Pediatrics and Neonatology最新文献_第5页

lncRNA HCP5 regulates inflammation and oxidative stress of neonatal sepsis via modulating miR-93–5p lncRNA HCP5通过调节miR-93-5p调节新生儿脓毒症的炎症和氧化应激。

IF 2.1 4区医学 Q2 PEDIATRICS

Pediatrics and Neonatology

Pub Date : 2025-11-01 DOI: 10.1016/j.pedneo.2024.10.013

Yueying Qi , Xin Li , Yuting Cai , Jiaxi Xie , Jinkai Yang

Background

Due to the high sensitivity to pathogenic microorganisms, newborns showed a high incidence and mortality of sepsis. The dysregulation of non-coding RNAs may play a key role in the immune regulation of neonatal sepsis. This study aimed to evaluate the potential function of lncRNA human histocompatibility leukocyte antigen complex P5 (HCP5) in the inflammation and oxidative stress of neonatal and to disclose its potential molecular mechanism.

Methods

The neonatal sepsis animal models were established with newborn rat pups by cecal ligation and perforation (CLP). The macrophage cells were induced by lipopolysaccharide (LPS) to mimic the sepsis injury. The expression of HCP5 was detected by polymerase chain reaction (PCR) and regulated by corresponding transfections. The inflammatory response was estimated by the levels of interleukin-6 (IL-6), interleukin-8 (IL-8), and tumor necrosis factor-α (TNF-α) using enzyme-linked immunosorbent assay (ELISA); and the oxidative stress was assessed by the levels of malondialdehyde (MDA) and superoxide dismutase (SOD). The proliferation of macrophage cells was evaluated by the CCK8 assay.

Results

HCP5 was significantly upregulated in neonatal sepsis rat models, of which the knockdown suppressed the inflammation and oxidative stress induced by CLP. In vitro, HCP5 was found to negatively regulate miR-93–5p in LPS-induced macrophage cells, which co-regulated the proliferation, inflammatory response, and oxidative stress in macrophage cells.

Conclusion

Upregulated HCP5 in neonatal sepsis rats regulated inflammation and oxidative stress, and it also modulated macrophage cell via regulating miR-93–5p.

背景：新生儿由于对病原微生物的高度敏感，脓毒症的发病率和死亡率较高。非编码rna的失调可能在新生儿败血症的免疫调节中起关键作用。本研究旨在评估lncRNA人组织相容性白细胞抗原复合物P5 （human histocompatibility leukocyte antigen complex P5, HCP5）在新生儿炎症和氧化应激中的潜在功能，并揭示其潜在的分子机制。方法：采用盲肠结扎穿孔法（CLP）建立新生儿脓毒症动物模型。采用脂多糖（LPS）诱导巨噬细胞模拟脓毒症损伤。采用聚合酶链反应（PCR）检测HCP5的表达，并通过相应的转染调节HCP5的表达。采用酶联免疫吸附试验（ELISA），通过白细胞介素-6 （IL-6）、白细胞介素-8 （IL-8）和肿瘤坏死因子-α (TNF-α)的水平来评估炎症反应；通过丙二醛（MDA）和超氧化物歧化酶（SOD）水平评估氧化应激。CCK8法检测巨噬细胞的增殖情况。结果：HCP5在新生儿脓毒症大鼠模型中显著上调，下调后可抑制CLP诱导的炎症和氧化应激。在体外实验中，我们发现HCP5在lps诱导的巨噬细胞中负调控miR-93-5p，共同调控巨噬细胞的增殖、炎症反应和氧化应激。结论：新生儿脓毒症大鼠HCP5上调可调节炎症和氧化应激，并通过调节miR-93-5p调节巨噬细胞。

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引用次数: 0

The outcome of kidney transplantation in lupus patients 狼疮患者肾移植的结果。

IF 2.1 4区医学 Q2 PEDIATRICS

Pediatrics and Neonatology

Pub Date : 2025-11-01 DOI: 10.1016/j.pedneo.2024.09.008

Ting-Chih Lin , Meng-Kun Tsai , Jyh-Hong Lee , Yao-Hsu Yang , Yu-Tsan Lin , Hsin-Hui Yu , Bor-Luen Chiang , Li-Chieh Wang

Background

Kidney transplantation represents a therapeutic option for individuals with end-stage renal disease due to lupus. However, the influence of lupus activity and immunosuppressive medications on graft survival remains a matter of concern and it has not been thoroughly elucidated.

