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Skin Involvement of Idiopathic Granulomatous Mastitis: Sonographic, Clinical, and Histopathological Features 特发性肉芽肿性乳腺炎的皮肤受累:超声、临床和组织病理学特征
IF 2 4区 医学 Q3 OBSTETRICS & GYNECOLOGY Pub Date : 2025-09-24 DOI: 10.1155/tbj/7224219
Fatih Işık, Erdal Pala, Fatih Alper, Sevilay Ozmen, Elif Demirci, Hasan Abbasguliyev, Müfide Nuran Akçay

Objectives: Idiopathic granulomatous mastitis (IGM) is a rare benign breast disease in which cutaneous involvement is insufficiently characterized. This study aimed to evaluate the sonographic, clinical, and histopathological features of skin manifestations in IGM.

Methods: We retrospectively analyzed 138 women with biopsy-proven IGM who underwent breast and skin ultrasonography between 2023 and 2024. Clinical cutaneous findings were documented, and 14 patients with visible skin lesions underwent additional punch biopsy for histopathological evaluation. Sonographic and clinical features were stratified according to symptom duration (0–3, 4–6, 7–9, and ≥ 10 weeks).

Results: Cutaneous lesions were identified in 84/138 patients (60.9%). Sonographic findings followed a sequential distribution: fibrous echogenicity loss in early disease (11/14, 78.6%), vacuolar structures at 4–6 weeks (11/19, 57.9%), dermo-subcutaneous blurring at 7–9 weeks (9/34, 26.5%), and advanced features such as fistula formation (11/17, 64.7%) and dermo-subcutaneous disruption (11/17, 64.7%) beyond 10 weeks. Clinical findings paralleled imaging, with erythema and papulopustular lesions predominating early (13/14, 92.9%), erythema nodosum peaking at 4–6 weeks (7/19, 36.8%), and ulceration and fistula formation emerging after ≥ 7 weeks (11/17, 64.7% at ≥ 10 weeks). Histopathological analysis of 14 skin biopsies demonstrated nonspecific inflammatory changes without granuloma formation.

Conclusions: IGM demonstrates sequential sonographic and clinical cutaneous patterns associated with symptom duration. Early erythematous and papulopustular changes progress to ulceration and fistula formation in prolonged disease. Although supportive in suggesting cutaneous involvement, these features are not diagnostic, and histopathological confirmation remains essential. Prospective studies are warranted to further define the clinical and histological course of cutaneous changes in IGM.

目的:特发性肉芽肿性乳腺炎(IGM)是一种罕见的乳腺良性疾病,其累及皮肤的特征不充分。本研究旨在评估IGM皮肤表现的超声、临床和组织病理学特征。方法:我们回顾性分析了2023年至2024年间接受乳腺和皮肤超声检查的138名活检证实的IGM女性。临床皮肤表现被记录下来,14例可见皮肤病变的患者进行了额外的穿刺活检以进行组织病理学评估。根据症状持续时间(0-3周、4-6周、7-9周、≥10周)对超声和临床特征进行分层。结果:138例患者中有84例(60.9%)发现皮肤病变。超声检查结果遵循顺序分布:早期病变纤维回声性丧失(11/14,78.6%),4-6周时空泡结构(11/19,57.9%),7-9周时真皮-皮下模糊(9/34,26.5%),10周后出现晚期特征,如瘘形成(11/17,64.7%)和真皮-皮下破坏(11/17,64.7%)。临床表现与影像学相似,早期以红斑和丘疹病变为主(13/14,92.9%),结节性红斑在4-6周达到高峰(7/19,36.8%),≥7周后出现溃疡和瘘管形成(11/17,≥10周64.7%)。14例皮肤活检的组织病理学分析显示非特异性炎症改变,无肉芽肿形成。结论:IGM显示了与症状持续时间相关的顺序超声和临床皮肤特征。早期的红斑和丘疹性改变进展为溃疡和瘘管形成的长期疾病。虽然支持提示皮肤受累,但这些特征不能诊断,组织病理学证实仍是必要的。有必要进行前瞻性研究,以进一步确定IGM皮肤变化的临床和组织学过程。
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引用次数: 0
Corrigendum to “Primary bilateral breast lymphoma in an elder male patient” “老年男性患者原发性双侧乳房淋巴瘤”的勘误表
IF 2 4区 医学 Q3 OBSTETRICS & GYNECOLOGY Pub Date : 2025-09-19 DOI: 10.1155/tbj/9821303

Y. Bozkaya, F. Oz Puyan, and B. Bimboga, “Primary bilateral breast lymphoma in an elder male patient,” The Breast Journal 25, no. 5 (2019): 1008-1009, https://doi.org/10.1111/tbj.13394.

In the article titled “Primary bilateral breast lymphoma in an elder male patient,” there was a spelling error in author Busem Binboga’s name in the author list, where Busem Bimboga should have read Busem Binboga. The corrected author list and affiliation list should be as follows:

Yakup Bozkaya1, Fulya Oz Puyan2, Busem Binboga2

1Clinic of Medical Oncology, Edirne State Hospital, Edirne, Turkey

2Department of Pathology, Faculty of Medicine, Trakya University, Edirne, Turkey

We apologize for this error.

