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Duchenne muscular dystrophy patients diagnosed at the asymptomatic stage: What are the benefits of early diagnosis? 在无症状阶段诊断的杜氏肌营养不良患者:早期诊断的好处是什么?
IF 1.3 4区 医学 Q3 REHABILITATION Pub Date : 2024-11-14 eCollection Date: 2025-06-01 DOI: 10.5606/tftrd.2024.15025
Filiz Meryem Sertpoyraz, Göksel Tanıgör, Figen Baydan, Murat Yıldırım Kale

Objectives: This study aimed to demonstrate whether a diagnosis given at the asymptomatic stage of patients with DMD can affect the clinical outcomes and to define the clinical characteristics of the patients.

Patients and methods: The cross-sectional study was conducted with 136 male patients (mean age: 8.8±3.7 years; range, 3 to 17 years) with DMD between March 2022 and February 2023. The patients were diagnosed through clinical presentation, pathology studies, and genetic testing. The demographic, clinical, and the laboratory data of the patients were recorded. The patients were evaluated in two groups: those diagnosed at the asymptomatic stage due to elevated creatine kinase (CK) and those diagnosed due to clinical symptoms. Patients were further stratified according to their age groups: those younger than 10 years and those aged 10 years or older. Hand grip, quadriceps muscle strength, and Vignos and Brooke motor functional assessment scales of the two groups were compared.

Results: In patients who were diagnosed with CK levels, CK elevation was significantly more common than other findings. When the age at diagnosis was evaluated, the age at diagnosis in those diagnosed with CK levels was statistically significantly lower than in those diagnosed with clinical findings. No significant difference was detected in clinical findings between the groups under the age of 10 years. Among patients aged 10 years or older, hand muscle strength, quadriceps muscle strength, and Vignos and Brooke motor function scale scores were significantly better in those diagnosed with CK levels compared to those diagnosed with clinical findings.

Conclusion: This study shows that early diagnosis in the preclinical period, which enables earlier medical treatment and rehabilitation, may have a positive effect on motor functions and the course of the disease.

目的:本研究旨在证明在DMD患者无症状期的诊断是否会影响临床结果,并确定患者的临床特征。患者与方法:横断面研究136例男性患者(平均年龄8.8±3.7岁;在2022年3月至2023年2月期间患有DMD。通过临床表现、病理研究和基因检测对患者进行诊断。记录患者的人口学、临床和实验室数据。患者分为两组:因肌酸激酶(CK)升高而诊断为无症状期的患者和因临床症状诊断为无症状期的患者。患者根据年龄进一步分层:小于10岁的和大于10岁的。比较两组握力、股四头肌力量、Vignos和Brooke运动功能评定量表。结果:在诊断为CK水平的患者中,CK升高明显比其他发现更常见。当评估诊断年龄时,诊断为CK水平的患者的诊断年龄明显低于诊断为临床表现的患者。10岁以下两组的临床表现无显著差异。在10岁及以上的患者中,被诊断为CK水平的患者的手部肌力、股四头肌肌力和Vignos和Brooke运动功能量表评分明显优于被诊断为临床表现的患者。结论:临床前期早期诊断有助于早期治疗和康复,可能对运动功能和病程有积极影响。
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引用次数: 0
The effect of height of lifting on dynamic postural control in low back pain patients and healthy subjects. 升降高度对腰痛患者和健康人动态姿势控制的影响。
IF 1.1 4区 医学 Q3 REHABILITATION Pub Date : 2024-10-31 eCollection Date: 2024-12-01 DOI: 10.5606/tftrd.2024.12768
Majid Shahbazi, Javad Sarrafzadeh, Ismail Ebrahimi Takamjani, Hossein Negahban

Objectives: The study investigated the influence of starting load position during lifting on postural control in nonspecific chronic low back pain (LBP) and healthy volunteers.

Patients and methods: The cross-sectional study included 20 healthy males (mean age: 31.8±7.4 years; range, 18 to 55 years) and 52 male patients (mean age: 33.4±9.2 years; range, 18 to 55 years) with chronic LBP between February 2016 and April 2018. Postural control characteristics were assessed by a force plate system. Center of pressure signals were obtained at a frequency of 100 Hz, and the mean of three trials was calculated. The participants were told to place their feet hip-width apart on the force plate while standing barefoot. They were then asked to lift a box weighing 10% of their body weight from the ground to waist height and then from waist height to overhead with straight elbows. They moved the box at their selected speed. The examinations began upon the examiner's command.

