Pub Date : 2025-10-20eCollection Date: 2025-10-01DOI: 10.1213/XAA.0000000000002067
Radu Podaru, Diego Gonzalez-Rivas, Javier Gallego Poveda, Concepcion Partida González
Anesthetic management for thoracic surgery in patients with single-lung physiology is challenging when mechanical ventilation is not possible or limited. Apneic oxygenation maintains oxygenation during apnea, facilitating lung collapse and optimal surgical exposure. We report a 50-year-old man with bilateral lung metastases from osteosarcoma who underwent left lung wedge resection 10 days after right pneumonectomy, using apneic oxygenation instead of conventional one-lung ventilation. This case demonstrates that apneic oxygenation may serve as a safe and effective alternative in selected patients. However, limitations such as hypercapnia and respiratory acidosis require careful patient selection, time constraints, and vigilant intraoperative monitoring.
{"title":"Apneic Oxygenation for Contralateral Uniportal Multiple Lung Resection After Right Pneumonectomy.","authors":"Radu Podaru, Diego Gonzalez-Rivas, Javier Gallego Poveda, Concepcion Partida González","doi":"10.1213/XAA.0000000000002067","DOIUrl":"https://doi.org/10.1213/XAA.0000000000002067","url":null,"abstract":"<p><p>Anesthetic management for thoracic surgery in patients with single-lung physiology is challenging when mechanical ventilation is not possible or limited. Apneic oxygenation maintains oxygenation during apnea, facilitating lung collapse and optimal surgical exposure. We report a 50-year-old man with bilateral lung metastases from osteosarcoma who underwent left lung wedge resection 10 days after right pneumonectomy, using apneic oxygenation instead of conventional one-lung ventilation. This case demonstrates that apneic oxygenation may serve as a safe and effective alternative in selected patients. However, limitations such as hypercapnia and respiratory acidosis require careful patient selection, time constraints, and vigilant intraoperative monitoring.</p>","PeriodicalId":56372,"journal":{"name":"A&A practice","volume":"19 10","pages":"e02067"},"PeriodicalIF":0.6,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145350331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-20eCollection Date: 2025-10-01DOI: 10.1213/XAA.0000000000002063
Gytaute Navikaite, Ursula Speck, Markus M Luedi, Ruben Klimke
Positive communication in perioperative medicine improves patient satisfaction, outcomes, and psychological safety. Grounded in the biopsychosocial model, it promotes shared decision-making and trust among patients and clinicians. It helps reduce anxiety and pain, but challenges remain. These include differing perceptions of "positive" communication, the stress of acute care, and limited research due to inconsistent methodologies and outcomes. Clinician well-being is crucial for sustaining positive interactions. Advancing the field requires evidence-based strategies and interdisciplinary collaboration to ensure effective, consistent communication in high-pressure settings and to bridge the gap between research and real-world clinical practice.
{"title":"Beyond Bedside Manner: Positive Communication in Perioperative Medicine.","authors":"Gytaute Navikaite, Ursula Speck, Markus M Luedi, Ruben Klimke","doi":"10.1213/XAA.0000000000002063","DOIUrl":"https://doi.org/10.1213/XAA.0000000000002063","url":null,"abstract":"<p><p>Positive communication in perioperative medicine improves patient satisfaction, outcomes, and psychological safety. Grounded in the biopsychosocial model, it promotes shared decision-making and trust among patients and clinicians. It helps reduce anxiety and pain, but challenges remain. These include differing perceptions of \"positive\" communication, the stress of acute care, and limited research due to inconsistent methodologies and outcomes. Clinician well-being is crucial for sustaining positive interactions. Advancing the field requires evidence-based strategies and interdisciplinary collaboration to ensure effective, consistent communication in high-pressure settings and to bridge the gap between research and real-world clinical practice.</p>","PeriodicalId":56372,"journal":{"name":"A&A practice","volume":"19 10","pages":"e02063"},"PeriodicalIF":0.6,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145350318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-15eCollection Date: 2025-10-01DOI: 10.1213/XAA.0000000000002064
Suvarna Kaniyil, Ananya Soman, Indu Susheela
Bernard-Soulier syndrome is a rare inherited bleeding disorder caused by a deficiency of the platelet surface glycoprotein Ib-IX-V complex, leading to defective platelet adhesion and increased bleeding risk. Catamenial hemothorax, a rare manifestation of thoracic endometriosis, involves recurrent intrapleural bleeding in synchrony with menstruation. Coexistence of both conditions poses significant challenges to perioperative anesthetic management due to compounded risks of hemorrhage and respiratory complications. We report the successful anesthetic management of a 22-year-old woman with coexisting Bernard-Soulier syndrome and catamenial hemothorax who underwent thoracotomy and pleurodesis, along with a brief review of the relevant literature.
