Zihan Yu, Junlong Li, Wuga Jiala, Kui Yang, Qiqi Song, Zheyu Li, Wenbo Ma
An iron-mediated direct chalcogenation of tyrosine-containing peptides has been developed. This protocol operates under mechanochemical conditions and exhibits broad functional group tolerance. Furthermore, the synthetic utility of this protocol was demonstrated by the late-stage functionalization of pharmaceutical compounds. Preliminary mechanistic studies indicated that a radical pathway is likely to be operative.
{"title":"Iron-Mediated Regioselective C–H Chalcogenation of Tyrosine Derivatives Using Mechanochemistry","authors":"Zihan Yu, Junlong Li, Wuga Jiala, Kui Yang, Qiqi Song, Zheyu Li, Wenbo Ma","doi":"10.1021/acs.joc.5c03001","DOIUrl":"https://doi.org/10.1021/acs.joc.5c03001","url":null,"abstract":"An iron-mediated direct chalcogenation of tyrosine-containing peptides has been developed. This protocol operates under mechanochemical conditions and exhibits broad functional group tolerance. Furthermore, the synthetic utility of this protocol was demonstrated by the late-stage functionalization of pharmaceutical compounds. Preliminary mechanistic studies indicated that a radical pathway is likely to be operative.","PeriodicalId":57,"journal":{"name":"Journal of Organic Chemistry","volume":"90 1","pages":""},"PeriodicalIF":4.354,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146110699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Taiyou Xu, Wanqiu Peng, Luhang Yang, Ya Hong, Xingxing Wu
Acridine scaffolds are key pharmacophores in bioactive molecules and functional materials that exhibit diverse biological activities. Although C9-functionalization methods of 9,10-dihydroacridines have advanced, the development of efficient and transition-metal-free strategies for direct heteroarylation of sp3 C-H bonds to access structurally diverse acridines is highly demanding. Herein, we report a KHMDS-mediated direct coupling of 9,10-dihydroacridines with readily available heteroaryl halides under mild and simple conditions. This approach enables rapid and modular access to 9-heteroaryl dihydroacridine derivatives. The resulting functionalized products can be readily transformed into a diverse set of (hetero)aryl-substituted acridinium salts, which shall inspire future applications in the design of photocatalysts and fluorescent dyes. Biological tests demonstrated potent and wide-ranging antifungal activity, underscoring the potential of these products as fungicide leads for agrochemical development.
{"title":"KHMDS-Mediated Direct Heteroarylation of C(sp<sup>3</sup>)-H Bonds of 9,10-Dihydroacridines and Analogues for Discovery of Potent Antimicrobial Agents.","authors":"Taiyou Xu, Wanqiu Peng, Luhang Yang, Ya Hong, Xingxing Wu","doi":"10.1021/acs.joc.5c02855","DOIUrl":"https://doi.org/10.1021/acs.joc.5c02855","url":null,"abstract":"<p><p>Acridine scaffolds are key pharmacophores in bioactive molecules and functional materials that exhibit diverse biological activities. Although C9-functionalization methods of 9,10-dihydroacridines have advanced, the development of efficient and transition-metal-free strategies for direct heteroarylation of sp<sup>3</sup> C-H bonds to access structurally diverse acridines is highly demanding. Herein, we report a KHMDS-mediated direct coupling of 9,10-dihydroacridines with readily available heteroaryl halides under mild and simple conditions. This approach enables rapid and modular access to 9-heteroaryl dihydroacridine derivatives. The resulting functionalized products can be readily transformed into a diverse set of (hetero)aryl-substituted acridinium salts, which shall inspire future applications in the design of photocatalysts and fluorescent dyes. Biological tests demonstrated potent and wide-ranging antifungal activity, underscoring the potential of these products as fungicide leads for agrochemical development.</p>","PeriodicalId":57,"journal":{"name":"Journal of Organic Chemistry","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146103180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yi Sun, Yanting Yang, Xiaobing Huang, Lin Yuan, Qiang Bian, Jun Ren, Zhongwen Wang
Utilizing a readily available and highly efficient organic photocatalyst (QXPT-NPy, 0.5 mol %) and inexpensive CBr4 (0.5 mol %) as a bromine radical precursor, the [3 + 2] cycloadditions of vinylcyclopropanes with alkenes/alkynes were successfully achieved under irradiation of 420 nm blue LEDs. A broad scope of alkenes and alkynes participated efficiently in the reaction, and structurally diverse cyclopentane and cyclopentene derivatives were afforded in up to 97% yield and 95:5 dr.