Results: Results indicated a significant difference (p<0.001) in all postural control variables in chronic LBP patients who lifted a load at different heights. In addition, there was a significant difference between all of the postural control measures of this study in healthy participants during load lifting at different heights (p<0.05), with the exception of the mediolateral standard deviation of velocity (p=0.067).

Conclusion: Different lifting heights impact LBP patients' and healthy people's postural control differently. Postural control was more challenging during waist-to-overhead lifting in the patient group. This may be due to a stiffening strategy. The central nervous system reduces postural sway at higher centers of mass.

目的:研究非特异性慢性腰痛(LBP)和健康志愿者在举重时起始负荷位置对姿势控制的影响。患者与方法:横断面研究纳入健康男性20例(平均年龄:31.8±7.4岁;年龄范围:18 ~ 55岁),男性52例(平均年龄:33.4±9.2岁;2016年2月至2018年4月期间患有慢性下腰痛的患者,年龄在18岁至55岁之间。通过力板系统评估姿势控制特性。在100 Hz频率下得到压力中心信号,并计算三次试验的平均值。参与者被告知,赤脚站立时,将双脚与臀部同宽放在测力板上。然后,他们被要求将一个重达自身体重10%的箱子从地面举到腰高,再从腰高举到头顶,肘部伸直。他们以选定的速度移动箱子。根据主考人的命令,考试开始了。结论:不同的升降高度对腰痛患者和正常人的姿势控制有不同的影响。在患者组中,腰举至头顶的姿势控制更具挑战性。这可能是由于强硬的策略。中枢神经系统减少高质量中心的姿势摇摆。
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引用次数: 0
Is it necessary to use a sling or abduction pillow sling after superior rotator cuff repair? A preliminary report. 上肩袖修复后是否需要使用吊带或外展枕吊带?初步报告。
IF 1.1 4区 医学 Q3 REHABILITATION Pub Date : 2024-10-31 eCollection Date: 2024-12-01 DOI: 10.5606/tftrd.2024.12653
İsmail Murad Pepe, Yavuz Şahbat, Emre Çalışal, Selçuk Yılmaz, İsmet Aslı Topcuoğlu, Ayça Aracı, Yıldız Erdoğanoğlu

Objectives: The study aimed to evaluate the effects of the use of a shoulder sling, shoulder sling with a pillow, or not using a sling on the shoulder functional score and pain levels following arthroscopic rotator cuff tear repair.

Patients and methods: This randomized prospective study was performed with 90 patients (49 males, 41 females; mean age: 56.2±12.2 year; range, 33 to 77 years) with a small-to-mid, full-thickness rotator cuff tear between July 2020 and October 2022. All patients underwent arthroscopic double-row repair. The nonsling group wore no sling, the sling group wore a sling, and the abduction pillow sling group wore a sling with an abduction pillow. The same rehabilitation program was performed. The Visual Analog Scale (VAS) score, Constant-Murley scores, and degrees of flexion and abduction were recorded preoperatively, on the 15th and 45th days, and at three months, six months, and one year.

Results: On the 15th postoperative day, the VAS score was found to be significantly lower in the nonsling group. On the 45th day, the Constant-Murley score was found to be significantly higher in the abduction pillow sling group. There was no significant difference between the groups regarding the Constant-Murley scores at three weeks, six months, and one year. The shoulder forward flexion angle was significantly lower in the nonsling group on the 45th day. There was no significant difference between the three groups in respect of the shoulder forward flexion at three months, six months, and one year.

Conclusion: No difference was determined between the groups at the six-month and one-year functional results. Not using a sling bandage can be recommended by reducing pain in the early postoperative period.