Methods

In this study, we conducted a retrospective review of 45 lupus patients who underwent kidney transplantation, with the aim of analyzing graft survival and identifying factors influencing the outcome of kidney transplantation in lupus patients.

Results

Graft survival rates at 1, 5, 10, 15, and 20 years were 98%, 98%, 88%, 85%, and 78%, respectively. Univariate logistic regression revealed hypertension, positive panel reactive antibodies against HLA class II antigens, retransplant, young age at lupus nephritis onset, low postoperative C4 levels, and HBsAg and/or anti-HBe antibody presence were significantly correlated with decreased graft survival (p < 0.05). Multiple regression confirmed the significant association of HBsAg and/or anti-HBe antibody with graft failure (p = 0.0161), with all patients testing negative for anti-HBc antibody. Preoperative markers (C3, C4, anti-dsDNA antibody) and recurrent lupus nephritis did not impact graft failure.

Conclusion

In lupus patients undergoing kidney transplantation, hepatitis B serology emerges as a potential singular predictor for graft failure, while preoperative lupus activity markers and recurrent lupus nephritis do not affect outcomes.

背景：对于狼疮引起的终末期肾病患者，肾移植是一种治疗选择。然而，狼疮活动和免疫抑制药物对移植物存活的影响仍然是一个值得关注的问题，并没有完全阐明。方法：本研究对45例接受肾移植的狼疮患者进行回顾性分析，目的是分析狼疮患者的移植物存活情况，并找出影响狼疮患者肾移植预后的因素。结果：移植1、5、10、15、20年生存率分别为98%、98%、88%、85%、78%。单因素logistic回归显示，高血压、HLAⅱ类抗体阳性、再移植、狼疮性肾炎发病年龄小、术后C4水平低、HBsAg和/或抗hbe抗体存在与移植物存活率降低显著相关(p)。在接受肾移植的狼疮患者中，乙型肝炎血清学成为移植失败的潜在单一预测因子，而术前狼疮活动标志物和复发性狼疮肾炎不影响结果。

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引用次数: 0

Vitamin D status and the adequacy of its supplementation during the first year of life in preterm infants in northern Japan 日本北部早产儿第一年的维生素D状况及其补充是否充足。

IF 2.1 4区医学 Q2 PEDIATRICS

Pediatrics and Neonatology

Pub Date : 2025-11-01 DOI: 10.1016/j.pedneo.2025.03.003

Fumikatsu Nohara , Toshio Okamoto , Kenta Takahashi , Tatsutoshi Sugiyama , Aiko Hashimoto , Mitsumaro Nii , Yukari Yamaki , Etsushi Tsuchida , Takashi Satou , Masaru Shirai , Ken Nagaya , Satoru Takahashi

Background

Vitamin D (VD) deficiency (VDD) is a major concern in preterm infants. The prevalence of VDD in mothers and infants varies between countries and is affected by a range of factors, such as geography and lifestyle. Thus, strategies aimed at preventing VDD must consider the status of each region. However, few reports have explored VDD in preterm infants in Japan and the safety and efficacy of VD supplementation in addressing VDD remain unclear.

Methods

This study was conducted between September 2019 and October 2022. The participants were 108 preterm infants who were divided into three groups based on their gestational age: <28 weeks (Group 1), 28–33 weeks (Group 2), and 34–36 weeks (Group 3). VD status at birth was assessed, and 25-hydroxyvitamin D (25OHD) levels and biochemical markers were monitored during supplementation with 400 IU/day of VD over the first year of life.

