEAK). The teeth were restored with composite resin. Microtensile bond strength testing (bonding area 0.46 mm2 ± 0.04 mm2, crosshead speed 1 mm/min) was performed after 24-h storage in distilled water (baseline) or after 2-day biological loading with S. mutans (demineralization 1 h / remineralization 5 h). The mode of fracture was recorded and exemplary sticks were evaluated under SEM.
Results: CTRL exhibited significantly higher μTBS at baseline in comparison to PRIM (p = 0.000), BOND (p = 0.002), and PEAK (p = 0.000). After undergoing the caries model, CTRL demonstrated significantly lower μTBS compared to DENT (p = 0.000), PRIM (p = 0.008), and PEAK (p = 0.000). The same behavior was observed for BOND vs DENT (p = 0.000), PRIM (p = 0.003), and PEAK (p = 0.001). After biological loading, DENT (p = 0.041), PRIM (p = 0.000), and BOND (p = 0.000) exhibited significantly fewer adhesive fractures than CTRL.
Conclusions: CHX addition to the primer protects dentin bond strength from declining after biological loading. Thus, it may offer some clinical advantage in terms of secondary caries inhibition around composite restorations. However, since loss of adhesion at baseline was less when 2% CHX was used as a dentin pre-treatment, it can be suggested as a safer option. so that bonding is not undermined by potential chemical interactions from CHX with the adhesives.
{"title":"Effect of Chlorhexidine-containing Etch-and-Rinse Adhesives on Dentin Microtensile Bond Strength after Biological Loading.","authors":"Christina Boutsiouki, Roland Frankenberger, Susanne Lücker, Norbert Krämer","doi":"10.3290/j.jad.b3801065","DOIUrl":"10.3290/j.jad.b3801065","url":null,"abstract":"<p><strong>Purpose: </strong>This study compared a 2%-CHX dentin pre-treatment with three CHX adhesives (experimentally admixed 0.1% CHX in primer or bonding agent, or industrially added 0.2% CHX in universal adhesive) by evaluating dentin bond strengths after biological loading in a fully automated artificial mouth model.</p><p><strong>Materials and methods: </strong>The occlusal dentin of 50 freshly extracted human third molars was exposed, and the teeth were randomly assigned to 5 groups according to the adhesive protocol (n = 10): 1. control, Scotchbond Multipurpose (3M Oral Care; CTRL); 2. 2% CHX dentin pre-treatment (DENT); 3. 0.1% CHX experimentally admixed into the primer (PRIM); 4. 0.1% CHX experimentally admixed into the bonding agent (BOND); 5. Peak Universal Bond containing 0.2% CHX (Ultradent; PEAK). The teeth were restored with composite resin. Microtensile bond strength testing (bonding area 0.46 mm2 ± 0.04 mm2, crosshead speed 1 mm/min) was performed after 24-h storage in distilled water (baseline) or after 2-day biological loading with S. mutans (demineralization 1 h / remineralization 5 h). The mode of fracture was recorded and exemplary sticks were evaluated under SEM.</p><p><strong>Results: </strong>CTRL exhibited significantly higher μTBS at baseline in comparison to PRIM (p = 0.000), BOND (p = 0.002), and PEAK (p = 0.000). After undergoing the caries model, CTRL demonstrated significantly lower μTBS compared to DENT (p = 0.000), PRIM (p = 0.008), and PEAK (p = 0.000). The same behavior was observed for BOND vs DENT (p = 0.000), PRIM (p = 0.003), and PEAK (p = 0.001). After biological loading, DENT (p = 0.041), PRIM (p = 0.000), and BOND (p = 0.000) exhibited significantly fewer adhesive fractures than CTRL.</p><p><strong>Conclusions: </strong>CHX addition to the primer protects dentin bond strength from declining after biological loading. Thus, it may offer some clinical advantage in terms of secondary caries inhibition around composite restorations. However, since loss of adhesion at baseline was less when 2% CHX was used as a dentin pre-treatment, it can be suggested as a safer option. so that bonding is not undermined by potential chemical interactions from CHX with the adhesives.</p>","PeriodicalId":55604,"journal":{"name":"Journal of Adhesive Dentistry","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10528909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Purpose: To evaluate the efficacy of different surface treatments on the bond strength of polyetherketoneketone (PEKK) to ceramic materials.
