Pediatrics and Neonatology最新文献

英文中文

Navigating the metabolic shadow of neuroprotection: Antenatal magnesium sulfate and neonatal parathyroid hormone suppression 导航神经保护的代谢阴影：产前硫酸镁和新生儿甲状旁腺激素抑制。

IF 2.1 4区医学 Q2 PEDIATRICS

Pediatrics and Neonatology

Pub Date : 2026-03-01 Epub Date: 2026-01-20 DOI: 10.1016/j.pedneo.2026.01.002

Chien-Yi Chen MD, PhD

引用次数: 0

Adenotonsillar hypertrophy and frequency of vaso-occlusive crisis in patients with sickle cell disease at Mulago hospital, Kampala: An unmatched case-control study 坎帕拉Mulago医院镰状细胞病患者的腺扁桃体肥大和血管闭塞危象的频率：一项无与伦比的病例对照研究。

IF 2.1 4区医学 Q2 PEDIATRICS

Pediatrics and Neonatology

Pub Date : 2026-03-01 Epub Date: 2025-07-09 DOI: 10.1016/j.pedneo.2025.01.017

Brian Muhereza , Christopher Ndoleriire , Grace Ndeezi , Sedrack Matsiko , Stella Nabawanga , Nakasagga Esther

Objectives

This unmatched case-control study compared the mean frequency of vaso-occlusive crisis in sickle cell disease patients aged 2–17 years with adenotonsillar hypertrophy (ATH) and those without at Mulago Hospital, Kampala, Central Uganda.

Methods

From September to December 2022, sickle cell disease patients aged 2–17 years were examined using headlight illumination, a tongue depressor, and a post-nasal x-ray to diagnose adenotonsillar hypertrophy. Social-demographic characteristics, medical history, and physical examination findings were recorded using a data collection form. Patients who had bone pain requiring hospitalization in the previous 6 months were regarded as having a vaso-occlusive crisis. Those with a diagnosis of ATH (cases) were compared to those without (controls). Data were collected and managed using an open data kit (ODK) and analysed using STATA version 16. A T-test was used to compare the mean frequency of vaso-occlusive crisis between Cases and Controls.

Results

There was a significant difference in the mean frequency of painful vaso-occlusive crises suffered in the previous 6 months between cases and controls (p value = 0.018). Age of 15–18 years [OR(CI):1.56, AOR:2.59; p = 0.047], females [OR(CI):1.68, AOR: 2.35; p = 0.003], snoring [OR(CI):12.01, AOR:8.4; p < 0.0001], and children who predominately breathe through the mouth [OR(CI):12.92, AOR:5.14; p = 0.001] were all associated with increased odds of adenotonsillar hypertrophy. Among disease-modifying factors, patients who were taking hydroxyurea [OR(CI): 2.16, AOR: 2.33; p = 0.027] had higher odds of adenotonsillar hypertrophy.

Conclusion

Children with sickle cell disease and adenotonsillar hypertrophy are at risk of suffering more pain vaso-occlusive crises compared to their healthy counterparts. The presence of obstructive adenotonsillar hypertrophy in children with sickle cell disease increases sickle cell morbidity, so more attention to these children through routine screening, diagnosis, and timely therapeutic intervention could reduce the morbidity.

目的：这项无与伦比的病例对照研究比较了乌干达中部坎帕拉Mulago医院2-17岁伴有腺扁桃体肥大（ATH）的镰状细胞病患者血管闭塞危机的平均频率。方法：2022年9月至12月，对2-17岁的镰状细胞病患者进行检查，使用前照灯照明，压舌板和鼻后x线检查诊断腺扁桃体肥大。使用数据收集表记录社会人口特征、病史和体检结果。在过去6个月内有骨痛需要住院治疗的患者被认为有血管闭塞危象。将诊断为ATH的患者（病例）与未诊断为ATH的患者（对照组）进行比较。使用开放数据工具包（ODK）收集和管理数据，并使用STATA版本16进行分析。使用t检验比较病例和对照组之间血管闭塞危象的平均频率。结果：前6个月疼痛性血管闭塞危象发生率与对照组比较差异有统计学意义（p值= 0.018）。年龄15-18岁[OR(CI):1.56, AOR:2.59；p = 0.047]，女性[OR(CI):1.68, AOR: 2.35；p = 0.003]，打鼾[OR(CI):12.01, AOR:8.4；结论：与健康儿童相比，镰状细胞病和腺扁桃体肥大的儿童有更多的疼痛血管闭塞危象的风险。镰状细胞病患儿存在阻塞性腺扁桃体肥大会增加镰状细胞的发病率，因此，通过常规筛查、诊断和及时的治疗干预，增加对这些患儿的关注，可以降低发病率。