研究目的该研究旨在评估使用肩部吊带、带枕肩部吊带或不使用肩部吊带对关节镜下肩袖撕裂修复术后肩部功能评分和疼痛程度的影响:这项随机前瞻性研究在 2020 年 7 月至 2022 年 10 月期间对 90 名小到中度全厚肩袖撕裂患者(49 名男性,41 名女性;平均年龄:56.2±12.2 岁;范围:33 至 77 岁)进行了研究。所有患者均接受了关节镜双排修复术。非吊带组不穿吊带,吊带组穿吊带,外展枕吊带组穿带有外展枕的吊带。采用相同的康复计划。术前、术后第15天和第45天、术后3个月、6个月和1年分别记录了视觉模拟量表(VAS)评分、Constant-Murley评分、屈曲度和外展度:结果:术后第 15 天,非吊带组的 VAS 评分明显较低。在术后第 45 天,外展枕吊衣组的 Constant-Murley 评分明显更高。在三周、六个月和一年时,各组的康斯坦茨-默里评分没有明显差异。第45天时,非吊衣组的肩前屈角度明显较低。在三个月、六个月和一年时,三组之间的肩关节前屈没有明显差异:结论:各组在六个月和一年的功能结果上没有差异。建议不使用吊带绷带,以减轻术后早期的疼痛。
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引用次数: 0
Trend of effects of various kinesiotaping methods on muscle contraction performance during fatigue: A randomized, crossover study. 不同运动胶带方法对疲劳时肌肉收缩性能影响的趋势:一项随机交叉研究。
IF 1.1 4区 医学 Q3 REHABILITATION Pub Date : 2024-10-31 eCollection Date: 2024-12-01 DOI: 10.5606/tftrd.2024.13605
Huan-Jui Yeh, Ruo-Yan Wu

Objectives: This study aims to investigate the effects of different kinesiotaping methods on muscle contraction of fatigued biceps.

Patients and methods: Between April 01, 2019 to September 30, 2019, a total of 24 adults (11 males, 13 females; mean age: 31.8±6.1 years; range, 24 to 47 years) were recruited in the study. Each participant needed to receive all four types of tape attachment, including facilitation attachment (from origin to insertion), relaxation attachment (from insertion to origin), cross attachment, and control attachment after fatigue procedure. The order of taping approaches was randomly assigned. The outcome parameters were maximal isometric contraction strength, peak contraction speed, maximal 10-s power, and isokinetic contraction work.

Results: The results revealed no significant differences among the four tape attachment methods for any of the parameters. However, the facilitation attachment exhibited the highest trend of improvement in all muscle contraction performance during fatigue, and the cross attachment exhibited the lowest trend of improvement in maximal isometric contraction and speed.

Conclusion: None of the kinesiotape attachment methods significantly enhanced the contraction of fatigued muscles regardless of the attachment direction, including origin to insertion, insertion to origin and cross. Facilitation attachment exhibited the most effective trend of improvement and is, therefore, recommended for clinical applications. Cross attachment was not suggested to use due to the least effective trend.

目的:探讨不同运动贴膜方法对疲劳二头肌肌肉收缩的影响。患者与方法:2019年4月1日至2019年9月30日,共24例成人(男11例,女13例;平均年龄:31.8±6.1岁;年龄从24岁到47岁不等)。每个参与者需要接受所有四种类型的胶带连接,包括促进连接(从原点到插入),放松连接(从插入到原点),交叉连接和疲劳过程后的控制连接。录音方法的顺序是随机分配的。结果参数为最大等距收缩强度、峰值收缩速度、最大10-s功率和等距收缩功。结果:四种贴带方法在各参数上均无显著差异。在疲劳状态下,促进型附着体对肌肉收缩性能的改善趋势最高,而交叉型附着体对最大等长收缩和速度的改善趋势最低。结论:无论贴附方向是原点到止点、止点到原点、交叉,所有的运动带贴附方式都不能明显增强疲劳肌肉的收缩。疏导依恋表现出最有效的改善趋势,因此推荐临床应用。由于效果趋势不佳,不建议使用交叉附着法。
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引用次数: 0
Health literacy status and its relationship with physical therapy and rehabilitation applications in patients with knee osteoarthritis. 膝关节骨关节炎患者的健康素养状况及其与物理治疗和康复应用的关系。
IF 1.1 4区 医学 Q3 REHABILITATION Pub Date : 2024-10-31 eCollection Date: 2024-12-01 DOI: 10.5606/tftrd.2024.13546
Lale Altan, Mehmet Akif Cila

Objectives: The study aimed to determine the level of health literacy in patients with knee osteoarthritis and investigate the relationship between health literacy and exercise approaches and physical therapy use.

Patients and methods: The cross-sectional study included 203 patients (143 females, 60 males; mean age: 63.5±9.2 years) between November 2018 and September 2019. Sociodemographic data, exercise habits, the number of applications to the physical medicine and rehabilitation outpatient clinic, and physical therapy applications were recorded. The Turkish Health Literacy Scale-32 (THLS-32), was used to determine health literacy. The Western Ontario and McMaster Universities Arthritis Index (WOMAC) was used to evaluate pain and physical function. The relationship between THLS-32 and the number of admissions to the outpatient clinic, the number of physical therapy applications, exercise frequency, and WOMAC scores were investigated.

