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Morbidity and drug prescribing patterns at a rural primary health care center of Bangladesh 孟加拉国农村初级卫生保健中心的发病率和药物处方模式
Pub Date : 2019-01-07 DOI: 10.3329/IMCJMS.V12I2.39661
H. Momtaz, Nehlin Tomalika, M. Mohsena, Mir Masudur Rhahman, N. Sultana, M. Sayeed
Background and objectives: World Health Organization (WHO) and the National Health Policy of Bangladesh have repeatedly been emphasizing on the use of essential drugs prescribed by generic names. The prescription monitoring studies provide a bridge between areas like rational use of drugs and evidence based medicine. Knowledge on distribution and burden of diseases in a community is essential for planning rational use of drugs in a community. The present study tried to determine the morbidity profile and drug prescribing practices of healthcare providers in a rural primary health care. Methods: The study was conducted at a rural health center located 50 Km north of capital city Dhaka. A semi-structured questionnaire was used for collecting data on socio-demographic conditions, clinical complaints and types of drugs prescribed. WHO prescribing indicators was used to find out the drug prescribing pattern. Results: A total of 583 patients were enrolled. Problems related to respiratory system (21.1%), musculoskeletal system (17.3%) and skin diseases (11.1%) were common reasons for visiting health centre. Oral drugs were prescribed with highest proportion (96.1%). More than half (62.6%) of the drugs were prescribed from essential drug list. About half (49.1%) were antibiotics and 45.6% of the drugs were prescribed in their generic name. Anti-microbial (64.5%), anti-peptic ulcer (43.1%) and NSAIDs (42.5%) were most frequently prescribed. Out of five WHO core prescription indicators, four were below the acceptable values. Conclusion: The study demonstrated that there is an urgent need to promote rational use of drugs among the healthcare providers. IMC J Med Sci 2018; 12(2): 50-56
背景和目标:世界卫生组织(世卫组织)和孟加拉国的国家卫生政策一再强调使用通用名称开具的基本药物。处方监测研究在合理用药和循证医学等领域之间架起了一座桥梁。了解社区的疾病分布和负担对于规划社区合理用药至关重要。本研究试图确定发病率概况和药物处方做法的卫生保健提供者在农村初级卫生保健。方法:研究在首都达卡以北50公里的一个农村卫生中心进行。使用半结构化问卷收集有关社会人口状况、临床投诉和处方药物类型的数据。采用世界卫生组织的处方指标,了解药物的处方模式。结果:共纳入583例患者。与呼吸系统(21.1%)、肌肉骨骼系统(17.3%)和皮肤疾病(11.1%)有关的问题是前往健康中心的常见原因。使用口服药物的比例最高(96.1%)。超过一半(62.6%)的药物来自基本药物清单。约一半(49.1%)为抗生素,45.6%的药物以其通用名称开处方。抗微生物药(64.5%)、抗消化性溃疡药(43.1%)和非甾体抗炎药(42.5%)最为常见。在世卫组织的五项核心处方指标中,有四项低于可接受值。结论:本研究表明,迫切需要在卫生保健提供者中促进合理用药。国际医学杂志2018;12 (2): 50-56
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引用次数: 3
Vitamin D and bone mineral density status among postmenopausal Bangladeshi women 孟加拉国绝经后妇女的维生素D和骨密度状况
Pub Date : 2019-01-07 DOI: 10.3329/IMCJMS.V12I2.39660
A. Ahmed, W. Haque, K. Uddin, Fadlul Azim Abrar, F. Afroz, Hasna Fahmima Huque, S. Afroze