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引用次数: 0

Unlocking the first year: Immunologic, hematologic, and lung health challenges in premature infants 解锁第一年：早产儿免疫、血液学和肺部健康挑战。

IF 2.1 4区医学 Q2 PEDIATRICS

Pediatrics and Neonatology

Pub Date : 2026-03-01 Epub Date: 2025-10-24 DOI: 10.1016/j.pedneo.2025.04.007

Sui-Ling Liao , Li-Chen Chen , Ming-Han Tsai , Man-Chin Hua , Chi Lin , Tsung-Chieh Yao , Kuan-Wen Su , Kuo-Wei Yeh , Jing-Long Huang , Shen-Hao Lai

Background

Data on the development of immune, hematologic, and lung function in preterm infants beyond the early postnatal period are limited. This study aimed to determine whether these systems in preterm infants mature to levels comparable to full-term infants by one year of age.

Methods

Toll-like receptor (TLR)-induced cytokine responses, prevalence of iron deficiency anemia, and infant lung function (ILFT) measurements were investigated in premature and full-term infants at 1 year of age.

Results

By the corrected age of 1 year, the prevalence of iron deficiency anemia was comparable between full-term (18.4 %) and preterm infants (22.7 %). However, preterm infants exhibited lower IL-6 and IL-10 responses to TLR7/8 and phytohemagglutinin stimulation compared to their full-term counterparts. While ILFT measurements showed no significant overall differences, infants born before 34 weeks of gestation had lower tidal volumes than late-preterm and full-term infants (p < 0.031).

Conclusion

There was no significant difference in the prevalence of anemia between full-term and preterm infants. However, preterm infants, especially those born before 34 weeks of gestation, may continue to show unique immunologic and pulmonary function profiles beyond infancy. These findings highlight the need for ongoing monitoring of preterm infants to address their unique health challenges.

背景：关于出生后早期早产儿免疫、血液学和肺功能发展的数据有限。本研究旨在确定早产儿的这些系统在一岁时是否成熟到与足月婴儿相当的水平。方法：研究1岁早产儿和足月婴儿toll样受体（TLR）诱导的细胞因子反应、缺铁性贫血的患病率和婴儿肺功能（ILFT）测量。结果：到1岁矫正时，缺铁性贫血的患病率在足月婴儿（18.4%）和早产儿（22.7%）之间是相当的。然而，与足月婴儿相比，早产儿对TLR7/8和植物血凝素刺激表现出较低的IL-6和IL-10反应。虽然ILFT测量显示没有显著的总体差异，但在妊娠34周之前出生的婴儿潮汐量低于晚早产儿和足月婴儿(p结论：足月婴儿和早产儿之间贫血患病率没有显著差异。然而，早产儿，特别是那些在妊娠34周前出生的早产儿，在婴儿期后可能继续表现出独特的免疫和肺功能。这些发现强调需要对早产儿进行持续监测，以解决他们独特的健康挑战。

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引用次数: 0

Alteration of the gut microbiota in children following SARS- CoV-2 infection in 2021 and 2022 pandemics 2021年和2022年大流行中SARS- CoV-2感染后儿童肠道微生物群的变化

IF 2.1 4区医学 Q2 PEDIATRICS

Pediatrics and Neonatology

Pub Date : 2026-03-01 Epub Date: 2025-07-22 DOI: 10.1016/j.pedneo.2025.06.005

Geng-Hao Bai , Hung-Yen Cheng , Sheng-Chieh Lin , Yi-Hsiang Hsu , Yin-Tai Tsai , Yu-Chen Yang , Yuan-Hung Wang , Shih-Yen Chen

Background

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused significant mortality and morbidity worldwide. Although the role of intestinal microbiota in adults with SARS-CoV-2 infection has been studied, limited research exists on children. This study was performed to investigate the clinical significance and association of intestinal microbiota composition in children with SARS-CoV-2 infection during the 2021 and 2022 pandemic waves in Taiwan.

