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HPV-related head and neck tumors – 10 years of experience with human papillomavirus vaccinations hpv相关的头颈部肿瘤- 10年的人乳头瘤病毒疫苗接种经验
Q4 Medicine Pub Date : 2017-11-16 DOI: 10.25121/NEWMED.2017.21.4.145
Karolina Raczkowska-Łabuda, Anna Gorzelnik, Jolanta Jadczyszyn, L. Zawadzka-Głos
In the recent years, there has been a rapid increase in the incidence of head and neck cancers in Europe. Every year, 6,000 persons in Poland are diagnosed with a neoplastic proliferative disease in the head and neck region. The risk of cancer of this group increases with age in both genders, with a peak incidence around the age of 64. A diagnosis of a head and neck tumor typically occurs between the age of 45 and 64. In many European countries, including Poland, the so-called “epidemiological phenomenon” is observed. Epidemiological phenomenon consists in an increasing incidence of head and neck cancers in persons under 40 years of age who had never smoked or abused alcohol. The profile of patient with head and neck cancer has changed. It is estimated that over 90% of men and 80% of women will be infected with at least one type of HPV in their lifetime. Half of the infections are caused by the oncogenic types. HPV type 16 is responsible for 90% of high-risk infections and increases the likelihood of human papillomavirus-related oropharyngeal cancers by 15 to 230 times, depending on the type of the virus. In the view of the differences in course and prognosis in patients with HPV-related cancers, these tumors have been excluded from the existing TNM staging system (tumor, nodes, metastasis), and a separate classification, only for this group of tumors, was created. HPV vaccines have been one of the most important steps in cancer prevention in the last few decades. In Poland, 3 different vaccines are included in the National Vaccination Program as recommended, but they are not reimbursed by the State. Keywords
近年来,欧洲头颈部癌症的发病率迅速上升。在波兰,每年有6 000人被诊断患有头颈部肿瘤增生性疾病。无论男女,这一群体患癌症的风险都随着年龄的增长而增加,在64岁左右发病率最高。头颈部肿瘤的诊断通常发生在45岁至64岁之间。在包括波兰在内的许多欧洲国家,观察到所谓的“流行病学现象”。流行病学现象是,从未吸烟或酗酒的40岁以下人群头颈癌发病率不断上升。头颈癌患者的情况发生了变化。据估计,超过90%的男性和80%的女性在其一生中至少会感染一种HPV。一半的感染是由致癌类型引起的。HPV 16型导致90%的高危感染,并使人乳头瘤病毒相关口咽癌的可能性增加15至230倍,这取决于病毒的类型。鉴于hpv相关肿瘤患者在病程和预后上的差异,我们将这些肿瘤排除在现有的TNM分期系统(肿瘤、淋巴结、转移)之外,并为这组肿瘤创建了一个单独的分类。在过去的几十年里,HPV疫苗一直是预防癌症最重要的步骤之一。在波兰,按照建议将三种不同的疫苗纳入国家疫苗接种计划,但国家不报销这些疫苗。关键字
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引用次数: 1
Sudden bilateral deep hearing loss in a child – case study 儿童突发性双侧深部听力损失的个案研究
Q4 Medicine Pub Date : 2017-11-15 DOI: 10.25121/newmed.2017.21.4.135
Jolanta Jadczyszyn, Karolina Raczkowska-Łabuda, Małgorzata Dębska-Rutkowska, L. Zawadzka-Głos
Introduction. Sudden bilateral deep hearing loss is very rare in children. Its estimated prevalence is 2% among children with hearing loss. The causes include acute acoustic trauma, vascular disorders of the inner ear, sudden viral or bacterial infection, and trauma of the inner ear. Noise is currently an important risk factor for hearing impairment. Groups that are particularly vulnerable to noise damage include children and young adults. The effects of noise include hearing impairment of different degree and the more and more commonly diagnosed extra auditory effects of noise in the form of anxiety, irritability, cognitive