{"title":"Visible Light-Mediated [3 + 2] Cycloadditions of Vinylcyclopropanes with Alkenes/Alkynes Using CBr4 and an Organic Photocatalyst","authors":"Yi Sun, Yanting Yang, Xiaobing Huang, Lin Yuan, Qiang Bian, Jun Ren, Zhongwen Wang","doi":"10.1021/acs.joc.5c02490","DOIUrl":"https://doi.org/10.1021/acs.joc.5c02490","url":null,"abstract":"Utilizing a readily available and highly efficient organic photocatalyst (QXPT-NPy, 0.5 mol %) and inexpensive CBr<sub>4</sub> (0.5 mol %) as a bromine radical precursor, the [3 + 2] cycloadditions of vinylcyclopropanes with alkenes/alkynes were successfully achieved under irradiation of 420 nm blue LEDs. A broad scope of alkenes and alkynes participated efficiently in the reaction, and structurally diverse cyclopentane and cyclopentene derivatives were afforded in up to 97% yield and 95:5 dr.","PeriodicalId":57,"journal":{"name":"Journal of Organic Chemistry","volume":"44 1","pages":""},"PeriodicalIF":4.354,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146110700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anastasia A. Smorodina,Mariia S. Iugova,Evgeny M. Buev,Taisiya I. Ichetovkina,Vladimir S. Moshkin,Vyacheslav Y. Sosnovskikh
Enamines serve as pivotal compounds in synthetic organic chemistry. Herein, a homologative enamination of aromatic aldehydes was achieved through three steps: [3 + 2] cycloaddition with nonstabilized azomethine ylide, quaternization with various alkyl halides, and eliminative ring-cleavage of oxazolidine core with sodium hydride in dimethyl sulfoxide. The obtained dialkylstyrylamines were employed as useful intermediates, furnishing a number of phenethylamines via reduction with sodium borohydride in good yields or were acylated with trifluoroacetic anhydride. We also demonstrated that the titled enamination could be performed in two step manner applying thermal ring-cleavage of 5-aryloxazolidine with trifluoroacetic anhydride, providing N-acylaminostyrenes in moderate yields. The proposed methodology for the homologative enamination features with gram-scale approach, readily available inexpensive materials, and simple laboratory techniques.
{"title":"Homologative Enamination of Aromatic Aldehydes as a Route to β-Dialkylaminostyrenes","authors":"Anastasia A. Smorodina,Mariia S. Iugova,Evgeny M. Buev,Taisiya I. Ichetovkina,Vladimir S. Moshkin,Vyacheslav Y. Sosnovskikh","doi":"10.1021/acs.joc.5c03028","DOIUrl":"https://doi.org/10.1021/acs.joc.5c03028","url":null,"abstract":"Enamines serve as pivotal compounds in synthetic organic chemistry. Herein, a homologative enamination of aromatic aldehydes was achieved through three steps: [3 + 2] cycloaddition with nonstabilized azomethine ylide, quaternization with various alkyl halides, and eliminative ring-cleavage of oxazolidine core with sodium hydride in dimethyl sulfoxide. The obtained dialkylstyrylamines were employed as useful intermediates, furnishing a number of phenethylamines via reduction with sodium borohydride in good yields or were acylated with trifluoroacetic anhydride. We also demonstrated that the titled enamination could be performed in two step manner applying thermal ring-cleavage of 5-aryloxazolidine with trifluoroacetic anhydride, providing N-acylaminostyrenes in moderate yields. The proposed methodology for the homologative enamination features with gram-scale approach, readily available inexpensive materials, and simple laboratory techniques.","PeriodicalId":57,"journal":{"name":"Journal of Organic Chemistry","volume":"30 1","pages":""},"PeriodicalIF":4.354,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146111264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Transition metal-catalyzed enantioselective alkene hydroalkynylation to construct a nonadjacent stereocenter, especially in cyclic systems, remains underexplored. Herein, we report an iridium-catalyzed enantioselective hydroalkynylation of cyclopentene substrates containing an amide as the directing group, affording cyclopentanes with nonadjacent 1,3-stereocenters with high regio-, diastereo-, and enantioselectivity. The alkynyl group in the product enables further transformations, providing a reliable route to enantioenriched cyclic compounds with nonadjacent stereocenters.