Results: The median THLS-32 of the patients was 33.8 (13-46.8). A statistically significant negative correlation was found between THLS-32 scores and the number of admissions to the physical medicine and rehabilitation outpatient clinic for knee pain in the last year, the number of physical therapies, the exercise frequency, and total WOMAC scores.

Conclusion: Increasing health literacy strengthens the capacities and participation of patients, reduces the costs of physical therapy, as well as medication costs, and consequently increases efficiency in the use of health services.

目的:本研究旨在确定膝关节骨性关节炎患者的健康素养水平,并探讨健康素养与运动方式和物理治疗使用之间的关系。患者和方法:横断面研究纳入203例患者(女性143例,男性60例;平均年龄:63.5±9.2岁(2018年11月至2019年9月)。记录社会人口统计资料、运动习惯、物理医学和康复门诊申请次数、物理治疗申请次数。采用土耳其健康素养量表-32 (THLS-32)来确定健康素养。使用西安大略和麦克马斯特大学关节炎指数(WOMAC)来评估疼痛和身体功能。探讨THLS-32与门诊就诊次数、物理治疗应用次数、运动频率和WOMAC评分之间的关系。结果:患者THLS-32的中位值为33.8(13-46.8)。THLS-32评分与近一年内膝关节疼痛就诊物理医学及康复门诊次数、物理治疗次数、运动频次、WOMAC总分呈显著负相关。结论:提高卫生素养可加强患者的能力和参与,降低物理治疗费用和药物费用,从而提高卫生服务的使用效率。
{"title":"Health literacy status and its relationship with physical therapy and rehabilitation applications in patients with knee osteoarthritis.","authors":"Lale Altan, Mehmet Akif Cila","doi":"10.5606/tftrd.2024.13546","DOIUrl":"https://doi.org/10.5606/tftrd.2024.13546","url":null,"abstract":"<p><strong>Objectives: </strong>The study aimed to determine the level of health literacy in patients with knee osteoarthritis and investigate the relationship between health literacy and exercise approaches and physical therapy use.</p><p><strong>Patients and methods: </strong>The cross-sectional study included 203 patients (143 females, 60 males; mean age: 63.5±9.2 years) between November 2018 and September 2019. Sociodemographic data, exercise habits, the number of applications to the physical medicine and rehabilitation outpatient clinic, and physical therapy applications were recorded. The Turkish Health Literacy Scale-32 (THLS-32), was used to determine health literacy. The Western Ontario and McMaster Universities Arthritis Index (WOMAC) was used to evaluate pain and physical function. The relationship between THLS-32 and the number of admissions to the outpatient clinic, the number of physical therapy applications, exercise frequency, and WOMAC scores were investigated.</p><p><strong>Results: </strong>The median THLS-32 of the patients was 33.8 (13-46.8). A statistically significant negative correlation was found between THLS-32 scores and the number of admissions to the physical medicine and rehabilitation outpatient clinic for knee pain in the last year, the number of physical therapies, the exercise frequency, and total WOMAC scores.</p><p><strong>Conclusion: </strong>Increasing health literacy strengthens the capacities and participation of patients, reduces the costs of physical therapy, as well as medication costs, and consequently increases efficiency in the use of health services.</p>","PeriodicalId":56043,"journal":{"name":"Turkish Journal of Physical Medicine and Rehabilitation","volume":"70 4","pages":"452-459"},"PeriodicalIF":1.1,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11868868/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143544671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of response to treatment in breast cancer-related lymphedema. 乳腺癌相关淋巴水肿治疗反应的评价。
IF 1.1 4区 医学 Q3 REHABILITATION Pub Date : 2024-10-31 eCollection Date: 2025-03-01 DOI: 10.5606/tftrd.2024.14691
Ezgi Yıldız Güvercin, Sibel Eyigör, Ece Çınar, Göksel Tanıgör, Menekşe Özgür İnbat, Sedef Çalışkan Kabayel

Objectives: The primary objective of this study was to assess and compare the response to the breast cancer-related lymphedema (BCRL) treatment with Breast Cancer-Related Lymphedema of the Upper Extremity (CLUE) scores, bioimpedance spectroscopy (BIS), and the volume-assessments /measurements. The secondary objective of the study was to investigate whether CLUE played a role in the treatment response and to examine its correlation with the other measures of lymphedema.