impairment, reduced intellectual ability, difficulty in falling asleep, circulatory disorders, hormonal disorders, and changes in social behavior. Case report. We present a case of a 9-year-old girl who experienced sudden bilateral deep hearing loss of the left ear, which was caused by a school bell during a school break. Six weeks after the sudden hearing loss in the left ear, hearing loss in the right ear of the unknown etiology appeared. The girl was in good general condition, no vertigo and balance impairment were observed. In the tonal audiometry, bilateral deep mixed hearing loss was observed. The treatment in the hospital included surgery in the form of bilateral explorative tympanotomy of the middle ear with anterior tympanocentesis and tube insertion, as well as conservative treatment: dexamethasone, vipocentin, piracetam, B vitamins, xylometazoline, and hyperbaric oxygen therapy. Hospitalization lasted 14 days. A complete recovery of hearing was achieved. Conclusion. Sudden bilateral deep hearing loss in children can be caused by an acute acoustic trauma. Studies show that noise is an important disturbing factor in the school environment and may be harmful. Noise levels of ca. 80-85 dB measured in corridors during school breaks and in sports halls may pose a risk of hearing impairment. The consequences of trauma caused by noise in children are very difficult to predict. It is important to recognize the problem early, as well as to introduce a proper diagnostic process and implement the treatment quickly, which is a key to the positive outcome. Keywords
介绍突发性双侧深部听力损失在儿童中非常罕见。据估计,其在听力损失儿童中的患病率为2%。病因包括急性声学创伤、内耳血管疾病、突然的病毒或细菌感染以及内耳创伤。噪音是目前听力受损的一个重要风险因素。特别容易受到噪音损害的群体包括儿童和年轻人。噪音的影响包括不同程度的听力障碍,以及越来越常见的诊断为焦虑、易怒、认知障碍、智力下降、入睡困难、循环系统紊乱、激素紊乱和社会行为变化的噪音的听觉外影响。病例报告。我们报告了一个9岁女孩的案例,她突然出现左耳双侧深部听力损失,这是由课间休息时的铃声引起的。左耳突发性听力损失6周后,出现了病因不明的右耳听力损失。女孩总体状况良好,未观察到眩晕和平衡障碍。在音调测听中,观察到双侧深度混合性听力损失。医院的治疗包括双侧探索性中耳鼓室切开术、前鼓室穿刺术和导管插入术,以及保守治疗:地塞米松、vipocentin、吡拉西坦、B族维生素、木甲唑啉和高压氧治疗。住院治疗持续了14天。听力完全恢复。结论儿童突发性双侧深部听力损失可由急性听觉创伤引起。研究表明,噪音是学校环境中一个重要的干扰因素,可能是有害的。课间休息时在走廊和体育馆测得的噪音水平约为80-85分贝,可能会造成听力受损的风险。噪音对儿童造成的创伤后果很难预测。重要的是要尽早认识到这个问题,并引入适当的诊断程序和快速实施治疗,这是取得积极结果的关键。关键词
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引用次数: 0
Effects of post-intubation laryngeal stenosis treatment depending on the grade of stenosis 插管后喉狭窄的治疗效果取决于狭窄程度
Q4 Medicine Pub Date : 2017-06-01 DOI: 10.25121/NEWMED.2017.21.3.77
L. Zawadzka-Głos, K. Ślączka
Introduction. Laryngeal stenosis as a complication of prolonged endotracheal intubation is a current problem in paediatric laryngology because of the growing population of prematurely born children. The aim of our study was to analyse the cases of post-intubation laryngeal stenosis in terms of the frequency and severity of the complications, as well as to evaluate the effects of endoscopic treatment. Material and methods. The study included 92 children treated for laryngeal stenosis. The analysis involved the comparison of the children in terms of the degree of subglottic stenosis and its effect on treatment. Laryngeal stenosis was treated with endoscopy, which was performed under general anaesthesia. Results. In the group of children with laryngeal stenosis, supraglottic stenosis was found in 9.78% of children, grade I subglottic stenosis occurred in 10.87% of children, grade II in 41.3% of children, grade