Y. Bozkaya, F. Oz Puyan和B. Bimboga,“老年男性患者的原发性双侧乳房淋巴瘤”,《乳腺杂志》25,第2期。5 (2019): 1008-1009, https://doi.org/10.1111/tbj.13394.In题为“一位老年男性患者的原发性双侧乳房淋巴瘤”的文章,作者名单中作者Busem Binboga的名字出现拼写错误,此处Busem Binboga应该读为Busem Binboga。更正后的作者名单和所属单位名单如下:Yakup bozkay1, Fulya Oz Puyan2, Busem binboga 21土耳其埃迪尔内埃迪尔内国家医院肿瘤医学诊所2土耳其埃迪尔内特拉基亚大学医学院病理学系我们为这个错误道歉。
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引用次数: 0
Corrigendum to “Analysis of Conventional Ultrasound and Contrast-Enhanced Ultrasound Features of Pseudoangiomatous Stromal Hyperplasia” “假性血管瘤间质增生的常规超声和增强超声特征分析”的勘误表
IF 2 4区 医学 Q3 OBSTETRICS & GYNECOLOGY Pub Date : 2025-09-19 DOI: 10.1155/tbj/9801706

H. Li, Q. Niu, C. Jia, et al., “Analysis of Conventional Ultrasound and Contrast-Enhanced Ultrasound Features of Pseudoangiomatous Stromal Hyperplasia,” The Breast Journal 2025 (2025): 6070736, https://doi.org/10.1155/tbj/6070736.

In the article titled “Analysis of Conventional Ultrasound and Contrast-Enhanced Ultrasound Features of Pseudoangiomatous Stromal Hyperplasia,” there was an error in affiliations 1 and 2 order. The corrected author list and affiliation list should be as follows:

Hui Li1,2, Qinghua Niu1, Chao Jia1, Gaoxiang Fan1, Long Liu1, Gang Li1, Penglin Zou1, Rong Wu1, Lianfang Du1, Jing Wang3, and Qiusheng Shi1

1Department of Ultrasound, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

2Department of Ultrasound, Huashan Hospital, Fudan University, Shanghai, China

3Department of Pathology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

We apologize for this error.

李宏,牛强,贾超,等,“假性血管瘤间质增生的常规超声和增强超声特征分析”,《乳腺杂志》2025 (2025):6070736,https://doi.org/10.1155/tbj/6070736.In文章标题“假性血管瘤间质增生的常规超声和增强超声特征分析”,在附属关系1和2的顺序上有错误。更正后的作者名单及归属名单应如下:李辉1,2,牛清华1,贾超1,范高翔1,刘龙1,李刚1,邹鹏林1,吴蓉1,杜连芳1,王静3,石秋生11上海交通大学医学院上海总医院超声科2上海复旦大学华山医院超声科3上海总医院病理科,上海交通大学医学院附属医院超声科,上海交通大学附属医院超声科,中国上海上海交通大学医学院,中国上海。我们为这个错误道歉。
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引用次数: 0
Corrigendum to “The Quest for Outpatient Mastectomy in COVID-19 Era: Barriers and Facilitators” “在COVID-19时代寻求门诊乳房切除术:障碍和促进因素”的勘误表
IF 2 4区 医学 Q3 OBSTETRICS & GYNECOLOGY Pub Date : 2025-09-16 DOI: 10.1155/tbj/9847254

L. J. van Zeelst, R. Derksen, C. H. W. Wijers, et al., “The Quest for Outpatient Mastectomy in COVID-19 Era: Barriers and Facilitators,” The Breast Journal 2022 (2022): 1863519, https://doi.org/10.1155/2022/1863519.

In the article titled “The Quest for Outpatient Mastectomy in COVID-19 Era: Barriers and Facilitators” there were errors in Figure 1 and Table 1.

In Figure 1 legends, inpatient mastectomy and outpatient mastectomy were attributed to the wrong colour. The corrected Figure 1 is shown below.

In Table 1, values in the polypharmacy rows were incorrect. The corrected Table 1 is shown below.

We apologize for this error.

L. J. van Zeelst, R. Derksen, C. H. W. Wijers等,“The Quest for门诊乳房切除术in COVID-19时代:Barriers and Facilitators”,The Breast Journal 2022 (2022): 1863519, https://doi.org/10.1155/2022/1863519.In文章标题为“The Quest for门诊乳房切除术in COVID-19时代:Barriers and Facilitators”,图1和表1中存在错误。在图1图例中,住院乳房切除术和门诊乳房切除术的颜色都是错误的。更正后的图1如下所示。在表1中,polypharmacy行中的值不正确。更正后的表1如下所示。我们为这个错误道歉。
{"title":"Corrigendum to “The Quest for Outpatient Mastectomy in COVID-19 Era: Barriers and Facilitators”","authors":"","doi":"10.1155/tbj/9847254","DOIUrl":"https://doi.org/10.1155/tbj/9847254","url":null,"abstract":"<p>L. J. van Zeelst, R. Derksen, C. H. W. Wijers, et al., “The Quest for Outpatient Mastectomy in COVID-19 Era: Barriers and Facilitators,” <i>The Breast Journal</i> 2022 (2022): 1863519, https://doi.org/10.1155/2022/1863519.</p><p>In the article titled “The Quest for Outpatient Mastectomy in COVID-19 Era: Barriers and Facilitators” there were errors in Figure 1 and Table 1.</p><p>In Figure 1 legends, inpatient mastectomy and outpatient mastectomy were attributed to the wrong colour. The corrected Figure 1 is shown below.</p><p>In Table 1, values in the polypharmacy rows were incorrect. The corrected Table 1 is shown below.</p><p>We apologize for this error.</p>","PeriodicalId":56326,"journal":{"name":"Breast Journal","volume":"2025 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/tbj/9847254","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145101691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Morphological Assessment of Breast Lesions With Type 2 Dynamic Curves Using DWI and T2WI Based on Breast Imaging Reporting and Data System Lexicon Descriptors 基于乳腺影像学报告和数据系统词汇描述符的DWI和T2WI 2型动态曲线乳腺病变形态学评估
IF 2 4区 医学 Q3 OBSTETRICS & GYNECOLOGY Pub Date : 2025-09-05 DOI: 10.1155/tbj/9957678
Liying Zhang, Gongsheng Zhu, Kefan Wang, Tongzhen Zhang, Lin Lu, Xin Zhao

Purpose: This study aimed to qualitatively assess the added diagnostic value of diffusion-weighted imaging (DWI) and T2-weighted imaging (T2WI), using Breast Imaging Reporting and Data System (BI-RADS) lexicon descriptors, in evaluating breast lesions with type 2 dynamic curves.