Results

Levels of 25OHD at birth were 10.0 (10.0–16.1), 10.5 (10.0–18.0), and 13.0 (10.0–19.0) nmol/L in Groups 1, 2, and 3, respectively. Infants in all three groups exhibited marked VDD. Their 25OHD levels gradually increased with VD supplementation before plateauing at 6 months. Nevertheless, VDD persisted in the majority of infants at 1 month of age. Serum intact parathyroid hormone levels peaked at 1 month of age and declined thereafter, negatively correlating with 25OHD levels. None of the infants exhibited symptoms of VD toxicity.

Conclusion

Preterm infants in northern Japan exhibited substantial VDD, regardless of gestational age. In our cohort, VD supplementation at 400 IU/day safely increased 25OHD levels. However, VD levels improved gradually over the months, and several of these infants developed secondary hyperparathyroidism. Further studies are warranted to determine the optimal VD supplementation dose for preterm infants in this region.

背景：维生素D （VD）缺乏症（VDD）是早产儿的一个主要问题。母亲和婴儿的VDD患病率因国家而异，并受到地理和生活方式等一系列因素的影响。因此，旨在预防VDD的战略必须考虑到每个区域的状况。然而，关于日本早产儿VDD的报道很少，补充VD治疗VDD的安全性和有效性仍不清楚。方法：本研究于2019年9月至2022年10月进行。参与者是108名早产儿，根据胎龄分为三组：结果：1、2和3组出生时25OHD水平分别为10.0（10.0-16.1）、10.5（10.0-18.0）和13.0 (10.0-19.0)nmol/L。三组婴儿均表现出明显的VDD。他们的25OHD水平随着VD的补充逐渐升高，在6个月时达到稳定。然而，大多数婴儿在1月龄时仍存在VDD。血清完整甲状旁腺激素水平在1月龄时达到峰值，随后下降，与25OHD水平呈负相关。没有婴儿表现出VD毒性症状。结论：无论胎龄大小，日本北部的早产儿都表现出大量的VDD。在我们的队列中，补充400 IU/天的VD可以安全地增加25OHD水平。然而，VD水平在几个月内逐渐改善，其中一些婴儿发展为继发性甲状旁腺功能亢进。需要进一步的研究来确定该地区早产儿的最佳VD补充剂量。

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引用次数: 0

Systemic air embolism 系统性空气栓塞。

IF 2.1 4区医学 Q2 PEDIATRICS

Pediatrics and Neonatology

Pub Date : 2025-11-01 DOI: 10.1016/j.pedneo.2025.09.001

Shau-Ru Ho , Hsin-Chung Huang , Po-Nien Tsao

引用次数: 0

Gastric lavage for neonates with coffee-ground hematemesis in early postnatal period: Randomized controlled trial. 产后早期咖啡渣呕血新生儿洗胃：随机对照试验。

IF 2.1 4区医学 Q2 PEDIATRICS

Pediatrics and Neonatology

Pub Date : 2025-11-01 DOI: 10.1016/j.pedneo.2025.05.014

M D Takashi Maeda, Yoshiaki Sato, Akihiro Hirakawa, Masahiro Nakatochi, Fumie Kinoshita, Takeshi Suzuki, Shintaro Ichimura, Hiroyuki Kidokoro, Jun-Ichi Kawada, Yoshiyuki Takahashi

Background: To evaluate the efficacy and safety of gastric lavage (GL) in neonates with coffee-ground hematemesis due to swallowing maternal blood by postnatal day 1.

Methods: This multicenter, randomized controlled trial included term neonates presenting coffee-ground hematemesis by postnatal day 1. Patients were randomly assigned to GL or non-GL groups. The primary outcome was the rate of feeding intolerance (FI) within 24 h. Secondary outcomes included onset of FI, residual gastric volume, vomiting episodes, weight changes, and bilirubin levels. Adverse events were monitored.

Results: Eighty neonates were analyzed (40 per group). FI occurred in 15.0 % of the GL group and 27.5 % of the non-GL group (p = 0.17). However, in the subgroup of neonates exclusively fed with formula, FI was significantly lower in the GL group than in the non-GL group (16.0 % vs. 47.4 %, p = 0.02). GL significantly reduced residual gastric volume but showed no significant differences in other secondary outcomes. No adverse events related to GL were observed. Post hoc analysis indicated that a larger sample size would be needed to detect statistical significance; and subgroup findings suggested potential benefit in selected populations.