Background and objectives: Low vitamin D is a global problem in all age groups as is osteoporosis in postmenopausal women. The present study was carried out in an urban hospital to assess serum 25-hydroxyvitamin D [25(OH)D] level and bone mineral density (BMD) in postmenopausal women (PMW) and to evaluate correlation between serum 25(OH)D levels and BMD. Methods: A single center cross-sectional study was conducted among 133 apparently healthy PMW aged 45 years and above with the history of complete cessation of menstruation over a period of more than 1 year. Serum 25(OH)D, BMD and serum intact parathyroid hormone (iPTH) were determined. Patients having both vitamin D and BMD values were analyzed for correlations. Similarly, correlation of vitamin D, iPTH and BMD were determined. Results: Among the study population, 63 (47.4%) had deficient (<20 ng/ml), 46 (34.6%) had insufficient (20-30ng/ml) and 24(18%) had sufficient (30-100ng/ml) levels of serum 25(OH)D. Among the 121 patients whose BMD was done, 52 (43.0%) and 60 (49.6%) had osteoporosis and osteopenia respectively. Serum iPTH levels were normal in 34 (89.5%) patients. The proportion of osteopenia and osteoporosis in vitamin D deficient group were 44.1% and 50.8% and in insufficient group 47.5 and 45.0%, respectively. Age had significant negative correlation with BMD value (r=-0.246, p=.005) and significant positive correlation with serum iPTH (r=0.358, p=.024). There was no statistically significant influence of serum 25(OH)D or iPTH on occurrence of osteoporosis (P=0.322 and P=0.592 respectively). Conclusion: A large proportion of postmenopausal women had low vitamin D levels and as well as osteopenia and osteoporosis. Low vitamin D level coexisted with low BMD. However, there was no correlation between serum 25(OH)D levels and BMD status. IMC J Med Sci 2018; 12(2): 44-49
背景和目的:低维生素D是所有年龄组的全球性问题,绝经后妇女骨质疏松症也是如此。本研究在某城市医院进行,旨在评估绝经后妇女(PMW)血清25-羟基维生素D [25(OH)D]水平与骨密度(BMD)的关系,并评价血清25(OH)D水平与BMD的相关性。方法:采用单中心横断面研究方法,对133例45岁及以上、月经完全停止1年以上、表面健康的经前女性进行研究。测定血清25(OH)D、骨密度、完整甲状旁腺激素(iPTH)。对同时具有维生素D和骨密度值的患者进行相关性分析。同样,测定了维生素D、iPTH和骨密度的相关性。结果:在研究人群中,63人(47.4%)血清25(OH)D缺乏(<20 ng/ml), 46人(34.6%)血清25(OH)D不足(20-30ng/ml), 24人(18%)血清25(OH)D充足(30-100ng/ml)。121例骨密度测定患者中,骨质疏松和骨质减少分别为52例(43.0%)和60例(49.6%)。34例(89.5%)患者血清iPTH水平正常。维生素D缺乏组骨量减少和骨质疏松的比例分别为44.1%和50.8%,维生素D不足组为47.5%和45.0%。年龄与BMD值呈显著负相关(r=-0.246, p= 0.005),与血清iPTH呈显著正相关(r=0.358, p= 0.024)。血清25(OH)D、iPTH对骨质疏松发生的影响无统计学意义(P=0.322、P=0.592)。结论:大量绝经后妇女存在维生素D水平低、骨质减少和骨质疏松症。低维生素D水平与低骨密度共存。然而,血清25(OH)D水平与BMD状态之间没有相关性。国际医学杂志2018;12 (2): 44-49
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引用次数: 8
Quality of life in patients with diabetes mellitus 糖尿病患者的生活质量
Pub Date : 2019-01-07 DOI: 10.3329/imcjms.v12i2.39666
Naima Ahmed, Nehlin Tomalika, M. M. Rhaman, H. Momtaz, M. Haque
Background and objectives: Diabetes mellitus (DM) perpetually affects the quality of life. This non-communicable lifelong disease usually develops micro and macro-vascular complications affecting vital organs. Thus, it reduces the functional capability of health as assessed by the health-related quality of life (HRQOL) measuring tools. It is not known, how much HRQOL of the diabetic population in Bangladesh is affected. Therefore, the objective of the present study was to estimate the levels of HRQOL of cases with DM attending a tertiary care hospital in Dhaka city. The study considered socioeconomic condition, nutritional status, duration of diabetes and treatment modalities while analyzing the HRQOL. Methods: This study was conducted