Materials and Methods: We retrospectively reviewed 181 breast lesions with type 2 dynamic curves in 181 consecutive patients who underwent 3-Tesla (3-T) magnetic resonance imaging (MRI). Trained radiologists assessed the morphological features of the lesions on dynamic contrast-enhanced (DCE) MRI, DWI, and T2WI using BI-RADS lexicon descriptors and measured the apparent diffusion coefficient (ADC). Statistical analysis was performed to compare variables in lesion type groups (mass-like group vs. nonmass-like group). Diagnostic performance was evaluated using the area under the receiver operating characteristic curve (AUC) and the DeLong test, with statistical significance at p < 0.05.

Results: In mass-like lesions, all morphological parameters significantly distinguished benign from malignant lesions on DCE, DWI, and T2WI (all p < 0.05). ADC values also showed significant differences (p < 0.05). The combined approach (DCE + DWI + T2WI) yielded the highest AUC (0.895), significantly outperforming the individual methods (all p < 0.05). In nonmass-like lesions, no parameter significantly predicted malignancy (all p > 0.05).

Conclusion: The addition of DWI and T2WI, interpreted using the BI-RADS lexicon descriptors, enhances the differential diagnosis of breast lesions with type 2 dynamic curves.

目的:本研究旨在利用乳腺成像报告与数据系统(BI-RADS)词汇描述符,定性评估乳腺2型动态曲线病变的弥散加权成像(DWI)和t2加权成像(T2WI)的附加诊断价值。材料和方法:我们回顾性分析了181例连续接受3-特斯拉(3-T)磁共振成像(MRI)的乳房2型动态曲线病变。训练有素的放射科医生使用BI-RADS词汇描述符评估病变在动态对比增强(DCE) MRI、DWI和T2WI上的形态学特征,并测量表观扩散系数(ADC)。对病变类型组(肿块样组与非肿块样组)的变量进行统计分析比较。采用受试者工作特征曲线下面积(AUC)和DeLong检验评价诊断效能,p <; 0.05有统计学意义。结果:在肿块样病变中,DCE、DWI、T2WI各形态参数均能显著区分良恶性病变(p < 0.05)。ADC值也有显著性差异(p < 0.05)。联合方法(DCE + DWI + T2WI)的AUC最高(0.895),显著优于单个方法(均p <; 0.05)。在非肿块样病变中,没有参数显著预测恶性(均p >; 0.05)。结论:使用BI-RADS词汇描述符对DWI和T2WI的增加进行解释,可以增强对2型动态曲线乳腺病变的鉴别诊断。
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引用次数: 0
Applicability of Oncotype DX Testing in a Diverse Breast Cancer Population in Hawaii Oncotype DX检测在夏威夷不同乳腺癌人群中的适用性
IF 2 4区 医学 Q3 OBSTETRICS & GYNECOLOGY Pub Date : 2025-09-01 DOI: 10.1155/tbj/9104103
Kyle Xia, Eileen Chen, Roxana Hu, Ian Pagano, Jami Fukui

Purpose: The Oncotype DX test is standardly used for patients with early-stage, hormone-receptor–positive, HER2-negative breast cancers to determine the benefit from chemotherapy and the likelihood of distant recurrence. The relationship between Oncotype DX recurrence scores and race/ethnicity is still being studied. This retrospective study aims to evaluate the relationship between Oncotype DX recurrence scores, race/ethnicity, and clinicopathological factors and to support the applicability of the Oncotype DX test for a diverse breast cancer population of Hawaii.

Materials and Methods: We evaluated 879 breast cancer cases diagnosed from January 2018–March 2022 within a major health system in Hawaii, 600 of which received Oncotype DX recurrence scores to provide prognostic and therapy-predictive information based on NCCN guidelines. Linear regression with both univariable (unadjusted) and multivariable (adjusted for all other variables) models was run on the 600 breast cancer cases that received Oncotype DX recurrence scores. The predictor variables were age at diagnosis, race, tumor size, ER/PR status, and histology.

Results: On multivariable analysis, we found statically significant differences in Oncotype DX recurrence scores according to age (60–69 vs. 18–49, p = 0.01), ER/PR status (PR-positive vs. PR-negative, p < 0.0001), histology (other vs. ductal, p = 0.004), and tumor size (2–5 cm vs. 0-1 cm, p = 0.0003). We found no significant differences in Oncotype DX recurrence scores according to race/ethnicity.

Conclusion: Our findings indicate that Oncotype DX recurrence scores are not variable according to race/ethnicity, highlighting the need for further research to understand the known disparities in breast cancer outcomes among different racial/ethnic groups. Our study supports the correlation between Oncotype DX recurrence scores and other factors and aligns with established prognostic trends for these variables in a diverse population. This study supports the applicability for the Oncotype DX test in a diverse breast cancer population of Hawaii.