Conclusions: GL did not significantly reduce the incidence of FI in neonates with coffee-ground hematemesis and thus it cannot be considered superior based on current results. However, it was well tolerated, and the study may have been underpowered. Exploratory analyses suggested potential benefits, particularly among formula-fed neonates, warranting further investigation.

背景：评价洗胃治疗产后第1天因吞母血而出现咖啡渣呕血的新生儿的疗效和安全性。方法：这项多中心随机对照试验纳入了出生后第1天出现咖啡渣呕血的足月新生儿。患者被随机分为GL组和非GL组。主要终点是24小时内进食不耐受（FI）的发生率。次要终点包括进食不耐受的发生、胃残量、呕吐次数、体重变化和胆红素水平。监测不良事件。结果：共分析80例新生儿，每组40例。GL组的FI发生率为15.0%，非GL组为27.5% （p = 0.17）。然而，在纯配方奶粉喂养的新生儿亚组中，GL组的FI显著低于非GL组（16.0%比47.4%,p = 0.02）。GL显著减少残胃量，但其他次要结局无显著差异。未观察到与GL相关的不良事件。事后分析表明，需要更大的样本量来检测统计显著性；亚组研究结果表明，在特定人群中可能有益处。结论：GL并没有显著降低咖啡渣呕血新生儿FI的发生率，因此根据目前的结果不能认为它是优越的。然而，它的耐受性很好，这项研究可能不够有力。探索性分析显示了潜在的益处，特别是对配方奶喂养的新生儿，值得进一步研究。

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引用次数: 0

Hepatic tumors in Iranian children: Characteristics and survival predictors 伊朗儿童肝脏肿瘤：特征和生存预测因素。

IF 2.1 4区医学 Q2 PEDIATRICS

Pediatrics and Neonatology

Pub Date : 2025-11-01 DOI: 10.1016/j.pedneo.2024.10.014

Fateme Ziyaee , Seyed Mohsen Dehghani , Mehdi Forooghi , Ali Bahador , Hamidreza Foroutan , Hamed Nikoupour , Bita Geramizadeh , Mahmood Haghighat , Mohammad Hadi Imanieh , Naser Honar , Iraj Shahramian , Maryam Ataollahi , Narges Ansary , Mehdi Ghasemian , Mahsa Rouhafshari , Zahra Radaei , Maryam Moradian Shahrebabaki , Mohammad Salehi Khatouni

Background

Hepatic tumors are rare in children. This study was conducted to determine the characteristics of liver masses in children and identify the independent predictors of their survival.

Methods

Medical records of children aged <18 years with a confirmed diagnosis of hepatic tumor diagnosed between January 2008 and December 2023 at two referral centers affiliated to Shiraz University of Medical Sciences, southern Iran, were reviewed.

Results

There were 153 children with hepatic tumors. The median age of the patients was 2 (IQR, 1–5) years. Abdominal pain and distension, and presence of a palpable mass and fever were the most common signs and symptoms at presentation. The most common tumor was hepatoblastoma (64.5 %) followed by hepatocellular carcinoma (HCC, 9.9 %). Right hepatectomy and hepatic segmentectomy were the most common surgical approach used. Children with hepatoblastoma were significantly (p < 0.001) younger than those with HCC. The risk of hepatoblastoma in males was twice that in females. Jaundice was not common in those with hepatoblastoma but it was in HCC. About a quarter of patients died. After adjusting for covariates, abdominal pain (adj OR = 4.90) and distension (adj OR = 3.17), and a diagnosis of HCC (adj OR = 13.63) were independent predictors of a poor prognosis.

Conclusions

The characteristics of pediatric hepatic tumors in our study were similar to those reported in most studies. Abdominal pain and distension and presence of HCC or jaundice were independent predictors of a poor prognosis.