in a tertiary care hospital in Dhaka city from July 2016 to June 2017. Patients with DM were considered eligible and were recruited. Those who were found to have complications like retinopathy, nephropathy, neuropathy, hypertension and stroke were excluded based on previous investigations. Once selected, the study protocol was described to each of the diabetic patients. If agreed, the participant was interviewed. Short Form health survey questionnaire (SF-36) was used for assessment of HRQOL. The assessment of physical health components included physical function, role physical, body pain, and general health. Mental health components were emotion, vitality and social function. Results: A total of 150 diabetic patients (m/f: 80/70) were included in the study. Comparisons of demographic variables between male and female participants showed no significant difference. As regards HRQOL, physical function score was significantly reduced among those who had diabetes for more than 10 years (p=0.049). General health component was significantly impaired among those who had higher BMI (<30kg/m2; p= 0.016) and post-prandial hyperglycemia. Longer duration of DM (>10yrs) and higher BMI significantly reduced components of mental health quality. Conclusion: The study revealed that the overall physical and mental quality of life was significantly affected by longer duration of diabetes, obesity and glycemic status. IMC J Med Sci 2018; 12(2): 73-79
背景和目的:糖尿病(DM)持续影响生活质量。这种非传染性终身疾病通常会产生影响重要器官的微血管和大血管并发症。因此,它降低了由健康相关生活质量(HRQOL)测量工具评估的健康功能。目前尚不清楚孟加拉国糖尿病人群的HRQOL有多少受到影响。因此,本研究的目的是估计在达卡市三级医院就诊的糖尿病患者的HRQOL水平。该研究在分析HRQOL时考虑了社会经济状况、营养状况、糖尿病持续时间和治疗方式。方法:本研究于2016年7月至2017年6月在达卡市一家三级医院进行。糖尿病患者被认为符合条件并被招募。那些发现有视网膜病变、肾病、神经病变、高血压和中风等并发症的患者根据之前的调查被排除在外。一旦选定,研究方案被描述给每一个糖尿病患者。如果同意,则对参与者进行访谈。采用SF-36健康问卷评估HRQOL。身体健康成分的评估包括身体功能、角色身体、身体疼痛和一般健康。心理健康成分包括情感、活力和社会功能。结果:共纳入150例糖尿病患者(m/f: 80/70)。男女参与者的人口学变量比较无显著差异。在HRQOL方面,10年以上糖尿病患者的身体功能评分明显降低(p=0.049)。BMI较高(10岁)的人一般健康成分显著受损,BMI较高的人心理健康质量成分显著降低。结论:研究显示,糖尿病、肥胖和血糖状态的持续时间越长,整体身心生活质量受到显著影响。国际医学杂志2018;12 (2): 73 - 79
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引用次数: 0
Correlation of serum intact parathyroid hormone and alkaline phosphatase in diabetic chronic kidney disease stage 3 to 5 patients with mineral bone disorders 3 ~ 5期糖尿病慢性肾病伴矿物质骨紊乱患者血清完整甲状旁腺激素与碱性磷酸酶的相关性
Pub Date : 2019-01-07 DOI: 10.3329/imcjms.v12i2.39665
M. Ananna, W. Haque, M. A. Rahim, T. Chowdhury, T. Samad, Mostarshid Billah, S. Iqbal
Introduction: Chronic kidney disease (CKD) amongst diabetic patients is a worldwide public health problem. It is associated with cardiovascular disease and CKD mineral bone disorder (CKD-MBD). Cardiovascular and MBD are important contributors of morbidity and mortality in CKD patients. Serum intact parathyroid hormone (iPTH) and alkaline phosphatase (ALP) are two important markers to identify and mange CKD-MBD. This study was designed to evaluate the relationship between serum iPTH and alkaline phosphatase in diabetic CKD stages 3-5 patients with MBD. Methods: This cross-sectional study was conducted in BIRDEM General Hospital, Dhaka, Bangladesh from January 2013 to December 2014. Diabetic patients suffering from stage 