III in 18.48% of children, and grade IV in 19.57% of children. Of 92 patients, only 41 were full-term (44.57%) and 51 (55.43%) were premature. In the treated group, full recovery and a reduction of laryngeal stenosis were noted in 44 (48%) and 38 children (41%), respectively, while the failure of treatment was reported in 10 patients, representing 11% of the population. In the group of premature infants, 20 children (39.22%) were cured, the condition improved in 22 cases (43.14%) and treatment failed in 9 patients (17.65%). Of 41 full-term children, full recovery was observed in 24 (58.54%), improvement in 16 (39.02%) and failure in one case (2.44%). There was also an increase in the risk of treatment failure in advanced stenosis of grade III and IV according to Cotton–Myer. Conclusions. Laryngeal stenosis is a common problem in premature infants. Endoscopic treatment is an effective surgical method. Failure of endoscopic treatment is related to the degree of stenosis. Grades III and IV are more difficult to treat. Keywords
介绍由于早产儿童的数量不断增加,喉狭窄作为长期气管插管的并发症是儿科喉科目前的一个问题。我们研究的目的是从并发症的频率和严重程度来分析插管后喉狭窄的病例,并评估内镜治疗的效果。材料和方法。该研究包括92名接受喉狭窄治疗的儿童。该分析涉及对儿童声门下狭窄程度及其治疗效果的比较。喉狭窄采用内镜治疗,在全身麻醉下进行。后果在喉狭窄的儿童组中,9.78%的儿童出现声门上狭窄,10.87%的儿童出现I级声门下狭窄,41.3%的儿童出现II级,18.48%的儿童发现III级,19.57%的儿童发现IV级。在92名患者中,只有41名是足月患者(44.57%),51名是早产患者(55.43%)。在治疗组中,44名儿童(48%)和38名儿童(41%)分别完全康复和喉狭窄减少,而10名患者(占总人数的11%)报告治疗失败。早产儿组治愈20例(39.22%),病情好转22例(43.14%),治疗失败9例(17.65%),改善16例(39.02%),失败1例(2.44%)。根据Cotton-Myer的数据,III级和IV级晚期狭窄的治疗失败风险也有所增加。结论。喉狭窄是早产儿常见的问题。内窥镜治疗是一种有效的手术方法。内镜治疗的失败与狭窄程度有关。III级和IV级更难治疗。关键词
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引用次数: 0
Why is a laryngologist interested in cervical cancer? Summary information about HPV vaccination 为什么喉科医生对癌症感兴趣?HPV疫苗接种总结信息
Q4 Medicine Pub Date : 2017-06-01 DOI: 10.25121/NEWMED.2017.21.3.84
Karolina Raczkowska-Łabuda, Anna Gorzelnik, L. Zawadzka-Głos
Human papillomavirus (HPV) vaccines have been available on the world market for more than 10 years. They became available in Polish pharmacies in 2007, although they were only included in the National Vaccination Program almost one year later. Currently in our country, the vaccination against human papillomavirus can be performed in a 3-dose schedule with a 2-valent, 4-valent or 9-valent vaccine. Clinical studies after 10 years of the presence of the vaccine in the market indicate that these vaccinations are an efficient measure for reducing the risk of HPV infection and of cervical cancer. The article compares HPV vaccination programs in Poland and around the world, presents the newest guidelines for the use of particular products, and discusses the characteristics of the products. The preventive role of vaccinations in HPV-dependent head and neck tumors, as well as the need for immunoprophylaxis in both girls and boys is underlined. The paper emphasizes the expected benefits of the implementation of population programs, both in social and financial aspects, on the example of countries which had already implemented such a solution. The aim of the article was to popularize the topic of vaccination against HPV in Poland and to support the initiative of the inclusion of HPV vaccination to the obligatory part of the National Vaccination Program. Keywords