Methods

Pediatric patients diagnosed with SARS-CoV-2 via real-time reverse transcription polymerase chain reaction were randomly enrolled from Shang-Ho Hospital. The study period covered the two SARS-CoV-2 outbreaks in Taiwan in 2021 and 2022. Medical records were reviewed for clinical manifestations and cycle threshold (Ct) values, and fecal microbiota enrichment analysis was performed using next-generation sequencing and the linear discriminant analysis effect size method.

Results

In total, 21 pediatric patients with confirmed SARS-CoV-2 infection were enrolled—8 from the 2021 pandemic and 13 from the 2022 pandemic. Compared with the 2021 cohort, children infected in 2022 exhibited significantly higher rates of hospitalization (P < 0.001), high fever (>39 °C) (P = 0.0002), and dehydration (P = 0.0001). By contrast, a higher prevalence of a family history of COVID-19 was observed in the 2021 group (P = 0.018). Permutational multivariate analysis of group dispersions (β-dispersion analysis) revealed a trend toward increased β-diversity in the 2021 group (P = 0.06394), along with a higher relative abundance of the genera Peptoniphilus, Fusobacterium, and Morganella.

Conclusion

Our study highlights differences in clinical presentations between the 2021 and 2022 SARS-CoV-2 pandemic waves and suggests an impact of infection on the gut microbiota in children, with marginally higher β-diversity observed in 2021. These findings provide a foundation for future research into the role of intestinal microbiota in pediatric SARS-CoV-2 infection.

背景：严重急性呼吸综合征冠状病毒2 （SARS-CoV-2）在世界范围内造成了显著的死亡率和发病率。虽然已经研究了肠道微生物群在成人SARS-CoV-2感染中的作用，但对儿童的研究有限。本研究旨在探讨台湾地区2021年和2022年大流行期间SARS-CoV-2感染儿童肠道菌群组成的临床意义及相关性。方法：随机选取上海上合医院经实时逆转录聚合酶链反应诊断为SARS-CoV-2的患儿。研究期间包括2021年和2022年在台湾发生的两次SARS-CoV-2疫情。临床表现和周期阈值（Ct）的医疗记录进行审查，并进行粪便微生物群富集分析使用下一代测序和线性判别分析效应量法。结果：共纳入21例确诊为SARS-CoV-2感染的儿科患者，其中8例来自2021年大流行，13例来自2022年大流行。与2021年的队列相比，2022年感染的儿童的住院率（P 39°C）（P = 0.0002）和脱水率（P = 0.0001）明显更高。相比之下，2021年组中有COVID-19家族史的患病率更高（P = 0.018）。群体分散度的多变量排列分析（β-分散度分析）显示，2021组的β-多样性呈增加趋势（P = 0.06394）， Peptoniphilus、Fusobacterium和Morganella属的相对丰度也较高。结论：我们的研究强调了2021年和2022年SARS-CoV-2大流行波的临床表现差异，并提示感染对儿童肠道微生物群的影响，2021年观察到的β多样性略高。这些发现为进一步研究肠道菌群在小儿SARS-CoV-2感染中的作用奠定了基础。

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引用次数: 0

Time is bowel: Recognizing a strangulated closed-loop obstruction in a child 时间就是肠道：识别儿童的绞窄性闭环阻塞。