Materials and methods: PEKK test specimens were separated into four groups according to surface treatments (group S: sandblasting; group A: acid etching; group SA: sandblasting + acid etching; group C: control). Surface roughness values of PEKK specimens were measured before and after surface treatment. After the prepared PEKK specimens were bonded to lithium-disilicate glass-ceramic specimens with resin cement, they were kept in distilled water at 37°C for 24 h. Half of the specimens in each surface treatment group were thermocycled. All test specimens underwent shear bond strength testing. Failure modes were assessed using light microscopy and SEM.
Results: Statistical analysis demonstrated that surface treatments created significant roughness on the PEKK surfaces (p = 0.005). While group S showed the highest roughness values, group A showed the lowest. Of the thermocycled test groups, the sandblasting + acid etching group obtained the highest shear bond strengths. Among the non-thermocycled test groups, the sandblasting surface treatment group achieved the highest shear bond strengths.
Conclusions: The application of surface treatments to enhance the bond strength of PEKK to ceramics has proven to be effective.
{"title":"Evaluation of the Bond Strength of Polyetherketoneketone to Dental Ceramic.","authors":"Bahar Tekli, Gulfem Ergun","doi":"10.3290/j.jad.b3710327","DOIUrl":"10.3290/j.jad.b3710327","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the efficacy of different surface treatments on the bond strength of polyetherketoneketone (PEKK) to ceramic materials.</p><p><strong>Materials and methods: </strong>PEKK test specimens were separated into four groups according to surface treatments (group S: sandblasting; group A: acid etching; group SA: sandblasting + acid etching; group C: control). Surface roughness values of PEKK specimens were measured before and after surface treatment. After the prepared PEKK specimens were bonded to lithium-disilicate glass-ceramic specimens with resin cement, they were kept in distilled water at 37°C for 24 h. Half of the specimens in each surface treatment group were thermocycled. All test specimens underwent shear bond strength testing. Failure modes were assessed using light microscopy and SEM.</p><p><strong>Results: </strong>Statistical analysis demonstrated that surface treatments created significant roughness on the PEKK surfaces (p = 0.005). While group S showed the highest roughness values, group A showed the lowest. Of the thermocycled test groups, the sandblasting + acid etching group obtained the highest shear bond strengths. Among the non-thermocycled test groups, the sandblasting surface treatment group achieved the highest shear bond strengths.</p><p><strong>Conclusions: </strong>The application of surface treatments to enhance the bond strength of PEKK to ceramics has proven to be effective.</p>","PeriodicalId":55604,"journal":{"name":"Journal of Adhesive Dentistry","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2022-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10432067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Renáta Martos, Melinda Szalóki, József Gáll, Attila Csík, Csaba Hegedűs
Purpose: To compare the bond durability of adhesives with 10-methacryloyloxydecyl dihydrogen phosphate (10-MDP) to low-viscosity bulk-fill composite.
Materials and methods: Four 10-MDP-containing adhesives (Tokuyama Bond Force II [TBF II], Tokuyama; Scotchbond Universal [SU], 3M Oral Care; Clearfil Universal Bond Quick [CL], Kuraray Noritake; and G-Premio Bond [GP], GC) and one 10-MDP-free adhesive (Heliobond [HB] Ivoclar Vivadent) as a control were applied to polished, air-abraded surfaces of randomly assigned SureFil SDR flow low-viscosity bulk-fill composite blocks. The application of the adhesives was followed by applying Tetric EvoCeram universal nanohybrid composite in layers. Each layered composite block was sliced into stick specimens with a hard-tissue microtome. Half of the groups were randomly selected and tested for microtensile bond strength (immediate group); the other groups were aged in a thermocyling machine for 5000 cycles, followed by testing microtensile bond strength (aged group). The adhesive interface was evaluated with scanning electron microscopy (SEM). Failure modes were observed using light microscopy. The results were evaluated with Levene's test, ANOVA, Welch's ANOVA, Tukey's test and the Z-test as appropriate (significance: p < 0.05).