目的:Oncotype DX检测标准用于早期、激素受体阳性、her2阴性乳腺癌患者,以确定化疗的获益和远处复发的可能性。Oncotype DX复发评分与种族/民族之间的关系仍在研究中。本回顾性研究旨在评估Oncotype DX复发评分、种族/民族和临床病理因素之间的关系,并支持Oncotype DX检测在夏威夷不同乳腺癌人群中的适用性。材料和方法:我们在夏威夷的一个主要卫生系统中评估了2018年1月至2022年3月诊断的879例乳腺癌病例,其中600例接受了Oncotype DX复发评分,以提供基于NCCN指南的预后和治疗预测信息。对600例接受Oncotype DX复发评分的乳腺癌病例进行单变量(未调整)和多变量(对所有其他变量进行调整)模型的线性回归。预测变量为诊断年龄、种族、肿瘤大小、ER/PR状态和组织学。结果:在多变量分析中,我们发现Oncotype DX复发评分在年龄(60-69 vs 18-49, p = 0.01)、ER/PR状态(PR阳性vs PR阴性,p < 0.0001)、组织学(其他vs导管,p = 0.004)和肿瘤大小(2-5 cm vs 0-1 cm, p = 0.0003)方面存在统计学差异。我们发现不同种族/民族的Oncotype DX复发评分无显著差异。结论:我们的研究结果表明,Oncotype DX复发评分不随种族/民族而变化,强调需要进一步研究以了解不同种族/民族之间乳腺癌结局的已知差异。我们的研究支持Oncotype DX复发评分与其他因素之间的相关性,并与不同人群中这些变量的既定预后趋势相一致。本研究支持Oncotype DX检测在夏威夷不同乳腺癌人群中的适用性。
{"title":"Applicability of Oncotype DX Testing in a Diverse Breast Cancer Population in Hawaii","authors":"Kyle Xia,&nbsp;Eileen Chen,&nbsp;Roxana Hu,&nbsp;Ian Pagano,&nbsp;Jami Fukui","doi":"10.1155/tbj/9104103","DOIUrl":"https://doi.org/10.1155/tbj/9104103","url":null,"abstract":"<p><b>Purpose:</b> The Oncotype DX test is standardly used for patients with early-stage, hormone-receptor–positive, HER2-negative breast cancers to determine the benefit from chemotherapy and the likelihood of distant recurrence. The relationship between Oncotype DX recurrence scores and race/ethnicity is still being studied. This retrospective study aims to evaluate the relationship between Oncotype DX recurrence scores, race/ethnicity, and clinicopathological factors and to support the applicability of the Oncotype DX test for a diverse breast cancer population of Hawaii.</p><p><b>Materials and Methods:</b> We evaluated 879 breast cancer cases diagnosed from January 2018–March 2022 within a major health system in Hawaii, 600 of which received Oncotype DX recurrence scores to provide prognostic and therapy-predictive information based on NCCN guidelines. Linear regression with both univariable (unadjusted) and multivariable (adjusted for all other variables) models was run on the 600 breast cancer cases that received Oncotype DX recurrence scores. The predictor variables were age at diagnosis, race, tumor size, ER/PR status, and histology.</p><p><b>Results:</b> On multivariable analysis, we found statically significant differences in Oncotype DX recurrence scores according to age (60–69 vs. 18–49, <i>p</i> = 0.01), ER/PR status (PR-positive vs. PR-negative, <i>p</i> &lt; 0.0001), histology (other vs. ductal, <i>p</i> = 0.004), and tumor size (2–5 cm vs. 0-1 cm, <i>p</i> = 0.0003). We found no significant differences in Oncotype DX recurrence scores according to race/ethnicity.</p><p><b>Conclusion:</b> Our findings indicate that Oncotype DX recurrence scores are not variable according to race/ethnicity, highlighting the need for further research to understand the known disparities in breast cancer outcomes among different racial/ethnic groups. Our study supports the correlation between Oncotype DX recurrence scores and other factors and aligns with established prognostic trends for these variables in a diverse population. This study supports the applicability for the Oncotype DX test in a diverse breast cancer population of Hawaii.</p>","PeriodicalId":56326,"journal":{"name":"Breast Journal","volume":"2025 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/tbj/9104103","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144923593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Real-World Efficacy of HLX02-Based Neoadjuvant Therapy in HER2-Positive Breast Cancer: Clinical Insights and Future Directions 基于hlx02的新辅助治疗在her2阳性乳腺癌中的实际疗效:临床见解和未来方向
IF 1.9 4区 医学 Q3 OBSTETRICS & GYNECOLOGY Pub Date : 2025-07-10 DOI: 10.1155/tbj/1653319
Zhengzhi Zhu, Jing Wang, Shikai Hong, Hong Gao, Jianjun Liu, Kuojun Ren, Shuhan Wang, Shengying Wang, Guoping Sun

Background: The efficacy of HLX02, a trastuzumab biosimilar, in combination with chemotherapy for treating metastatic breast cancer (BC) has been established as equivalent to the reference Herceptin. This study aimed to assess the treatment response of HLX02-based neoadjuvant therapy in HER2-positive BC, with a focus on HR-positive versus HR-negative subgroups. Additionally, we investigated the potential role of a CDK4/6 inhibitor in combination with anti-HER2 therapy.

Methods: This retrospective study included HER2-positive BC patients who received HLX02-based neoadjuvant therapy followed by curative surgery at Anhui Provincial Cancer Hospital between March 2021 and August 2023. Pathological complete response (pCR) rates were analyzed, and subgroup analyses evaluated predictors of pCR. In vitro experiments using BT-474 and MCF-7 cell lines assessed the effects of combining CDK4/6 inhibitors with anti-HER2 therapy on cell viability and apoptosis.

