Pediatrics and Neonatology最新文献

英文中文

Comparative analysis of hematology parameters and symptoms in children with HCMV infection across different age groups 不同年龄组HCMV感染儿童血液学参数及症状的比较分析

IF 2.1 4区医学 Q2 PEDIATRICS

Pediatrics and Neonatology

Pub Date : 2026-01-01 DOI: 10.1016/j.pedneo.2025.02.003

Yingying Wang , Zhou Zheng , Lijuan Kan , Dan Xiong , Xiuming Zhang

Background

Children are vulnerable to Human Cytomegalovirus (HCMV) infection, the majority of infections of which are asymptomatic, which often leads to missed diagnoses. Missing early diagnosis and treatment may have adverse consequences for the child. Therefore, the purpose of this study was to evaluate the hematological parameters and clinical symptoms in HCMV-infected infants and children under 6 years old.

Method

This study conducted a retrospective analysis of laboratory data from 223 children aged 0 day to 6 years who had undergone urine HCMV-DNA test at the Luohu People's Hospital. We categorized children into two groups based on the results of their urine HCMV-DNA test: the HCMV infected group and the HCMV non-infected group. Furthermore, we divided them into different age groups: 0–21 days, 22 days–<6 months, 6 months–<1 year, 1–<2 years, and 2–6 years.

Results

The lymphocyte percentage (L%) and lymphocyte count (LYM) of HCMV-infected children aged 0–6y were significantly higher than those of the control group (P < 0.05). The alanine aminotransferase (ALT) and γ-glutamyl transferase (GGT) of HCMV-infected children aged 0–<1y and aspartate aminotransferase (AST) of HCMV-infected children aged 0d–<2y were significantly higher than those of the control group (P < 0.05), but this difference was not evident among older children. We found that GGT was highest in HCMV-infected children aged 0–21d and decreased with the increase of age. Furthermore, our data indicate that older children exhibit a reduced diversity of illnesses after infection.

Conclusion

We conclude that HCMV infection can increase lymphocytes in the peripheral blood of children aged from 0 to 6 years and can cause more severe hepatobiliary injury in younger children.

背景：儿童易受人类巨细胞病毒（HCMV）感染，大多数感染无症状，这往往导致漏诊。错过早期诊断和治疗可能对儿童造成不良后果。因此，本研究的目的是评估hcmv感染的婴儿和6岁以下儿童的血液学参数和临床症状。方法：回顾性分析罗湖市人民医院223例0 ~ 6岁儿童尿液HCMV-DNA检测的实验室资料。我们根据尿液HCMV- dna检测结果将儿童分为两组：HCMV感染组和HCMV未感染组。结果：0 ~ 6岁HCMV感染患儿外周血淋巴细胞百分率（L%）和淋巴细胞计数（LYM）均显著高于对照组(P)。结论：HCMV感染可使0 ~ 6岁患儿外周血淋巴细胞升高，低龄患儿肝胆损伤更严重。

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引用次数: 0

Preventive effects of Larazotide acetate (AT-1001) on non-alcoholic fatty liver diseases (NAFLD) in a mouse model 醋酸拉唑肽（AT-1001）对小鼠非酒精性脂肪性肝病（NAFLD）的预防作用

IF 2.1 4区医学 Q2 PEDIATRICS

Pediatrics and Neonatology

Pub Date : 2026-01-01 DOI: 10.1016/j.pedneo.2025.01.016

Yu-Chen Huang , Jen-Shiu Chiang Chiau , Mei-Lein Cheng , Hung-Chang Lee , Wai-Tao Chan , Szu-Wen Chang , Yu-Cheng Chen , Chun-Yan Yeung , Chuen-Bin Jiang

引用次数: 0

Hepatopathy-thrombocytopenia syndrome and disease relapse in pediatric wilms tumor: A 20-year retrospective analysis in a single center 肝病-血小板减少综合征和儿童肾母细胞瘤的疾病复发：单中心20年回顾性分析

IF 2.1 4区医学 Q2 PEDIATRICS

Pediatrics and Neonatology

Pub Date : 2026-01-01 DOI: 10.1016/j.pedneo.2024.11.010

Chi-Yen Chen , Jui-Ju Tseng , Ke-Xin Chang , Chiung-Wen Liang , Li-Min Chen , Te-Kau Chang , Fang-Liang Huang

Background

Wilms tumor (WT) is the most common renal malignancy in children. With current treatments, the 5-year overall survival (OS) rate for children with WT is approximately 90 %. However, nearly 15 % of patients experience disease recurrence. A rare but severe treatment-related complication is hepatopathy-thrombocytopenia syndrome (HTS). In this study, we evaluated the characteristics, treatment outcomes, and complications of patients with WT, particularly focusing on HTS and relapse cases.