{"title":"Iridium-Catalyzed Desymmetric Hydroalkynylation of Cyclopentenes to Construct 1,3-Stereocenters","authors":"Tong Wan, En-Ze Lin, Huanrong Li, Bi-Jie Li","doi":"10.1021/acs.joc.5c02755","DOIUrl":"https://doi.org/10.1021/acs.joc.5c02755","url":null,"abstract":"Transition metal-catalyzed enantioselective alkene hydroalkynylation to construct a nonadjacent stereocenter, especially in cyclic systems, remains underexplored. Herein, we report an iridium-catalyzed enantioselective hydroalkynylation of cyclopentene substrates containing an amide as the directing group, affording cyclopentanes with nonadjacent 1,3-stereocenters with high regio-, diastereo-, and enantioselectivity. The alkynyl group in the product enables further transformations, providing a reliable route to enantioenriched cyclic compounds with nonadjacent stereocenters.","PeriodicalId":57,"journal":{"name":"Journal of Organic Chemistry","volume":"84 1","pages":""},"PeriodicalIF":4.354,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146110702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alexis S. Zamora-Vázquez, Diana E. Ramírez-Ornelas, Enrique Alvarado-Martínez, Fernando Hernández, Miguel A. Vázquez, Eduardo Peña-Cabrera
The Liebeskind-Srogl (LSCC) and Suzuki cross-coupling reactions were employed to prepare 10 formyl-substituted BODIPY dyes in high yields (64–98%). These derivatives were reacted with malononitrile, ethyl acetoacetate and ammonium hydroxide in a multicomponent reaction (MCR) to furnish highly substituted 4H-pyranes. In Method A, conventional heating was employed to prepare nine such derivatives in yields that range from 25 to 72%. In Method B, six derivatives were prepared under ultrasound-activation in 35–64% isolated yields and reduced reaction times. The photophysical properties of the 4H-pyranes thus prepared were measured. A rather low fluorescence quantum yield (ΦF = 0.61–5.67%) of the products was observed. Moreover, absorption and emission are in accordance with typical for BODIPY green-yellow region. Finally, it was observed excellent chromophore behavior (log εmax = 3.94–4.91 M–1 cm–1) and moderate Stokes shift values for the product series (599–728 cm–1), and finally 2,3,5,6-tetraarylBODIPY product with absorption and emission displaced to red (627 and 718 nm, respectively).
{"title":"BODIPYS in Multicomponent Reactions. Synthesis of BODIPY-4H-Pyran Hybrids","authors":"Alexis S. Zamora-Vázquez, Diana E. Ramírez-Ornelas, Enrique Alvarado-Martínez, Fernando Hernández, Miguel A. Vázquez, Eduardo Peña-Cabrera","doi":"10.1021/acs.joc.5c02560","DOIUrl":"https://doi.org/10.1021/acs.joc.5c02560","url":null,"abstract":"The Liebeskind-Srogl (LSCC) and Suzuki cross-coupling reactions were employed to prepare 10 formyl-substituted BODIPY dyes in high yields (64–98%). These derivatives were reacted with malononitrile, ethyl acetoacetate and ammonium hydroxide in a multicomponent reaction (MCR) to furnish highly substituted 4<i>H</i>-pyranes. In Method A, conventional heating was employed to prepare nine such derivatives in yields that range from 25 to 72%. In Method B, six derivatives were prepared under ultrasound-activation in 35–64% isolated yields and reduced reaction times. The photophysical properties of the 4<i>H</i>-pyranes thus prepared were measured. A rather low fluorescence quantum yield (Φ<sub>F</sub> = 0.61–5.67%) of the products was observed. Moreover, absorption and emission are in accordance with typical for BODIPY green-yellow region. Finally, it was observed excellent chromophore behavior (log ε<sub>max</sub> = 3.94–4.91 M<sup>–1</sup> cm<sup>–1</sup>) and moderate Stokes shift values for the product series (599–728 cm<sup>–1</sup>), and finally 2,3,5,6-tetraarylBODIPY product with absorption and emission displaced to red (627 and 718 nm, respectively).","PeriodicalId":57,"journal":{"name":"Journal of Organic Chemistry","volume":"34 1","pages":""},"PeriodicalIF":4.354,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146110698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A facile synthesis of dihydrocoumarin derivatives has been successfully accessed with ortho-hydroxyphenyl-substituted para-quinone methides (p-QMs) and ortho-hydroxy aromatic aldimines. The reaction proceeds through a Michael addition followed by an intramolecular phenolysis sequence. This cascade strategy provides structurally diverse 4-aryl-3,4-dihydrocoumarins in good to excellent yields with excellent diastereoselectivity. Moreover, this versatile method exhibits significant promise for the synthesis of natural products and biologically relevant compounds that possess a substituted coumarin skeleton.