Results: The study included 67 patients with a median age of 53 years. The overall pCR rate was 53.73%, with higher pCR rates observed in HR-negative patients compared to HR-positive patients (63.89% vs. 41.94%). Dual HER2 blockade with HLX02 and pertuzumab was associated with a numerically improved pCR rate (62.16%). ER expression significantly increased post-treatment, potentially indicating treatment resistance mechanisms. In vitro, the combination of CDK4/6 inhibitors with anti-HER2 therapy significantly reduced cell viability and promoted apoptosis in HR-positive, HER2-positive cell lines.

Conclusion: HLX02 demonstrates real-world efficacy as part of neoadjuvant therapy for HER2-positive BC, especially in HR-negative patients. The lower pCR rate in HR-positive patients highlights the need for additional strategies. Combining CDK4/6 inhibitors with anti-HER2 therapy presents a promising approach for HR-positive HER2-positive patients, warranting further clinical validation.

背景:曲妥珠单抗生物类似药HLX02联合化疗治疗转移性乳腺癌(BC)的疗效已被证实与参考药物赫赛汀相当。本研究旨在评估基于hlx02的新辅助治疗在her2阳性BC中的治疗反应,重点是hr阳性和hr阴性亚组。此外,我们研究了CDK4/6抑制剂与抗her2治疗联合的潜在作用。方法:本回顾性研究纳入了2021年3月至2023年8月在安徽省肿瘤医院接受基于hlx02的新辅助治疗并进行根治性手术的her2阳性BC患者。病理完全缓解(pCR)率进行分析,亚组分析评估pCR的预测因子。利用BT-474和MCF-7细胞系进行的体外实验评估了CDK4/6抑制剂联合抗her2治疗对细胞活力和凋亡的影响。结果:研究纳入67例患者,中位年龄53岁。总体pCR率为53.73%,hr阴性患者的pCR率高于hr阳性患者(63.89%比41.94%)。用HLX02和pertuzumab双重阻断HER2与pCR率的数值提高(62.16%)相关。ER表达在处理后显著增加,可能提示治疗耐药机制。在体外,CDK4/6抑制剂联合抗her2治疗可显著降低hr阳性和her2阳性细胞系的细胞活力,促进细胞凋亡。结论:HLX02作为her2阳性BC新辅助治疗的一部分具有实际疗效,特别是在hr阴性患者中。hr阳性患者较低的pCR率突出了采取其他策略的必要性。CDK4/6抑制剂联合抗her2治疗为hr阳性her2阳性患者提供了一种有希望的方法,需要进一步的临床验证。
{"title":"Real-World Efficacy of HLX02-Based Neoadjuvant Therapy in HER2-Positive Breast Cancer: Clinical Insights and Future Directions","authors":"Zhengzhi Zhu,&nbsp;Jing Wang,&nbsp;Shikai Hong,&nbsp;Hong Gao,&nbsp;Jianjun Liu,&nbsp;Kuojun Ren,&nbsp;Shuhan Wang,&nbsp;Shengying Wang,&nbsp;Guoping Sun","doi":"10.1155/tbj/1653319","DOIUrl":"https://doi.org/10.1155/tbj/1653319","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> The efficacy of HLX02, a trastuzumab biosimilar, in combination with chemotherapy for treating metastatic breast cancer (BC) has been established as equivalent to the reference Herceptin. This study aimed to assess the treatment response of HLX02-based neoadjuvant therapy in HER2-positive BC, with a focus on HR-positive versus HR-negative subgroups. Additionally, we investigated the potential role of a CDK4/6 inhibitor in combination with anti-HER2 therapy.</p>\u0000 <p><b>Methods:</b> This retrospective study included HER2-positive BC patients who received HLX02-based neoadjuvant therapy followed by curative surgery at Anhui Provincial Cancer Hospital between March 2021 and August 2023. Pathological complete response (pCR) rates were analyzed, and subgroup analyses evaluated predictors of pCR. In vitro experiments using BT-474 and MCF-7 cell lines assessed the effects of combining CDK4/6 inhibitors with anti-HER2 therapy on cell viability and apoptosis.</p>\u0000 <p><b>Results:</b> The study included 67 patients with a median age of 53 years. The overall pCR rate was 53.73%, with higher pCR rates observed in HR-negative patients compared to HR-positive patients (63.89% vs. 41.94%). Dual HER2 blockade with HLX02 and pertuzumab was associated with a numerically improved pCR rate (62.16%). ER expression significantly increased post-treatment, potentially indicating treatment resistance mechanisms. In vitro, the combination of CDK4/6 inhibitors with anti-HER2 therapy significantly reduced cell viability and promoted apoptosis in HR-positive, HER2-positive cell lines.</p>\u0000 <p><b>Conclusion:</b> HLX02 demonstrates real-world efficacy as part of neoadjuvant therapy for HER2-positive BC, especially in HR-negative patients. The lower pCR rate in HR-positive patients highlights the need for additional strategies. Combining CDK4/6 inhibitors with anti-HER2 therapy presents a promising approach for HR-positive HER2-positive patients, warranting further clinical validation.</p>\u0000 </div>","PeriodicalId":56326,"journal":{"name":"Breast Journal","volume":"2025 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/tbj/1653319","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144598512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of Conventional Ultrasound and Contrast-Enhanced Ultrasound Features of Pseudoangiomatous Stromal Hyperplasia 假性血管瘤间质增生的常规超声与增强超声特征分析
IF 1.9 4区 医学 Q3 OBSTETRICS & GYNECOLOGY Pub Date : 2025-07-10 DOI: 10.1155/tbj/6070736
Hui Li, Qinghua Niu, Chao Jia, Gaoxiang Fan, Long Liu, Gang Li, Penglin Zou, Rong Wu, Lianfang Du, Jing Wang, Qiusheng Shi

Purpose: To investigate the conventional ultrasound and contrast-enhanced ultrasound (CEUS) imaging features of pseudoangiomatous stromal hyperplasia (PASH).