人类乳头瘤病毒(HPV)疫苗在世界市场上已有10多年的历史。它们于2007年在波兰药店上市,尽管近一年后才被纳入国家疫苗接种计划。目前,在我国,针对人乳头瘤病毒的疫苗接种可以采用3剂计划,接种2价、4价或9价疫苗。疫苗上市10年后的临床研究表明,这些疫苗接种是降低HPV感染和癌症风险的有效措施。本文比较了波兰和世界各地的HPV疫苗接种计划,介绍了特定产品的最新使用指南,并讨论了产品的特点。强调了疫苗接种在HPV依赖性头颈部肿瘤中的预防作用,以及对女孩和男孩进行免疫预防的必要性。该文件以已经实施人口方案的国家为例,强调了实施人口方案在社会和财政方面的预期效益。这篇文章的目的是在波兰普及HPV疫苗接种的主题,并支持将HPV疫苗接种纳入国家疫苗接种计划的强制性部分的倡议。关键词
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引用次数: 2
Clinical characteristics of antrochoanal polyps in patients treated in the Department of Pediatric Otolaryngology of the Medical University of Warsaw 华沙医科大学儿科耳鼻喉科治疗的患者鼻鼻息肉的临床特点
Q4 Medicine Pub Date : 2017-06-01 DOI: 10.25121/NewMed.2017.21.3.71
A. Kasprzyk, Piotr Kwast, L. Zawadzka-Głos
Introduction. Antrochoanal polyp (ACP) is a benign lesion originating from the mucosa of the maxillary sinus, growing through the sinus’ ostium (natural or accessory) into the middle meatus and extending into the choana and nasopharynx. ACPs constitute 33% of all nasal polyps in children. Aim. The aim of this study was to evaluate the clinical characteristics of ACP in children treated in the Department of Pediatric Otolaryngology of the Medical University of Warsaw between January 2016 and April 2017. Material and methods. A retrospective analysis of 15 cases was conducted. The following clinical data were analyzed: sex, age, polyp side, associated pathologies, previous surgical procedures and their extent. Result. Ten boys and 5 girls with a mean age of 12.2 (range 9-16) years were included in the study. There were 9 right-sided lesions and 6 left-sided lesions. Seven patients have undergone previous operations, including one patient that had undergone the removal of ACP. Following comorbidities were observed: chronic rhinosinusitis, adenoid hypertrophy, deviated septum, inferior turbinate hypertrophy, otitis media with effusion, and allergy. Three patients underwent other surgical procedures during ACP removal. Conclusions. ACP can lead to unilateral nasal obstruction. Complete removal of the ACP is the key for the successful treatment. Keywords
介绍。鼻窦息肉(Antrochoanal polyp, ACP)是一种良性病变,起源于上颌窦粘膜,通过窦口(自然或副)生长到中道,并延伸到咽喉和鼻咽部。acp占儿童鼻息肉的33%。的目标。本研究的目的是评估2016年1月至2017年4月在华沙医科大学儿科耳鼻喉科治疗的儿童ACP的临床特征。材料和方法。对15例病例进行回顾性分析。分析以下临床资料:性别、年龄、息肉部位、相关病理、既往手术及范围。结果。10名男孩和5名女孩,平均年龄为12.2岁(范围9-16岁)。右侧病变9例,左侧病变6例。7名患者之前接受过手术,其中一名患者接受过ACP切除。观察到以下合并症:慢性鼻窦炎、腺样体肥大、鼻中隔偏曲、下鼻甲肥大、中耳炎伴积液和过敏。3例患者在ACP移除过程中接受了其他手术。结论。ACP可导致单侧鼻塞。完全去除ACP是治疗成功的关键。关键字
{"title":"Clinical characteristics of antrochoanal polyps in patients treated in the Department of Pediatric Otolaryngology of the Medical University of Warsaw","authors":"A. Kasprzyk, Piotr Kwast, L. Zawadzka-Głos","doi":"10.25121/NewMed.2017.21.3.71","DOIUrl":"https://doi.org/10.25121/NewMed.2017.21.3.71","url":null,"abstract":"Introduction. Antrochoanal polyp (ACP) is a benign lesion originating from the mucosa of the maxillary sinus, growing through the sinus’ ostium (natural or accessory) into the middle meatus and extending into the choana and nasopharynx. ACPs constitute 33% of all nasal polyps in children. Aim. The aim of this study was to evaluate the clinical characteristics of ACP in children treated in the Department of Pediatric Otolaryngology of the Medical University of Warsaw between January 2016 and April 2017. Material and methods. A retrospective analysis of 15 cases was conducted. The following clinical data were analyzed: sex, age, polyp side, associated