{"title":"DBU-Promoted Cascade Synthesis of Dihydrocoumarins from p-Quinone Methides and o-Hydroxy Aldimines","authors":"Yingpeng Su,Qinqin Ling,Caixia Yang,Zhengang Han,Haiyang He,Shufang Zhang,Jinjin Chang,Xiaolong Zhao,Congde Huo,Xiaolei Wang","doi":"10.1021/acs.joc.5c02600","DOIUrl":"https://doi.org/10.1021/acs.joc.5c02600","url":null,"abstract":"A facile synthesis of dihydrocoumarin derivatives has been successfully accessed with ortho-hydroxyphenyl-substituted para-quinone methides (p-QMs) and ortho-hydroxy aromatic aldimines. The reaction proceeds through a Michael addition followed by an intramolecular phenolysis sequence. This cascade strategy provides structurally diverse 4-aryl-3,4-dihydrocoumarins in good to excellent yields with excellent diastereoselectivity. Moreover, this versatile method exhibits significant promise for the synthesis of natural products and biologically relevant compounds that possess a substituted coumarin skeleton.","PeriodicalId":57,"journal":{"name":"Journal of Organic Chemistry","volume":"8 1","pages":""},"PeriodicalIF":4.354,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146097889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ke-Xin Huang,Ke-Xin Zhang,Cai-Jing Li,Ji-Ling Tan,Chang-Yin Li,Zhao-Yang Chen,Xue-Guo Liu
We have developed an efficient Pd-catalyzed tandem allylic substitution reaction for the synthesis of six-membered ring nucleoside analogues. This strategy employs α-purine-substituted acetophenones (α-purine-substituted acetone) as challenging dinucleophiles, which react with 2-methylenepropane-1,3-diyl diacetate to afford the corresponding products in high yields (up to 91%) across a broad range of substrates (21 examples). The use of commercially available catalysts, a broad substrate scope, and the potential application value of the products make this approach highly attractive and pioneering in the field.
{"title":"Synthesis of Six-Membered Ring Nucleoside Analogues through the Palladium-Catalyzed Tandem Allylic Substitution Reaction","authors":"Ke-Xin Huang,Ke-Xin Zhang,Cai-Jing Li,Ji-Ling Tan,Chang-Yin Li,Zhao-Yang Chen,Xue-Guo Liu","doi":"10.1021/acs.joc.5c02941","DOIUrl":"https://doi.org/10.1021/acs.joc.5c02941","url":null,"abstract":"We have developed an efficient Pd-catalyzed tandem allylic substitution reaction for the synthesis of six-membered ring nucleoside analogues. This strategy employs α-purine-substituted acetophenones (α-purine-substituted acetone) as challenging dinucleophiles, which react with 2-methylenepropane-1,3-diyl diacetate to afford the corresponding products in high yields (up to 91%) across a broad range of substrates (21 examples). The use of commercially available catalysts, a broad substrate scope, and the potential application value of the products make this approach highly attractive and pioneering in the field.","PeriodicalId":57,"journal":{"name":"Journal of Organic Chemistry","volume":"117 1","pages":""},"PeriodicalIF":4.354,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146097895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The reactions of NH-enaminones with dichloromethane (DCM) leading to the synthesis of methylene-bridged bis-enaminones have been realized under redox neutral conditions wherein the DCM acts as both the reaction medium and methylene donor. The substrates of bulk chemical DCM and easily accessible enaminones make the present method rather practical, thus enabling the efficient synthesis of methylene-bridged bis-pyrazoles via simple condensation of the methylene-bridged bis-enaminones with hydrazines under acid promotion.