Patients and methods: Between January 2019 and June 2019, a total of 40 patients (2 males, 38 females; mean age: 57.8±12.5 years; range, 45 to 70 years) who were diagnosed with unilateral Stage 2-3 BCRL and underwent treatment were included. The patients' upper extremity volumes were assessed and the patients were evaluated with the CLUE score, the Disabilities of the Arm, Shoulder, and Hand Outcome Measure (QuickDASH) score, BIS, and hand grip strength before and after the complete decongestive therapy.

Results: Correlation analyses revealed that CLUE total score and BIS values were correlated with the reduction in the volumes (p=0.04 and p<0.001, respectively). The CLUE total score was also found to be positively correlated with the BIS values (p<0.001). Hand grip strength and QuickDASH scores were not found to be correlated with the changes in the volume and CLUE total scores.

Conclusion: The development of a structured clinical assessment such as CLUE provides clinicians for a standardized evaluation for BCRL. The diagnosis of subclinical lymphedema can be detected earlier by using the BIS and CLUE scale and lymphedema comorbidity and treatment costs can be reduced.

目的:本研究的主要目的是评估和比较乳腺癌相关淋巴水肿(BCRL)治疗与上肢乳腺癌相关淋巴水肿(CLUE)评分、生物阻抗谱(BIS)和体积评估/测量的反应。该研究的次要目的是调查CLUE是否在治疗反应中起作用,并检查其与淋巴水肿其他指标的相关性。患者与方法:2019年1月- 2019年6月,共40例患者(男2例,女38例;平均年龄:57.8±12.5岁;范围45 - 70岁),诊断为单侧2-3期BCRL并接受治疗的患者。评估患者上肢容积,并采用CLUE评分、手臂、肩部和手部残疾结局测量(QuickDASH)评分、BIS和手部握力进行评估。结果:相关分析显示CLUE总分和BIS值与BCRL体积减少相关(p=0.04和p)。结论:CLUE等结构化临床评估的发展为临床医生对BCRL进行标准化评估提供了依据。使用BIS和CLUE量表可以更早地发现亚临床淋巴水肿的诊断,并且可以降低淋巴水肿的合并症和治疗费用。
{"title":"Evaluation of response to treatment in breast cancer-related lymphedema.","authors":"Ezgi Yıldız Güvercin, Sibel Eyigör, Ece Çınar, Göksel Tanıgör, Menekşe Özgür İnbat, Sedef Çalışkan Kabayel","doi":"10.5606/tftrd.2024.14691","DOIUrl":"https://doi.org/10.5606/tftrd.2024.14691","url":null,"abstract":"<p><strong>Objectives: </strong>The primary objective of this study was to assess and compare the response to the breast cancer-related lymphedema (BCRL) treatment with Breast Cancer-Related Lymphedema of the Upper Extremity (CLUE) scores, bioimpedance spectroscopy (BIS), and the volume-assessments /measurements. The secondary objective of the study was to investigate whether CLUE played a role in the treatment response and to examine its correlation with the other measures of lymphedema.</p><p><strong>Patients and methods: </strong>Between January 2019 and June 2019, a total of 40 patients (2 males, 38 females; mean age: 57.8±12.5 years; range, 45 to 70 years) who were diagnosed with unilateral Stage 2-3 BCRL and underwent treatment were included. The patients' upper extremity volumes were assessed and the patients were evaluated with the CLUE score, the Disabilities of the Arm, Shoulder, and Hand Outcome Measure (QuickDASH) score, BIS, and hand grip strength before and after the complete decongestive therapy.</p><p><strong>Results: </strong>Correlation analyses revealed that CLUE total score and BIS values were correlated with the reduction in the volumes (p=0.04 and p<0.001, respectively). The CLUE total score was also found to be positively correlated with the BIS values (p<0.001). Hand grip strength and QuickDASH scores were not found to be correlated with the changes in the volume and CLUE total scores.</p><p><strong>Conclusion: </strong>The development of a structured clinical assessment such as CLUE provides clinicians for a standardized evaluation for BCRL. The diagnosis of subclinical lymphedema can be detected earlier by using the BIS and CLUE scale and lymphedema comorbidity and treatment costs can be reduced.</p>","PeriodicalId":56043,"journal":{"name":"Turkish Journal of Physical Medicine and Rehabilitation","volume":"71 1","pages":"109-116"},"PeriodicalIF":1.1,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12012918/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144049756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Is there a relationship between blood inflammation markers and the severity of knee osteoarthritis? 血液炎症标志物与膝关节骨关节炎的严重程度之间是否存在关系?
IF 1.1 4区 医学 Q3 REHABILITATION Pub Date : 2024-10-31 eCollection Date: 2025-03-01 DOI: 10.5606/tftrd.2024.14862
Nazlı Karaman, Aslıhan Ulusoy, Mehmet Karaman

Objectives: This study aims to evaluate the monocyte-to-lymphocyte ratio (MLR), neutrophil-to-lymphocyte ratio (NLR), plateletto-lymphocyte ratio (PLR), and C-reactive protein (CRP)-to-albumin ratio levels between individuals with mild to moderate knee osteoarthritis (OA) and those with severe knee OA.