Methods

We conducted a retrospective observational study of WT cases from 2001 to 2021 at a tertiary care hospital in central Taiwan. Patient records were examined to collect information on age at diagnosis, sex, disease stage, treatment, tumor characteristics, treatment complications, and outcomes.

Results

We included 23 pediatric patients with untreated WT. Their median follow-up duration was 102 months. Their median age was 3.4 (0.8–10.8) years. The most common tumor stage was Stage II (9/23, 39.1 %), followed by Stage I (7/23, 30.4 %), III (5/23, 21.7 %), IV (1/23, 4.3 %), and V (1/23, 4.3 %). One patient with Stage IV disease had distant metastasis of the right atrium. Two patients with Stage III disease developed HTS during treatment. Relapse occurred in 3 (13 %) of 23 patients, and the average time to relapse from the initial diagnosis was 25 (range, 9–44) months. All patients survived during the follow-up period, but one continued to experience refractory lung recurrence. Two patients underwent hematopoietic stem cell transplantation for relapse/refractory disease. No disease-related mortality was noted. The 5-year event-free survival and OS rates were 86.2 % and 100 %, respectively.

Conclusion

Although WT generally has a favorable prognosis, physicians should remain mindful of potential treatment-associated complications and the risk of relapse when managing WT in children.

背景：肾母细胞瘤（Wilms tumor， WT）是儿童最常见的肾脏恶性肿瘤。在目前的治疗下，WT患儿的5年总生存率（OS）约为90%。然而，近15%的患者经历疾病复发。一种罕见但严重的治疗相关并发症是肝病-血小板减少综合征（HTS）。在这项研究中，我们评估了WT患者的特征、治疗结果和并发症，特别关注了HTS和复发病例。方法：我们对台湾中部一家三级医院2001年至2021年的WT病例进行回顾性观察研究。检查患者记录以收集诊断时的年龄、性别、疾病分期、治疗、肿瘤特征、治疗并发症和结局等信息。结果：我们纳入了23例未经治疗的WT患儿，他们的中位随访时间为102个月。中位年龄为3.4（0.8-10.8）岁。最常见的肿瘤分期为II期（9/ 23,39.1%），其次为I期（7/ 23,30.4%）、III期（5/ 23,21.7%）、IV期（1/ 23,4.3%）和V期（1/ 23,4.3%）。1例IV期患者右心房有远处转移。两名III期患者在治疗期间出现HTS。23例患者中有3例（13%）复发，从初次诊断到复发的平均时间为25个月（范围9-44个月）。所有患者在随访期间均存活，但有1例持续出现难治性肺复发。2例患者因复发/难治性疾病接受了造血干细胞移植。未发现与疾病相关的死亡率。5年无事件生存率和总生存率分别为86.2%和100%。结论：虽然WT通常具有良好的预后，但医生在处理儿童WT时应注意潜在的治疗相关并发症和复发风险。

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引用次数: 0

Trends in antibiotic resistance of urinary tract infections in young children, 2010–2023 2010-2023年幼儿尿路感染抗生素耐药性趋势

IF 2.1 4区医学 Q2 PEDIATRICS

Pediatrics and Neonatology

Pub Date : 2026-01-01 DOI: 10.1016/j.pedneo.2025.03.006

Peong Gang Park , Seon Hee Lim , Ji Yeon Song , Yo Han Ahn , Seong Heon Kim , Hee Gyung Kang

Background

Urinary tract infections (UTI) are the leading cause of severe bacterial infection in children under 24 months. Increasing antimicrobial resistance, particularly to third-generation cephalosporins, is a growing concern. This study examines recent resistance trends in young children with UTI in Korea.