{"title":"Anesthetic Management of a Patient With Bernard-Soulier Syndrome and Catamenial Hemothorax for Thoracotomy: A Case Report.","authors":"Suvarna Kaniyil, Ananya Soman, Indu Susheela","doi":"10.1213/XAA.0000000000002064","DOIUrl":"https://doi.org/10.1213/XAA.0000000000002064","url":null,"abstract":"<p><p>Bernard-Soulier syndrome is a rare inherited bleeding disorder caused by a deficiency of the platelet surface glycoprotein Ib-IX-V complex, leading to defective platelet adhesion and increased bleeding risk. Catamenial hemothorax, a rare manifestation of thoracic endometriosis, involves recurrent intrapleural bleeding in synchrony with menstruation. Coexistence of both conditions poses significant challenges to perioperative anesthetic management due to compounded risks of hemorrhage and respiratory complications. We report the successful anesthetic management of a 22-year-old woman with coexisting Bernard-Soulier syndrome and catamenial hemothorax who underwent thoracotomy and pleurodesis, along with a brief review of the relevant literature.</p>","PeriodicalId":56372,"journal":{"name":"A&A practice","volume":"19 10","pages":"e02064"},"PeriodicalIF":0.6,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145338250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-10eCollection Date: 2025-10-01DOI: 10.1213/XAA.0000000000002061
James Harvey Jones, Tetsuro Sakai
Preoperative optimization clinics enhance surgical outcomes by optimizing patients' health, reducing unnecessary tests, and minimizing cancellations. Artificial intelligence (AI) now promises to further advance these efforts by improving predictive modeling, automating risk assessments, and enabling personalized care strategies. AI models have shown particular strength in predicting postoperative complications, such as cardiovascular events. Tools like natural language processing (NLP) have also improved risk detection for conditions like alcohol misuse. The historical development of preoperative clinics-from Dr. J Alfred Lee's initial concept in 1949 to modern models like Enhanced Recovery After Surgery (ERAS) and Anesthesia Preoperative Evaluation Clinic (APEC)-laid the groundwork for today's integration of electronic health records (EHRs) and decision-support systems, now evolving toward AI-driven care. Machine-learning algorithms have proven superior to traditional models for predicting postoperative anemia, opioid dependence, diabetes complications, and mortality risks, thus offering precise stratification and resource optimization. Specific applications include AI-assisted anemia management, penicillin allergy delabelling, and opioid use prediction after major surgeries. AI also enhances patient education through tools like ChatGPT and improves smoking cessation efforts using conversational AI. NLP has demonstrated better accuracy than standard International Classification of Disease (ICD) codes in identifying risky alcohol use (>2 standard drinks per day before surgery). However, barriers to widespread adoption include data privacy, algorithmic bias, and clinician skepticism. Future studies should focus on validating AI models across diverse populations and integrating AI recommendations within clinical workflows while adhering to evolving regulatory standards. Ultimately, AI's incorporation into preoperative assessments could significantly boost the efficiency and impact of clinic resources, potentially shifting outcomes more favorably by improving the slope of resource utilization versus patient outcome curves. Continued research and refinement are essential for AI to achieve its full potential in perioperative medicine.