pathologies, previous surgical procedures and their extent. Result. Ten boys and 5 girls with a mean age of 12.2 (range 9-16) years were included in the study. There were 9 right-sided lesions and 6 left-sided lesions. Seven patients have undergone previous operations, including one patient that had undergone the removal of ACP. Following comorbidities were observed: chronic rhinosinusitis, adenoid hypertrophy, deviated septum, inferior turbinate hypertrophy, otitis media with effusion, and allergy. Three patients underwent other surgical procedures during ACP removal. Conclusions. ACP can lead to unilateral nasal obstruction. Complete removal of the ACP is the key for the successful treatment. Keywords","PeriodicalId":55698,"journal":{"name":"New Medicine","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41430454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Hemorrhage risk factors assessment in pediatric patients undergoing adenoidectomy/adenotonsillotomy 儿童腺样体切除术/腺扁桃体切开术患者出血危险因素评估
Q4 Medicine Pub Date : 2017-05-08 DOI: 10.25121/NEWMED.2017.21.2.39
Anna Gorzelnik, L. Zawadzka-Głos, A. Segiet, Karolina Raczkowska-Łabuda
Introduction. Hemorrhage is one of the most important complication of adenoidectomy (AT) and adenotonsillotomy (ATT) in children. The lack of hemostasis is an indication for Bellocq’s tamponade. Preoperative coagulation tests, complete blood count and blood type tests are taken to minimize the risk of bleeding after surgery. Material and methods. Data of 135 children with preoperative normal bleeding tests who underwent AT/ATT was collected. In study group (N = 41), postoperative hemorrhage requiring posterior nasal pack occurred. In the control group (N = 94), bleeding after AT/ATT resolved spontaneously and did not require nasal packing. Results. Hemorrhage was associated with older age. There was no relationship between hemorrhage and blood group, gender, type of the procedure and laboratory results obtained before the surgery. Conclusions. In our study, preoperative laboratory findings failed to effectively identify the patients at risk of hemorrhage after AT/ATT. However, a thorough medical interview and family history, as well as a detailed physical examination and laboratory testing might reveal bleeding disorders that had been asymptomatic. Keywords
介绍出血是儿童腺样体切除术(AT)和腺扁桃体切除术(ATT)最重要的并发症之一。止血不足是Bellocq填塞的一个指征。术前进行凝血测试、全血细胞计数和血型测试,以最大限度地降低术后出血的风险。材料和方法。收集135例接受AT/ATT术前正常出血检查的儿童的数据。在研究组(N=41)中,术后出血需要后鼻塞。在对照组(N=94)中,AT/ATT后出血自行消退,不需要鼻腔填塞。后果出血与年龄较大有关。出血和手术前的血型、性别、手术类型和实验室结果并没有关系。结论。在我们的研究中,术前实验室检查结果未能有效识别at/ATT后有出血风险的患者。然而,彻底的医学访谈和家族史,以及详细的身体检查和实验室检测,可能会发现无症状的出血性疾病。关键词
{"title":"Hemorrhage risk factors assessment in pediatric patients undergoing adenoidectomy/adenotonsillotomy","authors":"Anna Gorzelnik, L. Zawadzka-Głos, A. Segiet, Karolina Raczkowska-Łabuda","doi":"10.25121/NEWMED.2017.21.2.39","DOIUrl":"https://doi.org/10.25121/NEWMED.2017.21.2.39","url":null,"abstract":"Introduction. Hemorrhage is one of the most important complication of adenoidectomy (AT) and adenotonsillotomy (ATT) in children. The lack of hemostasis is an indication for Bellocq’s tamponade. Preoperative coagulation tests, complete blood count and blood type tests are taken to minimize the risk of bleeding after surgery. Material and methods. Data of 135 children with preoperative normal