Methods: Retrospective analysis of clinical and imaging data of 29 patients diagnosed with PASH from June 2014 to June 2023.

Results: The median age of the patients was 39 years. Linear/cystic hypoechoic areas could be detected within the lesion in 12 cases (41.4%), and in 17 cases, the lesions had extensive conventional ultrasound findings with no significant features. The ultrasound-measured lesion diameters were smaller than those measured in surgically resected lesions, and the statistical difference was highly significant (p < 0.01). Fifteen cases underwent CEUS examination, with 7 lesions (46.7%) demonstrating uniform enhancement and 8 lesions (53.3%) exhibiting nonuniform enhancement. Within the enhanced regions, perfusion defects were observed, all of which were of the patchy type. The areas of patchy perfusion defects corresponded to the linear/cystic hypoechoic regions observed in the conventional sonographic images of the lesions. The use of CEUS provided additional diagnostic clarity compared with conventional ultrasound. Specifically, the specificity for identifying PASH lesions increased from 35.7% with conventional ultrasound to 64.3% with CEUS, highlighting the value of CEUS in enhancing the diagnostic accuracy for PASH lesions.

Conclusion: This study suggests that linear/cystic hypoechoic areas on sonography may serve as crucial clues for the ultrasound diagnosis of PASH. The presence of diffuse patchy perfusion defects in CEUS contributes to the accurate diagnosis of PASH.

目的:探讨假性血管瘤性间质增生(PASH)的常规超声和增强超声(CEUS)成像特点。方法:回顾性分析2014年6月至2023年6月诊断为PASH的29例患者的临床及影像学资料。结果:患者中位年龄39岁。12例(41.4%)病变内可检出线状/囊性低回声区,17例病变常规超声表现广泛,无明显特征。超声测量的病变直径小于手术切除的病变直径,差异有高度统计学意义(p <;0.01)。15例行超声造影检查,均匀强化7例(46.7%),非均匀强化8例(53.3%)。增强区可见灌注缺损,均为斑片型。斑片状灌注缺损区域与常规超声图像中观察到的线性/囊性低回声区域相对应。与常规超声相比,超声造影提供了额外的诊断清晰度。其中,超声诊断PASH病变的特异性从常规超声的35.7%提高到超声造影的64.3%,突出了超声造影在提高PASH病变诊断准确性方面的价值。结论:超声显示线状/囊性低回声区可作为PASH超声诊断的重要线索。超声造影显示弥漫性斑状灌注缺损有助于PASH的准确诊断。
{"title":"Analysis of Conventional Ultrasound and Contrast-Enhanced Ultrasound Features of Pseudoangiomatous Stromal Hyperplasia","authors":"Hui Li,&nbsp;Qinghua Niu,&nbsp;Chao Jia,&nbsp;Gaoxiang Fan,&nbsp;Long Liu,&nbsp;Gang Li,&nbsp;Penglin Zou,&nbsp;Rong Wu,&nbsp;Lianfang Du,&nbsp;Jing Wang,&nbsp;Qiusheng Shi","doi":"10.1155/tbj/6070736","DOIUrl":"https://doi.org/10.1155/tbj/6070736","url":null,"abstract":"<div>\u0000 <p><b>Purpose:</b> To investigate the conventional ultrasound and contrast-enhanced ultrasound (CEUS) imaging features of pseudoangiomatous stromal hyperplasia (PASH).</p>\u0000 <p><b>Methods:</b> Retrospective analysis of clinical and imaging data of 29 patients diagnosed with PASH from June 2014 to June 2023.</p>\u0000 <p><b>Results:</b> The median age of the patients was 39 years. Linear/cystic hypoechoic areas could be detected within the lesion in 12 cases (41.4%), and in 17 cases, the lesions had extensive conventional ultrasound findings with no significant features. The ultrasound-measured lesion diameters were smaller than those measured in surgically resected lesions, and the statistical difference was highly significant (<i>p</i> &lt; 0.01). Fifteen cases underwent CEUS examination, with 7 lesions (46.7%) demonstrating uniform enhancement and 8 lesions (53.3%) exhibiting nonuniform enhancement. Within the enhanced regions, perfusion defects were observed, all of which were of the patchy type. The areas of patchy perfusion defects corresponded to the linear/cystic hypoechoic regions observed in the conventional sonographic images of the lesions. The use of CEUS provided additional diagnostic clarity compared with conventional ultrasound. Specifically, the specificity for identifying PASH lesions increased from 35.7% with conventional ultrasound to 64.3% with CEUS, highlighting the value of CEUS in enhancing the diagnostic accuracy for PASH lesions.</p>\u0000 <p><b>Conclusion:</b> This study suggests that linear/cystic hypoechoic areas on sonography may serve as crucial clues for the ultrasound diagnosis of PASH. The presence of diffuse patchy perfusion defects in CEUS contributes to the accurate diagnosis of PASH.</p>\u0000 </div>","PeriodicalId":56326,"journal":{"name":"Breast Journal","volume":"2025 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/tbj/6070736","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144598513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Application of Microwave Ablation Combined With Chai Hu Qing Gan Tang in the Treatment of Idiopathic Granulomatous Mastitis 微波消融联合柴胡清肝汤治疗特发性肉芽肿性乳腺炎的应用
IF 1.9 4区 医学 Q3 OBSTETRICS & GYNECOLOGY Pub Date : 2025-07-07 DOI: 10.1155/tbj/2731494
Hang Li, Bing Li, Haiying Chen, Xiaoli Liu, Hongling Wang, Guoliang Zhang

Objective: To investigate the efficacy of microwave ablation (MVA) combined with Chai Hu Qing Gan Tang (CHQGT) for idiopathic granulomatous mastitis (IGM).