Methods

A retrospective study was conducted on children under 24 months who presented with UTI to three university hospitals in Korea between 2010 and 2023. Children diagnosed with UTI and/or acute pyelonephritis with gram-negative bacteria identified in urine cultures were included. Antibiotic susceptibility data of antibiotics commonly used to treat pediatric UTI were collected, focusing on third-generation cephalosporins. Trends in resistance were analyzed according to age group, causative organism, and the presence of congenital anomalies of the kidney and urinary tract.

Results

A total of 10,029 children were included, with a mean age of 4.0 months (IQR, 2.3–6.6 months); 67.9 % were male, and Escherichia coli accounted for 84 % of isolates. Resistance to cefotaxime increased significantly from around 10 % in the early 2010s to over 30 % after 2020. This increasing trend was consistent regardless of age group, causative organism, or presence of congenital anomalies of the kidney and urinary tract, although it showed a decreasing trend after 2021.

Conclusions

There has been a significant rise in resistance to third-generation cephalosporins among young children with UTI in Korea over the past decade. These findings suggest a need to reconsider the empirical use of these antibiotics and consider alternative treatments to effectively manage UTI and prevent kidney scarring in Korean children.

背景：尿路感染（UTI）是24个月以下儿童严重细菌感染的主要原因。日益增加的抗菌素耐药性，特别是对第三代头孢菌素的耐药性日益引起关注。本研究调查了韩国尿路感染幼儿近期的耐药性趋势。方法：对2010年至2023年间在韩国三所大学医院就诊的24个月以下尿路感染患儿进行回顾性研究。被诊断为尿路感染和/或急性肾盂肾炎的儿童在尿培养中发现革兰氏阴性细菌。收集儿童尿路感染常用抗生素的药敏数据，重点收集第三代头孢菌素类药物。根据年龄、病原菌、有无肾、尿路先天性异常等因素分析耐药趋势。结果：共纳入患儿10029例，平均年龄4.0个月（IQR, 2.3 ~ 6.6个月）；男性占67.9%，大肠杆菌占84%。对头孢噻肟的耐药性显著增加，从2010年代初的10%左右增加到2020年后的30%以上。尽管在2021年之后呈下降趋势，但无论年龄组、致病生物或是否存在肾脏和泌尿道先天性异常，这种增长趋势都是一致的。结论：在过去十年中，韩国尿路感染幼儿对第三代头孢菌素的耐药性显著上升。这些发现表明，需要重新考虑这些抗生素的经验性使用，并考虑替代治疗，以有效地管理尿路感染和预防韩国儿童肾脏瘢痕形成。

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引用次数: 0

Cardiac tamponade as a rare life-threatening complication following umbilical venous catheter repositioning: a case report 心脏填塞是一种罕见的危及生命的并发症后，脐静脉导管重新定位：1例报告

IF 2.1 4区医学 Q2 PEDIATRICS

Pediatrics and Neonatology

Pub Date : 2026-01-01 DOI: 10.1016/j.pedneo.2025.08.007

Felix Hutmacher , Barbara Brotschi , Daniel Quandt , Martin Schweiger , Philipp Meyer , Philipp Baumann

引用次数: 0

Atypical presentations and neurosurgical Synergy in the treatment of paravertebral tumors in children: Lessons from a single institution 儿童椎旁肿瘤的非典型表现和神经外科协同治疗：来自单一机构的经验教训。

IF 2.1 4区医学 Q2 PEDIATRICS

Pediatrics and Neonatology

Pub Date : 2026-01-01 DOI: 10.1016/j.pedneo.2025.02.002

Wei-Hsiang Su , Yu-Cheng Chou , Chia-Man Chou , Sheng-Yang Huang , Hou-Chuan Chen

Background

This study aims to evaluate the surgical management and outcomes of pediatric paravertebral tumors, particularly focusing on dumbbell tumors, within a single medical center.

Methods

Employing a retrospective analysis at Taichung Veterans General Hospital from January 2016 to February 2022, we included pediatric patients diagnosed with paravertebral tumors confirmed via MRI and histopathology, who underwent surgical treatment. We aimed to assess the extent of tumor resection as the primary outcome, with postoperative complications, recurrence rates, and neurological function as secondary outcomes, utilizing descriptive statistics.