bleeding tests who underwent AT/ATT was collected. In study group (N = 41), postoperative hemorrhage requiring posterior nasal pack occurred. In the control group (N = 94), bleeding after AT/ATT resolved spontaneously and did not require nasal packing. Results. Hemorrhage was associated with older age. There was no relationship between hemorrhage and blood group, gender, type of the procedure and laboratory results obtained before the surgery. Conclusions. In our study, preoperative laboratory findings failed to effectively identify the patients at risk of hemorrhage after AT/ATT. However, a thorough medical interview and family history, as well as a detailed physical examination and laboratory testing might reveal bleeding disorders that had been asymptomatic. Keywords","PeriodicalId":55698,"journal":{"name":"New Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43272656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adenoidectomy and adenotonsillotomy in children less than 2 years of age – a retrospective analysis 2岁以下儿童腺样体切除术和腺扁桃体切除术的回顾性分析
Q4 Medicine Pub Date : 2017-05-06 DOI: 10.25121/NEWMED.2017.21.2.49
K. Siewiorek, Olga Siewiorek, Piotr Kwast, L. Zawadzka-Głos
Introduction. The function of the palatine and adenoid tonsils is to provide defence against respiratory and digestive pathogens. Continuous antigenic stimulation may lead to tonsillar hypertrophy, which can be an indication for their removal. Aim. The purpose of this study was to analyse the symptoms, comorbidities, type of procedure and adverse effects after surgery in children less than 2 years of age who underwent adenoidectomy or adenotonsillotomy. Material and methods. Children less than 2 years of age hospitalized in the years 20092016 in the Department of Pediatric Otolaryngology of the Medical University of Warsaw were included in the study. Among 5833 patients with tonsillar hypertrophy, 60 patients (29 girls, 31 boys) met the inclusion criteria. Reported symptoms, comorbidities, type of procedure, and adverse symptoms during the post-operative observation period were analysed in age subgroups. Results. Adenoidectomy was performed in 38 cases, and adenotonsillotomy – in 22 cases. 26 children had concomitant otitis media with effusion treated with myringotomy with or without tympanostomy tube insertion. In regard to the symptoms and type of the procedure, the level of statistical significance was not reached. Drops in blood oxygen saturation and fever were observed postoperatively in three children with comorbid conditions. Conclusions. Adenoidectomy and adenotonsillotomy with myringotomy with or without tympanostomy tube insertion are relatively safe and efficient procedures in children under 2 years of age. No evident correlation between the age of the child and the frequency of performing adenoidectomy in relation to adenotonsillotomy has been noted. Parents should be informed about the risk of regrowth and the possible need for a future reoperation. Keywords
介绍。腭扁桃体和腺样体的功能是提供对呼吸道和消化道病原体的防御。持续的抗原刺激可能导致扁桃体肥大,这可能是切除扁桃体的指征。的目标。本研究的目的是分析2岁以下儿童接受腺样体切除术或腺扁桃体切除术后的症状、合并症、手术类型和不良反应。材料和方法。2009年至2016年在华沙医科大学儿科耳鼻喉科住院的2岁以下儿童被纳入研究。5833例扁桃体肥大患者中,60例(女孩29例,男孩31例)符合纳入标准。术后观察期间报告的症状、合并症、手术类型和不良症状按年龄分组进行分析。结果。行腺样体切除术38例,腺扁桃体切除术22例。应用鼓膜切开术合并或不合并中耳膜造瘘管治疗中耳炎积液患儿26例。在症状和手术类型方面,没有达到统计学意义的水平。观察了3例合并并发症患儿术后血氧饱和度下降和发热情况。结论。对于2岁以下的儿童,腺样体切除术和腺扁桃体切开术联合鼓膜切开术伴或不伴鼓室造瘘管是相对安全有效的手术。与腺扁桃体切开术相比,儿童的年龄与进行腺样体切除术的频率之间没有明显的相关性。应告知家长再生的风险和未来可能需要再次手术。关键字