IF 2.1 4区医学 Q2 PEDIATRICS

Pediatrics and Neonatology

Pub Date : 2026-03-01 Epub Date: 2025-12-31 DOI: 10.1016/j.pedneo.2025.12.002

Chih-Hao Wang , Pei-Shan Tsai , Po-Chih Lin , Yi-Ting Yeh

引用次数: 0

Response to comments on “Clinical and methodological considerations on nasal high-frequency oscillation in very-low-birth-weight infants with RDS” 对“极低出生体重儿RDS鼻高频振荡的临床和方法学考虑”评论的回应。

IF 2.1 4区医学 Q2 PEDIATRICS

Pediatrics and Neonatology

Pub Date : 2026-03-01 Epub Date: 2026-01-22 DOI: 10.1016/j.pedneo.2025.12.006

Buu Quoc Dang , Thu-Tinh Nguyen

引用次数: 0

Nationwide singleton birth weight percentiles for gestational age in Taiwan in 2008–2017 台湾2008-2017年全国单胎出生体重百分位数。

IF 2.1 4区医学 Q2 PEDIATRICS

Pediatrics and Neonatology

Pub Date : 2026-03-01 Epub Date: 2025-06-20 DOI: 10.1016/j.pedneo.2025.03.010

Jia-Ling Wu , Chun-Heng Kuo , Chi-Nien Chen , Po-Nien Tsao , Chung-Yi Li , Hung-Yuan Li

Background

Establishing updated, population-based birth weight charts is essential for accurate classification of neonates as small for gestational age (SGA) or large for gestational age (LGA). The current birth weight charts in Taiwan have not been updated for over two decades, and the previous report has found an increasing trend in neonates with low birth weight (LBW) and preterm birth. This study aimed to develop updated birth weight charts and explore trends in LBW and preterm births using nationwide data.

Methods

This study analyzed 1,913,124 singleton live births from the data set of Taiwan Birth Notifications between 2008 and 2017. Birth weight percentiles were calculated for each completed gestational week and gender. A nonlinear, resistant smoothing technique was applied to develop smoothed birth weight-for-gestational-age percentile curves.

Results

The cohort included 994,175 male neonates and 918,949 female neonates. During the study period, the annual mean birth weight decreased significantly from 3098.10g to 3049.88g (p < 0.0001). A significant increase in the annual rate of LBW was observed, rising from 5.59 % in 2008 to 6.98 % in 2017 (p < 0.0001), coinciding with a slight and significant decrease in gestational age (p < 0.001) and a significantly declining proportion of foreign-born mothers (p < 0.0001) during the same period. In addition, birth weight percentiles by weeks of gestation in male and female singleton births were reported.

Conclusion

This study developed an updated, nationwide birth weight chart for Taiwan. An increasing rate of LBW was observed from 2008 to 2017. Further investigation into maternal and environmental factors contributing to these trends is warranted.

背景：建立更新的、基于人群的出生体重图对于准确地将新生儿分类为小胎龄（SGA）或大胎龄（LGA）至关重要。台湾目前的出生体重图表已超过二十年未更新，而先前的报告发现低出生体重（LBW）和早产的新生儿呈上升趋势。本研究旨在利用全国数据编制最新的出生体重图，并探讨低体重和早产的趋势。方法：本研究分析台湾省2008 - 2017年出生通报数据集中的1913,124例单胎活产婴儿。计算每个完成妊娠周和性别的出生体重百分位数。采用非线性抗平滑技术对出生体重-胎龄百分位数曲线进行了平滑处理。结果：该队列包括994,175名男婴和918,949名女婴。在研究期间，年平均出生体重从3098.10g显著下降到3049.88g (p)。结论：本研究为台湾建立了更新的全国出生体重图。从2008年到2017年，LBW呈上升趋势。有必要进一步调查造成这些趋势的产妇和环境因素。