Patients and methods: One hundred eighty-two participants (131 females, 51 males; mean age: 67.7±10.2 years; range, 43 to 91 years) affected by knee OA were involved in the cross-sectional retrospective study between January 2018 and January 2021. Kellgren and Lawrence (K-L) classification was performed in accordance with two-view (lateral and anteroposterior) plain radiograph examinations of each knee. The patients were grouped as follows: 98 patients had mild to moderate knee OA (K-L Grades 1-2), and 84 had severe knee OA (K-L Grades 3-4). Demographic data, neutrophil, monocyte, platelet, and lymphocyte levels, erythrocyte sedimentation rate, albumin, and CRP levels were documented. C-reactive protein-to-albumin ratio, NLR, MLR, and PLR levels were calculated.

Results: The MLR was significantly elevated in the severe knee OA group (p=0.047). A significant positive relationship was found with disease stage, MLR (r=0.206; p=0.005), and NLR levels (r=0.158; p=0.033). Receiver operating characteristic curve analyses for blood MLR demonstrated a sensitivity of 57% and specificity of 60%.

Conclusion: The study results suggest that while MLR and NLR may reflect the inflammatory response in knee OA, they are not highly diagnostic inflammatory markers that can be used to evaluate the severity or prognosis of the disease.

目的:本研究旨在评估轻度至中度膝骨关节炎(OA)患者与重度膝骨关节炎患者的单核细胞与淋巴细胞比值(MLR)、中性粒细胞与淋巴细胞比值(NLR)、血小板与淋巴细胞比值(PLR)和c反应蛋白与白蛋白比值(CRP)水平。患者和方法:共182例受试者(女性131例,男性51例;平均年龄:67.7±10.2岁;在2018年1月至2021年1月期间,研究人员对43至91岁的膝关节OA患者进行了横断面回顾性研究。Kellgren和Lawrence (K-L)分类是根据双视图(侧位和正位)x线平片检查进行的。患者分组如下:轻度至中度膝OA患者98例(K-L分级1-2),重度膝OA患者84例(K-L分级3-4)。记录了人口统计学数据、中性粒细胞、单核细胞、血小板和淋巴细胞水平、红细胞沉降率、白蛋白和CRP水平。计算c反应蛋白与白蛋白比值、NLR、MLR和PLR水平。结果:重度膝关节炎组MLR明显升高(p=0.047)。与疾病分期、MLR呈显著正相关(r=0.206;p=0.005), NLR水平(r=0.158;p = 0.033)。血液MLR的受试者工作特征曲线分析显示敏感性为57%,特异性为60%。结论:本研究结果提示,虽然MLR和NLR可以反映膝关节OA的炎症反应,但它们不是高度诊断的炎症标志物,不能用于评估疾病的严重程度或预后。
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引用次数: 0
The relationship of serum adiponectin and leptin levels with pain, function and intervertebral disc degeneration in patients with chronic low back pain. 慢性腰痛患者血清脂联素和瘦素水平与疼痛、功能和椎间盘退变的关系。
IF 1.1 4区 医学 Q3 REHABILITATION Pub Date : 2024-10-31 eCollection Date: 2024-12-01 DOI: 10.5606/tftrd.2024.14272
Nurcan Duran Taş, Birkan Sonel Tur, Berrin İmge Ergüder, Mustafa Durmaz

Objectives: The aim of this study was to investigate the relationship between serum adiponectin and leptin levels, which are cytokines released from fatty tissue, and pain, function and intervertebral disc degeneration (IVDD).

Patients and methods: Between January 2018 and November 2019, a total of 85 patients (34 males, 51 females; mean age: 42.1±10.7 years; range, 18 to 62 years) who were diagnosed with IVDD and 84 healthy volunteers (34 males, 50 females; mean age: 41.9±10.7 years; range, 22 to 64 years) were included in this cross-sectional study. The Visual Analog Scale (VAS, 0-10 cm) and Oswestry Disability Index (ODI) scales were used in the patient group. Serum adiponectin and leptin levels were measured in all participants. The grading of IVDD was determined using the Pfirrmann Classification.