术前优化诊所通过优化患者的健康状况、减少不必要的检查和最大限度地减少取消手术来提高手术效果。人工智能(AI)现在有望通过改进预测建模、自动化风险评估和实现个性化护理策略来进一步推进这些努力。人工智能模型在预测心血管事件等术后并发症方面表现出了特别的优势。自然语言处理(NLP)等工具也提高了对酒精滥用等情况的风险检测。术前诊所的历史发展——从1949年J . Alfred Lee医生最初的概念到现代模式,如手术后增强恢复(ERAS)和麻醉术前评估诊所(APEC)——为今天的电子健康记录(EHRs)和决策支持系统的整合奠定了基础,现在正在向人工智能驱动的护理发展。事实证明,机器学习算法在预测术后贫血、阿片类药物依赖、糖尿病并发症和死亡风险方面优于传统模型,从而提供了精确的分层和资源优化。具体应用包括人工智能辅助贫血管理、青霉素过敏去标签和大手术后阿片类药物使用预测。人工智能还通过ChatGPT等工具加强患者教育,并通过会话人工智能改善戒烟效果。在识别危险饮酒方面,NLP已证明比标准的国际疾病分类(ICD)代码更准确(手术前每天饮用2杯标准酒)。然而,广泛采用的障碍包括数据隐私、算法偏见和临床医生的怀疑。未来的研究应侧重于在不同人群中验证人工智能模型,并在遵守不断发展的监管标准的同时,将人工智能建议整合到临床工作流程中。最终,人工智能纳入术前评估可以显著提高临床资源的效率和影响,通过改善资源利用相对于患者结果曲线的斜率,可能更有利地改变结果。持续的研究和改进对于人工智能在围手术期医学中充分发挥其潜力至关重要。
{"title":"The Potential Impacts of Artificial Intelligence on Preoperative Optimization and Predicting Risks of Morbidity and Mortality: A Narrative Focused Review.","authors":"James Harvey Jones, Tetsuro Sakai","doi":"10.1213/XAA.0000000000002061","DOIUrl":"https://doi.org/10.1213/XAA.0000000000002061","url":null,"abstract":"<p><p>Preoperative optimization clinics enhance surgical outcomes by optimizing patients' health, reducing unnecessary tests, and minimizing cancellations. Artificial intelligence (AI) now promises to further advance these efforts by improving predictive modeling, automating risk assessments, and enabling personalized care strategies. AI models have shown particular strength in predicting postoperative complications, such as cardiovascular events. Tools like natural language processing (NLP) have also improved risk detection for conditions like alcohol misuse. The historical development of preoperative clinics-from Dr. J Alfred Lee's initial concept in 1949 to modern models like Enhanced Recovery After Surgery (ERAS) and Anesthesia Preoperative Evaluation Clinic (APEC)-laid the groundwork for today's integration of electronic health records (EHRs) and decision-support systems, now evolving toward AI-driven care. Machine-learning algorithms have proven superior to traditional models for predicting postoperative anemia, opioid dependence, diabetes complications, and mortality risks, thus offering precise stratification and resource optimization. Specific applications include AI-assisted anemia management, penicillin allergy delabelling, and opioid use prediction after major surgeries. AI also enhances patient education through tools like ChatGPT and improves smoking cessation efforts using conversational AI. NLP has demonstrated better accuracy than standard International Classification of Disease (ICD) codes in identifying risky alcohol use (>2 standard drinks per day before surgery). However, barriers to widespread adoption include data privacy, algorithmic bias, and clinician skepticism. Future studies should focus on validating AI models across diverse populations and integrating AI recommendations within clinical workflows while adhering to evolving regulatory standards. Ultimately, AI's incorporation into preoperative assessments could significantly boost the efficiency and impact of clinic resources, potentially shifting outcomes more favorably by improving the slope of resource utilization versus patient outcome curves. Continued research and refinement are essential for AI to achieve its full potential in perioperative medicine.</p>","PeriodicalId":56372,"journal":{"name":"A&A practice","volume":"19 10","pages":"e02061"},"PeriodicalIF":0.6,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145287850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-10eCollection Date: 2025-10-01DOI: 10.1213/XAA.0000000000002065
Onur Baran, Ayhan Şahin, Cavidan Arar
We report a case of a 53-year-old male with myasthenia gravis who underwent thymectomy via a full-length median sternotomy. To minimize opioid exposure and enhance postoperative recovery, a bilateral ultrasound-guided superficial parasternal intercostal plane (S-PIP) block was administered using 15 mL of 0.25% bupivacaine on each side before incision. Postoperative analgesia was maintained with paracetamol and dexketoprofen. No systemic opioids were required, and pain scores remained below 4 during the first 24 hours. The patient recovered uneventfully in the postoperative period. This case highlights the utility of S-PIP block as a safe and opioid-sparing technique in high-risk patients undergoing sternotomy.