{"title":"Nationwide singleton birth weight percentiles for gestational age in Taiwan in 2008–2017","authors":"Jia-Ling Wu , Chun-Heng Kuo , Chi-Nien Chen , Po-Nien Tsao , Chung-Yi Li , Hung-Yuan Li","doi":"10.1016/j.pedneo.2025.03.010","DOIUrl":"10.1016/j.pedneo.2025.03.010","url":null,"abstract":"<div><h3>Background</h3><div>Establishing updated, population-based birth weight charts is essential for accurate classification of neonates as small for gestational age (SGA) or large for gestational age (LGA). The current birth weight charts in Taiwan have not been updated for over two decades, and the previous report has found an increasing trend in neonates with low birth weight (LBW) and preterm birth. This study aimed to develop updated birth weight charts and explore trends in LBW and preterm births using nationwide data.</div></div><div><h3>Methods</h3><div>This study analyzed 1,913,124 singleton live births from the data set of Taiwan Birth Notifications between 2008 and 2017. Birth weight percentiles were calculated for each completed gestational week and gender. A nonlinear, resistant smoothing technique was applied to develop smoothed birth weight-for-gestational-age percentile curves.</div></div><div><h3>Results</h3><div>The cohort included 994,175 male neonates and 918,949 female neonates. During the study period, the annual mean birth weight decreased significantly from 3098.10g to 3049.88g (p < 0.0001). A significant increase in the annual rate of LBW was observed, rising from 5.59 % in 2008 to 6.98 % in 2017 (p < 0.0001), coinciding with a slight and significant decrease in gestational age (p < 0.001) and a significantly declining proportion of foreign-born mothers (p < 0.0001) during the same period. In addition, birth weight percentiles by weeks of gestation in male and female singleton births were reported.</div></div><div><h3>Conclusion</h3><div>This study developed an updated, nationwide birth weight chart for Taiwan. An increasing rate of LBW was observed from 2008 to 2017. Further investigation into maternal and environmental factors contributing to these trends is warranted.</div></div>","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":"67 2","pages":"Pages 133-138"},"PeriodicalIF":2.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144546309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Horseshoe pulmonary sequestration 马蹄肺隔离。

IF 2.1 4区医学 Q2 PEDIATRICS

Pediatrics and Neonatology

Pub Date : 2026-03-01 Epub Date: 2026-01-03 DOI: 10.1016/j.pedneo.2025.11.007

Lei Fan, Zhaotian Liu, Jianshe Zhao, Yi Lu

引用次数: 0

Optimizing oxygen delivery for neonatal resuscitation through self-inflating bags in settings without air-oxygen blenders 在没有空气-氧气混合器的情况下，通过自动充气袋优化新生儿复苏的氧气输送。

IF 2.1 4区医学 Q2 PEDIATRICS

Pediatrics and Neonatology

Pub Date : 2026-03-01 Epub Date: 2025-07-05 DOI: 10.1016/j.pedneo.2025.05.007

Tzu-Ching Sung , Hsiang-Chin Hsu , Yun-Ju Chen , Yuh-Jyh Lin , Chyi-Her Lin

Background

Resuscitation guidelines recommend fractional inspired oxygen (FiO₂) of 0.21–0.30 for infants at <35 weeks gestation. However, without an air-oxygen blender, an FiO₂ < 0.3 is difficult to achieve with a self-inflating resuscitation bag (SIRB). This study investigated the effects of adjustments to the oxygen flow rate (FR), peak inspiratory pressure (PIP), and ventilation rate (VR) on FiO₂ levels with SIRBs.

Methods

Two nondisposable SIRBs were used: a 280 mL bag (40 cm H₂O pop-off valve) and a 62 mL bag with a reservoir tube (25 and 40 cm H₂O pop-off valve). Both SIRBs were supplied with 100 % oxygen and connected to a flow meter, pressure gauge, oxygen analyzer, and test lung. FR (0.5, 1, 2, 5, or 10 L/min), PIP (20–29, 30–39, or ≥ 40 cm H₂O), and VR (40, 50, or 60/min) parameters were tested sequentially. FiO₂ was measured every 30 s for 150 s total, and each parameter combination was evaluated three times. Data were analyzed with a stepwise generalized linear model.

