Nitric oxide-cyclic guanosine 3',5'-monophosphate (cGMP)-cGMP dependent protein kinase signaling pathway is a key mechanism for the modulation of vascular function. The progress in this area of recent years was briefly summarized in this article, in particular, regarding the redox-dependent dimerization of the relevant signaling molecules and their physiological significance as well as the role of soluble guanylyl cyclase-derived cyclic inosine 3',5'-monophosphate as a new messenger for vasoconstriction.
{"title":"[Nitric Oxide Signaling Pathway and Vascular Activity].","authors":"Yuan-Sheng Gao","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Nitric oxide-cyclic guanosine 3',5'-monophosphate (cGMP)-cGMP dependent protein kinase signaling pathway is a key mechanism for the modulation of vascular function. The progress in this area of recent years was briefly summarized in this article, in particular, regarding the redox-dependent dimerization of the relevant signaling molecules and their physiological significance as well as the role of soluble guanylyl cyclase-derived cyclic inosine 3',5'-monophosphate as a new messenger for vasoconstriction.</p>","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":"48 1","pages":"58-62"},"PeriodicalIF":0.0,"publicationDate":"2017-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36243604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hydrogen sulfide (H2S),a colorless gas with a characteristic rotten-egg odor, has traditionally been considered to be a toxic environmental pollutant. Recently, a multitude of works have demonstrated that H2S was identified as the third gaseous signaling molecule alongside nitric oxide and carbon monoxide. Similar to other gaseous signaling molecules,H2S playeda pivotal role in the pathophysiological processes of cardiovascular disease due to its various biological activities, including anti-oxidative, antiapoptotic, proangiogenic, vasodilating capacities, modulating endothelial nitric oxide synthase activity, and so on. However, the mechanisms of H2S underlying the process remained unclear. In the present review, we summarized the current knowledge on the regulatory effects of H2S on disorders of immune inflammation in cardiovascular disease and underlying molecular mechanisms. A better understanding of the biochemical function of H2S might provide a new therapeutic strategy for cardiovascular diseases.
{"title":"[Role Ofhydrogen Sulfide on Inflammatory Immune Disorders in Cardiovascular Diseases].","authors":"Li-Long Pan, Xin-Hua Liu, Yi-Zhun Zhu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Hydrogen sulfide (H2S),a colorless gas with a characteristic rotten-egg odor, has traditionally been considered to be a toxic environmental pollutant. Recently, a multitude of works have demonstrated that H2S was identified as the third gaseous signaling molecule alongside nitric oxide and carbon monoxide. Similar to other gaseous signaling molecules,H2S playeda pivotal role in the pathophysiological processes of cardiovascular disease due to its various biological activities, including anti-oxidative, antiapoptotic, proangiogenic, vasodilating capacities, modulating endothelial nitric oxide synthase activity, and so on. However, the mechanisms of H2S underlying the process remained unclear. In the present review, we summarized the current knowledge on the regulatory effects of H2S on disorders of immune inflammation in cardiovascular disease and underlying molecular mechanisms. A better understanding of the biochemical function of H2S might provide a new therapeutic strategy for cardiovascular diseases.</p>","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":"48 1","pages":"30-6"},"PeriodicalIF":0.0,"publicationDate":"2017-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36244595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Di Wu, Ze-Mei Zhu, Si-Si Yang, Shui-Dong Feng, Hong-Yan Ling
{"title":"[Notch signaling: A new regulator of metabolism].","authors":"Di Wu, Ze-Mei Zhu, Si-Si Yang, Shui-Dong Feng, Hong-Yan Ling","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":"47 6","pages":"459-63"},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36215445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Noncoding RNAs, including long noncoding RNAs (IncRNAs) and microRNAs (miRNAs), are close to myogenesis, regulating of muscle fiber type and muscle diseases. Recently, circulating ncRNAs have become research focus for they could as potential biomarkers for the screening and early diagnosis of some diseases. We are confident that the role of nccoding RNAs during skeletal muscle development will bring potential target for treatment of muscle diseases in the future.
{"title":"[Regulative Role For Noncoding RNAs During Skeletal Muscle Development and Disease].","authors":"Sheng-Ju Chen, Fei Wang, Yue Zhou, Xiao-Ping Chen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Noncoding RNAs, including long noncoding RNAs (IncRNAs) and microRNAs (miRNAs), are close to myogenesis, regulating of muscle fiber type and muscle diseases. Recently, circulating ncRNAs have become research focus for they could as potential biomarkers for the screening and early diagnosis of some diseases. We are confident that the role of nccoding RNAs during skeletal muscle development will bring potential target for treatment of muscle diseases in the future.</p>","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":"47 6","pages":"401-6"},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36216005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Exercises participate in dialogues between gut microbiota and the immune system].","authors":"Chun-Yan Li, Su-Jie Zhang, Rui Li","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":"47 6","pages":"473-7"},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36215443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Research advances on effect of high density lipoprotein to the part of microbial infections].","authors":"Zhen-Wang Zhao, Chao-Ke Tang","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":"47 6","pages":"425-9"},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36216017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Regulatory networks of non-coding RNAs in the development of brown/beige adipocytes].","authors":"Si-Si Yang, Di Wu, Jian-Qian He, Ze-Mei Zhu, Shui-Dong Feng, Hong-Yan Ling","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":"47 6","pages":"439-44"},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36216019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Skeletal muscle repair after injury includes three stages which are inflammation, repair and tissue remodeling. The ability of Skeletal muscle to regenerate in response to injury is solely dependen on the activation, proliferation and differentiation of satellite cells. After skeletal muscle injury, hepatocyte growth factor (HGF) can regular muscle satellite cell function in the manner of autocrine, paracrine or endocrine, thus affecting the regeneration of damaged skeletal muscle. Studies about the mechanism have shown that HGF may bind to its receptor, e-met, to start the relevant signaling pathways involved in skeletal muscle satellite cell activation, proliferation, differentiation and migration, which affects skeletal muscle regeneration process.
{"title":"[The Role of Hepatocyte Growth Factor in Keletal Muscle Regeneration]","authors":"Li-Fang Zheng, Pei-Jie Chen, Wei-Hua Xiao","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Skeletal muscle repair after injury includes three stages which are inflammation, repair and tissue remodeling. The ability of Skeletal muscle to regenerate in response to injury is solely dependen on the activation, proliferation and differentiation of satellite cells. After skeletal muscle injury, hepatocyte growth factor (HGF) can regular muscle satellite cell function in the manner of autocrine, paracrine or endocrine, thus affecting the regeneration of damaged skeletal muscle. Studies about the mechanism have shown that HGF may bind to its receptor, e-met, to start the relevant signaling pathways involved in skeletal muscle satellite cell activation, proliferation, differentiation and migration, which affects skeletal muscle regeneration process.</p>","PeriodicalId":58541,"journal":{"name":"生理科学进展","volume":"47 6","pages":"407-12"},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36216010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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