Methods: 480 patients were divided into the CHQGT combination group (CHQGT + MVA), corticosteroid combination group (glucocorticoids + MVA) and control group (glucocorticoids), with 160 cases in each group. Data on patient information, treatment effects, adverse effects and breast appearance were collected. Network pharmacology was used to identify the effective active ingredients and target information of CHQGT. The Gene Cards database was used to obtain the relevant targets of IGM, and the drug-component–common target relationship network was constructed using Cytoscape 3.9.1 software.

Results: All treatment groups showed significant differences in Visual Analog Scale score, Hamilton Depression Rating Scale score, Hamilton Anxiety Rating Scale, mass size and the total effective rate (p < 0.001). There was a statistically significant difference in the rate of excellent breast shape between the three groups after treatment (p < 0.001), with the rate higher in the CHQGT liver decoction combined with glucocorticoids treatment group compared with the control group. There was a statistically significant difference in the incidence of adverse reactions and recurrence rate between the three groups within 2 years after treatment (p < 0.001), with the incidence of adverse reactions and recurrence rate higher in the control group than in the glucocorticoid combination and CHQGT decoction combination groups. Network pharmacology identified 199 active ingredients and 23 drug-disease targets of CHQGT. The molecular docking results showed that the main active components screened had good binding activity with their corresponding target proteins.

Conclusion: The combination of CHQGT and MWA is comparable in overall therapeutic efficacy to the combination of glucocorticoids and MWA. However, the CHQGT and MWA combination is superior in reducing lump size, alleviating patient pain and accelerating recovery.

目的:探讨微波消融(MVA)联合柴虎清肝汤(CHQGT)治疗特发性肉芽肿性乳腺炎(IGM)的疗效。方法:480例患者分为CHQGT联合组(CHQGT + MVA)、糖皮质激素联合组(糖皮质激素+ MVA)和对照组(糖皮质激素),每组160例。收集了患者信息、治疗效果、不良反应和乳房外观的数据。采用网络药理学方法,鉴定中药复方清芪多糖的有效活性成分和靶点信息。利用Gene Cards数据库获取IGM相关靶点,利用Cytoscape 3.9.1软件构建药物组分-公共靶点关系网络。结果:各治疗组在视觉模拟量表评分、汉密尔顿抑郁评定量表评分、汉密尔顿焦虑评定量表评分、质量大小及总有效率(p <;0.001)。三组患者治疗后乳房形态优良率差异有统计学意义(p <;0.001),且CHQGT肝汤联合糖皮质激素治疗组的发生率高于对照组。三组患者治疗后2年内不良反应发生率及复发率比较,差异均有统计学意义(p <;0.001),对照组不良反应发生率和复发率均高于糖皮质激素联合用药组和CHQGT汤剂联合用药组。网络药理学鉴定出CHQGT的199个有效成分和23个药物-疾病靶点。分子对接结果表明,筛选到的主要活性成分与其对应的靶蛋白具有良好的结合活性。结论:CHQGT联合MWA的总体疗效与糖皮质激素联合MWA相当。然而,CHQGT和MWA联合在减小肿块大小、减轻患者疼痛和加速恢复方面具有优势。
{"title":"Application of Microwave Ablation Combined With Chai Hu Qing Gan Tang in the Treatment of Idiopathic Granulomatous Mastitis","authors":"Hang Li,&nbsp;Bing Li,&nbsp;Haiying Chen,&nbsp;Xiaoli Liu,&nbsp;Hongling Wang,&nbsp;Guoliang Zhang","doi":"10.1155/tbj/2731494","DOIUrl":"https://doi.org/10.1155/tbj/2731494","url":null,"abstract":"<div>\u0000 <p><b>Objective:</b> To investigate the efficacy of microwave ablation (MVA) combined with Chai Hu Qing Gan Tang (CHQGT) for idiopathic granulomatous mastitis (IGM).</p>\u0000 <p><b>Methods:</b> 480 patients were divided into the CHQGT combination group (CHQGT + MVA), corticosteroid combination group (glucocorticoids + MVA) and control group (glucocorticoids), with 160 cases in each group. Data on patient information, treatment effects, adverse effects and breast appearance were collected. Network pharmacology was used to identify the effective active ingredients and target information of CHQGT. The Gene Cards database was used to obtain the relevant targets of IGM, and the drug-component–common target relationship network was constructed using Cytoscape 3.9.1 software.</p>\u0000 <p><b>Results:</b> All treatment groups showed significant differences in Visual Analog Scale score, Hamilton Depression Rating Scale score, Hamilton Anxiety Rating Scale, mass size and the total effective rate (<i>p</i> &lt; 0.001). There was a statistically significant difference in the rate of excellent breast shape between the three groups after treatment (<i>p</i> &lt; 0.001), with the rate higher in the CHQGT liver decoction combined with glucocorticoids treatment group compared with the control group. There was a statistically significant difference in the incidence of adverse reactions and recurrence rate between the three groups within 2 years after treatment (<i>p</i> &lt; 0.001), with the incidence of adverse reactions and recurrence rate higher in the control group than in the glucocorticoid combination and CHQGT decoction combination groups. Network pharmacology identified 199 active ingredients and 23 drug-disease targets of CHQGT. The molecular docking results showed that the main active components screened had good binding activity with their corresponding target proteins.</p>\u0000 <p><b>Conclusion:</b> The combination of CHQGT and MWA is comparable in overall therapeutic efficacy to the combination of glucocorticoids and MWA. However, the CHQGT and MWA combination is superior in reducing lump size, alleviating patient pain and accelerating recovery.</p>\u0000 </div>","PeriodicalId":56326,"journal":{"name":"Breast Journal","volume":"2025 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/tbj/2731494","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144573798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Underserved Patient Populations With Metastatic Breast Cancer: A Review of Progress and Remaining Challenges 治疗不足的转移性乳腺癌患者群体:进展和仍然存在的挑战的回顾
IF 1.9 4区 医学 Q3 OBSTETRICS & GYNECOLOGY Pub Date : 2025-06-30 DOI: 10.1155/tbj/2461234
Fatima Cardoso, Rachel Wuerstlein, Tomoyuki Aruga, Renate Haidinger, Matteo Lambertini, Christine Benjamin, Elisenda Llabrés Valentí, Carmen Criscitiello, Matti Aapro, Generosa Grana, Sharon S. Gentry, Eduard Vrdoljak