Results

FiO₂ levels stabilized after 60–90 s of bagging across all settings, ranging from 0.27 to 0.82 and 0.40–1.0 for the 280 and 62 mL SIRBs, respectively. A higher FR increased FiO₂ levels, whereas a higher PIP decreased FiO₂ levels. VR increases did not affect FiO₂ except at an FR ≥ 5 L/min. An FiO₂ < 0.30 was achievable only with the 280 mL SIRB at 0.5 L/min FR and PIP >40 cm H₂O. FR had the greatest effect (R² = 0.4916) on FiO₂. SIRB, PIP, VR, and bagging duration further improved the model's predictive power (R² = 0.9578).

Conclusions

A suitable SIRB, FR, PIP, and VR are crucial for FiO₂ titration in resuscitation. Further validation of these findings in clinical studies is warranted.

背景：复苏指南建议，对于2岁< 0.3的婴儿，分数吸入氧（FiO2）为0.21-0.30，使用自充气复苏袋（SIRB）很难实现。本研究探讨了氧流量（FR）、吸气峰值压力（PIP）和通气量（VR）的调整对sibr患者FiO2水平的影响。方法：使用2个非一次性sibr: 280 mL袋（40 cm H2O弹出阀）和62 mL袋（25和40 cm H2O弹出阀）。两个sirb都提供100%氧气，并连接到流量计、压力表、氧气分析仪和测试肺。依次检测FR（0.5、1、2、5或10 L/min）、PIP（20-29、30-39或≥40 cm H2O）和VR（40、50或60/min）参数。FiO2每30 s测量一次，共150 s，每个参数组合评估3次。采用逐步广义线性模型对数据进行分析。结果：在所有设置下，在装袋60-90秒后，FiO2水平稳定，280 mL和62 mL sibr分别为0.27至0.82和0.40-1.0。较高的FR增加FiO2水平，而较高的PIP降低FiO2水平。除FR≥5 L/min外，VR升高不影响FiO2。FiO2 < 0.30只有在280 mL SIRB、0.5 L/min FR和PIP bb0 40 cm H2O条件下才能实现。FR对FiO2的影响最大（R2 = 0.4916）。SIRB、PIP、VR和装袋时间进一步提高了模型的预测能力（R2 = 0.9578）。结论：适宜的SIRB、FR、PIP和VR对复苏中FiO2滴定至关重要。在临床研究中进一步验证这些发现是有必要的。

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引用次数: 0

Quantification of post-COVID-19 symptoms and pulmonary functional capacity in children with COVID-19 COVID-19儿童COVID-19后症状和肺功能的量化

IF 2.1 4区医学 Q2 PEDIATRICS

Pediatrics and Neonatology

Pub Date : 2026-03-01 Epub Date: 2025-07-30 DOI: 10.1016/j.pedneo.2024.08.009

Jeng-Hung Wu , Ching-Chia Wang , Yi Pan , Frank Leigh Lu , En-Ting Wu

Background

Children with coronavirus disease 2019 (COVID-19) present with mild but persistent pulmonary disease. Limited studies have explored post-infection aerobic capacity and quantification of symptoms. This study aimed to quantify post-COVID-19 fatigue, dyspnea, and pulmonary functional capacity while exploring associated factors.

Methods

This prospective cohort study enrolled 6–12-year-old children with COVID-19. Participants’ parents completed questionnaires assessing post-COVID-19 fatigue (Pediatric Quality of Life Inventory Multidimensional Fatigue Scale, including general, sleep, and cognition, with high scores indicating less severity) and dyspnea (Modified Medical Research Council Dyspnea Scale). Six-minute walk tests (6MWT) were performed with records of distances to assess pulmonary functional capacity.

Results

This study enrolled 21 children with seven (33 %) exhibiting persistent symptoms post-COVID-19 infection. These children had a lower COVID-19 vaccination rate (57 % vs. 100 %, p = 0.026) and a reduced sleep-related fatigue scale (69.0 vs. 80.4, p = 0.043) than those without persistent symptoms. Nineteen children performed the 6MWT achieving a mean distance of 623 m (standard deviation, SD: 231) and a mean Z-score of 2.8 (SD: 1.4). Linear regression analysis identified older age as a risk factor for fatigue (β-coefficient −0.45, p = 0.040), and the cognitive fatigue scale correlated with the Z-score of the 6MWT distances (β-coefficient: −0.56, p = 0.013).