背景：肝脏肿瘤在儿童中很少见。本研究旨在确定儿童肝脏肿块的特征，并确定其生存的独立预测因素。方法：查阅老年儿童病历。结果：153例肝肿瘤患儿。患者中位年龄为2岁（IQR， 1-5岁）。腹痛和腹胀，可触及肿块和发热是最常见的症状和体征。最常见的肿瘤是肝母细胞瘤（64.5%），其次是肝细胞癌（HCC, 9.9%）。右肝切除术和肝节段切除术是最常用的手术入路。结论：本研究中儿童肝脏肿瘤的特征与大多数研究报道的特征相似。腹痛和腹胀以及存在HCC或黄疸是预后不良的独立预测因素。

{"title":"Hepatic tumors in Iranian children: Characteristics and survival predictors","authors":"Fateme Ziyaee , Seyed Mohsen Dehghani , Mehdi Forooghi , Ali Bahador , Hamidreza Foroutan , Hamed Nikoupour , Bita Geramizadeh , Mahmood Haghighat , Mohammad Hadi Imanieh , Naser Honar , Iraj Shahramian , Maryam Ataollahi , Narges Ansary , Mehdi Ghasemian , Mahsa Rouhafshari , Zahra Radaei , Maryam Moradian Shahrebabaki , Mohammad Salehi Khatouni","doi":"10.1016/j.pedneo.2024.10.014","DOIUrl":"10.1016/j.pedneo.2024.10.014","url":null,"abstract":"<div><h3>Background</h3><div>Hepatic tumors are rare in children. This study was conducted to determine the characteristics of liver masses in children and identify the independent predictors of their survival.</div></div><div><h3>Methods</h3><div>Medical records of children aged <18 years with a confirmed diagnosis of hepatic tumor diagnosed between January 2008 and December 2023 at two referral centers affiliated to Shiraz University of Medical Sciences, southern Iran, were reviewed.</div></div><div><h3>Results</h3><div>There were 153 children with hepatic tumors. The median age of the patients was 2 (IQR, 1–5) years. Abdominal pain and distension, and presence of a palpable mass and fever were the most common signs and symptoms at presentation. The most common tumor was hepatoblastoma (64.5 %) followed by hepatocellular carcinoma (HCC, 9.9 %). Right hepatectomy and hepatic segmentectomy were the most common surgical approach used. Children with hepatoblastoma were significantly (p < 0.001) younger than those with HCC. The risk of hepatoblastoma in males was twice that in females. Jaundice was not common in those with hepatoblastoma but it was in HCC. About a quarter of patients died. After adjusting for covariates, abdominal pain (adj OR = 4.90) and distension (adj OR = 3.17), and a diagnosis of HCC (adj OR = 13.63) were independent predictors of a poor prognosis.</div></div><div><h3>Conclusions</h3><div>The characteristics of pediatric hepatic tumors in our study were similar to those reported in most studies. Abdominal pain and distension and presence of HCC or jaundice were independent predictors of a poor prognosis.</div></div>","PeriodicalId":56095,"journal":{"name":"Pediatrics and Neonatology","volume":"66 6","pages":"Pages 573-578"},"PeriodicalIF":2.1,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144046347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Motor skills as early indicators for cognitive development in preterm infants with very low birth weight 运动技能是极低出生体重早产儿认知发展的早期指标。

IF 2.1 4区医学 Q2 PEDIATRICS

Pediatrics and Neonatology

Pub Date : 2025-11-01 DOI: 10.1016/j.pedneo.2025.01.010

Yen Ting Chen , Sot-Fu Lei , Chia-Hua Tang , Hsiu-Man Lin , Yueh-Tang Weng , Chen-Yu Yeh , Kai-Cheng Hsu , Ya-Lun Wu , Huang-Tsung Kuo

Background

Preterm babies born with very low birth weight (VLBW, birth weight <1500 g) have inferior long-term neurodevelopmental outcomes to term babies. This study aimed to identify early predictive neurodevelopmental factors for future cognitive outcomes that could serve as indicators for early intervention strategies.