Breast cancer presents a significant risk to public health and is the primary cause of cancer-related death in women. Awareness of metastatic breast cancer (mBC) continues to increase, and advances have been made; however, challenges remain for many patient populations that do not receive equal opportunities along the treatment pathway. The Underserved Patient Population (UPP) Coalition Task Force, a group of international experts in mBC, held meetings between 2022 and 2023 to prioritise the needs of UPPs and propose solutions. The key unmet needs identified included the following: delayed diagnosis of mBC due to difficulties in the presentation of patients to the healthcare system and a lack of primary care physician and non–breast cancer specialist understanding of the signs and symptoms of mBC; difficulty navigating the mBC patient pathway due to suboptimal use of multidisciplinary care and limited communication between HCPs; unequal access to the most appropriate mBC treatment options and supportive therapy due to the unconscious bias of HCPs, and direct and indirect financial toxicity for patients; and negative impact on QoL resulting from the limited uptake of shared decision-making, low prioritisation of patient preferences and a lack of personalised care. This paper aims to shine light on initiatives supporting underserved patients with mBC, illustrate the remaining gaps in care and call upon the global community to change how care is delivered to UPPs.

乳腺癌对公众健康构成重大威胁,是妇女癌症相关死亡的主要原因。对转移性乳腺癌(mBC)的认识不断提高,并取得了进展;然而,对于许多患者群体来说,挑战仍然存在,他们在治疗过程中没有获得平等的机会。服务不足患者群体(UPP)联盟工作队是由mBC的一组国际专家组成的工作组,该工作组在2022年至2023年期间举行了会议,以确定UPP的优先需求并提出解决方案。确定的未满足的关键需求包括:由于患者难以向医疗保健系统介绍,以及缺乏初级保健医生和非乳腺癌专家对mBC体征和症状的了解,导致mBC诊断延迟;由于多学科护理的不理想使用和HCPs之间有限的沟通,难以导航mBC患者路径;由于医务人员的无意识偏见,无法获得最适当的mBC治疗方案和支持治疗,以及对患者的直接和间接经济毒性;共同决策的有限采用、患者偏好的低优先级以及缺乏个性化护理对生活质量产生负面影响。本文旨在阐明支持服务不足的mBC患者的举措,说明护理方面的剩余差距,并呼吁国际社会改变向upp提供护理的方式。
{"title":"Underserved Patient Populations With Metastatic Breast Cancer: A Review of Progress and Remaining Challenges","authors":"Fatima Cardoso,&nbsp;Rachel Wuerstlein,&nbsp;Tomoyuki Aruga,&nbsp;Renate Haidinger,&nbsp;Matteo Lambertini,&nbsp;Christine Benjamin,&nbsp;Elisenda Llabrés Valentí,&nbsp;Carmen Criscitiello,&nbsp;Matti Aapro,&nbsp;Generosa Grana,&nbsp;Sharon S. Gentry,&nbsp;Eduard Vrdoljak","doi":"10.1155/tbj/2461234","DOIUrl":"https://doi.org/10.1155/tbj/2461234","url":null,"abstract":"<div>\u0000 <p>Breast cancer presents a significant risk to public health and is the primary cause of cancer-related death in women. Awareness of metastatic breast cancer (mBC) continues to increase, and advances have been made; however, challenges remain for many patient populations that do not receive equal opportunities along the treatment pathway. The Underserved Patient Population (UPP) Coalition Task Force, a group of international experts in mBC, held meetings between 2022 and 2023 to prioritise the needs of UPPs and propose solutions. The key unmet needs identified included the following: delayed diagnosis of mBC due to difficulties in the presentation of patients to the healthcare system and a lack of primary care physician and non–breast cancer specialist understanding of the signs and symptoms of mBC; difficulty navigating the mBC patient pathway due to suboptimal use of multidisciplinary care and limited communication between HCPs; unequal access to the most appropriate mBC treatment options and supportive therapy due to the unconscious bias of HCPs, and direct and indirect financial toxicity for patients; and negative impact on QoL resulting from the limited uptake of shared decision-making, low prioritisation of patient preferences and a lack of personalised care. This paper aims to shine light on initiatives supporting underserved patients with mBC, illustrate the remaining gaps in care and call upon the global community to change how care is delivered to UPPs.</p>\u0000 </div>","PeriodicalId":56326,"journal":{"name":"Breast Journal","volume":"2025 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/tbj/2461234","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144515125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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Breast Journal
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