Results: There was a significant difference in the bond strength between 10-MDP-containing adhesives and the 10-MDP-free adhesive in all groups. Aging significantly decreased the bond strength in all adhesive groups. There was no significant difference in the bond strength durability among the 10-MDP-containing adhesives.
Conclusion: Application of 10-MDP-containing adhesives has an advantageous effect on the air-abraded SDR composite surface compared with 10-MDP-free adhesive. The composition of 10-MDP-containing adhesives did not influence the bond strength. Aging diminishes the bond strength durability of 10-MDP-containing adhesives.
目的:比较含 10-甲基丙烯酰氧癸基磷酸二氢酯(10-MDP)的粘合剂与低粘度膨体填充复合材料的粘接耐久性:将四种含 10-MDP 的粘合剂(Tokuyama Bond Force II [TBFⅡ],Tokuyama;Scotchbond Universal [SU],3M Oral Care;Clearfil Universal Bond Quick [CL],Kuraray Noritake;G-Premio Bond [GP],GC)和一种不含 10-MDP 的粘合剂(Heliobond [HB],Ivoclar Vivadent)作为对照,应用于随机分配的 SureFil SDR flow 低粘度散装填充复合材料块的抛光气磨表面。涂抹粘合剂后,再分层涂抹 Tetric EvoCeram 通用纳米混合复合材料。用硬组织显微切片机将每层复合材料块切成棒状试样。随机选取一半组别进行微拉伸粘接强度测试(即时组);另一半组别在热固化机中老化 5000 次,然后测试微拉伸粘接强度(老化组)。用扫描电子显微镜(SEM)对粘合界面进行了评估。使用光学显微镜观察失效模式。结果酌情采用 Levene 检验、方差分析、Welch 方差分析、Tukey 检验和 Z 检验进行评估(显著性:P < 0.05):在所有组别中,含 10-MDP 的粘合剂与不含 10-MDP 的粘合剂的粘合强度都有明显差异。老化会明显降低所有粘合剂组的粘合强度。结论:结论:与不含 10-MDP 的粘合剂相比,使用含 10-MDP 的粘合剂对空气降解的 SDR 复合材料表面具有优势。含 10-MDP 的粘合剂的成分不会影响粘合强度。老化会降低含 10-MDP 粘合剂的粘接强度耐久性。
{"title":"Comparative Analysis of Bond Strength Durability of 10-Methacryloyloxydecyl Dihydrogen Phosphate-Containing Adhesives on a Low-Viscosity Bulk-Fill Composite Surface.","authors":"Renáta Martos, Melinda Szalóki, József Gáll, Attila Csík, Csaba Hegedűs","doi":"10.3290/j.jad.b3608775","DOIUrl":"10.3290/j.jad.b3608775","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the bond durability of adhesives with 10-methacryloyloxydecyl dihydrogen phosphate (10-MDP) to low-viscosity bulk-fill composite.</p><p><strong>Materials and methods: </strong>Four 10-MDP-containing adhesives (Tokuyama Bond Force II [TBF II], Tokuyama; Scotchbond Universal [SU], 3M Oral Care; Clearfil Universal Bond Quick [CL], Kuraray Noritake; and G-Premio Bond [GP], GC) and one 10-MDP-free adhesive (Heliobond [HB] Ivoclar Vivadent) as a control were applied to polished, air-abraded surfaces of randomly assigned SureFil SDR flow low-viscosity bulk-fill composite blocks. The application of the adhesives was followed by applying Tetric EvoCeram universal nanohybrid composite in layers. Each layered composite block was sliced into stick specimens with a hard-tissue microtome. Half of the groups were randomly selected and tested for microtensile bond strength (immediate group); the other groups were aged in a thermocyling machine for 5000 cycles, followed by testing microtensile bond strength (aged group). The adhesive interface was evaluated with scanning electron microscopy (SEM). Failure modes were observed using light microscopy. The results were evaluated with Levene's test, ANOVA, Welch's ANOVA, Tukey's test and the Z-test as appropriate (significance: p < 0.05).</p><p><strong>Results: </strong>There was a significant difference in the bond strength between 10-MDP-containing adhesives and the 10-MDP-free adhesive in all groups. Aging significantly decreased the bond strength in all adhesive groups. There was no significant difference in the bond strength durability among the 10-MDP-containing adhesives.</p><p><strong>Conclusion: </strong>Application of 10-MDP-containing adhesives has an advantageous effect on the air-abraded SDR composite surface compared with 10-MDP-free adhesive. The composition of 10-MDP-containing adhesives did not influence the bond strength. Aging diminishes the bond strength durability of 10-MDP-containing adhesives.</p>","PeriodicalId":55604,"journal":{"name":"Journal of Adhesive Dentistry","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2022-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40710164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Purpose: This study investigated the effects of mechanical and chemical pretreatment of polyetherketoneketone (PEKK) on shear bond strength (SBS) to root dentin using two types of resin cement.