Results: There was no significant difference in serum adiponectin (p=0.35) and leptin (p=0.19) levels between the patient group and the control group. No relationship was found between serum adiponectin and leptin levels and pain intensity (VAS), pain duration, and disability (ODI) in patients with low back pain. No relationship was found between the severity of IVDD as evidenced by magnetic resonance imaging (MRI) and adiponectin (p=0.18) and leptin (p=0.11) levels. There was a positive correlation between the severity of disc degeneration and body mass index (r=0.35, p=0.008) and waist circumference (r=0.34, p=0.01).

Conclusion: Serum adipokine levels were not associated with low back pain symptoms and IVDD severity as evidenced by MRI. These findings suggest that the effects of obesity on chronic low back pain and disc degeneration cannot be explained by systemic inflammatory effects alone.

目的:本研究的目的是探讨血清脂联素和瘦素水平(脂肪组织释放的细胞因子)与疼痛、功能和椎间盘退变(IVDD)之间的关系。患者与方法:2018年1月至2019年11月,共85例患者(男34例,女51例;平均年龄:42.1±10.7岁;年龄从18岁到62岁不等)和84名健康志愿者(34名男性,50名女性;平均年龄:41.9±10.7岁;年龄在22岁至64岁之间)的患者被纳入了这项横断面研究。患者组采用视觉模拟评分(VAS, 0 ~ 10 cm)和Oswestry残疾指数(ODI)评分。测量了所有参与者的血清脂联素和瘦素水平。IVDD的分级采用Pfirrmann分级法。结果:患者组与对照组血清脂联素(p=0.35)、瘦素(p=0.19)水平差异无统计学意义。腰痛患者血清脂联素和瘦素水平与疼痛强度(VAS)、疼痛持续时间和残疾(ODI)之间没有关系。磁共振成像(MRI)显示,IVDD的严重程度与脂联素(p=0.18)和瘦素(p=0.11)水平没有关系。椎间盘退变严重程度与体重指数(r=0.35, p=0.008)、腰围(r=0.34, p=0.01)呈正相关。结论:经MRI证实,血清脂肪因子水平与腰痛症状和IVDD严重程度无关。这些发现表明,肥胖对慢性腰痛和椎间盘退变的影响不能仅仅用全身炎症效应来解释。
{"title":"The relationship of serum adiponectin and leptin levels with pain, function and intervertebral disc degeneration in patients with chronic low back pain.","authors":"Nurcan Duran Taş, Birkan Sonel Tur, Berrin İmge Ergüder, Mustafa Durmaz","doi":"10.5606/tftrd.2024.14272","DOIUrl":"https://doi.org/10.5606/tftrd.2024.14272","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of this study was to investigate the relationship between serum adiponectin and leptin levels, which are cytokines released from fatty tissue, and pain, function and intervertebral disc degeneration (IVDD).</p><p><strong>Patients and methods: </strong>Between January 2018 and November 2019, a total of 85 patients (34 males, 51 females; mean age: 42.1±10.7 years; range, 18 to 62 years) who were diagnosed with IVDD and 84 healthy volunteers (34 males, 50 females; mean age: 41.9±10.7 years; range, 22 to 64 years) were included in this cross-sectional study. The Visual Analog Scale (VAS, 0-10 cm) and Oswestry Disability Index (ODI) scales were used in the patient group. Serum adiponectin and leptin levels were measured in all participants. The grading of IVDD was determined using the Pfirrmann Classification.</p><p><strong>Results: </strong>There was no significant difference in serum adiponectin (p=0.35) and leptin (p=0.19) levels between the patient group and the control group. No relationship was found between serum adiponectin and leptin levels and pain intensity (VAS), pain duration, and disability (ODI) in patients with low back pain. No relationship was found between the severity of IVDD as evidenced by magnetic resonance imaging (MRI) and adiponectin (p=0.18) and leptin (p=0.11) levels. There was a positive correlation between the severity of disc degeneration and body mass index (r=0.35, p=0.008) and waist circumference (r=0.34, p=0.01).</p><p><strong>Conclusion: </strong>Serum adipokine levels were not associated with low back pain symptoms and IVDD severity as evidenced by MRI. These findings suggest that the effects of obesity on chronic low back pain and disc degeneration cannot be explained by systemic inflammatory effects alone.</p>","PeriodicalId":56043,"journal":{"name":"Turkish Journal of Physical Medicine and Rehabilitation","volume":"70 4","pages":"468-475"},"PeriodicalIF":1.1,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11868858/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143544257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ultrasound-guided injections for plantar fasciitis. 超声引导下足底筋膜炎注射。
IF 1.3 4区 医学 Q3 REHABILITATION Pub Date : 2024-10-31 eCollection Date: 2025-06-01 DOI: 10.5606/tftrd.2024.15430
Pelin Analay, Ahmad J Abdulsalam, Murat Kara, Levent Özçakar
{"title":"Ultrasound-guided injections for plantar fasciitis.","authors":"Pelin Analay, Ahmad J Abdulsalam, Murat Kara, Levent Özçakar","doi":"10.5606/tftrd.2024.15430","DOIUrl":"10.5606/tftrd.2024.15430","url":null,"abstract":"","PeriodicalId":56043,"journal":{"name":"Turkish Journal of Physical Medicine and Rehabilitation","volume":"71 2","pages":"260-261"},"PeriodicalIF":1.3,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12305630/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144755229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The value of inspiratory muscle training on poststroke sarcopenia and its effect on rehabilitation outcomes: A randomized controlled trial. 吸气肌肉训练对脑卒中后肌肉疏松症的价值及其对康复效果的影响:随机对照试验
IF 1.1 4区 医学 Q3 REHABILITATION Pub Date : 2024-10-31 eCollection Date: 2024-12-01 DOI: 10.5606/tftrd.2024.13942
Qianping Zhao, Chenlan Shao, Yongzheng Wang, Weiwei Zhao, Liang Wang, Wei Zhou, Hui Gou, Yuxing Mo, Tingting Chen