我们报告一例53岁男性重症肌无力患者通过全长胸骨正中切开术行胸腺切除术。为了减少阿片类药物暴露并促进术后恢复,在切口前每侧使用15 mL 0.25%布比卡因进行双侧超声引导下的浅胸骨旁肋间平面(S-PIP)阻滞。术后用扑热息痛和右酮洛芬维持镇痛。不需要全身性阿片类药物,疼痛评分在前24小时保持在4以下。患者术后恢复平稳。该病例强调了S-PIP阻滞作为一种安全且节省阿片类药物的技术在高危胸骨切开术患者中的应用。
{"title":"Superficial Parasternal Intercostal Plane Block for Pain Control Following Thymectomy via Midline Sternotomy: A Case Report.","authors":"Onur Baran, Ayhan Şahin, Cavidan Arar","doi":"10.1213/XAA.0000000000002065","DOIUrl":"https://doi.org/10.1213/XAA.0000000000002065","url":null,"abstract":"<p><p>We report a case of a 53-year-old male with myasthenia gravis who underwent thymectomy via a full-length median sternotomy. To minimize opioid exposure and enhance postoperative recovery, a bilateral ultrasound-guided superficial parasternal intercostal plane (S-PIP) block was administered using 15 mL of 0.25% bupivacaine on each side before incision. Postoperative analgesia was maintained with paracetamol and dexketoprofen. No systemic opioids were required, and pain scores remained below 4 during the first 24 hours. The patient recovered uneventfully in the postoperative period. This case highlights the utility of S-PIP block as a safe and opioid-sparing technique in high-risk patients undergoing sternotomy.</p>","PeriodicalId":56372,"journal":{"name":"A&A practice","volume":"19 10","pages":"e02065"},"PeriodicalIF":0.6,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145287722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-24eCollection Date: 2025-09-01DOI: 10.1213/XAA.0000000000002044
Dhatri Jonna, Ruma Thakuria, Ranjay Mahaseth, Kunal Biswakarma
Anesthetic management of central airway tumors is challenging due to airway obstruction, lack of a definitive airway, and shared airway with surgeon. While a nasogastric tube (NGT) is primarily designed for feeding and administration of medication, it can be an auxiliary device in emergency situations, when airway anatomy poses a significant obstacle to traditional ventilation methods. We describe the use of an NGT as an alternative airway conduit to bypass the tumor and maintain ventilation in a case with a distal tracheal tumor causing complete airway occlusion.
{"title":"Unconventional Application of a Nasogastric Tube for Effective Rescue Ventilation During Rigid Bronchoscopic Tumor Removal: A Case Report.","authors":"Dhatri Jonna, Ruma Thakuria, Ranjay Mahaseth, Kunal Biswakarma","doi":"10.1213/XAA.0000000000002044","DOIUrl":"10.1213/XAA.0000000000002044","url":null,"abstract":"<p><p>Anesthetic management of central airway tumors is challenging due to airway obstruction, lack of a definitive airway, and shared airway with surgeon. While a nasogastric tube (NGT) is primarily designed for feeding and administration of medication, it can be an auxiliary device in emergency situations, when airway anatomy poses a significant obstacle to traditional ventilation methods. We describe the use of an NGT as an alternative airway conduit to bypass the tumor and maintain ventilation in a case with a distal tracheal tumor causing complete airway occlusion.</p>","PeriodicalId":56372,"journal":{"name":"A&A practice","volume":"19 9","pages":"e02044"},"PeriodicalIF":0.6,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145132956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-23eCollection Date: 2025-09-01DOI: 10.1213/XAA.0000000000002053
Prabu Gunasekaran, Rasheeda Darville, Abeer Alomari, Danielle Alvares, Victoria Bains, Emma Robertson, Pranab Kumar, Yasmine Hoydonckx, Ehtesham Baig, Ryan S D'Souza, Anuj Bhatia
Spinal cord stimulation (SCS) is effective for some pain syndromes, but inappropriate referrals can frustrate patients and misuse resources. This retrospective study reviewed 370 patients referred to a Neuromodulation for Pain Program (NPP) from July 2022 to June 2024. Of these, 241 were deemed appropriate for SCS. The SCS-appropriate group had higher pain intensity, more neuropathic pain, and lower opioid use. Inappropriate referrals were often from family physicians. Key factors associated with inappropriateness included low pain intensity, lack of neuropathic features, and high opioid use. Enhancing referral quality through targeted education may improve care and system efficiency.