Materials and methods: A total of 100 PEKK specimens were prepared and polished. Sixty specimens were mechanically treated by sandblasting (50-µm Al2O3 for 10 s at 0.2-0.25 MPa), and the remaining 40 were untreated. Self-adhesive resin cement and conventional resin cement were used. PEKK specimens bonded to root dentin using self-adhesive resin cement were classified into three groups by pretreatment method: (1) untreated PEKK, (2) mechanical pretreatment (sandblasted PEKK), and (3) both mechanical and chemical pretreatment (PEKK sandblasting as well as application of Scotchbond Universal; 3M Oral Care). Conventional resin cement was pretreated following the same steps (1-3) as those followed for self-adhesive specimens. Each group included 10 specimens. PEKK specimens after surface treatments were examined using SEM. SBS tests were performed using a universal testing machine, and data were statistically analyzed using one-way ANOVA and Tukey's multiple comparison test (p < 0.05).
Results: No significant difference was observed between cements with and without sandblasting. However, self-adhesive specimens with both mechanical and chemical pretreatments demonstrated higher SBS than other cements with or without pretreatment.
Conclusion: Mechanical pretreatment by sandblasting did not improve the PEKK-root dentin SBS. However, combined mechanical (sandblasting) and chemical pretreatment (ScotchBond Universal) significantly improved the SBS between the PEKK and root dentin.
{"title":"Effect of Surface Treatments of Polyetherketoneketone as a Post Material on Shear Bond Strength to Root Dentin using Two Types of Resin Cement.","authors":"Masaaki Kasahara, Tomoko Someya, Masayuki Hattori","doi":"10.3290/j.jad.b3608791","DOIUrl":"10.3290/j.jad.b3608791","url":null,"abstract":"<p><strong>Purpose: </strong>This study investigated the effects of mechanical and chemical pretreatment of polyetherketoneketone (PEKK) on shear bond strength (SBS) to root dentin using two types of resin cement.</p><p><strong>Materials and methods: </strong>A total of 100 PEKK specimens were prepared and polished. Sixty specimens were mechanically treated by sandblasting (50-µm Al2O3 for 10 s at 0.2-0.25 MPa), and the remaining 40 were untreated. Self-adhesive resin cement and conventional resin cement were used. PEKK specimens bonded to root dentin using self-adhesive resin cement were classified into three groups by pretreatment method: (1) untreated PEKK, (2) mechanical pretreatment (sandblasted PEKK), and (3) both mechanical and chemical pretreatment (PEKK sandblasting as well as application of Scotchbond Universal; 3M Oral Care). Conventional resin cement was pretreated following the same steps (1-3) as those followed for self-adhesive specimens. Each group included 10 specimens. PEKK specimens after surface treatments were examined using SEM. SBS tests were performed using a universal testing machine, and data were statistically analyzed using one-way ANOVA and Tukey's multiple comparison test (p < 0.05).</p><p><strong>Results: </strong>No significant difference was observed between cements with and without sandblasting. However, self-adhesive specimens with both mechanical and chemical pretreatments demonstrated higher SBS than other cements with or without pretreatment.</p><p><strong>Conclusion: </strong>Mechanical pretreatment by sandblasting did not improve the PEKK-root dentin SBS. However, combined mechanical (sandblasting) and chemical pretreatment (ScotchBond Universal) significantly improved the SBS between the PEKK and root dentin.</p>","PeriodicalId":55604,"journal":{"name":"Journal of Adhesive Dentistry","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2022-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40710165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}