Objectives: The purpose of the study was to validate the effectiveness of inspiratory muscle training (IMT) in preventing poststroke sarcopenia and to examine the impact of IMT on the prognosis for stroke recovery.

Patients and methods: In the randomized controlled trial, 367 patients with a first stroke event between December 2021 and May 2023 were randomly allocated to an experimental group and a control group. Of the patients, 329 (179 males, 150 females; mean age: 61.0±8.7 years; range, 35 to 78 years) completed the experiment and were included in the analyses (experimental group, n=164; control group, n=165). Both groups received conventional neurological rehabilitation treatment, and the experimental group also received IMT. The incidence of poststroke sarcopenia and pneumonia during four weeks of treatment were examined and compared. Additionally, an analysis was conducted on the variations between the two groups in maximal inspiratory pressure (MIP), modified Rankin scale (mRS), trunk impact scale (TIS), and modified Barthel index (MBI).

Results: Following four weeks of therapy, the experimental group experienced a reduced incidence of poststroke sarcopenia (p=0.004) and pneumonia (p=0.017) than the control group. The trial group performed better than the control group in MBI (p=0.002), TIS (p<0.001), MIP (p<0.001), and mRS (p=0.011) scores after intervention.

Conclusion: In conclusion, the findings demonstrate that early IMT can significantly lower the risk of poststroke sarcopenia and pneumonia while also improving the prognosis for stroke patients' recovery.

目的:本研究的目的是验证吸气肌训练(IMT)在预防脑卒中后肌肉减少症中的有效性,并探讨IMT对脑卒中恢复预后的影响。患者和方法:在随机对照试验中,367例于2021年12月至2023年5月期间首次发生脑卒中事件的患者被随机分为实验组和对照组。患者329例(男179例,女150例;平均年龄:61.0±8.7岁;年龄范围:35 ~ 78岁)完成实验并纳入分析(实验组,n=164;对照组,n=165)。两组患者均接受常规神经康复治疗,实验组患者同时接受IMT治疗。观察并比较4周治疗期间脑卒中后肌肉减少症和肺炎的发生率。分析两组患者最大吸气压力(MIP)、改良Rankin量表(mRS)、躯干冲击量表(TIS)和改良Barthel指数(MBI)的差异。结果:治疗4周后,实验组脑卒中后肌肉减少症(p=0.004)和肺炎(p=0.017)的发生率均低于对照组。试验组在MBI (p=0.002)、TIS (p)方面均优于对照组。结论:早期IMT可显著降低脑卒中后肌少症和肺炎的发生风险,改善脑卒中患者的康复预后。
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Turkish Journal of Physical Medicine and Rehabilitation
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