Conclusion

Children with post-COVID-19 symptoms had lower vaccination rates and higher sleep-related fatigue levels. Older children experienced more severe fatigue and the performance of 6MWT correlated with cognition-related fatigue scale.

背景：2019冠状病毒病（COVID-19）患儿表现为轻度但持续性肺部疾病。有限的研究探讨了感染后的有氧能力和症状的量化。本研究旨在量化covid -19后的疲劳、呼吸困难和肺功能，同时探索相关因素。方法：这项前瞻性队列研究纳入了6-12岁的COVID-19儿童。参与者的父母完成了评估covid -19后疲劳的问卷（儿科生活质量量表多维疲劳量表，包括一般、睡眠和认知，得分高表明严重程度较低）和呼吸困难（修订医学研究委员会呼吸困难量表）。进行6分钟步行试验（6MWT），记录距离以评估肺功能容量。结果：本研究纳入了21名儿童，其中7名（33%）在covid -19感染后表现出持续症状。与没有持续症状的儿童相比，这些儿童的COVID-19疫苗接种率较低（57%对100%，p = 0.026），睡眠相关疲劳量表较低（69.0对80.4,p = 0.043）。19名儿童进行了6MWT，平均距离为623 m（标准差，SD: 231），平均z分数为2.8 （SD: 1.4）。线性回归分析发现，年龄是疲劳的危险因素（β-系数为-0.45,p = 0.040），认知疲劳量表与6MWT距离的z -得分相关（β-系数为-0.56,p = 0.013）。结论：出现covid -19后症状的儿童疫苗接种率较低，睡眠相关疲劳水平较高。年龄越大的儿童疲劳程度越严重，6MWT的表现与认知相关疲劳量表相关。

{"title":"Quantification of post-COVID-19 symptoms and pulmonary functional capacity in children with COVID-19","authors":"Jeng-Hung Wu , Ching-Chia Wang , Yi Pan , Frank Leigh Lu , En-Ting Wu","doi":"10.1016/j.pedneo.2024.08.009","DOIUrl":"10.1016/j.pedneo.2024.08.009","url":null,"abstract":"<div><h3>Background</h3><div>Children with coronavirus disease 2019 (COVID-19) present with mild but persistent pulmonary disease. Limited studies have explored post-infection aerobic capacity and quantification of symptoms. This study aimed to quantify post-COVID-19 fatigue, dyspnea, and pulmonary functional capacity while exploring associated factors.</div></div><div><h3>Methods</h3><div>This prospective cohort study enrolled 6–12-year-old children with COVID-19. Participants’ parents completed questionnaires assessing post-COVID-19 fatigue (Pediatric Quality of Life Inventory Multidimensional Fatigue Scale, including general, sleep, and cognition, with high scores indicating less severity) and dyspnea (Modified Medical Research Council Dyspnea Scale). Six-minute walk tests (6MWT) were performed with records of distances to assess pulmonary functional capacity.</div></div><div><h3>Results</h3><div>This study enrolled 21 children with seven (33 %) exhibiting persistent symptoms post-COVID-19 infection. These children had a lower COVID-19 vaccination rate (57 % vs. 100 %, p = 0.026) and a reduced sleep-related fatigue scale (69.0 vs. 80.4, p = 0.043) than those without persistent symptoms. Nineteen children performed the 6MWT achieving a mean distance of 623 m (standard deviation, SD: 231) and a mean Z-score of 2.8 (SD: 1.4). Linear regression analysis identified older age as a risk factor for fatigue (β-coefficient −0.45, p = 0.040), and the cognitive fatigue scale correlated with the Z-score of the 6MWT distances (β-coefficient: −0.56, p = 0.013).</div></div><div><h3>Conclusion</h3><div>Children with post-COVID-19 symptoms had lower vaccination rates and higher sleep-related fatigue levels. Older children experienced more severe fatigue and the performance of 6MWT correlated with cognition-related fatigue scale.</div></div>","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":"67 2","pages":"Pages 190-194"},"PeriodicalIF":2.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144857117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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