{"title":"Dichloromethane as a Carbon Source for the Base Promoted Synthesis of Methylene-Bridged Bis-Enaminones and Bis-Pyrazoles","authors":"Wanting Liang,Jingyan Liu,Jie-Ping Wan,Yunyun Liu","doi":"10.1021/acs.joc.5c02633","DOIUrl":"https://doi.org/10.1021/acs.joc.5c02633","url":null,"abstract":"The reactions of NH-enaminones with dichloromethane (DCM) leading to the synthesis of methylene-bridged bis-enaminones have been realized under redox neutral conditions wherein the DCM acts as both the reaction medium and methylene donor. The substrates of bulk chemical DCM and easily accessible enaminones make the present method rather practical, thus enabling the efficient synthesis of methylene-bridged bis-pyrazoles via simple condensation of the methylene-bridged bis-enaminones with hydrazines under acid promotion.","PeriodicalId":57,"journal":{"name":"Journal of Organic Chemistry","volume":"40 1","pages":""},"PeriodicalIF":4.354,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146098073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Transition metal (TM)-catalyzed direct C–H amination on free and fused pyridines is challenging, while it is much easier for their N-oxide derivatives. Unfortunately, most TM-catalysis is commonly used for nondeoxyamination and often limited to specific N-oxide and amine substrates. We herein disclose a combination of a copper(I) catalyst and dppf for deoxygenated oxidative C–N coupling of azine N-oxides to realize facile aminations on their parent azines, wherein dppf plays a crucial role in the deoxygenation step in the catalytic cycle. Moreover, this protocol tolerates a wider variety of N-oxides and free alicyclic amines to promise broader application potential.
过渡金属（TM）催化游离吡啶和熔融吡啶的直接C-H胺化是具有挑战性的，而它们的n -氧化物衍生物则容易得多。不幸的是，大多数tm催化通常用于非脱氧胺化，并且通常仅限于特定的n -氧化物和胺底物。我们在此公开了一种铜(I)催化剂与dppf的组合，用于azine n -氧化物的脱氧氧化C-N偶联，以实现其母体azine上的易胺化，其中dppf在催化循环中的脱氧步骤中起关键作用。此外，该方案可耐受更广泛的n -氧化物和游离脂环胺，以保证更广泛的应用潜力。
{"title":"One-Step Deoxygenated Oxidative C–N Coupling of Azine N-Oxides with Alicyclic Amines via Copper(I) Catalyst-dppf Cooperation","authors":"Yanrui Wang,Weiqi Zhu,Jiangbin Yang,Zihui Lu,Yu Ding,Jianchun Wang,Honghua Rao","doi":"10.1021/acs.joc.5c02699","DOIUrl":"https://doi.org/10.1021/acs.joc.5c02699","url":null,"abstract":"Transition metal (TM)-catalyzed direct C–H amination on free and fused pyridines is challenging, while it is much easier for their N-oxide derivatives. Unfortunately, most TM-catalysis is commonly used for nondeoxyamination and often limited to specific N-oxide and amine substrates. We herein disclose a combination of a copper(I) catalyst and dppf for deoxygenated oxidative C–N coupling of azine N-oxides to realize facile aminations on their parent azines, wherein dppf plays a crucial role in the deoxygenation step in the catalytic cycle. Moreover, this protocol tolerates a wider variety of N-oxides and free alicyclic amines to promise broader application potential.","PeriodicalId":57,"journal":{"name":"Journal of Organic Chemistry","volume":"34 1","pages":""},"PeriodicalIF":4.354,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146098074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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