3-5 CKD with MBD and not on dialysis, were consecutively and purposively included in this study. Along with base-line characteristics, clinical and laboratory data including serum alkaline phosphatase and iPTH levels were recorded for all patients. Data were analyzed by using SPSS version 20.0 and Pearson’s correlation test was applied to evaluate the relationship between iPTH and serum ALP. Results: Total patients were 306, of which 166 (54.2%) were males and 140 females (45.8%). Mean age of the study population was 56.5±11.3 years. Mean duration of diabetes mellitus (DM) and CKD were 12.8±7.6 and 2.9±1.7 years respectively. Among the study population, 49 (16.0%) were in CKD stage 3, 90 (29.4%) in stage 4 and rest 167 (54.6%) in stage 5. The mean HbA1c level did not differ significantly (p>0.05 by ANOVA) amongst CKD-MBD stage 3, 4 and 5 cases. Mean±SE values of glycated haemoglobin (HbAlc %), serum creatinine (mg/dl), urea (mg/dl), calcium (mg/dl), phosphate (mg/dl), ALP (U/L) and iPTH (pg/ml) of total study population were 7.77±0.12, 6.8±0.17, 141.1±4.33, 8.1±0.07, 5.2±0.11, 164.1±7.74 and 229.7±8.64 respectively. Out of total cases, serum ALP was raised in only 53.9% CKD-MBD cases compared to 76.8% for iPTH. Serum iPTH level was found elevated in 79.6%, 83.3% and 72.5% CKD-MBD stage 3, 4 and 5 cases respectively while in comparison, serum ALP was found raised in 44.8%, 54.4% and 56.2% cases respectively. On correlation analysis between serum iPTH and ALP, the r values observed were 0.074, 0.231 and 0.046 for stage 3, 4 and 5 CKD-MBD cases respectively. Conclusion: The results of current study showed that most diabetic stage 3-5 pre-dialysis CKD-MBD patients had raised serum iPTH. In comparison, significantly low number of cases had raised serum ALP. IMC J Med Sci 2018; 12(2): 80-85
糖尿病患者中的慢性肾脏疾病(CKD)是一个世界性的公共卫生问题。它与心血管疾病和CKD矿物质骨障碍(CKD- mbd)有关。心血管疾病和MBD是CKD患者发病率和死亡率的重要因素。血清完整甲状旁腺激素(iPTH)和碱性磷酸酶(ALP)是鉴别和治疗CKD-MBD的两个重要指标。本研究旨在评估3-5期糖尿病CKD合并MBD患者血清iPTH与碱性磷酸酶的关系。方法:本横断面研究于2013年1月至2014年12月在孟加拉国达卡BIRDEM总医院进行。连续、有目的地纳入3-5期CKD合并MBD且未进行透析的糖尿病患者。除了基线特征外,还记录了所有患者的临床和实验室数据,包括血清碱性磷酸酶和iPTH水平。应用SPSS 20.0对数据进行分析,应用Pearson相关检验评价iPTH与血清ALP的关系。结果:患者306例,其中男性166例(54.2%),女性140例(45.8%)。研究人群的平均年龄为56.5±11.3岁。糖尿病(DM)和CKD的平均病程分别为12.8±7.6年和2.9±1.7年。在研究人群中,49例(16.0%)为CKD 3期,90例(29.4%)为4期,其余167例(54.6%)为5期。CKD-MBD 3期、4期和5期患者的平均HbA1c水平无显著差异(方差分析p>0.05)。研究人群糖化血红蛋白(HbAlc %)、血清肌酐(mg/dl)、尿素(mg/dl)、钙(mg/dl)、磷酸盐(mg/dl)、ALP (U/L)和iPTH (pg/ml)的平均±SE值分别为7.77±0.12、6.8±0.17、141.1±4.33、8.1±0.07、5.2±0.11、164.1±7.74和229.7±8.64。在所有病例中,只有53.9%的CKD-MBD患者血清ALP升高,而iPTH患者血清ALP升高为76.8%。CKD-MBD 3期、4期和5期患者血清iPTH升高的分别为79.6%、83.3%和72.5%,ALP升高的分别为44.8%、54.4%和56.2%。3期、4期、5期CKD-MBD患者血清iPTH与ALP的相关性分析r值分别为0.074、0.231、0.046。结论:目前的研究结果显示,大多数糖尿病3-5期透析前CKD-MBD患者血清iPTH升高。相比之下,血清ALP升高的病例明显较少。国际医学杂志2018;12 (2): 80 - 85
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引用次数: 0
Image processing of health insurance claims 健康保险索赔的图像处理
Pub Date : 1990-02-01 DOI: 10.5555/88960.88967
NiberdingMichael
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引用次数: 0
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IMC Journal of Medical Science
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