The persistence of pathogenic microorganisms in low-moisture foods (LMFs) poses a public health concern, as they can survive under dry conditions and resist conventional heat treatments. Despite the fact that LMFs do not support microbial growth, outbreaks and recalls have demonstrated their vulnerability to contamination. Conventional decontamination methods, such as fumigation and thermal treatments, have been widely used; however, these techniques may lead to undesirable effects, including toxic residues in the former and nutrient loss and quality degradation in the latter. To address these challenges, a range of novel thermal and non-thermal technologies have been explored for their potential to inactivate pathogens in LMFs. This review provides a critical assessment of studies evaluating decontamination methods applied to LMFs, considering their microbial inactivation mechanisms, effectiveness, and impact on product quality properties. Comparisons between various technologies are drawn, highlighting their advantages and limitations. Additionally, the concept of hurdle technology, which involves the combination of multiple treatments to enhance microbial control while preserving food integrity, is discussed as a promising approach for improving LMF safety.