Methods

This longitudinal cohort study enrolled 146 VLBW preterm infants, identified between 2011 and 2020. Each child underwent four neurodevelopmental assessments (at ages 6,12, 24, and 60 months) using the Bayley-III and Wechsler Preschool and Primary Scale of Intelligence-IV examinations. Correlation and linear regression analyses were performed to determine the correlation between early neurodevelopmental status and late cognitive outcomes. We concurrently considered neonatal medical complications and socioeconomic variables as risk factors to develop a prediction model of cognitive outcomes at five years old.

Results

A total of 146 VLBW children, born with a mean weight of 1090.4 ± 229.6 g and a mean gestational age of 28.2 ± 2.0 weeks, were evaluated. At 6 months of age, motor outcome was the only factor that exhibited a significant correlation with cognitive development at 5 years of age (p < 0.01, r = 0.242). The strength of the correlation between motor and cognitive function increased with age, reaching greater significance at 12 and 24 months (p < 0.001, r = 0.409 and 0.472, respectively). The linear regression model demonstrated that neonatal medical conditions and Bayley motor score at six months old predicted 26% of the variance in the Full-Scale Intelligence Quotient (FSIQ) at five years old.

Conclusion

The results of the present study show that motor function was the earliest and persistent predictor of FSIQ. This underscores the importance of prioritizing motor development in interventions as early as six months of age, which could substantially advance the timing of early intervention programs.

背景：出生体重极低的早产儿早产儿出生时体重极低（VLBW，出生体重方法）：这项纵向队列研究共招募了 146 名 VLBW 早产儿，这些婴儿是在 2011 年至 2020 年间确认的。每个孩子都接受了四次神经发育评估（6、12、24 和 60 个月大时），分别使用 Bayley-III 和 Wechsler Preschool and Primary Scale of Intelligence-IV 考试。我们进行了相关分析和线性回归分析，以确定早期神经发育状况与晚期认知结果之间的相关性。我们同时考虑了新生儿医疗并发症和社会经济变量等风险因素，从而建立了五岁时认知结果的预测模型：共评估了 146 名超低体重儿，他们出生时的平均体重为 1090.4 ± 229.6 克，平均胎龄为 28.2 ± 2.0 周。在 6 个月大时，运动结果是唯一与 5 岁时认知发展有显著相关性的因素（p 结论：在 6 个月大时，运动结果是唯一与 5 岁时认知发展有显著相关性的因素：本研究结果表明，运动功能是最早且持续预测 FSIQ 的因素。这凸显了早在 6 个月大时就在干预中优先考虑运动发育的重要性，这可大大提前早期干预计划的时间安排。

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引用次数: 0

Non-invasive simple predictors of biliary atresia in cholestatic infants – A preliminary report 胆汁淤积症婴儿胆道闭锁的无创简单预测指标-初步报告。

IF 2.1 4区医学 Q2 PEDIATRICS

Pediatrics and Neonatology

Pub Date : 2025-11-01 DOI: 10.1016/j.pedneo.2024.11.006

Yu-Hsueh Hsiao , Wei-Li Hung , Yao-Jong Yang , Fang-Ting Lu , Fang-Min Liao , Cheng-Yu Chen , Jia-Feng Wu

Background

Biliary atresia (BA) and other cholestatic liver diseases of early infancy share many similar clinical manifestations. We intended to investigate easy and popular non-invasive parameters to assist the differential diagnosis of BA among cholestatic infants.

Methods

We enrolled 145 consecutive cholestatic infants (43.03 ± 2.00 days) who underwent cholestatic workups at our hospital as the study cohort, and another 27 cholestatic infants (47.78 ± 13.33 days) who received their initial cholestatic workups and laboratory tests at four other 4 hospitals as the validation cohort. The clinical data were surveyed retrospectively using a cross-sectional design.