Results

In the given period, four pediatric patients, two males and two females aged 53–204 months, were treated at our institute for paravertebral tumors using CT and MRI for diagnosis. The tumors were located in the posterior mediastinum (3 patients) and retroperitoneum (1 patient), with varied MRI findings. Diagnoses included Ganglioneuroma, Schwannoma, Plexiform neurofibroma, and Spindle cell sarcoma. Treatments involved minimally invasive surgeries, with three cases using intraoperative neurological monitoring. Despite a mean operative time of 376 min and a 13-day average hospital stay, one patient experienced recurrence requiring chemotherapy, another had distant metastasis, and one died at a two-year median follow-up.

Conclusions

Our study concludes that CT and MRI are crucial for diagnosing paravertebral tumors and planning surgery, and a multidisciplinary approach is essential for optimal functional preservation in pediatric patients. These findings emphasize the necessity for ongoing research to refine treatment strategies and improve patient outcomes in this complex clinical area.

背景：本研究旨在评估单一医疗中心内小儿椎旁肿瘤的手术治疗和预后，特别是哑铃型肿瘤。方法：回顾性分析2016年1月至2022年2月在台中退伍军人总医院就诊的经MRI和组织病理学确诊为椎旁肿瘤并接受手术治疗的患儿。我们的目的是评估肿瘤切除程度作为主要结局，术后并发症、复发率和神经功能作为次要结局，采用描述性统计。结果：我院收治小儿椎旁肿瘤患者4例，男2例，女2例，年龄53 ~ 204月龄。肿瘤位于后纵隔（3例）和腹膜后（1例），MRI表现各不相同。诊断包括神经节神经瘤、神经鞘瘤、丛状神经纤维瘤和梭形细胞肉瘤。治疗包括微创手术，其中3例采用术中神经监测。尽管平均手术时间为376分钟，平均住院时间为13天，但有1例患者复发需要化疗，另1例有远处转移，1例在中位随访2年期间死亡。结论：我们的研究表明，CT和MRI对于诊断脊柱旁肿瘤和计划手术至关重要，多学科方法对于儿科患者的最佳功能保存至关重要。这些发现强调了在这个复杂的临床领域进行研究以完善治疗策略和改善患者预后的必要性。

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引用次数: 0

Juvenile primary central nervous system vasculitis 青少年原发性中枢神经系统血管炎。

IF 2.1 4区医学 Q2 PEDIATRICS

Pediatrics and Neonatology

Pub Date : 2026-01-01 DOI: 10.1016/j.pedneo.2025.10.003

Chia-Li Hsu , Shun-Tai Yang , Jing-Kai Loo , Phui-Ly Liew , Yung-Ting Kuo

引用次数: 0

Kikuchi-Fujimoto disease presenting as the initial symptom of erythema multiforme 菊池-藤本病以多形性红斑为首发症状。

IF 2.1 4区医学 Q2 PEDIATRICS

Pediatrics and Neonatology

Pub Date : 2026-01-01 DOI: 10.1016/j.pedneo.2025.11.002

Masaki Shimizu , Shuya Kaneko , Tomonori Suzuki

引用次数: 0

Outcome prediction in newborns with hypoxic–ischemic encephalopathy 新生儿缺氧缺血性脑病的预后预测。

IF 2.1 4区医学 Q2 PEDIATRICS

Pediatrics and Neonatology

Pub Date : 2026-01-01 DOI: 10.1016/j.pedneo.2025.11.001

Jao-Shwann Liang MD., Ph.D.

引用次数: 0

Air leak syndrome: Pneumopericardium 漏气综合征：心包气

IF 2.1 4区医学 Q2 PEDIATRICS

Pediatrics and Neonatology

Pub Date : 2026-01-01 DOI: 10.1016/j.pedneo.2025.08.008

Zhiren Wang , Dexin Yan , Yifeng Zheng

引用次数: 0

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全部化学•材料生命科学医学物理工程技术环境•农林材料科学地球科学法学管理学化学环境科学与生态学计算机科学教育学经济学农林科学人文科学生物学数学物理与天体物理心理学综合性期刊其他工业工程理学历史学农学文学信息工程

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Pediatrics and Neonatology

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