{"title":"Appropriate Selection or Poor Triaging: Assessment of Patient Profiles Presenting to a Neuromodulation for Pain Program at a Tertiary Academic Center.","authors":"Prabu Gunasekaran, Rasheeda Darville, Abeer Alomari, Danielle Alvares, Victoria Bains, Emma Robertson, Pranab Kumar, Yasmine Hoydonckx, Ehtesham Baig, Ryan S D'Souza, Anuj Bhatia","doi":"10.1213/XAA.0000000000002053","DOIUrl":"10.1213/XAA.0000000000002053","url":null,"abstract":"<p><p>Spinal cord stimulation (SCS) is effective for some pain syndromes, but inappropriate referrals can frustrate patients and misuse resources. This retrospective study reviewed 370 patients referred to a Neuromodulation for Pain Program (NPP) from July 2022 to June 2024. Of these, 241 were deemed appropriate for SCS. The SCS-appropriate group had higher pain intensity, more neuropathic pain, and lower opioid use. Inappropriate referrals were often from family physicians. Key factors associated with inappropriateness included low pain intensity, lack of neuropathic features, and high opioid use. Enhancing referral quality through targeted education may improve care and system efficiency.</p>","PeriodicalId":56372,"journal":{"name":"A&A practice","volume":"19 9","pages":"e02053"},"PeriodicalIF":0.6,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145126642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-23eCollection Date: 2025-09-01DOI: 10.1213/XAA.0000000000002060
Elif Sarikaya Ozel, Mehmet Gokhan Taflan
The biceps femoris short head (BiFeS) block is a novel, ultrasound-guided, motor-sparing regional anesthesia technique targeting the posterolateral sensory innervation of the knee. We present two unilateral total knee arthroplasty (TKA) cases in which BiFeS was combined with adductor canal block (ACB) under spinal anesthesia. Blocks were administered postoperatively, before the onset of pain. Both patients had low pain scores, preserved quadriceps and ankle motor function, minimal morphine consumption (6 mg and 5 mg), and high Quality of Recovery-15 (QoR-15) scores (140 and 137). BiFeS may be a valuable adjunct to ACB for multimodal analgesia in TKA.
{"title":"Ultrasound-Guided Biceps Femoris Short Head Block for Posterolateral Knee Analgesia After Total Knee Arthroplasty: A Case Report.","authors":"Elif Sarikaya Ozel, Mehmet Gokhan Taflan","doi":"10.1213/XAA.0000000000002060","DOIUrl":"10.1213/XAA.0000000000002060","url":null,"abstract":"<p><p>The biceps femoris short head (BiFeS) block is a novel, ultrasound-guided, motor-sparing regional anesthesia technique targeting the posterolateral sensory innervation of the knee. We present two unilateral total knee arthroplasty (TKA) cases in which BiFeS was combined with adductor canal block (ACB) under spinal anesthesia. Blocks were administered postoperatively, before the onset of pain. Both patients had low pain scores, preserved quadriceps and ankle motor function, minimal morphine consumption (6 mg and 5 mg), and high Quality of Recovery-15 (QoR-15) scores (140 and 137). BiFeS may be a valuable adjunct to ACB for multimodal analgesia in TKA.</p>","PeriodicalId":56372,"journal":{"name":"A&A practice","volume":"19 9","pages":"e02060"},"PeriodicalIF":0.6,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145126581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-23eCollection Date: 2025-09-01DOI: 10.1213/XAA.0000000000002062
Edward Ho, Brett Simpson, Natalie Anne Smith, Simon Harper
Succinylcholine is widely used in anesthesia for electroconvulsive therapy (ECT). Succinylcholine apnea is a recognized rare complication. A patient's dormant, undiagnosed, genetic pseudocholinesterase deficiency was clinically triggered and unmasked by the combination of long-term rivastigmine therapy and succinylcholine used in ECT, resulting in post-ictal succinylcholine apnea. In subsequent treatments, low-dose rocuronium was successfully used instead. Clinicians providing electroconvulsive therapy should consider potential interactions between cholinesterase-inhibiting drugs and succinylcholine or use alternative neuromuscular blocking drugs.
{"title":"Genetic Pseudocholinesterase Deficiency Unmasked After Succinylcholine-Rivastigmine Interaction: A Case Report.","authors":"Edward Ho, Brett Simpson, Natalie Anne Smith, Simon Harper","doi":"10.1213/XAA.0000000000002062","DOIUrl":"10.1213/XAA.0000000000002062","url":null,"abstract":"<p><p>Succinylcholine is widely used in anesthesia for electroconvulsive therapy (ECT). Succinylcholine apnea is a recognized rare complication. A patient's dormant, undiagnosed, genetic pseudocholinesterase deficiency was clinically triggered and unmasked by the combination of long-term rivastigmine therapy and succinylcholine used in ECT, resulting in post-ictal succinylcholine apnea. In subsequent treatments, low-dose rocuronium was successfully used instead. Clinicians providing electroconvulsive therapy should consider potential interactions between cholinesterase-inhibiting drugs and succinylcholine or use alternative neuromuscular blocking drugs.</p>","PeriodicalId":56372,"journal":{"name":"A&A practice","volume":"19 9","pages":"e02062"},"PeriodicalIF":0.6,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145126584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}