Results

We demonstrated that the “GGT∗D-bil” was significantly higher in the BA group than in the non-BA group in the study cohort (p < 0.001). The Receiver operating characteristic curve analysis of the study cohort identified the “GGT∗D-bil” cutoff >510 mg U/dL.L for the best prediction of BA among cholestatic infants (92 % area under the curve, p < 0.001). The sensitivity and negative predictive value (NPV) for predicting BA among cholestatic infants are 100 % in the study cohort. In the validation cohort, the “GGT∗D-bil” > 510 mg U/dL.L also achieved good sensitivity and NPV (92.31 % and 90.91 %, respectively) for the prediction of BA.

Conclusions

We demonstrated that an easy parameter, “GGT∗D-bil” > 510 mg U/dL.L, may be used as part of the non-invasive cholestatic workups to assist in the diagnosis of BA among cholestatic infants in our study and validation cohorts. The application of this parameter is easy and not limited by the resources of the hospitals.

背景：小儿早期胆汁闭锁（BA）与其他胆汁淤积性肝病具有许多相似的临床表现。我们打算研究简单和流行的非侵入性参数，以协助鉴别诊断胆汁淤积婴儿BA。方法：选取145例（43.03±2.00天）在我院连续接受胆汁淤积检查的患儿作为研究队列，另选取27例（47.78±13.33天）在其他4家医院接受首次胆汁淤积检查和实验室检查的患儿作为验证队列。采用横断面设计对临床资料进行回顾性调查。结果：我们证明了在研究队列中，BA组的“GGT∗D-bil”显著高于非BA组（p 510 mg U/dL）。L为预测胆汁淤积婴儿BA的最佳方法（曲线下面积92%，p 510 mg U/dL）。L预测BA的灵敏度和净现值（NPV）均较好（分别为92.31%和90.91%）。结论：我们证明了一个简单的参数，“GGT * D-bil”> 510 mg U/dL。L，在我们的研究和验证队列中，可作为无创胆汁淤积检查的一部分，以协助胆汁淤积婴儿BA的诊断。该参数的应用简单，不受医院资源的限制。

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引用次数: 0

Congenital neck mass – What approach? 先天性颈部肿块-什么方法？

IF 2.1 4区医学 Q2 PEDIATRICS

Pediatrics and Neonatology

Pub Date : 2025-11-01 DOI: 10.1016/j.pedneo.2023.12.015

Catarina Freitas , Liliana Teixeira , Ana Cristina Freitas , Luísa Neiva-Araújo

引用次数: 0

Critical appraisal on neural tube defects and their complexities 神经管缺陷及其复杂性的批判性评价。

IF 2.1 4区医学 Q2 PEDIATRICS

Pediatrics and Neonatology

Pub Date : 2025-11-01 DOI: 10.1016/j.pedneo.2024.07.015

Fouziya Shaikh , Mallica Sanadhya , Safa Kaleem , Tiya Verma , Richard L. Jayaraj , Faizan Ahmad

Neural tube defects (NTDs), as a group of diseases, are congenital disabilities due to incomplete closure of the neural tube along its length, which otherwise forms the fully developed brain and spinal cord. An amalgamation of genetic, nutritional, and environmental factors plays a role in causing NTDs. They develop relatively early, within the first month of pregnancy-the time of neurulation, which could indicate that the pathogenesis of these diseases could stem from even pre-pregnancy causes like folic acid deficiency. This article provides an overview of the various etiology of NTDs and how they interact, as well as various preventive and curative measures like folic acid and inositol supplementation, stem cell transplant, and postnatal surgery. Identifying potential risk factors can help clinicians develop better management techniques beyond the limited scope of the presently used prophylactic and treatment methods.

神经管缺损（神经管缺损）是由于神经管沿其长度不完全闭合而形成的先天性残疾，是一类疾病。遗传、营养和环境因素的综合作用在造成被忽视热带病方面发挥了作用。它们发展相对较早，在怀孕的第一个月，也就是神经发育的时间，这可能表明这些疾病的发病机制甚至可能源于怀孕前的原因，比如叶酸缺乏。本文概述了NTDs的各种病因及其相互作用，以及各种预防和治疗措施，如补充叶酸和肌醇，干细胞移植和产后手术。识别潜在的风险因素可以帮助临床医生开发更好的管理技术，超越目前使用的预防和治疗方法的有限范围。

引用次数: 0