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引用次数: 1
Changes in plantar pressure distribution after long-distance running 长跑后足底压力分布的变化
Q4 Medicine Pub Date : 2017-04-10 DOI: 10.25121/NEWMED.2017.21.2.58
Rohan Anna, Nyc Małgorzata, Rogóż Anna, Fugiel Jarosław
1Department of Human Anatomy, Wroclaw Medical University, Poland Head of Department: Professor Bohdan Gworys, MD, PhD 2Faculty of Technology and Natural Science, Karkonoska State College, Jelenia Góra, Poland Dean of Faculty: Wioletta Palczewska, MD, PhD 3Vertex, Rehabilitation Unit, Wroclaw, Poland 4Department of Biostructure, University School of Physical Education, Wroclaw, Poland Head of Department: Professor Teresa Sławińska-Ochla, MD, PhD
1波兰弗罗茨瓦夫医科大学人体解剖系系主任:Bohdan Gworys教授,医学博士2波兰耶莱尼亚卡尔科诺斯卡州立学院技术与自然科学学院Góra系主任:Wioletta Palczewska,医学博士3波兰弗罗茨瓦夫康复中心vertex 4波兰弗罗茨瓦夫大学体育学院生物结构系系主任:Teresa教授Sławińska-Ochla,医学博士,博士
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引用次数: 3
praCtiCal aspECts of nutritional thErapy and Blood gluCosE lEvEl in CritiCally ill patiEnts 危重病人营养治疗与血糖水平的实用问题
Q4 Medicine Pub Date : 2017-03-31 DOI: 10.5604/01.3001.0009.7845
Jacek Wadełek
the main goal of nutritional support in critically ill patients is to minimize the negative protein balance by avoiding starvation, with the purpose of maintaining muscular, immune, and cognitive function, as well as to enhance recovery. nutrition can be given either by the enteral or the parenteral route. Patients should be provided with nutritional substrates, because starvation or underfeeding in intensive care unit (icu) patients is associated with increased morbidity and mortality. the guidelines of european society for clinical nutrition and Metabolism (esPen) and canadian society for clinical nutrition (cscn) recommend the initiation of enteral nutrition within 24-48 hours after the admission to icu. total parenteral nutrition (tPn), if indicated, should also be initiated within the first 24-48 hours after icu admission. the minimal amount of carbohydrate required is about 2 g of glucose/body weight per day. hyperglycemia above 180mg/dl (>10 mmol/l) may have fatal consequences for critically ill patients and should also be avoided. insulin therapy should be initiated for persistent hyperglycemia, with decision threshold no greater than 180 mg/dl, with a target glycemia range of 140 to 180 mg/dl for the majority of critically ill patients. intravenous insulin infusions adjusted according to validated protocols with demonstrated safety and efficacy are preferred.
危重患者营养支持的主要目标是通过避免饥饿来减少负蛋白平衡,以维持肌肉、免疫和认知功能,并促进康复。营养可以通过肠内或肠外途径给予。应向患者提供营养基质,因为重症监护病房(icu)患者的饥饿或营养不良与发病率和死亡率增加有关。欧洲临床营养与代谢学会(esPen)和加拿大临床营养学会(cscn)的指南建议在入住icu后24-48小时内开始肠内营养。全肠外营养(tPn),如有指征,也应在icu入院后24-48小时内开始。每天所需的最低碳水化合物量约为2克葡萄糖/体重。高血糖超过180mg/dl (bbb10 mmol/l)可能对危重患者造成致命后果,也应避免。对于持续高血糖应开始胰岛素治疗,判断阈值不大于180 mg/dl,大多数危重患者的血糖目标范围为140 ~ 180 mg/dl。根据经过验证的方案调整静脉注射胰岛素,并证明其安全性和有效性。
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引用次数: 0
Renal blood supply and fluid therapy 肾血补液疗法
Q4 Medicine Pub Date : 2017-03-31 DOI: 10.5604/01.3001.0009.7844
K. Csaba, L. Medve, T. Gondos
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引用次数: 0
期刊
New Medicine
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